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| 1 | Ketogenic diet alleviates colitis by reduction of colonic group 3 innate lymphoid cells through altering gut microbiome显示文摘Accumulating evidence suggests that ketogenic diets(KDs)mediate the rise of circulating ketone bodies and exert a potential antiinflammatory effect;however,the consequences of this unique diet on colitis remain unknown.We performed a series of systematic studies using a dextran sulfate sodium(DSS)animal model of inflammatory colitis.Animals were fed with a KD,low-carbohydrate diet(LCD),or normal diet(ND).Germ-free mice were utilized in validation experiments.Colon tissues were analyzed by transcriptome sequencing,RT2 profiler PCR array,histopathology,and immunofluorescence.Serum samples were analyzed by metabolic assay kit.Fecal samples were analyzed by 16S rRNA gene sequencing,liquid chromatography-mass spectrometry and gas chromatography-mass spectrometry.We observed that KD alleviated colitis by altering the gut microbiota and metabolites in a manner distinct from LCD.Quantitative diet experiments confirmed the unique impact of KD relative to LCD with a reproducible increase in Akkermansia,whereas the opposite was observed for Escherichia/Shigella.After colitis induction,the KD protected intestinal barrier function,and reduced the production of R0Ryt+CD3_group 3 innate lymphoid cells(ILC3s)and related inflammatory cytokines(IL-17a,IL-18,IL-22,Ccl4).Finally,fecal microbiota transplantation into germ-free mice revealed that the KD-mediated colitis inhibition and ILC3 regulation were dependent on the modification of gut microbiota.Taken together,our study presents a global view of microbiome-metabolomics changes that occur during KD colitis treatment,and identifies the regulation of gut microbiome and ILC3s as novel targets involving in IBD dietary therapy. | Cheng Kong Xuebing Yan Yongqiang Liu Linsheng Huang Yefei Zhu Jide He Renyuan Gao Matthew F.Kalady Ajay Goel Huanlong Qin Yanlei Ma | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 8 |
| 2 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 3 | Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma显示文摘Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer(NSCLC)risk,biological mechanisms of these variants remain largely unknown.By integrating a large-scale genotype data of 15581 lung adenocarcinoma(AD)cases,8350 squamous cell carcinoma(SqCC)cases,and 27355 controls,as well as multiple transcriptome and epigenomic databases,we conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibility variants.We identified 3064 credible risk variants for NSCLC,which were overrepresented in enhancer-like and promoter-like histone modification peaks as well as DNase I hypersensitive sites.Transcription factor enrichment analysis revealed that USF1 was AD-specific while CREB1 was SqCC-specific.Functional annotation and genebased analysis implicated 894 target genes,including 274 specifics for AD and 123 for SqCC,which were overrepresented in somatic driver genes(ER=1.95,P=0.005).Pathway enrichment analysis and Gene-Set Enrichment Analysis revealed that AD genes were primarily involved in immune-related pathways,while SqCC genes were homologous recombination deficiency related.Our results illustrate the molecular basis of both wellstudied and new susceptibility loci of NSCLC,providing not only novel insights into the genetic heterogeneity between AD and SqCC but also a set of plausible gene targets for post-GWAS functional experiments. | Na Qin Yuancheng Li Cheng Wang Meng Zhu Juncheng Dai Tongtong Hong Demetrius Albanes Stephen Lam Adonina Tardon Chu Chen Gary Goodman Stig EBojesen Maria Teresa Landi Mattias Johansson Angela Risch H-Erich Wichmann Heike Bickeboller Gadi Rennert Susanne Arnold Paul Brennan John KField Sanjay Shete Loic Le Marchand Olle Melander Hans Brunnstrom Geoffrey Liu Rayjean JHung Angeline Andrew Lambertus AKiemeney Shan Zienolddiny Kjell Grankvist Mikael Johansson Neil Caporaso Penella Woll Philip Lazarus Matthew BSchabath Melinda CAldrich Victoria LStevens Guangfu Jin David CChristiani Zhibin Hu Christopher IAmos Hongxia Ma Hongbing Shen | 2021 | Frontiers of Medicine2021，15，2： | 3 |
| 4 | Diversification and phylogenetic correlation of functional traits for co-occurring understory species in the Chinese boreal forest显示文摘Functional traits impact species interactions,community composition,and ecosystem functioning.However,few studies have focused on the diversification and phylogenetic correlation of multiple functional traits over geological time.We conducted phylogenetic comparative analysis for boreal forest understory species in northeast China to examine the diversification and phylogenetic correlation in several functional traits:leaf area(LA),leaf carbon content(LCC),leaf dry matter content(LDMC),leaf nitrogen content(LNC),plant height(PH),and specific leaf area(SLA).Phylogenetic signals showed that there were very low levels of phylogenetic niche conservatism(PNC)in understory leaf-related traits and plant height,suggesting divergence of functional traits for the co-occurring understory species.The disparity through time analyses(DTT)indicated that trait disparities mainly originated during recent divergence events and there were no differences in the observed trait disparities compared with that expected under Brownian motion.Furthermore,we found both positive and negative phylogenetic correlations among the measured functional traits.The very low levels of PNC suggest that these functional traits diverged among co-occurring understory species,and that those species are distantly phylogenetically related.The phylogenetic correlations among traits may be caused by both positively and negatively correlated adaptions that correspond to resource acquisition strategies.This study provides evidence that divergence in functional traits may reflect understory adaptions to boreal conditions. | Bo Liu Jin-Long Zhang Matthew KLau Xu-Gao Wang Yu Liang Tian-Xiao Ma | 2023 | Journal of Systematics and Evolution2023，61，2： | 2 |
| 5 | Impact of liver cirrhosis on mortality in patients with community-acquired bacteremia显示文摘 | Shey-Ying Chen Chu-Lin Tsai Chien-Hao Lin Chien-Chang Lee Wen-Chu Chiang Jiun-Ling Wang Matthew Huei-Ming Ma Shyr-Chyr Chen Wen-Jone Chen Shan-Chwen Chang | 2009 | Diagnostic Microbiology & Infectious Disease2009，，2： | 1 |
| 6 | Effect of renal impair ment on the pharmacokinetics,efficacy,and safety of albiglutide显示文摘 | Yong MA Wald JA Matthews JE | 2014 | Postgrad M ed2014，126，3： | 1 |
| 7 | Letrozole in the neoadjuvant setting: the P024 trial显示文摘 | MATTHEW J CYNTHIA MA | 2007 | Breast Cancer Res Treat2007，105，1： | 1 |
| 8 | Safety,tolerability,pharmacodynamics and pharmacokinetics of albiglutide,a long-act-ing glucagon-like peptide-1 mimetic,in healthy subjects显示文摘 | Bush MA Matthews JE De Boever EH | 2009 | Diabetes Obes Metab2009，11，5： | 1 |
| 9 | Nitric oxide-mediated regulation of chemosensitivity in cancer cells显示文摘 | Matthews NE Adams MA Maxwell LR | 2001 | J Nail Cancer Inst2001，93，24： | 1 |
| 10 | Intravitreal Bevacizumab (Avastin) in the Treatment of Proliferative Diabetic Retinopathy显示文摘 | Robert L. Avery Joel Pearlman Dante J. Pieramici Melvin D. Rabena Alessandro A. Castellarin Ma’an A. Nasir Matthew J. Giust Robert Wendel Arun Patel | 2006 | Ophthalmology2006，，10： | 1 |
| 11 | Safety,tolerability,pharmacodynamics and pharmacokinetics of albiglutide,a long-acting glucagon-like peptide-1 mimetic,in healthy subjects显示文摘 | Bush MA Matthews JE De Boever EH | 2009 | Diabetes Obes M etab2009，11，5： | 1 |
| 12 | Weight loss with liraglufide, a once- daily htanan glucagon-like peptide-1 analogue for type 2 diabetes treamaent as monotheraqgy or added to mefformin, is primarily as a result of a reduction in fat tissue显示文摘 | Jendle J Nauek MA Matthews DR | 2009 | Diabetes Obes Metab2009，11，12： | 1 |
| 13 | Enhanced dendritic cell antigen capture via Toll-like receptor-induced aetin remodeling显示文摘 | West MA Wallin RP Matthews SP | 2004 | Science2004，305，5687： | 1 |
| 14 | Expression ratios of the Bcl-2 family proteins and disease activity in multiple sclerosis显示文摘 | Sharief MK Matthews H Noori MA | 2003 | J Neuroimmunol2003，134，12： | 1 |
| 15 | Nitric oxide-mediated regulation of chemosensitivity in cancer cells显示文摘 | Matthews NE Adams MA Maxwell LR | 2001 | J Natl Cancer Inst2001，93，24： | 1 |
| 16 | Synthesis of multiple Pseudomonas aeruginosa biofilm matrix exopolysaccharides is post‐transcriptionally regulated显示文摘 | Luyan Ma Juan Wang Shiwei Wang Erin M. Anderson Joseph S. Lam Matthew R. Parsek Daniel J. Wozniak | 2012 | Environmental Microbiology2012，，8： | 1 |
| 17 | A randomised crossover trial of chemotherapy in the home: patient preferences and cost analysis显示文摘 | Rischin D White MA Matthews JP | 2000 | Med J Australia2000，173，3： | 1 |
| 18 | Immediate short-duration hy- pothermia provides long-term protection in an in viw) model of trau- matic axonal injury显示文摘 | Ma M Matthews BT Lampe JW | 2009 | Exp Neurol2009，215，1： | 1 |
| 19 | Nitric oxide-mediated reg- ulation of chemosensitivity in cancer eells显示文摘 | Matthews NE Adams MA Maxwell LR | 2001 | J Natl Cancer Inst2001，93，24： | 1 |
| 20 | A randomised crossover trial of chemotherapy in the home: patient preferences and cost analysis显示文摘 | Rischin D White MA Matthews JP | 2000 | Med J Aust2000，173，3： | 1 |
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