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| 1 | NADPH debt drives redox bankruptcy:SLC7A11/xCT-mediated cystine uptake as a double-edged sword in cellular redox regulation显示文摘Cystine/glutamate antiporter solute carrier family 7 member 11(SLC7A11;also known as xCT)plays a key role in antioxidant defense by mediating cystine uptake,promoting glutathione synthesis,and maintaining cell survival under oxidative stress conditions.Recent studies showed that,to prevent toxic buildup of highly insoluble cystine inside cells,cancer cells with high expression of SLC7A11(SLC7A11high)are forced to quickly reduce cystine to more soluble cysteine,which requires substantial NADPH supply from the glucose-pentose phosphate pathway(PPP)route,thereby inducing glucose-and PPP-dependency in SLC7A11high cancer cells.Limiting glucose supply to SLC7A11high cancer cells results in significant NADPH“debt”,redox“bankruptcy”,and subsequent cell death.This review summarizes our current understanding of NADPH-generating and-consuming pathways,discusses the opposing role of SLC7A11 in protecting cells from oxidative stresseinduced cell death such as ferroptosis but promoting glucose starvationeinduced cell death,and proposes the concept that SLC7A11-mediated cystine uptake acts as a double-edged sword in cellular redox regulation.A detailed understanding of SLC7A11 in redox biology may identify metabolic vulnerabilities in SLC7A11high cancer for therapeutic targeting. | Xiaoguang Liu Yilei Zhang Li Zhuang Kellen Olszewski Boyi Gan | 2021 | Genes & Diseases2021，8，6： | 7 |
| 2 | Advances in the development of new biomarkers for Alzheimer’s disease显示文摘Alzheimer’s disease(AD)is a complex,heterogeneous,progressive disease and is the most common type of neurodegenerative dementia.The prevalence of AD is expected to increase as the population ages,placing an additional burden on national healthcare systems.There is a large need for new diagnostic tests that can detect AD at an early stage with high specificity at relatively low cost.The development of modern analytical diagnostic tools has made it possible to determine several biomarkers of AD with high specificity,including pathogenic proteins,markers of synaptic dysfunction,and markers of inflammation in the blood.There is a considerable potential in using microRNA(miRNA)as markers of AD,and diagnostic studies based on miRNA panels suggest that AD could potentially be determined with high accuracy for individual patients.Studies of the retina with improved methods of visualization of the fundus are also showing promising results for the potential diagnosis of the disease.This review focuses on the recent developments of blood,plasma,and ocular biomarkers for the diagnosis of AD. | Timofey O.Klyucherev Pawel Olszewski Alena A.Shalimova Vladimir N.Chubarev Vadim V.Tarasov Misty M.Attwood Stina Syvänen Helgi B.Schiöth | 2022 | Translational Neurodegeneration2022，11，1： | 2 |
| 3 | Hematopoietic stem cell transplantation using unrelated cord-blood versus matched sibling marrow in pediatric bone marrow failure syndrone:one center's experience显示文摘 | Haut PR Olszewski M | 1999 | Peddiatr-Transplant1999，3，4： | 1 |
| 4 | Complexity o{ neural mechanisms underlying overconsumption of sug-ar in scheduled feeding: involvement of opioids, orexin, oxytocin and NPY显示文摘 | Olszewski PK Shaw TJ Grace MK | 2009 | Peptides2009，30，2： | 1 |
| 5 | Gibberellin signaling: Biosynthesis, catabolism, and response pathways显示文摘 | Olszewski N Sun TP Gubler F 2002 | 2002 | Plant Cell2002，14，： | 1 |
| 6 | Overall signalized intersections Engineering, 1993 (119) delay, stopped delay and stops at 显示文摘 | OLSZEWSKI P | 1993 | Journal of Transportation1993，，： | 1 |
| 7 | Gibberenllin signaling: Biosynthesis, catabolism, and response pathways显示文摘 | Olszewski N Sun T Gubler F | 2002 | Plant Cell2002，，： | 1 |
| 8 | Predictive value of HER-2 receptor,P53,bcl-2 and bax proteins, MIB- 1 antibody, estrogen and progesterone receptor expression in breast cancer patients receiving adjuvant tamoxifen显示文摘 | Pienkowski T Olszewski W Kraszewska E | 2002 | Eur J Cancer2002，38，： | 1 |
| 9 | The genome sequence and evolution of baculoviruses显示文摘 | HERNIOU E A OLSZEWSKI J A CORY J S | 2003 | Annu Rev Entomol2003，48，： | 1 |
| 10 | The obesity gene,TMEM18,is of ancient origin,found in majority of neuronal cells in all major brain regions and associated with obesity in severely obese children显示文摘 | Almen M S Jacobsson J A Shaik J H Olszewski P K Cedernaes J Alsio J Sreedharan S Levine A S Fredriksson R Marcus C and Schioth H B | | 0，，： | 1 |
| 11 | Chemokines, cytokines, and growth factors in keratinoeytes and dermal endothelia cells in the margin of chronic diabetic foot ulcers显示文摘 | GALKOWSKA H WOJEWODZKA U OLSZEWSKI WL | 2006 | Wound Repair Regen2006，14，5： | 1 |
| 12 | Three methods for accurate quantification of plaque volume in coronary arteries显示文摘 | Medina R Wahle A Olszewski ME | 2003 | The International Journal of Cardiovascular Imaging2003，19，： | 1 |
| 13 | Surgical trauma evokes arise in the frequency of hernatopoietic progenitor cell and cytokine levels in blood circulation显示文摘 | Crzelak I Olszewski L Zaloska M | 1998 | Eur Surg Res1998，30，： | 1 |
| 14 | Low recruitment of immune cells with increased expression of endothelial adhesion molecules in margins of the chronic diabetic foot ulcers显示文摘 | Galkowska H Wojewodzka U Olszewski WL | 2005 | Wound Repair Regen2005，13，3： | 1 |
| 15 | Homocysteine and lipid metabolism in atherogenisis :effect of of the homocysteine thiolactonyl derivates, thioretinaco and thioretinamide显示文摘 | Mccully KS Olszewski AJ Vezaridis MP | 1990 | A therosclerosis1990，83，23： | 1 |
| 16 | Effect of nociceptin/orphanin FQ on food intake in rats that differ in diet preference显示文摘 | Olszewski PK Grace MK Sanders JB | 2002 | Pharmacol Biochem Behav2002，73，3： | 1 |
| 17 | Can the interleukin 1 receptor antagonist ( IL - Ira) response to enteral be a marker of anti - inflammatory in malnourished patients after pancreaticoduodeneetomy显示文摘 | Slotwinski R Olszewski WL Slotkowski M | 2007 | JOP2007，8，6： | 1 |
| 18 | Administration of the cervical torsion test by the examination of doppler's blood flows in vertebral arteries and basilar artery in patients with degenerative cervical spine changes显示文摘 | Olszewski J Zalewski P Machala W | 1994 | Otolaryngol Pol1994，48，6： | 1 |
| 19 | The association between positional vertebral and basilar artery flow lesion and preualence of vertigo in patients with cervical spondylosis显示文摘 | OLSZEWSKI J MAJAK J PIETKIEWICZ P | 2006 | Otolaryngology-Head & Neck Surgery2006，134，4： | 1 |
| 20 | The validity of in vivo tooth volume determinations from cone-beam com- puted tomography显示文摘 | Liu Y Olszewski R Alexandroni ES | 2010 | Angle Orthod2010，80，1： | 1 |
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