|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Comparisons between centrifuge and numerical modeling results for slope toppling failure显示文摘This paper presents series studies on the toppling mechanism by centrifuge tests and numerical simulations. Two different discrete element methods, i.e., the continuum-based discrete element method(CDEM) and the discontinuous deformation analysis(DDA), are adopted. The modeling results show that both the methods can accurately capture the failure modes of the centrifuge tests, including three distinct zones and two failure surfaces. Comparisons are made between the physical test and numerical simulation results. The critical inclination angle of the tilting table where the slope models are fixed on can be moderately predicted by the two methods, with different degrees of precision. The error between the test results and the simulated results is within 1% for the slope models without rock-bridges by both CDEM and DDA. However, it is amplified for the staggered-joint models that simulate the rock-bridges. With DDA, the average error is about 5%, and the maximum error is up to 17%. While with CDEM, the errors for the aligned-joint models are ranged from 1% to 6%, and it is from 10% to 29% for the staggered-joint models. The two numerical methods show the capability in simulating toppling failure of blocky rock mass with and without rock-bridges. The model with rock-bridges which provides a certain bending resistance is more stable than the one without any rock-bridge. In addition, the two failure surfaces were observed, which is different from the common understanding that only one failure surface appears. | CHEN ZuYu GONG WenJun MA GuoWei WANG Jie HE Lei XING YiChuan XING JianYing | 2015 | Science China(Technological Sciences)2015，58，9： | 18 |
| 2 | Breast milk macronutrient composition and the associated factors in urban Chinese mothers显示文摘 | Yang Titi Zhang Yumei Ning Yibing You Lili Ma Defu Zheng Yingdong Yang Xiaoguang Li Wenjun Wang Junkuan Wang Peiyu | 2014 | Chinese Medical Journal2014，，9： | 17 |
| 3 | Early evaluation of growth traits of Larix kaempferi clones显示文摘Early selection is an important method to shorten the breeding cycle for tree species, which may differ in the time for early selection.To evaluate the early selected time for Larix kaempferi, tree height and diameter at breast height of 57 L.kaempferi clones were measured over many different growth years.The results indicated that, except for age × clone interaction for diameter at breast height(P = 0.741), there were significant differences among all variation sources(P < 0.01).The coefficient of phenotypic variation ranged from 14.89 to 35.65%for height and from 19.17 to 23.86% for diameter at breast height in different growth years.The repeatability of height and of diameter at breast height among clones was high,ranging from 0.6181 to 0.8531(height) and from 0.8443 to0.8497(diameter at breast height), in different growth years.There were significant positive correlations between all pairs of growth traits except between height in the 2 nd growth year and height in the 30 th growth year; and between height in the 2 nd growth year × diameter at breast height in the 30 th growth year.With a comprehensive evaluation method and a selection ratio of 10%, L65,L1, L62, L9, L15, and L78 were selected as excellent clones in the 30 th growth year.Their average values of height and diameter at breast height were 9.81 and 16.57%higher than the overall average, representing genetic gains of 6.46 and 13.99%, respectively.This study provides a theoretical foundation for the genetic improvement of L.kaempferi. | Yanyan Pan Shuchun Li Chenglu Wang Wenjun Ma Guiyou Xu Lili Shao Kailong Li Xiyang Zhao Tingbo Jiang | 2018 | Journal of Forestry Research2018，29，4： | 10 |
| 4 | Research progress in pathogenic genes of hereditary non-syndromic mid-frequency deafness显示文摘听觉缺陷被看作世界范围的最流行的缺陷。在世界上的几乎 6 亿个人受不了温和或中等的听觉缺陷,一估计了 10% 人的人口。基因因素在这混乱的致病起一个重要作用。世袭听觉损失被划分成 syndromic 听觉损失(与另外的异例联系了) 并且 non-syndromic 听觉损失(没与另外的异例联系) 。约 80% 基因聋是 non-syndromic。根据听见损失的频率,世袭 non-syndromic 听觉损失能被划分成高度 -- ,中间 -- ,低 -- ,并且全部频率的听觉损失。中间频率的 sensorineural 听觉损失,或一张碗状的听力敏度图的听力测的发现,是不平常的。直到现在,仅仅, 7 loci 被连接了到中间频率的听觉损失。四仅仅基因 midfrequency 聋基因,也就是 DFNA10 (EYA4 ) , DFNA8/12 (TECTA ) , DFNA13 (COL11A2 ) , DFNA44 (CCDC50 ) ,迄今为止被报导了。这评论总结四基因的研究进步引起注意到中间频率的聋基因。 | Wenjun Xia Fei Liu Duan Ma | 2016 | Frontiers of Medicine2016，10，2： | 8 |
| 5 | IGF-1 alleviates ox-LDL-induced inflammation via reducing HMGB1 release in HAECs显示文摘动脉粥样硬化, multifactorial 长期的煽动性的反应,仔细与氧化地修改的低密度的脂蛋白(ox-LDL ) 被联系。(HMGB1 ) 高活动性的组盒子 1 是 DNA 有约束力的蛋白质,它在从房间的版本之上展出有势力煽动性的行动。(IGF-1 ) 像胰岛素的生长因素 1 能包括增长和 anti-apoptosis 得到细胞的回答的一个全部剧目。然而,在发炎的 IGF-1 的角色仍然是不清楚的。在现在的学习,我们试图在发炎和内在的机制调查 IGF-1 的角色。人的大动脉的 endothelial 房间被 ox-LDL (50 g/ml ) 刺激导致发炎。细胞间的粘附分子 1 的表示(ICAM-1 ) 被西方的污点分析和 immunofluorescence 估计。HMGB1 的版本被连接酶的 immunosorbent 试金决定。IGF-1 受体(IGF-1R ) 表示被反向的抄写聚合酶链反应和西方的污点分析估计。IGF-1R phosphorylation 被西方的污点分析决定。Ox-LDL 刺激减少了 IGF-1R mRNA 和蛋白质表示,但是增加了 HMGB1 版本。IGF-1 处理减少了 ox-LDL-induced ICAM-1 表示,潜在地通过减少 HMGB1 释放 picropodophyllin,一个 IGF-1R 特定的禁止者,增加了煽动性的反应。在结论, IGF-1 能由减少 HMGB1 版本减轻 ox-LDL-induced 发炎,建议在煽动性的疾病的 IGF-1 的一个意外有益的角色。 | Xiaofeng Yu Chunyan Xing Yinghua Pan Housheng Ma Jie Zhang Wenjun Li | 2012 | Acta Biochimica et Biophysica Sinica2012，44，9： | 8 |
| 6 | Allele-defined genome reveals biallelic differentiation during cassava evolution显示文摘Dear Editor,Generation of heterozygous genomes by hybridization between or within species can help maintain plant diversity and serve as a potential source of new species(Baek et al.,2018).Moreover,genomic heterozygosity is associated with genomic coadaptation,developmental stability,and heterosis.Accurate definition of alleles in haplotypes is necessary to precisely characterize allelic variation controlling agriculturally important traits(Shi et al.,2019).Currently,most released genomes have mosaic assembly of haplotypes due to random selection or collapse of alleles during genome assembly(Shi et al.,2019),which masked allelic variation and functional differentiation of divergent alleles in heterozygous species. | Wei Hu Changmian Ji Haitao shi Zhe Liang Zehong Ding Jianqiu Ye Wenjun Ou Gang Zhou Weiwei Tie Yan Yan Jinghao Yang Xiaoying Yang Yunxie Wei Zhiqiang Jin Jianghui Xie Ming Peng Wenquan Wang Anping Guo Biyu Xu Jianchun Guo Songbi Chen Liming Ma Mingcheng Wang Yang Zhou Xiaolong Li Ruoxi Li Siyi Guo Xinhui Xiao Zhongqing Wan Feifei An Jie Zhang Qingyun Leng Yin Li Ray Ming Kaimian Li | 2021 | Molecular Plant2021，14，6： | 8 |
| 7 | Dosage effect of multiple genes accounts for multisystem disorder of myotonic dystrophy type 1显示文摘Multisystem manifestations in myotonic dystrophy type 1(DM1)may be due to dosage reduction in multiple genes induced by aberrant expansion of CTG repeats in DMPK,including DMPK,its neighboring genes(SIX5 or DMWD)and downstream MBNLh However,direct evidence is lacking.Here,we develop a new strategy to generate mice carrying multigene heterozygous mutations to mimic dosage reduction in one step by injection of haploid embryonic stem cells with mutant Dmpk,Six5 and Mbnll into oocytes.The triple heterozygous mutant mice exhibit adult-onset DM1 phenotypes.With the additional mutation in Dmwd,the quadruple heterozygous mutant mice recapitulate many major manifestations in congenital DM1.Moreover,muscle stem cells in both models display reduced sternness,providing a unique model for screening small molecules for treatment of DM1.Our results suggest that the complex symptoms of DM1 result from the reduced dosage of multiple genes. | Qi Yin Hongye Wang Na Li Yifu Ding Zhenfei Xie Lifang Jin Yan Li Qiong Wang Xinyi Liu Liuqing Xu Qing Li Yongjian Ma Yanbo Cheng Kai Wang Cuiqing Zhong Qian Yu Wei Tang Wanjin Chen Wenjun Yang Fan Zhang Chen Ding Lan Bao Bin Zhou Ping Hu Jinsong Li | 2020 | Cell Research2020，30，2： | 7 |
| 8 | Occurrence and bioaccumulation of polybrominated diphenyl ethers in sediments and paddy ecosystems of Liaohe River Basin, northeast China显示文摘Concentrations of 16 polybrominated diphenyl ether(PBDE) congeners were measured in river sediments, paddy soils and three species of paddy-field organisms(crab, loach and carp) collected from the Liaohe River Basin, northeastern China. The total contents of PBDEs(∑_(16)PBDEs) in sediments and paddy soils were in the ranges of 273.4–3246.3 pg/g dry weight(dw), and 192.1–1783.8 pg/g dw, respectively. BDE 209 was the dominant congener both in sediments and paddy soils. The concentrations of ∑_(16)PBDEs in sediments were significantly higher than those in the adjacent paddy soils, indicating a potential transport of PBDEs from river to paddy ecosystems via river water irrigation. The biota–soil accumulation factor(BSAF) was calculated as the ratio between the lipid-normalized concentration in paddyfield organisms and the total organic carbon-normalized concentration in paddy soil. The average BSAF values of ∑15PBDEs followed the sequence of crab(3.6) > loach(3.3) > carp(2.1). BDE 154 had the highest BSAF value, and a parabolic trend between BSAF values of individual PBDE congeners and their log KOWvalues was observed. In view of the fact that crab had the larger BSAF value and higher lipid content, the ecological risk and health risk for crab cultivation in paddy fields should be of particular concern. | Xindong Ma Haijun Zhang Wenjun Yao Wen Guo Depeng Li Ziwei Yao Jiping Chen | 2016 | Journal of Environmental Sciences2016，28，5： | 6 |
| 9 | Comparative Study on Rain Splash Erosion of Representative Soils in China显示文摘As the first event of soil erosion, rain splash erosion supplies materials for subsequent transportation and en-trainment. The Loess Plateau, the southern hilly region and the Northeast China are subject to serious soil and water loss; however, the characteristics of rain splash erosion in those regions are still unclear. The objectives of the study are to ana-lyze the characteristics of splash erosion on loess soil, red soil, purple soil and black soil, and to discuss the relationship between splash erosion and soil properties. Soil samples spatially distributed in the abovementioned regions were col-lected and underwent simulated rainfalls at a high intensity of 1.2mm/min, lasting for 5, 10, 15, and 20min, respectively. Rain splash and soil crust development were analyzed. It shows that black soil sample from Heilongjiang Province corre-sponds to the minimum splash erosion amount because it has high aggregate content, aggregate stability and organic mat-ter content. Loess soil sample from Inner Mongolia corresponds to the maximum splash erosion amount because it has high content of sand particles. Loess soil sample from Shanxi Province has relatively lower splash erosion amount be-cause it has high silt particle content and low aggregate stability easily to be disrupted under rainfalls with high intensity. Although aggregate contents of red soil and purple soil samples from Hubei and Guangdong provinces are high, the sta-bility is weak and prone to be disrupted, so the splash erosion amount is medium. Splash rate which fluctuates over time is observed because soil crust development follows a cycling processes of formation and disruption. In addition, there are two locations of soil crust development, one appears at the surface, and the other occurs at the subsurface. | CHENG Qinjuan CAI Qiangguo MA Wenjun | 2008 | Chinese Geographical Science2008，18，2： | 6 |
| 10 | Structural Traces of Secondary Faults(Fractures) along the Main Faults and Their Reliability as Kinematic Indicators显示文摘Secondary/minor structures occurring along the main fault surfaces are important indicators for judging the kinematic characteristics of faults.However,many factors can lead to the formation of these structures,which results in the difficulty for rapid judgment and application in the fields.A series of secondary faults/fractures developed due to the movement of main faults are the most important and widespread phenomena in the scope of brittle deformation.The morphology of the main fault surfaces is vari... | Jin ZHANG Jinyi LI Zongjin MA Wenjun REN | 2011 | Acta Geologica Sinica(English Edition)2011，85，5： | 5 |
| 11 | Safety and effectiveness of Traditional Chinese Medicinal herbs for diabetic foot:a systematic review and Meta-analysis显示文摘OBJECTIVE: To evaluate the safety and effectiveness of traditional Chinese medicinal herbs(TCMHs) as an adjunctive treatment for diabetic foot(DF).METHODS: The sources used were Pub Med(1966 to August 2015), the Cochrane Library(1988 to August 2015), the Excerpta Medica Database(1974 to August 2015), Wiley(1807 to August 2015), Ovid(1988 to August 2015), Clinical Trials.gov(1993 to August 2015), the Cochrane Central Register of Controlled Trials(1966 to August 2015), China Science and Technology Journal Database(1994 to August2015), Chi CTR(2007 to August 2015), Sino Med(1978 to August 2015), the China National Knowledge Infrastructure(1984 to August 2015), Wanfang Data Knowledge Service Platform(1998 to August 2015), and the Traditional Chinese Medical Literature Analysis and Retrieval System(TCMLARS)(1984 to August 2015). Studies were identified and selected, and the data were extracted by two independent reviewers. The Cochrane Risk of Bias tool was used to assess the quality of studies. Revman 5.2 software was used for data synthesis and analysis.RESULTS: Sixteen studies were included based on the selection criteria. Of these, seven studies had low bias risk and one had high bias risk. In the overall analysis, TCMHs resulted in a significantly higher total effective rate(OR 5.08; 95% CI 3.50 to7.36; P < 0.000 01), cure rate(OR 2.12; 95% CI1.63 to 2.77; P < 0.000 01), and shorter time to ulcer healing(SMD-0.64; 95% CI-0.89 to-0.40;P < 0.000 01) when compared with non-TCMHs treated DF. The analysis also revealed that significantly fewer amputations occurred in TCMHs patients(OR 0.36; 95% CI 0.20 to 0.65; P = 0.0007).Sensitivity analysis indicated that the findings of the Meta-analysis were robust to study quality,and the funnel plot of the Egger test showed no publication bias.CONCLUSION: TCMHs intervention appears to be more effective for DF, with a similar safety profile,when compared with non-TCMHs treatments, although this result requires further verification with more well-designed studies. | Chen Shuo Ma Jianwei Xu Limei Niu Tianhui Dong Jing Liu Wenjun Han Qi | 2017 | Journal of Traditional Chinese Medicine2017，37，6： | 5 |
| 12 | Arsenic(V)removal from groundwater by GE-HL nanofiltration membrane:effects of arsenic concentration,pH,and co-existing ions显示文摘A laboratory-scale investigation was performed to study arsenic(As(V))removal by negatively charged GE-HL nanofiltration(NF)membrane in simulated drinking water.Effects of As(V)concentration(0–200μg·L–1),pH,and co-ions and counter-ions were investigated.The NF membrane presented good stability,and the rejection rates exceeded 90%.The rejection rates of As(V)decreased with the increase of As(V)concentration,while it increased with the increase of pH(reached 96%at pH 6.75).Moreover,a negative relationship was observed between the co-existing ions of Cl^(–),Na^(+),SO_(4)^(2–),and Ca^(2+)and the removal of As(V),in which bivalent ions presented more significant effects than monovalent ions. | Xiaowei WANG Wenjun LIU Desheng LI Weifang MA | 2009 | Frontiers of Environmental Science & Engineering2009，3，4： | 5 |
| 13 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 14 | Nonfatal Child Pedestrian Injury in Two Urban Cities of Guangdong Province,China:Results from a Cross-sectional Survey显示文摘Objective To describe the epidemiological characteristics of nonfatal child pedestrian injuries and provide information to help understand an important public-health problem.Methods This was a school-based,cross-sectional questionnaire survey.The sample (42 750 children) was obtained from two urban cities of Guangdong Province,China,using multi-stage randomized sampling.Information was collected by the respondents self-reporting in the classroom.Results The incidence rate of nonfatal child pedestrian injuries in the cities was 2.0%.Boys had a higher incidence rate (2.6%) than girls (1.4%).Compared to other children,those aged 10 years are at the highest risk.The primary places of occurrence were sidewalks,residential roads,and crosswalks.High-risk behavior of the children immediately prior to injury included mid-block crossings,playing on roads,and crossing on red lights.The major vehicles that caused pedestrian injuries were bicycles,car or vans,and motorcycles.Bruises,fractures,and injuries to the internal organs were the top three types of injuries.Almost 40% of victims were hospitalized,and nearly 30% of the victims suffered long-term disabilities.Conclusion This study shows that nonfatal child pedestrian injuries are a very serious public-health problem in the urban cities of Guangdong.Based on the epidemiological characteristics,prevention strategies and further research should be carried out to reduce the occurrence of injuries. | MA WenJun NIE ShaoPing XU HaoFeng XU YanJun XIE HuiYan ZHANG YuRun | 2011 | Biomedical and Environmental Sciences2011，24，4： | 4 |
| 15 | Electrospinning of hydroxypropyl methylcellulose trimellitate solutions显示文摘Nonwoven fiber mats of hydroxypropyl methylcellulose trimellitate(HPMCT) with potential applications in controlled delivery of drugs and scaffolds for tissue cultures have been successfully fabricated by electrospinning of HPMCT solutions.The formation and diameters of HPMCT fibers fabricated by electrospinning were strongly influenced by the solvents employed,electrostatic field strength,and solution concentrations.The electrospun products generated from all HPMCT solutions with various weight-average molecular weights in methanol/dichloromethane(1:1) solvent consisted of clustered beads,while methanol/dichloromethane(1:5) solvent helped to generate smooth,uniform,submicron fibers.From the relationship between specific viscosity and molecular weight in different solvents,it could be concluded that methanol/dichloromethane(1:5) solvent enhanced the molecular entanglements,improved the viscosity of the solutions,thus helped to generate smooth fibers.When all the other variables were kept constant,the concentration range suitable for electrospinning was between 10% and 16%(wt),and the average fiber diameter increased as the concentration increased.When all the other variables were kept constant,the average fiber diameter decreased as the strength of the electrostatic field increased.Electrospinning the solutions of two compounds with similar structure,hydroxypropyl methylcellulose phthalate(HPMCP) and HPMCT,we found that the fibers electrospun from HPMCP were thicker than that from HPMCT,which is attributed to the fact that the solution's conductivity of HPMCT(containing two free carboxyl groups) is higher than that of HPMCP(containing only one free carboxyl group). | MA Gang,SHAO ZiQiang,WANG WenJun,WANG FeiJun,TAN LingLing & LIAO Bing School of Material,Beijing Institute of Technology,Beijing 100081,China | 2010 | Science China Chemistry2010，53，1： | 3 |
| 16 | High-temperature mechanical properties of as-extruded AZ80 magnesium alloy at different strain rates显示文摘The mechanical properties of as-extruded AZ80 magnesium alloy at temperatures of 450-525℃ and strain rates of 3.0 s^(−1)and 0.15 s^(−1)were investigated by tensile tests.Zero ductility of alloy appeared at 500℃ with a strain rate of 0.15 s^(−1),while the zero strength and zero ductility of the alloy were obtained nearly simultaneously at 525℃ with a strain rate of 3.0 s^(−1).The results indicated that the lower strain rate accelerated the arrival of zero ductility.As the temperature increased,the failure mode of the alloy developed from trans-granular fracture to cleavage fracture and then to inter-granular fracture with the feature of sugar-like grains and fusion traces.The existence of the low-melting composite ofβ-Mg_(17)Al_(12) and Al_(8)Mn_(5) particles segregated near the Mg_(17)Al_(12) phase along grain boundaries were demonstrated to be the reason for the brittle fracturing of the AZ80 alloy at high temperatures.Furthermore,microstructural evolution at temperatures approaching the solidus temperature was discussed to clarify magnesium alloy’s high temperature deformation mechanism. | Wenjun Liu Bin Jiang Hongchen Xiang Qing Ye Shengqi Xia Siqiang Chen Jiangfeng Song Yanlong Ma Mingbo Yang | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，7： | 3 |
| 17 | Expression of orphan nuclear receptor NR4A2 in gastric cancer cells confers chemoresistance and predicts an unfavorable postoperative survival of gastric cancer patients with chemotherapy显示文摘 | Yifang Han Hui Cai Liye Ma Yibo Ding Xiaojie Tan Wenjun Chang Wei Guan Yan Liu Qiuxia Shen Yongwei Yu Hongwei Zhang Guangwen Cao | 2013 | Cancer2013，，19： | 2 |
| 18 | Exploration and implementation of commonality valuation method in commercial aircraft family design显示文摘Commercial aircraft family design can reduce development costs, shorten development cycles, and expand the market coverage of aircraft. Commercial aircraft family development has become one of the most important features of modern aircraft design. This paper explores the effects of commonality on different aircraft models in a commercial aircraft family. The existing product commonality indexes are summarized and their limitations in the application to aircraft design are discussed. Then a new component commonality index is proposed based on the component decomposition structure. A model for calculating the aircraft program value is established,which considers development costs, manufacturing costs, sale price, operation costs and residual costs. The effects of aircraft commonality on time and economic costs of both development and manufacturing, and on sale price, are analyzed and quantified. The commonality evaluation strategy is obtained, which features comprehensive consideration of the aircraft program value and time costs. The break-even analysis of aircraft is proceeded on the basis of costs and price data. By using a real option method, the strategy considers the uncertainty of the aircraft program and the flexibility of the manufacturer. This strategy proves to be rational and applicable to aircraft design based on the calculation of three examples and the analysis of parameter sensitivity. | Yongjie ZHANG Zheng YANG Xianchao MA Wenjun DONG Dayong DONG Zhaoguang TAN Shuai ZHANG | 2019 | Chinese Journal of Aeronautics2019，32，8： | 2 |
| 19 | Association Between COVID-19 Vaccination Coverage and Case Fatality Ratio:a Comparative Study—Hong Kong SAR,China and Singapore,December 2021–March 2022显示文摘Summary What is already known about this topic?Hong Kong Special Administrative Region(SAR),China and Singapore are both facing considerable Omicron variant epidemic.However,the overwhelmed medical system and high case fatality ratio(CFR)just occurred in Hong Kong SAR,China but not in Singapore.What is added by this report?The low vaccination coverage in Hong Kong SAR,China,especially among the older adults,is shown to be a primary reason of its recent high CFR.What are the implications for public health practice?Facing the potential epidemic risk,non-vaccinated,non-fully-vaccinated,and non-booster-vaccinated people in China,especially the elderly,should get any type of accessible vaccine,which could save lives when the infection unfortunately befalls. | Guanhao He Sui Zhu Di Fu Jianpeng Xiao Jianguo Zhao Ziqiang Lin Tao Liu Xiaofeng Liang Wenjun Ma | 2022 | China CDC weekly2022，4，30： | 2 |
| 20 | Efficacy of Sijunzi decoction(四君子汤) on limb weakness in spleen Qi deficiency model rats through adenosine monophosphate-activated protein kinase/unc-51 like autophagy activating kinase 1 signaling显示文摘OBJECTIVE:To investigate the efficacy of Sijunzi decoction(四君子汤)on limb weakness in a rat model of spleen Qi deficiency(SQD),and to study its effect on mitophagy in skeletal muscle through adenosine monophosphate-activated protein kinase(AMPK)/unc-51 like autophagy activating kinase 1(ULK1)signaling.METHODS:SQD model rats were produced by fasting combined with forced swimming method for15 d.After model assessment,rats were randomly divided into four groups of 10[low/middle/high(L/M/H)Sijunzi decoction dose groups and a normal saline(S)group].Limb holding power(HP)and body mass(BM)were measured after 2 weeks of treatment.Following euthanasia,quadriceps femoris were dissected and myofiber and mitochondrial morphology were observed by transmission electron microscopy(TEM).Mitochondrial membrane potential(MMP),adenosine triphosphatase(ATP)and reactive oxygen species(ROS)levels were determined using colorimetric methods,and immunoblot analysis of Microtubule-associated protein light chain 3(LC3)and Sequestosome 1(p62)was performed to monitor mitophagy and AMPK/ULK1 signaling.RESULTS:Compared with control(C)group rats,in the S group,HP was reduced,the myofiber Z line was disordered,mitochondria were scattered,and numerous vacuoles and mitophagy were observed.MMP and ATP levels were reduced,ROS levels were elevated,and LC3B expression,and p-AMPKα(Thr172)/AMPKα,p-ULK1(Ser555)/ULK1,and p-Raptor(Ser792)/Raptor ratios were increased,while p62 expression and p-mT OR(Ser2448)/mT OR and p-ULK1(Ser757)/ULK1 ratios were decreased.After treatment,compared with the S group,HP was improved in M and H groups but not in the L group.Mitophagy was reduced in M,H and L groups but the Z line was disordered and vacuolization remained in the L group.ATP levels were elevated in M,H and L groups,and MMPs were elevated in M and H groups but not in the L group.ROS levels were decreased in M,H and L groups,as were LC3B expression and p-Raptor(Ser792)/Raptor ratios,while p62 expression and p-mT OR(Ser2448)/mT OR and p-ULK1(Ser757)/ULK1 ratios were increased in M and H groups but not in the L group.p-AMPKα(Thr172)/AMPKαand p-ULK1(Ser555)/ULK1 ratios were decreased in M,H and L groups.CONCLUSIONS:Sijunzi decoction improved HP,possibly by inhibiting mitophagy via suppression of AMPK/ULK1 signaling.This restored mitochondrial morphology and improved oxidative phosphorylation,which contributed to recovery of limb weakness in SQD model rats. | LIU Wenjun XU Xinzhu DUAN Zhiyuan LIANG Xicai MA Dan LI Gege XIE Xin CHAI Jiyan CHEN Jing SHAN Dehong | 2021 | Journal of Traditional Chinese Medicine2021，41，4： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员