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| 1 | 3DPMD-Arc-based additive manufacturing with titanium powder as raw material显示文摘The study aims to demonstrate the suitability of the 3DPMD for the production of titanium components with and without reinforcing particles in layer-by-layer design. Various demonstrators are prepared and analyzed. The microstructure, the porosity and the hardness values of the different structures are compared with each other through metallographic cross-sections. The uniform distribution of the carbides and the interaction with the matrix was analyzed by SEM and EDX.The miller-test method(ASTM G75-07) was used to determine data for the relative abrasivity of the structures. In summary, 3DPMD offers the possibility to produce titanium structures with and without reinforced particles. Using automated routines, it is possible to generate metal structures using welding robots directly from the CAD drawings. Microstructures and properties are directly related to the process and therefore material-process-property relationships are discussed within this work. | Hoefer Kevin Mayr Peter | 2019 | China Welding2019，28，1： | 12 |
| 2 | Role of interleukin-1 and its antagonism of hepatic stellate cell proliferation and liver fibrosis in the Abcb4^(-/-) mouse model显示文摘AIM: To study the interleukin-1(IL-1) pathway as a therapeutic target for liver fibrosis in vitro and in vivo using the ATP-binding cassette transporter b4^(-/-)(Abcb4^(-/-)) mouse model.METHODS: Female and male Abcb4^(-/-) mice from 6 to 13 mo of age were analysed for the degree of cholestasis(liver serum tests), extent of liver fibrosis(hydroxyproline content and Sirius red staining) and tissue-specific activation of signalling pathways such as the IL-1 pathway [quantitative polymerase chain reaction(q PCR)]. For in vivo experiments, murine hepatic stellate cells(HSCs) were isolated via pronasecollagenase perfusion followed by density gradient centrifugation using female mice. Murine HSCs were stimulated with up to 1 ng/m L IL-1β with or without 2.5 μg/m L Anakinra, an IL-1 receptor antagonist, respectively. The proliferation of murine HSCs was assessed via the Brd U assay. The toxicity of Anakinra was evaluated via the fluorescein diacetate hydrolysis(FDH) assay. In vivo 8-wk-old Abcb4^(-/-) mice with an already fully established hepatic phenotype were treated with Anakinra(1 mg/kg body-weight daily intraperitoneally) or vehicle and liver injury and liver fibrosis were evaluated via serum tests, q PCR, hydroxyproline content and Sirius red staining. RESULTS: Liver fibrosis was less pronounced in males than in female Abcb4^(-/-) animals as defined by a lower hydroxyproline content(274 ± 64 μg/g vs 436 ± 80 μg/g liver, respectively; n = 13-15; P < 0.001; MannWhitney U-test) and lower m RNA expression of the profibrogenic tissue inhibitor of metalloproteinase-1(TIMP)(1 ± 0.41 vs 0.66 ± 0.33 fold, respectively; n = 13-15; P < 0.05; Mann-Whitney U-test). Reduced liver fibrosis was associated with significantly lower levels of F4/80 m RNA expression(1 ± 0.28 vs 0.71 ± 0.41 fold, respectively; n = 12-15; P < 0.05; Mann-Whitney U-test) and significantly lower IL-1β m RNA expression levels(1 ± 0.38 vs 0.44 ± 0.26 fold, respectively; n = 13-15; P < 0.001; Mann-Whitney U-test). No gender differences in the serum liver parameters [bilirubin; alanine aminotransferase(ALT); aspartate aminotransferase and alkaline phosphatase(AP)] were found. In vitro, the administration of IL-1β resulted in a significant increase in HSC proliferation [0.94 ± 0.72 arbitrary units(A.U.) in untreated controls, 1.12 ± 0.80 A.U. at an IL-1β concentration of 0.1 ng/m L and 1.18 ± 0.73 A.U. at an IL-1β concentration of 1 ng/m L in samples from n = 6 donor animals; P < 0.001; analyses of variance(ANOVA)]. Proliferation was reduced significantly by the addition of 2.5 μg/m L Anakinra(0.81 ± 0.60 A.U. in untreated controls, 0.92 ± 0.68 A.U. at an IL-1β concentration of 0.1 ng/m L, and 0.91 ± 0.69 A.U. at an IL-1β concentration of 1 ng/m L; in samples from n = 6 donor animals; P < 0.001; ANOVA) suggesting an anti-proliferative effect of this clinically approved IL-1 receptor antagonist. The FDH assay showed this dose to be non-toxic in HSCs. In vivo, Anakinra had no effect on the hepatic hydroxyprolinecontent, liver serum tests(ALT and AP) and profibrotic(collagen 1α1, collagen 1α2, transforming growth factor-β, and TIMP-1) and anti-fibrotic [matrix metalloproteinase 2(MMP2), MMP9 and MMP13 ] gene expression after 4 wk of treatment. Furthermore, the hepatic IL-1β and F4/80 m RNA expression levels were unaffected by Anakinra treatment.CONCLUSION: IL-1β expression is associated with the degree of liver fibrosis in Abcb4^(-/-) mice and promotes HSC proliferation. IL-1 antagonism shows antifibrotic effects in vitro but not in Abcb4^(-/-) mice. | Florian P Reiter Ralf Wimmer Lena Wottke Renate Artmann Jutta M Nagel Manuel O Carranza Doris Mayr Christian Rust Peter Fickert Michael Trauner Alexander L Gerbes Simon Hohenester Gerald U Denk | 2016 | World Journal of Hepatology2016，8，8： | 3 |
| 3 | Plasma MicroRNA Profiling Reveals Loss of Endothelial MiR-126 and Other MicroRNAs in Type 2 Diabetes显示文摘 | Anna Zampetaki Stefan Kiechl Ignat Drozdov Peter Willeit Ursula Mayr Marianna Prokopi Agnes Mayr Siegfried Weger Friedrich Oberhollenzer Enzo Bonora Ajay Shah Johann Willeit Manuel Mayr | 2010 | Circulation Research2010，，6： | 3 |
| 4 | Prospective Study on Circulating MicroRNAs and Risk of Myocardial Infarction显示文摘 | Anna Zampetaki Peter Willeit Lindsey Tilling Ignat Drozdov Marianna Prokopi Jean-Marie Renard Agnes Mayr Siegfried Weger Georg Schett Ajay Shah Chantal M. Boulanger Johann Willeit Philip J. Chowienczyk Stefan Kiechl Manuel Mayr | 2012 | Journal of the American College of Cardiology2012，，： | 2 |
| 5 | Osteoprotegerin Is a Risk Factor for Progressive Atherosclerosis and Cardiovascular Disease显示文摘 | Stefan Kiechl Georg Schett Gregor Wenning Kurt Redlich Martin Oberhollenzer Agnes Mayr Peter Santer Josef Smolen Werner Poewe Johann Willeit | 2004 | Circulation: Journal of the American Heart Association2004，，18： | 2 |
| 6 | EVA Assists in Collection Build ngv Using ILL Data for Patron-Driven Acquisition 显示文摘 | Ania LOpez Peter Mayr | | Interlending and Document Supply0，203，4： | 1 |
| 7 | Bristle-like integumentary structuws at the tail of the homed dinosaur Psittacosaurus 显示文摘 | Mayr G M Peters D S Plodowski G | 2002 | Naturwissenschafcen2002，89，： | 1 |
| 8 | Welding Advanced Martensitic Creep-Resistant Steels With Boron Containing Filler Metal显示文摘 | Susanne Baumgartner Gerhard Posch Peter Mayr | 2012 | Welding in the World2012，，7： | 1 |
| 9 | Immune responses and protection against foot-and-mouth disease virus (FMDV) challenge in swine vaccinated with adenovirus-FMDV constructs显示文摘 | Gregory A Mayr Vivian O’Donnell Jarasvech Chinsangaram Peter W Mason Marvin J Grubman | 2001 | Vaccine2001，，： | 1 |
| 10 | STR analysis of artificially degraded DNA-results of a collaborative European exercise 显示文摘 | Peter MS Bender K Mayr WR | 2004 | Forensic Sci Int2004，139，： | 1 |
| 11 | Deficiency of the mitochondrial phosphate carrier presenting as myopathy and cardiomyopathy in a family with three affected children显示文摘 | Johannes A. Mayr Franz A. Zimmermann Rita Horváth Hans-Christian Schneider Benedikt Schoser Elke Holinski-Feder Birgit Czermin Peter Freisinger Wolfgang Sperl | 2011 | Neuromuscular Disorders2011，，11： | 1 |
| 12 | Transient -State and Steady-State Kinetic Studies of the Mechanism of NADPH-Dependent Aldehyde Reduction Catalyzed by Xylose Reductase from the Yeast Candida tenuis显示文摘 | Bernd Nidetzky Mario Klimacek Peter Mayr | 2001 | Biochemistry2001，40，10： | 1 |
| 13 | A well-preserved Archaeopteryx specimen with theropod features显示文摘 | MAYR G POHL B PETERS D S | 2005 | Science2005，310，： | 1 |
| 14 | Plasma MicroRNA Profiling Reveals Loss of Endothelial MiR-126 and Other MicroRNAs in Type 2 Diabetes显示文摘 | Anna Zampetaki Stefan Kiechl Ignat Drozdov Peter Willeit Ursula Mayr Marianna Prokopi Agnes Mayr Siegfried Weger Friedrich Oberhollenzer Enzo Bonora Ajay Shah Johann Willeit Manuel Mayr | 2010 | Circulation Research2010，，6： | 1 |
| 15 | Immune responses and protection against foot-and-mouth disease virus (FMDV) challenge in swine vaccinated with adenovirus-FMDV constructs显示文摘 | Gregory A Mayr Vivian O’Donnell Jarasvech Chinsangaram Peter W Mason Marvin J Grubman | 2001 | Vaccine2001，，15： | 1 |
| 16 | 采用电子能量损失谱成像技术对富铬钢的析出相进行综合分析显示文摘本文采用先进的扫描透射电子显微镜方法,研究含Cr为9%的硼合金化钢在热处理过程和蠕变测试过程中的微观组织的演变规律,并对于硼元素的作用进行了重点探讨。通过扫描透射电子显微镜获得的电子能量损失谱图像能提供具有高的空间和能量分辩率的碳、氮、铁、铬、钒的组成定量图(单位为atoms/nm3),这些图包含了丰富的元素信息。对包含在M23(C,B)6颗粒中的MX析出相进行了鉴定,并分析了其中的硼含量。为了识别氮化钒颗粒向复杂的氮化物(改性Z相)的早期转变过程,通过应用二元直方图分析对能量过滤透射电子显微镜(TEM)的元素图谱进行处理。另外,该研究绘制了蠕变检测样品的原奥氏体晶界图,并通过能量过滤透射电子显微镜,电子能量损失和X射线光谱图对析出相进行了鉴别。 | ALBU Mihaela MAYR Peter HOFER Ferdinand KOTHLEITNER Gerald | 2012 | 冶金分析2012，32，12： | 0 |
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