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| 1 | Inverting the Classroom: A Gateway to Creating an Inclusive Learning Environment显示文摘 | MaureenJ. Lage GlennJ. Platt Michael Treglia | 2000 | The Journal of Economic Education2000，，1： | 17 |
| 2 | The Internet and the Inverted Classroom显示文摘 | MaureenJ. Lage Glenn Platt | 2000 | The Journal of Economic Education2000，，1： | 4 |
| 3 | New horizons for uncommon mutations in non-small cell lung cancer: BRAF, KRAS, RET, MET, NTRK, HER2显示文摘The 2004 discovery of EGFR mutations,followed by ALK rearrangements,ushered in a targeted therapy era for advanced non-small cell lung cancer(NSCLC).Tyrosine kinase inhibitors targeting gene alterations have substantially improved survival and quality of life for patients with NSCLC.In the last decade,rearrangements of the ROS1 oncogene have been incorporated into healthcare practice that are applicable to another small subgroup of patients who benefit from similar targeted strategies.Recent genome studies of lung adenocarcinoma have identified other possible therapeutic targets,including RET,NTRK fusions,c-MET alterations,and activating mutations in KRAS,BRAF,and HER2,all with frequencies greater than 1%.Lung cancers harbouring these genome changes can potentially be treated with agents approved for other indications or under clinical development.This review updates the therapeutic arsenal that especially targets those genes. | Maria Eugenia Olmedo Raquel Cervera Luis Cabezon-Gutierrez Yolanda Lage Elena Corral de la Fuente Ana Gomez Rueda1,Xabier Mielgo-Rubio Juan Carlos Trujillo Felipe Counago | 2022 | World Journal of Clinical Oncology2022，13，4： | 3 |
| 4 | Role of the prophenoloxidase-activating system in invertebrate immunity显示文摘 | Kenneth S?derh?ll Lage Cerenius | 1998 | Current Opinion in Immunology1998，，1： | 2 |
| 5 | Murine model to study brain,behavior and immunity during hepatic encephalopathy显示文摘AIM:To propose an alternative model of hepatic encephalopathy(HE) in mice,resembling the human features of the disease.METHODS:Mice received two consecutive intraperitoneal injections of thioacetamide(TAA) at low dosage(300 mg/kg).Liver injury was assessed by serum transaminase levels(ALT) and liver histology(hematoxylin and eosin).Neutrophil infiltration was estimated by confocal liver intravital microscopy.Coagulopathy was evaluated using prolonged prothrombin and partial thromboplastin time.Hemodynamic parameters were measured through tail cuff.Ammonia levels were quantified in serum and brain samples.Electroencephalography(EEG) and psychomotor activity score were performed to show brain function.Brain edema was evaluated using magnetic resonance imaging.RESULTS:Mice submitted to the TAA regime developed massive liver injury,as shown by elevation of serum ALT levels and a high degree of liver necrosis.An intense hepatic neutrophil accumulation occurred in response to TAA-induced liver injury.This led to mice mortality and weight loss,which was associated with severe coagulopathy.Furthermore,TAA-treated mice presented with increased serum and cerebral levels of ammonia,in parallel with alterations in EEG spectrum and discrete brain edema,as shown by magnetic resonance imaging.In agreement with this,neuropsychomotor abnormalities ensued 36 h after TAA,fulfilling several HE features observed in humans.In this context of liver injury and neurological dysfunction,we observed lung inflammation and alterations in blood pressure and heart rate that were indicative of multiple organ dysfunction syndrome.CONCLUSION:In summary,we describe a new murine model of hepatic encephalopathy comprising multiple features of the disease in humans,which may provide new insights for treatment. | Lindisley Ferreira Gomides Pedro Elias Marques Bruno Engler Faleiros Rafaela Vaz Pereira Sylvia Stella Amaral Thais Reis Lage Gustavo Henrique Souza Resende Patricia Alves Maia Guidine Giselle Foureaux Fabíola Mara Ribeiro Fabiana Paiva Martins Marco Antonio Peliky Fontes Anderson José Ferreira Remo Castro Russo Mauro Martins Teixeira Márcio Flávio Moraes Antonio Lúcio Teixeira Gustavo Batista Menezes | 2014 | World Journal of Hepatology2014，6，4： | 2 |
| 6 | Oral delivery of DNA vaccines using attenuated Salmonella typhimurium as carrier显示文摘 | Darji A zur Lage S Garbe A J | 2000 | FEMS Immunol Med Microbiol2000，27，4： | 1 |
| 7 | Supercritical fluid extraction and high -performance liquid chromatography -fluorescence detection method for pelycyclic aromatic hydrocarbons investigation in vegetable oil显示文摘 | Lage Yusty M A Cortizo Davina J L | 2005 | Food Control2005，16，： | 1 |
| 8 | Bethesda criteria for microsatellite instability testing: impact on the detection of new cases of Lynch syn- drome显示文摘 | Serrano M Lage P Belga S | 2012 | Faro Cancer2012，1，4： | 1 |
| 9 | Comparison of Different Measures for Hand-arm Vibration Exposure显示文摘 | Lage Burstrǒm Ronnie Lundstrǒm Mats Hagberg | 1998 | Safety Science1998，28，1： | 1 |
| 10 | Angiotensin Ⅱ contributes to arterial compliance in congestive heart failure显示文摘 | Lage SG Kopel L Medeiros CC | 2002 | Am J Physiol Heart Circ Physiol2002，283，4： | 1 |
| 11 | Multiple mechanisms confer different drug-resistant phenotypes in pancreatic carcinoma cells显示文摘 | Lage H Dietel M | 2002 | J Cancer Res Clin Oncol2002，128，7： | 1 |
| 12 | Homozygous mutation Arg768Trp in the ABC-transporter encoding gene ABCC2/cMOAT/ABCE2 causes Dubin-Johnson syndrome in a Caucasian patient显示文摘 | Materna V Lage H | 2003 | J Hum Genet2003，48，9： | 1 |
| 13 | Two Types of Non-Linear Pressure-Drop Versus Flow-Rate Relation Observed for Saturated Porous Media 显示文摘 | Lage J L Antohe B V Nield D A | 1997 | ASME Fluids Engine1997，119，3： | 1 |
| 14 | AMPK:a metabolic gauge regulating whole-body energy homeostasis显示文摘 | LAGE R DIéGUEZ C VIDAL-PUIG A | 2008 | Trends in Molecular Medicine2008，14，12： | 1 |
| 15 | Transport of phosphatidylserine via MDR1 (multidrug resistance 1) P-glycoprotein in a human gastric carcinoma cell line显示文摘 | Pohl A Lage H Muller P | 2002 | Biochem J2002，，1： | 1 |
| 16 | The RELQUAL Scale:A Measure of Relationship Quality in Export Market Ventures显示文摘 | Carmen Lages Cristiana Raquel Lages Luis Filipe Lages | 2005 | Journal of Business Research2005，，： | 1 |
| 17 | Fractionation of eucalyptus wood in acetic acid media显示文摘 | VASQUEZ D LAGE M A PARAJ0 J C | 1992 | Bioresource Technology1992，40，2： | 1 |
| 18 | (2000)Inverting the classroom: A gateway to creating an inelusive learning enviromnent显示文摘 | Lage MJ & Platt GJ & Tregiia M | 2000 | The Journal af Eeconomic Education2000，31，1： | 1 |
| 19 | Ultrasound-guided retrograde intubation显示文摘 | Vieira D Lages N Dias J | 2013 | Anaesthesia2013，68，10： | 1 |
| 20 | Intervention in informalcaregivers who take care of older people after a stroke(InCARE) : study protocolfor a randomised trial 显示文摘 | Araujo 0 Lage I Cabrita J | 2015 | J AdvNurs2015，71，10： | 1 |
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