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| 1 | Allele-defined genome reveals biallelic differentiation during cassava evolution显示文摘Dear Editor,Generation of heterozygous genomes by hybridization between or within species can help maintain plant diversity and serve as a potential source of new species(Baek et al.,2018).Moreover,genomic heterozygosity is associated with genomic coadaptation,developmental stability,and heterosis.Accurate definition of alleles in haplotypes is necessary to precisely characterize allelic variation controlling agriculturally important traits(Shi et al.,2019).Currently,most released genomes have mosaic assembly of haplotypes due to random selection or collapse of alleles during genome assembly(Shi et al.,2019),which masked allelic variation and functional differentiation of divergent alleles in heterozygous species. | Wei Hu Changmian Ji Haitao shi Zhe Liang Zehong Ding Jianqiu Ye Wenjun Ou Gang Zhou Weiwei Tie Yan Yan Jinghao Yang Xiaoying Yang Yunxie Wei Zhiqiang Jin Jianghui Xie Ming Peng Wenquan Wang Anping Guo Biyu Xu Jianchun Guo Songbi Chen Liming Ma Mingcheng Wang Yang Zhou Xiaolong Li Ruoxi Li Siyi Guo Xinhui Xiao Zhongqing Wan Feifei An Jie Zhang Qingyun Leng Yin Li Ray Ming Kaimian Li | 2021 | Molecular Plant2021，14，6： | 8 |
| 2 | Insights into the formation of secondary organic carbon in the summertime in urban Shanghai显示文摘To investigate formation mechanisms of secondary organic carbon(SOC) in Eastern China,measurements were conducted in an urban site in Shanghai in the summer of 2015. A period of high O_3 concentrations(daily peak > 120 ppb) was observed, during which daily maximum SOC concentrations exceeding 9.0 μg/(C·m^3). Diurnal variations of SOC concentration and SOC/organic carbon(OC) ratio exhibited both daytime and nighttime peaks. The SOC concentrations correlated well with O_x(= O_3+ NO_2) and relative humidity in the daytime and nighttime, respectively, suggesting that secondary organic aerosol formation in Shanghai is driven by both photochemical production and aqueous phase reactions. Single particle mass spectrometry was used to examine the formation pathways of SOC. Along with the daytime increase of SOC, the number fraction of elemental carbon(EC) particles coated with OC quickly increased from 38.1% to 61.9% in the size range of 250–2000 nm, which was likely due to gas-to-particle partitioning of photochemically generated semi-volatile organic compounds onto EC particles. In the nighttime, particles rich in OC components were highly hygroscopic, and number fraction of these particles correlated well with relative humidity and SOC/OC nocturnal peaks. Meanwhile, as an aqueous-phase SOC tracer, particles that contained oxalate-Fe(III) complex also peaked at night. These observations suggested that aqueous-phase processes had an important contribution to the SOC nighttime formation. The influence of aerosol acidity on SOC formation was studied by both bulk and single particle level measurements, suggesting that the aqueous-phase formation of SOC was enhanced by particle acidity. | Ci Zhang Xiaohui Lu Jinghao Zhai Hong Chen Xin Yang Qi Zhang Qianbiao Zhao Qingyan Fu Fei Sha Jing Jin | 2018 | Journal of Environmental Sciences2018，30，10： | 3 |
| 3 | An Android Malware Detection System Based on Feature Fusion显示文摘In order to improve the detection efficiency of Android malicious application, an Android malware detection system based on feature fusion is proposed on three levels. Feature fusion especially emphasizes on ten categories, which combines static and dynamic features and includes 377 features for classification. In order to improve the accuracy of malware detection, attribute subset selection and principle component analysis are used to reduce the dimensionality of fusion features. Random forest is used for classification. In the experiment, the dataset includes 43,822 benign applications and 8,454 malicious applications. The method can achieve 99.4% detection accuracy and 0.6% false positive rate. The experimental results show that the detection method can improve the malware detection efficiency in Android platform. | LI Jian WANG Zheng WANG Tao TANG Jinghao YANG Yuguang ZHOU Yihua | 2018 | Chinese Journal of Electronics2018，27，6： | 3 |
| 4 | MicroRNA-101 Inhibited Postinfarct Cardiac Fibrosis and Improved Left Ventricular Compliance via the FBJ Osteosarcoma Oncogene/Transforming Growth Factor-β1 Pathway显示文摘 | Zhenwei Pan Xuelin Sun Hongli Shan Ning Wang Jinghao Wang Jinshuai Ren Shuya Feng Liangjun Xie Chunying Lu Ye Yuan Yang Zhang Ying Wang Yanjie Lu Baofeng Yang | 2012 | Circulation2012，，7： | 2 |
| 5 | Global optimization over a box via canonical dual function显示文摘 | ZHU Jinghao WANG Chao GAO David Yang | 2011 | Journal of Computational and Applied Mathematics2011，，235： | 1 |
| 6 | Selecting an Appropriate Experimental Animal Model for Cholangiocarcinoma Research显示文摘Cholangiocarcinoma(CCA)is a highly aggressive biliary tree malignancy with intrahepatic and extra-hepatic sub-types that differ in molecular pathogeneses,epidemiology,clinical manifestations,treatment,and prognosis.The over-all prognosis and patient survival remains poor because of lack of early diagnosis and effective treatments.Preclini-cal in vivo studies have become increasingly paramount as they are helpful not only for the study of the fundamental molecular mechanisms of CCA but also for developing novel and effective therapeutic approaches of this fatal cancer.Recent advancements in cell and molecular biology have made it possible to mimic the pathogenicity of human CCA in chemical-mechanical,infection-induced inflammatory,implantation,and genetically engineered animal models.This review is intended to help investigators understand the particular strengths and weaknesses of the currently used in vivo animal models of human CCA and their related mod-eling techniques to aid in the selection of the one that is the best for their research needs. | Man Li Xueli Zhou Wei Wang Baoan Ji Yu Shao Qianyu Du Jinghao Yao Yan Yang | 2022 | Journal of Clinical and Translational Hepatology2022，10，4： | 1 |
| 7 | microRNA‐124 Regulates Cardiomyocyte Differentiation of Bone Marrow‐Derived Mesenchymal Stem Cells Via Targeting STAT3 Signaling显示文摘 | Benzhi Cai Jianping Li Jinghao Wang Xiaobin Luo Jing Ai Yanju Liu Ning Wang Haihai Liang Mingyu Zhang Nan Chen Gang Wang Shu Xing Xin Zhou Baofeng Yang Xinyue Wang Yanjie Lu | 2012 | STEM CELLS2012，，8： | 1 |
| 8 | Injectable cartilage matrix hydrogel loaded with cartilage endplate stem cells engineered to release exosomes for non-invasive treatment of intervertebral disc degeneration显示文摘Low back pain,mainly caused by intervertebral disc degeneration(IVDD),is a common health problem;however,current surgical treatments are less than satisfactory.Thus,it is essential to develop novel non-invasive surgical methods for IVDD treatment.Here,we describe a therapeutic strategy to inhibit IVDD by injecting hydrogels modified with the extracellular matrix of costal cartilage(ECM-Gels)that are loaded with cartilage endplate stem cells(CESCs).After loaded with CESCs overexpressing Sphk2(Lenti-Sphk2-CESCs)and injected near the cartilage endplate(CEP)of rats in vivo,ECM-Gels produced Sphk2-engineered exosomes(Lenti-Sphk2-Exos).These exosomes penetrated the annulus fibrosus(AF)and transported Sphk2 into the nucleus pulposus cells(NPCs).Sphk2 activated the phosphatidylinositol 3-kinase(PI3K)/p-AKT pathway as well as the intracellular autophagy of NPCs,ultimately ameliorating IVDD.This study provides a novel and efficient non-invasive combinational strategy for IVDD treatment using injectable ECM-Gels loaded with CESCs that express Sphk2 with sustained release of functional exosomes. | Liwen Luo Junfeng Gong Zhouguang Wang Yao Liu Jiaming Cao Jinghao Qin Rui Zuo Hongyu Zhang Shuai Wang Ping Zhao Di Yang Mengjie Zhang Yanqiu Wang Junfeng Zhang Yue Zhou Changqing Li Bing Ni Zhiqiang Tian MingHan Liu | 2022 | Bioactive Materials2022，7，9： | 1 |
| 9 | Optimization of synergistic energy storage density and efficiency for eco-friendly (Na_(0.5)Bi_(0.5))_(0.6)Sr_(0.4)TiO_(3)-based relaxor ferroelectric ceramics显示文摘Inspired by increasing demand of advanced pulsed power capacitors,the development of lead-free dielectric ceramic capacitors with high energy storage density and temperature-insensitive performance are extremely crucial.Herein,the lead-free relaxor ferroelectric ceramics based on(1-x)(Na_(0.5)Bi_(0.5))0.6Sr_(0.4)TiO_(3-x)Sr_(0.7)La_(0.2)ZrO_(3)[abbreviated as(1-x)NBST-xSLZ]are prepared by the solid-state reaction route.The large recoverable energy density(Wrec)of 3.45 J/cm^(3) and efficiency(h)of 90.1%are simultaneously realized in 0.86NBST-0.14SLZ ceramic due to increased breakdown strength.Furthermore,both the Wrec and h of 0.86NBST-0.14SLZ ceramic display superior of thermal stability(20e180C),frequency stability(1e1000 Hz),and cycle stability(10^(4))within a satisfactory range of variation.In addition,the 0.86NBST-0.14SLZ ceramic can also achieve a large current density(CD)of 625 A/cm^(2),an ultrahigh power density(PD)of 50 MW/cm^(3) and a fast discharge rate(t0.90)of 160.8 ns at 160 kV/cm.These results demonstrate that the 0.86NBST-0.14SLZ ceramic could be a highly competitive and ecofriendly relaxor ferroelectric material for next-generation pulsed power capacitors. | Hu Di Pan Zhongbin Wu Lukang Yang Fan Tang Luomeng Zhao Jinghao Shen Yihao Chen Yuyun Li Peng Zhai Jiwei Liu Jinjun | 2021 | Journal of Materiomics2021，7，4： | 0 |
| 10 | 中国出兵朝鲜的意识形态因素显示文摘中国1950年10月出兵朝鲜,进行抗美援朝作战,既是出于自身安全利益的考量,同时意识形态因素也起了相当重要的作用。因为信奉阶级斗争的理论,因此中国共产党不仅在国内政治斗争中严格地以阶级划线,在国际政治问题上也同样坚信自己只能与共产党国家互相帮助,才能避免在帝国主义势力的包围中立于不败之地。 | Yang Kuisong Yu Jinghao(Translated ) | 2006 | Social Sciences in China2006，27，4： | 0 |
| 11 | Single-nucleus transcriptomics reveals a gatekeeper role for FoxP1 in primate cardiac aging显示文摘Aging poses a major risk factor for cardiovascular diseases,the leading cause of death in the aged population.However,the cell type-specific changes underlying cardiac aging are far from being clear.Here,we performed single-nucleus RNA-sequencing analysis of left ventricles from young and aged cynomolgus monkeys to define cell composition changes and transcriptomic alterations across different cell types associated with age.We found that aged cardiomyocytes underwent a dramatic loss in cell numbers and profound fluctuations in transcriptional profles.Via transcription regulatory network analysis,we identified FOxP1,a core transcription factor in organ development,as a key downregulated factor in aged cardiomyocytes,concomitant with the dysregulation of FoxP1 target genes associated with heart function and cardiac diseases.Consistently,the deficiency of FOxP1 led to hypertrophic and senescent phenotypes in human embryonic stem cell-derived cardiomyocytes.Altogether,our findings depict the celiular and molecular landscape of ventricular aging at the single-cell resolution,and identify drivers for primate cardiac aging and potential targets for intervention against cardiac aging and associated diseases. | Yiyuan Zhang Yandong Zheng Si Wang Yanling Fan Yanxia Ye Yaobin Jing Zunpeng Liu Shanshan Yang Muzhao Xiong Kuan Yang Jinghao Hu Shanshan Che Qun Chu Moshi Song Guang-Hui Liu Weiqi Zhang Shuai Ma Jing Qu | 2023 | Protein & Cell2023，14，4： | 0 |
| 12 | Enhancement of morphological and emission stability of deep-blue small molecular emitter via a universal side-chain coupling strategy for optoelectronic device显示文摘Film morphology of emissive layers is crucial to the performance and stability of solution-processable organic light-emitting diodes(OLEDs). Compared to the interpenetration of conjugated polymer chain,small molecular emitter with a flexible side chain always presents easily aggregation upon external treatment, and caused π-electronic coupling, which is undesirable for the efficiency and stability of deep-blue OLEDs. Herein, we proposed a side-chain coupling strategy to enhance the film morphological an emission stability of solution-processable small molecular deep-blue emitter. In contrary to “parent” MC8 TPA,the crosslinkable styryl and vinyl units were introduced as ended unit at the side-chain of Cm TPA and OEYTPA. Interestingly, Cm TPA and OEYTPA films present a relatively stable morphology and uniform deep-blue emission after thermal annealing(160 ℃) in the atmosphere, different to the discontinuous MC8 TPA annealed film. Besides, compared to the Cm TPA and OEYTPA ones, serious polaron formation in the MC8 TPA annealed film also negative to the deep-blue emission, according to transient absorption analysis. Therefore, both Cm TPA and OEYTPA annealed film obtained at 140 ℃ present an excellent deep-blue ASE behavior with a 445 nm, but absence for MC8 TPA ones, associated with the disruption of annealed films. Finally, enhancement of device performance based on Cm TPA and OEYTPA film(~40%)after thermal annealing with a similar performance curves also confirmed the assumption above. Therefore, these results also supported the effectiveness of our side-chain coupling strategy for optoelectronic applications. | Ning Sun Han Gao Lili Sun Jingxi An Man Xu Chen Sun Yamin Han Jinyi Lin Jiangli Cai Mingjian Ni Liangliang He Jinghao Yang Zhoulu Wang Lubing Bai Xinwen Zhang Qi Wei Xuehua Ding Chengrong Yin Linghai Xie Wei Huang | 2022 | Chinese Chemical Letters2022，33，2： | 0 |
| 13 | Experiment on inducing apoptosis of melanoma cells by micro-plasma jet显示文摘As a promising cancer treatment method,cold atmospheric plasma has received widespread attention in recent years.However,previous research has focused more on how to realize and expand the anti-cancer scope of plasma jet.There are also studies on the killing of small-scale cancer cells,but the effects of plasma jet on normal cells and normal cell clusters have been ignored.Therefore,we proposed a 50μm sized micro-plasma jet device,and used the device to treat melanoma cells(A-375)and human glial cells(HA1800)to evaluate their anti-cancer effects and effects on normal cells.The experimental results show that this kind of micro-plasma jet device can effectively inactivate cancer cells in a short period of time,while having little effect on normal cells.This work provides a certain experimental basis for the application offine plasma jet to clinically inactivate cancer cells. | Hua Li Qihao Shi Yanhua Yang Jinghao Qi Yuhan Zhang Fengyun Wang Xiaoxia Du Wenxiang Xiao | 2024 | Nanotechnology and Precision Engineering2024，7，1： | 0 |
| 14 | Universal 4-qualifiable fluorene-based building blocks for potential optoelectronic applications显示文摘In the design of conjugated molecules,modular production enables materials to easily realize structure modification and precisely tune their photoelectrical property.Construction of a novel and universal building block is crucial to design and manufacture high performance and stable conjugated molecules for optoelectronic application.Herein,we originally demonstrated a universal 4-qualifiable fluorene-based building block,which is a fundamental molecular segment to functionalize and obtain novel conjugated materials.Compared to the traditional modification at 9-site,additional 4-position functionalization provided an exciting blueprint to not only tune electronic structure and excited state via p-n molecular design engineering and space charge-transfer strategy,but also allow for optimizing intermolecular arrangement and obtaining solution-processing ability.The introduction of the 4-site substituent in fluorene based semiconductors may endow materials with unique properties.Finally,we successfully prepared two stable deep-blue light-emitting conjugated polymer,PODOPF and PODOF,by utilizing the 4-substituent fluorene based building block.It is believable that the performance,stability and processibility of reported outstanding fluorene-based conjugated molecules can be further optimized based on this universal building block. | Xiang An Jinghao Yang Man Xu Lili Sun Lubing Bai Kai Wang Zhiqiang Zhuo Yingying Zheng Jinyi Lin Xuehua Ding Yuyu Liu Linghai Xie Chengrong Yin Wei Huang | 2022 | Chinese Chemical Letters2022，33，12： | 0 |
| 15 | Expert Consensus on Nutritional Support for Children with Congenital Heart Disease(2023 Edition)显示文摘The second edition of the expert consensus on pediatric nutrition was formed based on a global update of pedia-tric nutrition guidelines or consensus worldwide,the management of congenital heart disease,and the results of multi-center clinical nutrition research for congenital heart disease following thefirst Chinese consensus edition of 2016.The consensus was also shaped by the results of three discussion sessions and two questionnaires con-ducted by the 13-member collaboration group.This process was informed by both clinical guidelines and expert consensus.The quality of literature,both in English and Chinese,and the level of recommendations were evaluated using the Grading of Recommendations Assessment,Development,and Evaluations(GRADE)system. | Xuming Mo Wei Cai Jirong Qi Zhuoming Xu Ying Wang Weihui Yan Shoujun Li Nianguo Dong Xinxin Chen Jinfen Liu Qiang Shu Jimei Chen Haibo Zhang Hao Zhang Quansheng Xing Qi An Xiaofeng Li Xu Wang Yan He Junwu Su Taibing Fan Teng Ming Weibing Tang Li Hong Jinghao Zheng Ming Ye Guocheng Sun Yiqun Ding Liang Tao Yifeng Yang Zhongshi Wu Hua Cao Qiang Wang Keming Yang Libing Zhang Ping Wen Yanqin Cui Bo Zhai Yong Zou Qingya Tang Rui Chen Chun Wu Zhiyu Feng Caixia Liu Yaping Mi Rufang Zhang Ke Lin Xin Li Mingan Pi Xiangming Fan Shanshan Shi Peng Huang Zhengxia Pan Jiafeng Qi Renwei Chen Shuguang Tao Yaqin Shu Huifeng Zhang Lan Jiang Min Da Nishant Patel Liang Hu Cardiac Surgery Group of Pediatric Surgery Society of Chinese Medical Association and Parenteral Enteral Nutrition Society of Chinese Medical Association | 2023 | Congenital Heart Disease2023，18，6： | 0 |
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