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| 1 | Effect of Discontinuous Administration of β -glucan and Glycyrrhizin on the Growth and Immunity of Pacific White Shrimp Litopenaeus Vannamei显示文摘 | Nan Bai Kangsen Mai Wenbing Zhang Hongming Ma Qinghui Ai Xiaojie Wang | 2010 | Feed & Livestock2010，3，3： | 20 |
| 2 | Effects of Dietary β-Glucan and Glycyrrhizin on Non-Specific Immunity and Disease Resistance of the Sea Cucumber (Apostichopus japonicus Selenka) Challenged with Vibrio splendidus显示文摘Sea cucumbers, Apostichopus japonicus Selenka, were fed diets containing non-immunostimulant (basal diet), 0.2% β-glucan and 0.02% glycyrrhizin in a recirculatory water system for 45 days, and subsequently challenged with Vibrio splendidus by injection at 1.0×108 cfu/sea cucumber for 15 days.Phagocytic capacity (PC), intracellular superoxide anion production (ISAP), ly-sozyme (LSZ) activity and superoxide dismutase (SOD) activity in the coelomic fluid were analyzed on the 0th, 5th, 10th and 15th days after injection.Results showed that after the 45-day feeding period, PC, ISAP, LSZ activity and SOD activity in sea cucumbers fed with dietary β-glucan or glycyrrhizin were significantly higher than in those fed with the basal diet.On the 5th day after infection, all the immune parameters examined in the sea cucumbers injected with V.splendidus decreased in value significantly.On the 15th day, PC, ISAP and LSZ activity returned to levels similar to those on the 0th day.For the sea cucumbers injected with saline, there were no significant differences in all the immune parameters examined and in the cumulative morbidity during the 15-day challenging trial.After injecting with V.splendidus, the cumulative morbidity of sea cucumbers fed with the basal diet was significantly higher than those fed with dietary β-glucan or glycyrrhizin when challenged with V.splendidus challenged sea cucumber fed with the basal diet was significantly higher than those fed with dietary β-glucan or glycyrrhizin.There was no significant difference in cumulative morbidity between the dietary β-glucan and glycyrrhizin treatments over time. | CHANG Jie ZHANG Wenbing MAI Kangsen MA Hongming XU Wei | 2010 | Journal of Ocean University of China2010，9，4： | 12 |
| 3 | Recent Progress in Automotive Gasoline Direct Injection Engine Technology显示文摘Gasoline direct injection(GDI)engines are currently the dominant powertrains for passenger cars.With the implementation of increasingly stringent fuel consumption and emission regulationsworldwide,GDI engines are facing challenges owing to high particulate matter emissions and a tendency to knock,leading to a change in the research and design(R&D)issues compared with those in the twentieth century.This paper reviews the progress in research regarding GDI engine technologies over the past 20 years,focusing on combustion system configurations,and also highlights common issues in GDI R&D,including pre-ignition and deto-knock,soot formation and PM emissions,injector deposits and gasoline compression ignition(GCI).First,an overview of recent developments in the field as driven by regulations is provided,following which progress in injection and combustion systems is examined.Third,the review addresses the occurrence and mechanism of deto-knock and considers means of suppressing this phenomenon.The fourth section discusses soot formation mechanisms and particulate matter emission characteristics of GDI engines and describes the application of gasoline particulate filter(GPF)after-treatment.The subsequent section summarizes studies regarding injector deposit formation,as well as pioneering research into GCI combustion modes.Finally,a summary and future prospects for GDI engine technologies are provided. | Shijin Shuai Xiao Ma Yanfei Li Yunliang Qi Hongming Xu | 2018 | Automotive Innovation2018，1，2： | 8 |
| 4 | Mutation analyses of integrated HBV genome in hepatitis B patients显示文摘Little has been learnt in the last 30 years about detection of HBV genome as well as its mutation analysis between hepatitis B fathers (HBF) and their children. In this study, we used nest polymerase chain reaction (PCR), fluorescence in situ hybridization (FISH), and DNA sequencing analysis, to examine the integrated HBV genome in paraffin-embedded testis tissues, which were taken as samples from HBF, and in peripheral blood mononuclear cells (PBMC) from 74 cases of HBFs and their children who were born after their fathers’ HBV infection (caHBF). We found that HBV DNA existed in testis tissues, mainly in the basilar parts of the seminiferous tubules, and also in PBMC of HBF. It was also documented that there were point mutations of poly-loci, insertions and deletions of nucleotides in integrated HBV genomes, and the types of gene mutations in the HBFs were similar to those in caHBF. This study addresses the major types of gene mutations in integrated HBV genome in human patients and also presents reliable evidence of possible genetic transmission of hepatitis B. | Peilin Wang Xiuhai Wang Shuying Cong Hongming Ma Xuecheng Zhang | 2008 | Journal of Genetics and Genomics2008，35，2： | 6 |
| 5 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 6 | Can semipermeable membranes coating materials influence in vivo performance for paliperidone tri-layer ascending release osmotic pump tablet:In vitro evaluation and in vivo pharmacokinetics study显示文摘One purpose of this study was to develop a paliperidone(PAL)tri-layer ascending release pushepull osmotic pump(TA-PPOP)tablet which could meet the needs of clinical applications.And another purpose was to investigate whether different coating materials influenced in vivo performance of TA-PPOP.The ascending release mechanism of this trilayer delivery system on theory was elaborated.TA-PPOP was prepared by means of coating with cellulose acetate(CA)or ethyl cellulose(EC).Several important influence factors such as different core tablet compositions and different coating solution ingredients involved in the formulation procedure were investigated.The optimization of formulation and process was conducted by comparing different in vitro release behaviors of PAL.In vitro dissolution studies indicated that both the two formulations of different coating materials were able to deliver PAL at an ascending release rate during the whole 24 h test.The in vivo pharmacokinetics study showed that both self-made PPOP tablets with different coating had a good in vitro-in vivo correlation(IVIVC)and were bioequivalent with the brand product,which demonstrated no significant influence of the coating materials on the in vivo release acceleration of TA-PPOP. | Guangjing Li Yongjun Wang Hongming Chen Donglei Leng Panqin Ma Yanjie Dong Lifang Gao Zhonggui He | 2015 | Asian Journal of Pharmaceutical Sciences2015，10，2： | 4 |
| 7 | Development and validation of a rapid and sensitive UHPLCeMS/MS method for the determination of paliperidone in beagle dog plasma显示文摘In order to evaluate the pharmacokinetic profile of paliperidone extended-release tablets in vivo,a simple and rapid ultra-high performance liquid chromatographyetandem mass spectrometry(UHPLCeMS/MS)method was developed and validated for the determination of paliperidone in beagle dog plasma.Paliperidone and diazepam(internal standard)were extracted from plasma samples with diethyl ether,and then separated on a C_(18) column(2.1×50 mm,2.6 mm)under gradient elution with methanol-0.1%formic acid at a flow rate of 0.3 ml/min.The compounds were detected using a triple-quadrupole mass spectrometer equipped with an electrospray ionization(ESI)source.The validated method was linear over the concentration range of 1.00-1000.00 ng/ml and the lower limit of quantitation was 1.00 ng/ml.The intra-day and inter-day precision values were not more than 15%(relative standard deviation<20%at low levels),while the accuracy was within±10%of nominal values.The validated UHPLC-MS/MS method was successfully applied to an oral pharmacokinetic study of paliperidone extended-release tablets in a beagle dog. | Hongming Chen Longshan Zhao Guangjing Li Donglei Leng Panqin Ma Lijin Tong Tianhong Zhang | 2014 | Asian Journal of Pharmaceutical Sciences2014，9，5： | 3 |
| 8 | Combustion characteristics and emissions of 2-methylfuran compared to 2,5-dimethylfuran, gasoline and ethanol in a DISI engine显示文摘 | Chongming Wang Hongming Xu Ritchie Daniel Akbar Ghafourian Jose Martin Herreros Shijin Shuai Xiao Ma | 2013 | Fuel2013，，： | 1 |
| 9 | Ultra-High Speed Imaging and OH-LIF Study of DMF and MF Combustion in a DISI Optical Engine显示文摘 | Xiao Ma Hongming Xu Changzhao Jiang Shijin Shuai | 2014 | Applied Energy2014，，： | 1 |
| 10 | A low-power,area-efficient all-digital delay-locked loop for DDR3 SDRAM controller显示文摘A new low-power,area efficiency all-digital delay-locked loop(ADDLL)circuit is proposed for DDR3application.The ADDLL can process the input clock frequency ranging from 333 MHz to 800 MHz(DDR3-667/800/1066/1600)by using Phase Detector(PD),Delay Control Delay Line(DCDL),Digital Loop Filter Controller(DLFC)and Delay Generator(DG).To achieve 1.6 Gb/s/pin operation,a novel DCDL scheme is employed.The DCDL has a small delay with a shunt capacitor based digitally controlled delay element.A splitcontrol thermometer-code generator generates the control voltages used to set a current in the current-starved inverters.The testchip fabricated with a 40-nm CMOS process gives the ADDLL data rate of 667 Mbps–1.6 Gbps.Experimental results that show the power consumption is 1.87 m W at 1.1 V with active area is 0.0137mm2. | CHEN HongMing MA Song WANG Liu ZHANG Hao PAN KenYi CHENG YuHua | 2014 | Science China(Information Sciences)2014，57，12： | 1 |
| 11 | Abel inversion using legendre wavelets expansion显示文摘 | MA Shuiliang GAO Hongming ZHANG Guangjun | 2007 | Journal of Quantitative Spectroscopy and Radiative Transfer2007，107，： | 1 |
| 12 | Activities of selected digestive enzymes during larval development of large yellow croaker ( Pseudosciaena crocea )显示文摘 | Hongming Ma Chantal Cahu José Zambonino Hairui Yu Qingyuan Duan Marie-Madeleine Le Gall Kangsen Mai | 2004 | Aquaculture2004，，1： | 1 |
| 13 | Anewstagingsystemfornasopharyngealcarcinoma inChina显示文摘 | HongM Ma J | 1994 | IntJRadiatOncolBi2 ol Phys1994，30，： | 1 |
| 14 | Combustion characteristics and emissions of 2-methylfuran compared to 2,5-dimethylfuran, gasoline and ethanol in a DISI engine显示文摘 | Chongming Wang Hongming Xu Ritchie Daniel Akbar Ghafourian Jose Martin Herreros Shijin Shuai Xiao Ma | 2013 | Fuel2013，，： | 1 |
| 15 | Multiple forms of alpha-2 macroglobulin in shrimp Fennero- penaeus chinesis and their transcriptional response to WSSV or Vibrio pathogen infection 显示文摘 | Ma Hongming Wang Bing Zhang Jiquan | 2010 | Dev Comp Immunol2010，34，6： | 1 |
| 16 | Interaction of dietary Bacillus subtilis and fructooligosaccharide on the growth performance, non-specific immunity of sea cucumber, Apostichopus japonicus显示文摘 | Qin Zhang Hongming Ma Kangsen Mai Wenbing Zhang Zhiguo Liufu Wei Xu | 2010 | Fish and Shellfish Immunology2010，，2： | 1 |
| 17 | Effects of dietary β-glucan on the growth, immune responses and resistance of sea cucumber, Apostichopus japonicus against Vibrio splendidus infection显示文摘 | Yancui Zhao Hongming Ma Wenbing Zhang Qinghui Ai Kangsen Mai Wei Xu Xiaojie Wang Zhiguo Liufu | 2011 | Aquaculture2011，，3： | 1 |
| 18 | Interaction of dietary Bacillus subtilis and fructooligosaccharide on the growth performance, non-specific immunity of sea cucumber, Apostichopus japonicus显示文摘 | Qin Zhang Hongming Ma Kangsen Mai Wenbing Zhang Zhiguo Liufu Wei Xu | 2010 | Fish and Shellfish Immunology2010，，2： | 1 |
| 19 | Interaction of dietary Ba-cillus subtilis and fructooligosaccharide on the growth performance,non-specific immunity of sea cucumber,Apostichopus japonicus显示文摘 | Zhang Qin Ma hongming Mai Kangseng | 2010 | Fish and Shellfish Immunology2010，29，20： | 1 |
| 20 | Cloning and characterization of an actin gene of Chlamys farreri and the phylogenetic analysis of mollusk actins显示文摘 | Hongming Ma Kangsen Mai Zhiguo Liufu Wei Xu | | 0，，： | 1 |
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