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| 1 | Evidential method to identify influential nodes in complex networks显示文摘Identifying influential nodes in complex networks is still an open issue. In this paper, a new comprehensive centrality measure is proposed based on the Dempster-Shafer evidence theory.The existing measures of degree centrality, betweenness centrality and closeness centrality are taken into consideration in the proposed method. Numerical examples are used to illustrate the effectiveness of the proposed method. | Hongming Mo Cai Gao Yong Deng | 2015 | Journal of Systems Engineering and Electronics2015，26，2： | 7 |
| 2 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 3 | Selective depression action of taurine in flotation separation of specularite and chlorite显示文摘Chlorite,as the most representative gangue mineral associated with specularite,of which the separation of these two minerals is difficult.This paper investigated the depression effect of taurine on specularite/chlorite separation via flotation experiments,adsorption tests,contact angle measurements,Zeta potential detection,FT-IR measurements,and XPS analyses.The results of single mineral flotation indicated that chlorite could be depressed selectively by taurine with the recovery of less than 30%,but the floatability of specularite remains high with recovery rate of 81.77%at pH 10.The artificial mixed mineral flotation results confirmed the effectiveness of taurine as a depressant.Surface adsorption,contact angle,and Zeta potential detection revealed taurine primarily adsorbs on the chlorite surface,which hampered the DDA’s subsequent adsorption and results in the chlorite’s poor floatability.The FT-IR spectra and XPS analyses provided further proof that taurine adsorbed on chlorite surface as an electron donor,and part of the electrons transferred from the sulfonic acid group of taurine to metal ions during the adsorption process.In addition,the hydrogen bond between amino-group of taurine and O ions in chlorite surface was also formed in the adsorption process.Finally,optimized adsorption configurations of taurine on chlorite surfaces were proposed. | Mingyang Li Cheng Yang Zhaoyang Wu Xiangpeng Gao Xiong Tong Xiankun Yu Hongming Long | 2022 | International Journal of Mining Science and Technology2022，32，3： | 4 |
| 4 | Can semipermeable membranes coating materials influence in vivo performance for paliperidone tri-layer ascending release osmotic pump tablet:In vitro evaluation and in vivo pharmacokinetics study显示文摘One purpose of this study was to develop a paliperidone(PAL)tri-layer ascending release pushepull osmotic pump(TA-PPOP)tablet which could meet the needs of clinical applications.And another purpose was to investigate whether different coating materials influenced in vivo performance of TA-PPOP.The ascending release mechanism of this trilayer delivery system on theory was elaborated.TA-PPOP was prepared by means of coating with cellulose acetate(CA)or ethyl cellulose(EC).Several important influence factors such as different core tablet compositions and different coating solution ingredients involved in the formulation procedure were investigated.The optimization of formulation and process was conducted by comparing different in vitro release behaviors of PAL.In vitro dissolution studies indicated that both the two formulations of different coating materials were able to deliver PAL at an ascending release rate during the whole 24 h test.The in vivo pharmacokinetics study showed that both self-made PPOP tablets with different coating had a good in vitro-in vivo correlation(IVIVC)and were bioequivalent with the brand product,which demonstrated no significant influence of the coating materials on the in vivo release acceleration of TA-PPOP. | Guangjing Li Yongjun Wang Hongming Chen Donglei Leng Panqin Ma Yanjie Dong Lifang Gao Zhonggui He | 2015 | Asian Journal of Pharmaceutical Sciences2015，10，2： | 4 |
| 5 | Analysis of Gas-Solid Flow Characteristics in a Spouted Fluidized Bed Dryer by Means of Computational Particle Fluid Dynamics显示文摘In order to grasp the particle flow characteristics and energy consumption of industrial fluidized spouted beds,we conduct numerical simulations on the basis of a Computational Particle Fluid Dynamics(CPFD)approach.In particular,the traction model of Wen-Yu-Ergun is used and different inlet conditions are considered.Using a low-speed fluidizing gas,the flow state of the particles is better and the amount of particles accumulated at the bottom of the bed wall becomes smaller.For the same air intake,the energy loss of a circular nozzle is larger than that of a square nozzle. | Hongming Zhou Haozheng Gao Zheng Fang Jiangxin Yang Mingge Wu | 2020 | Fluid Dynamics & Materials Processing2020，16，4： | 3 |
| 6 | The Agpat4/LPA axis in colorectal cancer cells regulates antitumor responses via p38/p65 signaling in macrophages显示文摘Lipid metabolic reprogramming plays an essential role in regulating the progression of colorectal cancer(CRC).However,the effect of lysophosphatidic acid(LPA)metabolism on CRC development is incompletely characterized.Here,we compared the mRNA levels of human CRC tissues to those of paracarcinoma tissues and focused on the notably enriched LPA metabolic pathways.We identified and verified that 1-acylglycerol-3-phosphate O-acyltransferase 4(Agpat4)was aberrantly expressed in CRC tissues and predicted poor survival in CRC patients.Manipulating Agpat4 expression in CRC cells did not affect the growth or migration of CRC cells in vitro,whereas Agpat4 silencing suppressed CRC cell growth in subcutaneous and peritoneal xenograft models.Mechanistically,Agpat4 silencing-induced LPA release from CRC cells and polarized macrophages to an M1-like phenotype through LPA receptors 1 and 3.This M1 activation,characterized by elevated p38/p65 signaling and increased proinflammatory cytokines,promoted the infiltration and activation of CD4+and CD8+T cells in the tumor microenvironment.Modulation of the Agpat4/LPA/p38/p65 axis regulated macrophage polarization,T-cell activity and CRC progression.Notably,combined therapy with LPA and regular chemotherapy drugs synergistically suppressed CRC development.Taken together,our results showed that the Agpat4/LPA axis in CRC cells regulated p38/p65 signaling-dependent macrophage polarization,T-cell activation,and CRC progression.The Agpat4/LPA/p38/p65 axis might represent a potential target for therapy in the clinic. | Dapeng Zhang Rongchen Shi Wei Xiang Xia Kang Bo Tang Chuan Li Linfeng Gao Xuan Zhang Lili Zhang Rongyang Dai Hongming Miao | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 3 |
| 7 | Current Density Distribution in Double-Sided GTAW Process显示文摘A three dimensional current density distribution in double-sided gas tungsten arc welding (GTAW) proces is performed. The current density distribution field is evaluated by numerically solving Maxwell equations in the domain of the workpiece. In the boundary condition, the current density on. the workpiece surface is assumed as Gaussian distribution. Results show that the current distribution in DSAW is different from single side arc welding, it is more concentrated and the relative location of the two torches influence the current distribution greatly. | Hongming GAO Lin WU and Honggang DONG National Key Laboratory of Advanced Welding Production Technology, Harbin institute of Technology, Harbin 150001, China | 2001 | Journal of Materials Science & Technology2001，17，1： | 2 |
| 8 | Interface Behavior of Copper and Steel by Plasma-MIG Hybrid Arc Welding显示文摘Plasma-MIG hybrid arc welding is a hybrid heating source welding method which is composed of plasma arc and MIG arc. During Plasma-MIG hybrid arc welding process, the interface behavior of copper and steel dissimilar alloy is investigated. The results show that electromagnetic stirring effect decreases and the heat input increases with the increase of outer plasma current in the hybrid arc welding process. The interface diffusion and interface thickness is controlled by the tradeoff of electromagnetic stirring effect degradation and heat input increase. The interface diffusion and interface thickness are controlled by decreasing the electromagnetic stirring force and increasing the heat input with the increase of plasma current in Cu/Fe plasma-MIG hybrid arc welding process. | Tao YANG Hongming GAO Shenghu ZHANG Lin WU | 2013 | Acta Metallurgica Sinica(English Letters)2013，26，3： | 2 |
| 9 | Current Density Distribution in Gas Tungsten Arc Welding Process显示文摘Heat transfer and fluid flow in a weld pool had been simulated for several decades, which underwent from theoretically analysis to numerical solutions. Because of the complexity of the welding process, many ideal assumptions were made to simplify the question. This makes the solution somewhat not complied with the practical conditions. In previous papers, the current distribution in the weld pool is assumed as axi-symmetrical, and so does the electromagnetic forces, which plays an important role in determining the fluid flow field. Actually the current distribution is different from the assumption. In this paper; a three dimensional current distribution in Gas Tungsten Arc Welding (GTAW) process is performed. The current density distribution field is evaluated by numerically solving Maxwell’s equations in the domain of the workpiece. In the boundary condition, the current density on the top surface is assumed as Gaussian distribution. Results show that the current distribution in GTAW is not axi-symmetrical, and the relative location of the torch and the earth clamp influence the current distribution greatly. | Hongming GAO Lin WU Honggang DONG National Key Laboratory of Advanced Welding Production Technology, Harbin Institute of Technology, Harbin, 150001, China | 2000 | Journal of Shanghai Jiaotong university(Science)2000，5，1： | 2 |
| 10 | Therapeutic silencing miR-146b-5p improves cardiac remodeling in a porcine model of myocardial infarction by modulating the wound reparative phenotype显示文摘Fibrotic remodeling is an adverse consequence of immune response-driven phenotypic modulation of cardiac cells following myocardial infarction(Ml).MicroRNA-146b(miR-146b)is an active regulator of immunomodulation,but its function in the cardiac inflammatory cascade and its clinical implication in fibrotic remodeling following Ml remain largely unknown.Herein,miR-146b-5p was found to be upregulated in the infarcted myocardium of mice and the serum of myocardial ischemia patients.Gain-and loss-of-function experiments demonstrated that miR-146b-5p was a hypoxia-induced regulator that governed the pro-fibrotic phenotype transition of cardiac cells.Overexpression of miR-146b-5p activated fibroblast proliferation,migration,and fibroblast-to-myofibroblast transition,impaired endothelial cell function and stress survival,and disturbed macrophage paracrine signaling.Interestingly,the opposite effects were observed when miR-146b-5p expression was inhibited.Luciferase assays and rescue studies demonstrated that the miR-146b-5p target genes mediating the above phenotypic modulations included interleukin 1 receptor associated kinase 1(IRAKI)and carcinoembryonic antigen related cell adhesion molecule 1(CEACAM1).Local delivery of a miR-146b-5p antagomir significantly reduced fibrosis and cell death,and upregulated capillary and reparative macrophages in the infarcted myocardium to restore cardiac remodeling and function in both mouse and porcine Ml models.Local inhibition of miR-146b-5p may represent a novel therapeutic approach to treat cardiac fibrotic remodeling and dysfunction following Ml. | Yiteng Liao Hao Li Hao Cao Yun Dong Lei Gao Zhongmin Liu Junbo Ge Hongming Zhu | 2021 | Protein & Cell2021，12，3： | 1 |
| 11 | Effect of process parameters on temperature distribution in twin-electrode TIG coupling arc 显示文摘 | Zhang Guangjun Xiong Jun Gao Hongming | 2012 | Journal of Quantitative Spectroscopy & Ra- diative Transfer2012，113，： | 1 |
| 12 | Abel inversion using legendre wavelets expansion显示文摘 | MA Shuiliang GAO Hongming ZHANG Guangjun | 2007 | Journal of Quantitative Spectroscopy and Radiative Transfer2007，107，： | 1 |
| 13 | Palladium within ionic liquid functionalized mesoporous silica SBA-15 and its catalytic application in room-temperature Suzuki coupling reaction显示文摘 | Peng Han Hongming Zhang Xuepeng Qiu Xiangling Ji Lianxun Gao | 2008 | Journal of Molecular Catalysis. A, Chemical2008，，1： | 1 |
| 14 | Characteristic of hyper- baric GMAW metal transfer at 1 - 12 bar argon environment显示文摘 | Li Kai Gao Hongming Li Haichao | 2014 | Advanced Materials Research2014，900，： | 1 |
| 15 | Teleteaching approach for sensor-based arc welding telerobotic system显示文摘 | Li Haichao Gao Hongming Wu Lin | 2007 | Industrial Robot2007，34，5： | 1 |
| 16 | Object detection using spatial histogram features 显示文摘 | ZHANG Hongming GAO Wen CHEN Xilin ZHAO Debin | 2006 | Image and Vision Computing2006，24，4： | 1 |
| 17 | Object detection using spatial histogram features 显示文摘 | Zhang Hongming Wen Gao Chen Xilin | 2006 | Image and Vision Computing2006，24，4： | 1 |
| 18 | Droplet transition for plasma-MIG welding on aluminium alloys 显示文摘 | Bai Yan Gao Hongming Qiu Ling | 2010 | Transac- tion of Nonferrous Metals Society of China2010，20，： | 1 |
| 19 | Bispecific immune molecule PD1-IL2v: a new therapeutic strategy for pancreatic ductal adenocarcinoma显示文摘Recently,Piper and Hoen et al.reported a new immunotherapy for pancreatic cancer in orthotopic pancreatic ductal adenocarcinoma(PDAC)KPC tumor model.1 They found that a murine PD-1-targeted IL-2 variant complex(PD1-IL2v),in combination with radiation therapy(RT),can inhibit PDAC growth and metastasis by immune system,and induce a lasting immunological memory response to the tumor. | Yuan Gao Liqing Yu Hongming Miao | 2023 | Signal Transduction and Targeted Therapy2023，8，11： | 0 |
| 20 | Evolution of Weyl nodes in Ni-doped thallium niobate pyrochlore Tl_(2-x)Ni_(x)Nb_(2)O_(7)显示文摘The magnetic Weyl semimetal(WSM)is important for fundamental physics and potential applications due to its spontaneous magnetism,robust band topology,and enhanced Berry curvature.It possesses many unique quantum effects,including a large intrinsic anomalous Hall effect,Fermi arcs,and chiral anomaly.In this work,using ab initio calculations,we propose that Nidoped pyrochlore Tl2Nb2O7is a magnetic WSM caused by the exchange field splitting on bands around its quadratic band crossing point.The exchange field tuned by Ni 3d on-site Coulomb interaction parameter U drives the evolution of Weyl nodes and the resulting topological phase transition.As Weyl nodes can exist at generic points in the Brillouin zone and are hard to identify exactly,their creation and annihilation,i.e.,the change in their number,chirality,and distribution,have been consistently confirmed with a combined theoretical approach,which employs parity criterion,symmetry indicator analysis,and the Wilson loop of the Wannier center.We find that Weyl nodes remain in a large range of U and are close to the Fermi level,which makes the experimental observation very possible.We think that this method and our proposal of magnetic WSM will be useful in finding more WSMs and add to the understanding of the topological phase transition. | Yuefang Hu Changming Yue Danwen Yuan Jiacheng Gao Zhigao Huang Zhong Fang Chen Fang Hongming Weng Wei Zhang | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，9： | 0 |
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