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| 1 | Comprehensive evaluation of the metabolic effects of insect meal from Tenebrio molitor L.in growing pigs by transcriptomics, metabolomics and lipidomics显示文摘Background:The hypothesis was tested that insect meal(IM)as protein source influences intermediary metabolism of growing pigs.To test this,30 male,5-week-old crossbred pigs were randomly assigned to 3 groups of 10 pigs each with similar body weights(BW)and fed isonitrogenous diets either without(CON)or with 5%IM(IM5)or 10%IM(IM10)from Tenebrio molitor L.for 4 weeks and key metabolic tissues(liver,muscle,plasma)were analyzed using omics-techniques.Results:Most performance parameters did not differ across the groups,whereas ileal digestibilities of most amino acids were 6.7 to 15.6%-units lower in IM10 than in CON(P<0.05).Transcriptomics of liver and skeletal muscle revealed a total of 166 and 198,respectively,transcripts differentially expressed between IM10 and CON(P<0.05).Plasma metabolomics revealed higher concentrations of alanine,citrulline,glutamate,proline,serine,tyrosine and valine and a lower concentration of asparagine in IM10 than in CON(P<0.05).Only one out of fourteen quantifiable amino acid metabolites,namely methionine sulfoxide(MetS),in plasma was elevated by 45%and 71%in IM5 and IM10,respectively,compared to CON(P<0.05).Plasma concentrations of both,major carnitine/acylcarnitine species and bile acids were not different across groups.Lipidomics of liver and plasma demonstrated no differences in the concentrations of triacylglycerols,cholesterol and the main phospholipids,lysophospholipids and sphingolipids between groups.The percentages of all individual phosphatidylcholine(PC)and phosphatidylethanolamine(PE)species in the liver showed no differences between groups,except those with 6 double bonds(PC 38:6,PC 40:6,PE 38:6,PE 40:6),which were markedly lower in IM10 than in CON(P<0.05).In line with this,the percentage of C22:6n-3 in hepatic total lipids was lower in IM10 than in the other groups(P<0.05).Conclusions:Comprehensive analyzes of the transcriptome,lipidome and metabolome of key metabolic tissues indicate that partial or complete replacement of a conventional protein source by IM in the diet has only a weak impact on the intermediary metabolism of growing pigs.Thus,it is concluded that IM from Tenebrio molitor L.can be used as a dietary source of protein in pigs without causing adverse effects on metabolism. | Sandra Meyer Denise K.Gessner Maria S.Braune Theresa Friedhoff Erika Most Marcus Höring Gerhard Liebisch Holger Zorn Klaus Eder Robert Ringseis | 2020 | Journal of Animal Science and Biotechnology2020，11，2： | 4 |
| 2 | 近岸风力发电机及其电磁场对鱼类的影响显示文摘随着近岸风力发电场大规模的开发,应用各种技术的海底电缆的数量也不断增加。风力发电场使用不同类型的电缆,这些电缆或用于内涡轮传输,或用于变压器阵列传输,以及变压器向岸上传输。由于通过海底电缆的电流会产生电磁场,因此人们关注磁场对鱼类可能产生的影响。研究显示,有些鱼类对磁敏感,因为它们要利用地磁场进行定位。这就意味着,如果地磁场发生局部改变,鱼体的空间格局将受到影响。当某一地区存在长期固定的磁暴露时,还应在鱼类的生理方面加以考虑,尤其对于那些较少进行迁移的鱼。虽然已有研究显示磁场能够影响鱼类,但目前只有有限的证据证实风力发电机的水下电缆产生的电磁场对鱼类会有影响。对于波罗的海欧洲鳗鲡的研究显示,这种影响并不是很重要。本文中,我们对海上输电所用的海底电缆类型进行了综述,对其产生的磁场性质进行了描述,同时总结了磁场对鱼类的影响,并探讨了这种影响与近岸风力发电场所用电缆之间的关系。 | Marcus C.hman Peter Sigray Hkan Westerberg 张晓琴 | 2007 | AMBIO-人类环境杂志2007，36，B12： | 4 |
| 3 | Right Portal Vein Ligation Combined With In Situ Splitting Induces Rapid Left Lateral Liver Lobe Hypertrophy Enabling 2-Staged Extended Right Hepatic Resection in Small-for-Size Settings显示文摘 | Andreas A. Schnitzbauer Sven A. Lang Holger Goessmann Silvio Nadalin Janine Baumgart Stefan A. Farkas Stefan Fichtner-Feigl Thomas Lorf Armin Goralcyk Rüdiger H?rbelt Alexander Kroemer Martin Loss Petra Rümmele Marcus N. Scherer Winfried Padberg Alfred K? | 2012 | Annals of Surgery2012，，3： | 2 |
| 4 | Optimal management of the pancreatic remnant after pancreaticoduodenectomy 显示文摘 | Marcus ST Cohen H Ranson JHC | 1995 | Ann Surg1995，221，： | 2 |
| 5 | 显示文摘 | Marcus J A M | 1994 | J Organomet Chem1994，482，： | 1 |
| 6 | Refined food addiction:a classic substance use disorder 显示文摘 | IFLAND J R PREUSS H G MARCUS M T | 2009 | Med Hypothe- ses2009，72，5： | 1 |
| 7 | Opaque Fi- nancial Reports, R2, and Crash Risk 显示文摘 | Hutton A P Marcus A J Tehranian H | 2009 | Journal of Financial E- conomies2009，94，1： | 1 |
| 8 | Optimal management of the pancreatic remnant after pancreaticoduodenectomy显示文摘 | Marcus S Cohen H Ranson J | 1995 | Ann Surg1995，221，6： | 1 |
| 9 | The reversibility of subitaneous and diapause egg production by individual females of Labidocera aestiva(Copepoda: Calanoida) 显示文摘 | Marcus N H | 1982 | Biol Bull1982，162，1： | 1 |
| 10 | Tyrosinase inhibitory polyphenols from roots of morus lhou 显示文摘 | Seong H J Young B R Marcus J C et a1 | 2009 | Journal of Agricultural and Food Chemistry2009，57，4： | 1 |
| 11 | Modelling the developmentof cortical systems networks显示文摘 | Marcus K Claus C H | 2004 | Neurocomputing2004，58，58： | 1 |
| 12 | Observations of First-Order Liquid-to-Hexatic and Hexatic-to-Solid Phase Transitions in a Confined Colloid Suspension显示文摘 | MARCUS A H RICE S A | 1996 | Phys Rev Lett1996，77，12： | 1 |
| 13 | Intercomparison of surface analysis of thin aluminum oxide films显示文摘 | OLEFJORD I MATHIEU H J MARCUS P | 1990 | Surface and Interface Analysis1990，15，： | 1 |
| 14 | Preoperative as- sessment of breast cancer: sonography versus MR imaging 显示文摘 | Alexander H Andrea T Marcus S | 2002 | AJR2002，179，： | 1 |
| 15 | The obesity gene,TMEM18,is of ancient origin,found in majority of neuronal cells in all major brain regions and associated with obesity in severely obese children显示文摘 | Almen M S Jacobsson J A Shaik J H Olszewski P K Cedernaes J Alsio J Sreedharan S Levine A S Fredriksson R Marcus C and Schioth H B | | 0，，： | 1 |
| 16 | Neoadjuvant chemotherapy with CPT-11 and cisplatin downstages locally advanced gastric cancer显示文摘 | Newman E Marcus SG Potmesil M Sewak S Yee H Sorich J | 2002 | J Gastrointest Surg2002，6，22： | 1 |
| 17 | Opaque financial reports, R2, and crash risk 显示文摘 | HuRon A P Marcus A J Tehranian H | 2009 | Journal ofeFinancial Economics2009，94，1： | 1 |
| 18 | Effects of synthetic and naturally occurring flavonoids on metabolic activation of benzopyrene in hamster embryo cell cultures显示文摘 | CHAE Y H HO D K CASSADY J M COOK V M MARCUS C B BAIRD W M | 1992 | Chemico-biological Interactions1992，82，2： | 1 |
| 19 | Opaque Financial Re- ports,R2, and Crash Risk显示文摘 | Hutton A P Marcus A J Tehranian H | 2009 | Journal of Financial Economics2009，94，1： | 1 |
| 20 | FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex显示文摘 | Marta Muzio Arul M Chinnaiyan Frank C Kischkel Karen O’Rourke Andrej Shevchenko Jian Ni Carsten Scaffidi James D Bretz Mei Zhang Reiner Gentz Matthias Mann Peter H Krammer Marcus E Peter Vishva M Dixit | 1996 | Cell1996，，： | 1 |
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