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| 1 | The Qitai radio telescope显示文摘This study presents a general outline of the Qitai radio telescope(QTT)project.Qitai,the site of the telescope,is a county of Xinjiang Uygur Autonomous Region of China,located in the east Tianshan Mountains at an elevation of about 1800 m.The QTT is a fully steerable,Gregorian-type telescope with a standard parabolic main reflector of 110 m diameter.The QTT has adopted an umbrella support,homology-symmetric lightweight design.The main reflector is active so that the deformation caused by gravity can be corrected.The structural design aims to ultimately allow high-sensitivity observations from 150 MHz up to115 GHz.To satisfy the requirements for early scientific goals,the QTTwill be equipped with ultra-wideband receivers and large field-of-view multi-beam receivers.A multi-function signal-processing system based on RFSo C and GPU processor chips will be developed.These will enable the QTT to operate in pulsar,spectral line,continuum and Very Long Baseline Interferometer(VLBI)observing modes.Electromagnetic compatibility(EMC)and radio frequency interference(RFI)control techniques are adopted throughout the system design.The QTT will form a world-class observational platform for the detection of lowfrequency(nano Hertz)gravitational waves through pulsar timing array(PTA)techniques,pulsar surveys,the discovery of binary black-hole systems,and exploring dark matter and the origin of life in the universe.The QTT will also play an important role in improving the Chinese and international VLBI networks,allowing high-sensitivity and high-resolution observations of the nuclei of distant galaxies and gravitational lensing systems.Deep astrometric observations will also contribute to improving the accuracy of the celestial reference frame.Potentially,the QTT will be able to support future space activities such as planetary exploration in the solar system and to contribute to the search for extraterrestrial intelligence. | Na Wang Qian Xu Jun Ma Zhiyong Liu Qi Liu Hailong Zhang Xin Pei Maozheng Chen Richard N.Manchester Kejia Lee Xingwu Zheng Hans J.Kärcher Wulin Zhao Hongwei Li Dongwei Li Martin Süss Matthias Reichert Zhongyi Zhu Congsi Wang Mingshuai Li Rui Li Ning Li Guljaina Kazezkhan Wenming Yan Gang Wu Lang Cui Ming Zhang Haitao Li | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，8： | 14 |
| 2 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 3 | Fluorescence kinetics of aqueous solutions of tetracycline and its complexes with Mg^3+ and Ca^2+ 显示文摘 | SIEGFRIED S MATTHIAS O S GEORG B | 2003 | Photochem Photobiol Sci2003，2，11： | 1 |
| 4 | Anti -angiogenic treatment strategies for malignant brain tumor 显示文摘 | Matthias K Gabriele S Peter McB | 2000 | J Neuro Oncol2000，50，： | 1 |
| 5 | Dispersion of a dense cylindrical cloud in a calm atmosphere显示文摘 | Matthias C S | 1990 | Journal of Hazardous Materials1990，，24： | 1 |
| 6 | Dendritic cell vaccination:new hope for the treatment of metastasized endocrine malignancies显示文摘 | Matthias S Jochen S | 2003 | Ternd Endocrinol Metab2003，14，4： | 1 |
| 7 | The network of psychological variables in patients with diabetes and their importance for quality oflife and metabolic control显示文摘 | Thea S Herbert F | 2002 | Diabetes Care2002，25，1： | 1 |
| 8 | Inflammatory cytokines and the risk to develop type 2 diabetes:results of the prospective population-based european prospective investigation into cancer and nutrition (EPIC)-Potsdam study显示文摘 | JOACHIM S ANJA K MATTHIAS M | 2003 | Diabetes2003，52，3： | 1 |
| 9 | Dispersion of a dense cylindrical cloud in a turbulent atmosphere显示文摘 | Matthias C S | 1992 | Journal of Hazardous Materials1992，30，2： | 1 |
| 10 | Dietary patterns and their association with food and nutrient intake in the European Prospective Investigation into Cacer and Nutrition-Potsdam study显示文摘 | Matthias B S | 2001 | British Journal of Nutrition2001，85，： | 1 |
| 11 | Long-term biocompat-ibility of a corrodible peripheral iron stent in the porcinedescending aorta 显示文摘 | Matthias PXarola H Tirza S | 2006 | Biomaterials2006，27，28： | 1 |
| 12 | Measuring optimistic self-beliefs:a Chinese adaptation of the general self-efficacy scale显示文摘 | ZHANG J X RALF S MATTHIAS J | 1995 | Journal of Applied Psychology1995，38，3： | 1 |
| 13 | Histone deacetylase inhibitors: Signalling towards p21cip1/waf1显示文摘 | Matthias O Regine S | 2007 | The Int J BiochemCell Biol2007，39，： | 1 |
| 14 | Wall material and capping effects on microlysimeter temperatures and evaporation显示文摘 | Evett S R Warrick A W Matthias A D | 1995 | Soil Science Society of America Journal1995，59，2： | 1 |
| 15 | Individual versus group behavior and the role of the decision making procedure in gift-exchange experiments 显示文摘 | Kocher M G Matthias S | 2007 | Empirical2007，34，： | 1 |
| 16 | Individual versus group behavior and the role of the decision making procedure in gift-exchange experiments显示文摘 | Kocher M G Matthias S | 2007 | Empirica2007，34，1： | 1 |
| 17 | Xyr1 receives the lactose induction signal and regulates lactose metabolism in Hypocereajecorina 显示文摘 | Astrid R S Matthias G S | 2007 | FEBS Letters2007，581，21： | 1 |
| 18 | Rsbu-Dependent regulation of Staphylococcus epidermidis biofilm formation is mediated via the alternative sigma factor σB by repression of the negative regulator gene icaR显示文摘 | Knobloch JK-M Jager S Matthias | 2004 | Infect Immun2004，72，7： | 1 |
| 19 | Efficient global optimization of expensive black-box functions显示文摘 | Donald R J Matthias S William J W | 1998 | Journal of Global Optimization1998，13，4： | 1 |
| 20 | Protein kinase A- mediated phosphorylation of the RASSF1A tumour suppressor at Serine 203 and regulation of RASSF1A function显示文摘 | Richter AM Undraga S Matthias R et aI | 2010 | Europe- an Journal of Cancer2010，46，： | 1 |
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