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| 1 | Extensively drug-resistant bacteria are an independent predictive factor of mortality in 130 patients with spontaneous bacterial peritonitis or spontaneous bacteremia显示文摘AIM: To evaluate the epidemiology and outcomes of culture-positive spontaneous bacterial peritonitis(SBP) and spontaneous bacteremia(SB) in decompensated cirrhosis.METHODS: We prospectively collected clinical, laboratory characteristics, type of administered antibiotic, susceptibility and resistance of bacteria to antibiotics in one hundred thirty cases(68.5% males) with positive ascitic fluid and/or blood cultures during the period from January 1, 2012 to May 30, 2014. All patients with SBP had polymorphonuclear cell count in ascitic fluid > 250/mm3. In patients with SB a thorough study did not reveal any other cause of bacteremia. The patients were followed-up for a 30-d periodfollowing diagnosis of the infection. The final outcome of the patients was recorded in the end of follow-up and comparison among 3 groups of patients according to the pattern of drug resistance was performed.RESULTS: Gram-positive-cocci(GPC) were found in half of the cases. The most prevalent organisms in a descending order were Escherichia coli(33), Enterococcus spp(30), Streptococcus spp(25), Klebsiella pneumonia(16), S. aureus(8), Pseudomanas aeruginosa(5), other Gram-negative-bacteria(GNB)(11) and anaerobes(2). Overall, 20.8% of isolates were multidrug-resistant(MDR) and 10% extensively drugresistant(XDR). Health-care-associated(HCA) and/or nosocomial infections were present in 100% of MDR/XDR and in 65.5% of non-DR cases. Meropenem was the empirically prescribed antibiotic in HCA/nosocomial infections showing a drug-resistance rate of 30.7% while third generation cephalosporins of 43.8%. Meropenem was ineffective on both XDR bacteria and Enterococcus faecium(E. faecium). All but one XDR were susceptible to colistin while all GPC(including E. faecium) and the 86% of GNB to tigecycline. Overall 30-d mortality was 37.7%(69.2% for XDR and 34.2% for the rest of the patients)(log rank, P = 0.015). In multivariate analysis, factors adversely affecting outcome included XDR infection(HR = 2.263, 95%CI: 1.005-5.095, P = 0.049), creatinine(HR = 1.125, 95%CI: 1.024-1.236, P = 0.015) and INR(HR =1.553, 95%CI: 1.106-2.180, P = 0.011).CONCLUSION: XDR bacteria are an independent lifethreatening factor in SBP/SB. Strategies aiming at restricting antibiotic overuse and rapid identification of the responsible bacteria could help improve survival. | Alexandra Alexopoulou Larisa Vasilieva Danai Agiasotelli Kyriaki Siranidi Sophia Pouriki Athanasia Tsiriga Marina Toutouza Spyridon P Dourakis | 2016 | World Journal of Gastroenterology2016，22，15： | 19 |
| 2 | IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality显示文摘 | Zhang Hong Neuh?fer Patrick Song Liang Rabe Bj?rn Lesina Marina Kurkowski Magdalena U Treiber Matthias Wartmann Thomas Regnér Sara Thorlacius Henrik Saur Dieter Weirich Gregor Yoshimura Akihiko Halangk Walter Mizgerd Joseph P Schmid Roland | 2013 | Journal of Clinical Investigation2013，，3： | 2 |
| 3 | Insulin resistance impairs sustained response rate to peginterferon plus ribavirin in chronic hepatitis C patients显示文摘 | Manuel Romero-Gómez Maria Del Mar Viloria Raúl J. Andrade Javier Salmerón Moisés Diago Conrado M. Fernández-Rodríguez Raquel Corpas Marina Cruz Lourdes Grande Luis Vázquez Paloma Mu?oz-de-Rueda Pilar López-Serrano Ana Gila María L. Gutiérrez Celia Pérez A | 2005 | Gastroenterology2005，，3： | 2 |
| 4 | Analyzing predictors of graft survival in patients undergoing liver transplantation with donors aged 70 years and over显示文摘AIM To increase the number of available grafts.METHODS This is a single-center comparative analysis performed between April 1986 and May 2016. Two hundred and twelve liver transplantation(LT) were performed with donors ≥ 70 years old(study group). Then, we selected the first cases that were performed with donors < 70 years old immediately after the ones that were performed with donors ≥ 70 years old(control group).RESULTS Graft and patient survivals were similar between both groups without increasing the risk of complications, especially primary non-function, vascular complications and biliary complications. We identified 5 risk factors as independent predictors of graft survival: recipient hepatitis C virus(HCV)-positivity [hazard ratio(HR) = 2.35; 95% confidence interval(CI): 1.55-3.56; P = 0.00]; recipient age(HR = 1.04; 95%CI: 1.02-1.06; P = 0.00); donor age X model for end-stage liver disease(D-MELD)(HR = 1.00; 95%CI: 1.00-1.00; P = 0.00); donor value of serum glutamic-pyruvic transaminase(HR = 1.00; 95%CI: 1.00-1.00; P = 0.00); and donor value of serum sodium(HR = 0.96; 95%CI: 0.94-0.99; P = 0.00). After combining D-MELD and recipient age we obtained a new scoring system that we called DR-MELD(donor age X recipient age X MELD). Graft survival significantly decreased in patients with a DR-MELD score ≥ 75000, especially in HCV patients(77% vs 63% at 5 years in HCV-negative patients, P = 0.00; and 61% vs 25% at 5 years in HCV-positive patients; P = 0.00). CONCLUSION A DR-MELD ≥ 75000 must be avoided in order to obtain the best results in LT with donors ≥ 70 years old. | Oscar Caso-Maestro Carlos Jiménez-Romero Iago Justo-Alonso Jorge Calvo-Pulido David Lora-Pablos Alberto Marcacuzco-Quinto Félix Cambra-Molero Alvaro García-Sesma Marina Pérez-Flecha Carlos Munoz- Arce Carmelo Loinaz-Segurola Alejandro Manrique-Municio | 2018 | World Journal of Gastroenterology2018，24，47： | 2 |
| 5 | Porcine circovirus type 2 (PCV2) Cap and Rep proteins are involved in the development of cell-mediated immunity upon PCV2 infection显示文摘 | Maria Fort Marina Sibila Miquel Nofrarías Eva Pérez-Martín Alex Olvera Enric Mateu Joaquim Segalés | 2010 | Veterinary Immunology and Immunopathology2010，，3： | 2 |
| 6 | Renal agenesis and the absence of enteric neurons in mice lacking GDNF显示文摘 | SANCHEZ INMACULIDA SILOS SANTIAGO | 1996 | Nature1996，382，： | 1 |
| 7 | A topology control approach for utilizing multiple channels in multi-radio wireless Mesh networks显示文摘 | MARINA M K DAS S R SUBRAMANIAN A P | 2010 | Computer Networks2010，54，2： | 1 |
| 8 | Nitric oxide promotes proliferation and plasminogen activator production by coronary venular endothelium through endogenous bFGF显示文摘 | Astrid P Fabrizio L | 1997 | Circ Res1997，80，6： | 1 |
| 9 | On the behavior and ductility of reinforced concrete coupling beams of shear walls显示文摘 | Theodosios P Tassios Marina Moretti Antonios Bezas | 1996 | ACI Structural Journal1996，93，6： | 1 |
| 10 | Identification of native angiotensin-I converting enzyme inhibitory peptides in commercial soybean based infant formulas using HPLC-Q-ToF- MS 显示文摘 | PUCHALSKA P GARCLA M C MARINA M L | 2014 | Food Chemistry2014，157，： | 1 |
| 11 | A study of caffeine binding to human serum albumin显示文摘 | ANITA K MARINA K SLAVKO P GRETA P | 2005 | Croat Chem Acta2005，78，1： | 1 |
| 12 | A topology con- trol approach for utilizing multiple channels in multi-radio wireless mesh networks显示文摘 | MARINA M K DAS S R SUBRAMANIAN A P | 2010 | Computer Networks2010，54，2： | 1 |
| 13 | Contribution of electrospray mass spectromea'y for the characterization, design, and development of nitrido technetium and rhenium heterocomplexes as potential radiopharmaceuticals显示文摘 | Tisato F B Cristina P Marina F R | 2004 | Mass Spectrometry Reviews2004，23，5： | 1 |
| 14 | Inactivation of Mycobacterium avium with chlorine dioxide 显示文摘 | Vicuna-Reyes J P Luh J Marinas B J | 2008 | Water Res2008，42，67： | 1 |
| 15 | Interference in MTT cell viability assay in activated macrophage cell line显示文摘 | Marina P Sonia S Umberto B | 2003 | Anal Biochem2003，313，2： | 1 |
| 16 | Polymorphisms in exons 6 and 7 of the ABO locus and their association with venous thrombosis in young Brazilian patients显示文摘 | Sabrina G Paiva Adriano P Sabino Maria G Carvalho Daniel D Ribeiro Karina B Gomes Mariana S Santos Marina S Oliveira Geralda G Lages Luci MS Dusse Ana Paula Fernandes | 2009 | Blood Coagulation & Fibrinolysis2009，，2： | 1 |
| 17 | Adiponectin and Functional Adiponectin Receptor 1 Are Expressed by Airway Epithelial Ceils in Chronic Obstructive Pulmonary Disease 显示文摘 | Marina M Cho JY Alexa P | 2009 | The Journal of Immunology2009，182，： | 1 |
| 18 | A topology control approach for utilizing multiple channels in multi-radio wireless mesh networks显示文摘 | Marina M K Das S R Subramanian A P | 2010 | Computer Networks2010，54，2： | 1 |
| 19 | Stigmasterols from Typha latifolia显示文摘 | MARINA D G PIETRO M LUCIO P | 1990 | Journal of Natural Products1990，33，6： | 1 |
| 20 | ( Raphidophyceae ) Ichthyotoxicity of to damselfish (Acanthochromis polycanthus ) : the synergistic role of reactive oxygen species and free fatty acids显示文摘 | Marshall J A Nichols Chattonella marina P D Hamilton B | 2003 | Harmful Algae2003，2，4： | 1 |
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