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| 1 | 颈动脉血管重构患者核因子κB的变化及意义显示文摘目的探讨颈动脉血管重构患者核因子(NF)-κB的变化及意义。方法对老年体检人员血管行超声检测,选择38例具有颈动脉硬化血管重构者为研究对象(颈动脉重构组),以同龄颈动脉正常的老年人36例为对照组。常规检测心电图、胸片、血液生化等指标,同时用免疫组化方法检测外周血单核细胞NF-κB活化表达率。用直线回归分析法探讨颈动脉血管重构与NF-κB活化率的相关性。结果 1颈动脉重构组与对照组比较,颈动脉内径较对照组增宽,内膜-中层厚度(IMT)及斑块积分显著增加。2颈动脉重构组外周血单核细胞NF-κB活化率显著高于对照组(P<0.05)。3颈动脉重构组NF-κB水平与颈动脉IMT、颈动脉斑块积分呈显著正相关。结论颈动脉重构与NF-κB活化率密切相关,NF-κB可能参与了颈动脉重构及粥样斑块形成的过程。 | 郑舒展 李郁 罗兴林 | 2015 | 中国老年学杂志2015，35，7： | 1 |
| 2 | Vasoprotective effects of rice bran water extract on rats fed with high-fat diet显示文摘Objective:To elucidate the protective effects of rice bran water extract on the expression of endothelial nitric oxide synthase(e NOS),nuclear factor-kappa B(NF-k B),and a cluster of differentiation 36(CD36) in the vasculature of high-fat diet-fed rats.Methods:Male Sprague-Dawley rats were divided into three groups.Group I served as control,Group II was treated with high-fat diet,and Group III was treated with high-fat diet and rice bran water extract at 2 205 mg/kg/day.After four weeks,the metabolic parameters,malondialdehyde as a marker of oxidative stress,and histological features of the aorta were evaluated.The levels of transcripts and proteins in aorta were determined by real-time PCR and Western blot analysis,respectively.Results:In comparison with the Group II,rice bran water extract administration resulted in a significant reduction in body weight,visceral fat tissue weights,blood glucose levels,and serum total-cholesterol and free fatty acid levels in Group III.Serum triglyceride levels tended to decrease in the Group III.Also,rice bran water extract administration obviously decreased malondialdehyde levels in both serum and aorta.Interestingly,rice bran water extract treatment demonstrated a significant up-regulation of e NOS expression and down-regulation of NF-k B p65 and CD36 expressions.Nonetheless,all groups showed normal histology of aorta.Conclusions:Rice bran water extract exhibited vasoprotective effects in the high-fat diet-induced obesity condition by modulating the expression of e NOS,NF-kB,and CD36 and metabolic parameters. | Narongsuk Munkong Pintusorn Hansakul Bhornprom Yoysungnoen Ariyaphong Wongnoppavich Seewaboon Sireeratawong Noppamat Kaendee Nusiri Lerdvuthisopon | 2016 | Asian Pacific Journal of Tropical Biomedicine2016，6，9： | 0 |
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