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| 1 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 2 | Fluorescence kinetics of aqueous solutions of tetracycline and its complexes with Mg^3+ and Ca^2+ 显示文摘 | SIEGFRIED S MATTHIAS O S GEORG B | 2003 | Photochem Photobiol Sci2003，2，11： | 1 |
| 3 | All-ceramic posts and cores:The state of the art显示文摘 | Spiros O Koutayas Matthias Kern | 1999 | Quintessence International1999，6，30： | 1 |
| 4 | Acrylamide: more than just another food toxicant? 显示文摘 | KARL E MATTHIAS O | 2003 | Eur J Pediatr2003，162，： | 1 |
| 5 | Combining Laser Chemical Processing and Aerosol Jet Printing:a Laboratory Scale Feasibility Study显示文摘 | DREW Kristine HOPMAN Sybille H(..O)RTEIS Matthias | | 0，，： | 1 |
| 6 | Histone deacetylase inhibitors: Signalling towards p21cip1/waf1显示文摘 | Matthias O Regine S | 2007 | The Int J BiochemCell Biol2007，39，： | 1 |
| 7 | FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex显示文摘 | Marta Muzio Arul M Chinnaiyan Frank C Kischkel Karen O’Rourke Andrej Shevchenko Jian Ni Carsten Scaffidi James D Bretz Mei Zhang Reiner Gentz Matthias Mann Peter H Krammer Marcus E Peter Vishva M Dixit | 1996 | Cell1996，，： | 1 |
| 8 | Influence of preoperative skin sealing with cyanoacrylate on microbial contamination of surgical wounds following trauma surgery: a prospective ,blinded ,controlled observational study显示文摘 | Georg D Matthias N O jan A | 2014 | International Journal of Infectious Diseases2014，29，12： | 1 |
| 9 | FIRMS:A Mapping System for Future Internet Routing显示文摘 | MICHAEL M MATTHIAS H MICHAEL H(o)fling | | 0，，08： | 1 |
| 10 | Efficacy of hyperventilation,blood pressure elevation,and metabolic suppression therapy in controlling intracranial pressure after head injury显示文摘 | Matthias O | 2002 | J Neurosurgery2002，97，5： | 1 |
| 11 | High-Temperature Contact Formation on n-Type Silicon:Basic Reactions and Contact Model for Seed-Layer Contacts显示文摘 | Matthias H(o)rteis Tobias Gutberlet Armin Reller | 2010 | Advanced Functional Materials2010，20，3： | 1 |
| 12 | Investigation of physical and chemical property changes of ultra low-k SiOCH in aspect of cleaning and chemical repair processes 显示文摘 | THOMAS O MATTHIAS S DANIEL F | 2010 | Micro- electronic Engineering2010，87，1： | 1 |
| 13 | Intracellular and intraalveolar localization of surfactant protein A (SP- A ) in the parenchymal region of the human lung显示文摘 | Matthias O Georg J Klaus - Michael M | 2002 | Am J Respir Cell Mol Biol2002，26，1： | 1 |
| 14 | Efficacy of hyperventilation,blood pressure elevation,and metabolic suppression therapy in controlling intracranial pressure after head injury显示文摘 | Matthias O | 2002 | J Neurosurgery2002，97，5： | 1 |
| 15 | Conversion of biliver- din to bilirubin by biliverdin reductase contributes to endotheli- al cell protection by heine oxygenase -1 evidence for direct and indirect antioxidant actions ofbilirubin 显示文摘 | Thomas J Marcus H Matthias O | 2010 | Orig J Mel cell Car-diol2010，49，2： | 1 |
| 16 | PrPc capping in T cells promotes its association with the lipid raft proteins reggie-1 and reggie-2 and leads to signal transduction显示文摘 | Claudia A O S Matthias F L Marianne F W | 2004 | The Faseb Journal2004，9，2： | 1 |
| 17 | Influence of catecholamines on cytokine production and expression of adhesion molecules of human neutrophils in vitro 显示文摘 | Matthias Wahle Timm Greulich Christoph G O Baerwald | 2005 | Immunobiology2005，210，1： | 1 |
| 18 | Laparoscopy in patients over 60 years old: a prospective, randomized evaluation of laparoscopic versus open adnexectomy显示文摘 | Buchweitz O Matthias S Muller-Steinhardt M | 2005 | Am J Obstet Gynecol2005，193，4： | 1 |
| 19 | Pharmacological Characterization of SAR407899, a Novel Rho-Kinase Inhibitor显示文摘 | Matthias L?hn Oliver Plettenburg Yuri Ivashchenko Aimo Kannt Armin Hofmeister Dieter Kadereit Matthias Schaefer Wolfgang Linz Markus Kohlmann Jean-Marc Herbert Philip Janiak Stephen E. O’Connor Hartmut Ruetten | 2009 | Hypertension2009，，3： | 1 |
| 20 | Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis显示文摘 | Andrew G Renehan Marcel Zwahlen Christoph Minder Sarah T O’Dwyer Stephen M Shalet Matthias Egger | 2004 | The Lancet2004，，9418： | 1 |
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