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| 1 | Piglets cloned from induced pluripotent stem cells显示文摘 | Nana Fan Jijun Chen Zhouchun Shang Hongwei Dou Guangzhen Ji Qingjian Zou Lu Wu Lixiazi He Fang Wang Kai Liu Na Liu Jianyong Han Qi Zhou Dengke Pan Dongshan Yang Bentian Zhao Zhen Ouyang Zhaoming Liu Yu Zhao Lin Lin Chongming Zhong Quanlei Wang Shouqi Wang Ying Xu Jing Luan Yu Liang Zhenzhen Yang Jing Li Chunxia Lu Gabor Vajta Ziyi Li Hongsheng Ouyang Huayan Wang Yong Wang Yang Yang Zhonghua Liu Hong Wei Zhidong Luan Miguel A Esteban Hongkui Deng Huanming Yang Duanqing Pei Ning Li Gang Pei Lin Liu Yutao Du Lei Xiao Liangxue Lai | 2013 | Cell Research2013，23，1： | 12 |
| 2 | Multicenter study of the clinicopathological features and recurrence risk prediction model of early-stage breast cancer with low-positive human epidermal growth factor receptor 2 expression in China (Chinese Society of Breast Surgery 021)显示文摘Background:Breast cancer with low-positive human epidermal growth factor receptor 2(HER2)expression has triggered further refinement of evaluation criteria for HER2 expression.We studied the clinicopathological features of early-stage breast cancer with low-positive HER2 expression in China and analyzed prognostic factors.Methods:Clinical and pathological data and prognostic information of patients with early-stage breast cancer with low-positive HER2 expression treated by the member units of the Chinese Society of Breast Surgery and Chinese Society of Surgery of Chinese Medical Association,from January 2015 to December 2016 were collected.The prognostic factors of these patients were analyzed.Results:Twenty-nine hospitals provided valid cases.From 2015 to 2016,a total of 25,096 cases of early-stage breast cancer were treated,7642(30.5%)of which had low-positive HER2 expression and were included in the study.After ineligible cases were excluded,6486 patients were included in the study.The median follow-up time was 57 months(4-76 months).The disease-free survival rate was 92.1%at 5 years,and the overall survival rate was 97.4%at 5 years.At the follow-up,506(7.8%)cases of metastasis and 167(2.6%)deaths were noted.Multivariate Cox regression analysis showed that tumor stage,lymphvascular invasion,and the Ki67 index were related to recurrence and metastasis(P<0.05).The recurrence risk prediction model was established using a machine learning model and showed that the area under the receiving operator characteristic curve was 0.815(95%confidence interval:0.750-0.880).Conclusions:Early-stage breast cancer patients with low-positive HER2 expression account for 30.5%of all patients.Tumor stage,lymphvascular invasion,and the Ki67 index are factors affecting prognosis.The recurrence prediction model for breast cancer with low-positive HER2 expression based on a machine learning model had a good clinical reference value for predicting the recurrence risk at 5 years.Trial registration:ChiCTR.org.cn,ChiCTR2100046766. | Ling Xin Qian Wu Chongming Zhan Hongyan Qin Hongyu Xiang Ling Xu Jingming Ye Xuening Duan Yinhua Liu Chinese Society of Breast Surgery(CSBrS) Chinese Society of Surgery of Chinese Medical Association | 2022 | Chinese Medical Journal2022，，6： | 9 |
| 3 | Cordycepin promotes browning of white adipose tissue through an AMP-activated protein kinase(AMPK)-dependent pathway显示文摘Obesity is a worldwide epidemic. Promoting browning of white adipose tissue(WAT)contributes to increased energy expenditure and hence counteracts obesity. Here we show that cordycepin(Cpn), a natural derivative of adenosine, increases energy expenditure, inhibits weight gain, improves metabolic profile and glucose tolerance, decreases WAT mass and adipocyte size, and enhances cold tolerance in normal and high-fat diet-fed mice. Cpn markedly increases the surface temperature around the inguinal WAT and turns the inguinal fat browner. Further investigations show that Cpn induces the development of brown-like adipocytes in inguinal and, to a less degree, epididymal WAT depots. Cpn also increases the expression of uncoupling protein 1(UCP1) and other thermogenic genes in WAT and3T3-L1 differentiated adipocytes, in which AMP-activated protein kinase(AMPK) plays an important role. Our results provide novel insights into the function of Cpn in regulating energy balance, and suggest a potential utility of Cpn in the treatment of obesity. | Guihong Qi Yue Zhou Xiaopo Zhang Jiaqi Yu Xin Li Xiaoxue Cao Chongming Wu Peng Guo | 2019 | Acta Pharmaceutica Sinica B2019，9，1： | 6 |
| 4 | Study on purification and ultrastructure of a baculovirus in Penaeus chinensis显示文摘 | Shi Tuo, Kong Jie, Bao Zhenmin, Liu Ping and Wang Chongming (Huanghai Sea Fisheries Research Institute, Qingdao 266071, China)Liang Xingming, (College of Marine Life Sciences, Ocean University of Qingdao, Qingdao 266003, China) | 1998 | Acta Oceanologica Sinica1998，17，4： | 4 |
| 5 | Syringaresinol-4-O-β-D-glucoside alters lipid and glucose metabolism in HepG2 cells and C2C12 myotubes显示文摘Syringaresinol-4-O-β-D-glucoside(SSG), a furofuran-type lignan, was found to modulate lipid and glucose metabolism through an activity screen of lipid accumulation and glucose consumption, and was therefore considered as a promising candidate for the prevention and treatment of metabolic disorder,especially in lipid and glucose metabolic homeostasis. In this study, the effects of SSG on lipogenesis and glucose consumption in Hep G2 cells and C2C12 myotubes were further investigated. Treatment with SSG significantly inhibited lipid accumulation by oil red O staining and reduced the intracellular contents of total lipid, cholesterol and triglyceride in Hep G2 cells. No effect was observed on cell viability in the MTT assay at concentrations of 0.1–10 μmol/L. SSG also increased glucose consumption by Hep G2 cells and glucose uptake by C2C12 myotubes. Furthermore, real-time quantitative PCR revealed that the beneficial effects were associated with the down-regulation of sterol regulatory element-binding proteins-1c,-2(SREBP-1c,-2), fatty acid synthase(FAS), acetyl CoA carboxylase(ACC) and hydroxyl methylglutaryl CoA reductase(HMGR), and up-regulation of peroxisome proliferator-activated receptors alpha and gamma(PPARα and PPARγ). SSG also significantly elevated transcription activity of PPARγtested by luciferase assay. These results suggest that SSG is an effective regulator of lipogenesis and glucose consumption and might be a candidate for further research in the prevention and treatment of lipid and glucose metabolic diseases. | Shuai Wang Chongming Wu Xin Li Yue Zhou Quanyang Zhang Fuchao Ma Jianhe Wei Xiaopo Zhang Peng Guo | 2017 | Acta Pharmaceutica Sinica B2017，7，4： | 3 |
| 6 | Overexpressing HRS1 Confers Hypersensitivity to Low Phosphate-Elicited Inhibition of Primary Root Growth in Arabidopsis thaliana显示文摘Phosphate (Pi) deficiency causes dramatic root system architecture(RSA) changes in higher plants.Here we report that overexpression of HRS1 leads to enhanced sensitivity to low Pi-elicited inhibition of primary root growth in Arabidopsis thaliana seedlings.Bioinformatic investigations uncovered that HRS1 and its six homologs encode putative G2-like transcription factors in Arabidopsis.Analysis of promoter::GUS reporter lines revealed that HRS1 transcripts were present mainly in the root hair region and root hair cells under Pi-sufficient conditions.Pi deprivation increased HRS1 expression level and expanded its expression domain.Although HRS1 knockout mutant did not differ from wild type(WT) control irrespective of Pi status,its overexpression lines were significantly more susceptible to low Pi-elicited primary root shortening.In both WT and HRS1 overexpression seedlings,low Pi-induced primary root shortening was accompanied by enhanced root hair cell differentiation,but this enhancement occurred to a greater extent in the latter genotype.Collectively,our data suggest that HRS1 may be involved in the modulation of primary root and root hair growth in Pi-deprived Arabidopsis seedlings,and provide useful clues for further research into the function of HRS1 and its homologs and the mechanisms behind RSA changes under Pi-deficient conditions. | Hong Liu Huixia Yang Chongming Wu Juanjuan Feng Xin Liu Huanju Qin Daowen Wang | 2009 | Journal of Integrative Plant Biology2009，51，4： | 3 |
| 7 | Ameliorating Effect and Potential Mechanism of Camellia Oil on Constipated Mice显示文摘Constipation is a global epidemic. To evaluate the ameliorating effect of camellia oil on constipation,two slowtransit costive mice models were established by water deprivation or sucralfate gavage. Administration of camellia oil( 4. 0 and 8. 0 mL/kg/day) significantly shortened the defecation time,increased defecation mass and fecal water content,with efficacies comparable to that of hemp seed oil. Intestinal propulsion test showed that camellia oil significantly enhanced the propelling rates of the charcoal powder in the intestine. Meanwhile,camellia oil also significantly decreased the serum levels of nitric oxide( NO),nitric oxide synthase( NOS) and vasoactive intestinal peptide( VIP) and increased serum substance P in costive animals. These results suggested that camellia oil can largely relieve slowtransit constipation and enhance the gastrointestinal motility through modulation of serum gastrointestinal motility key factors such as NO,NOS and VIP and substance P. | Liangshun Cao Tianyu Liu Chunhui Cai Yan Li Chongming Wu | 2018 | Journal of Beijing Institute of Technology2018，27，2： | 2 |
| 8 | Unified constant-frequency integration control of active power filters-steady-state and dynamics显示文摘 | Qiao Chongming Smedley K M Maddaleno F | 2001 | IEEE Transactions on Power Electronics2001，16，3： | 1 |
| 9 | Unified constant-frequency integration control of three phase standard bridge boost recti- tiers with power factor correction显示文摘 | CHONGMING Q SMEDLEY K M | 2003 | IEEE Trans on Industrial Electronics2003，50，1： | 1 |
| 10 | Unified constant freq- uency integration control of three-phase standard bridge boost rectifiers with power factor correction显示文摘 | Chongming Q Smedley K M | 2003 | IEEE Transactions on Industrial Electronics2003，50，1： | 1 |
| 11 | Hypoglycemic effect of Belamcanda chinensis leaf extract in normal and STZ-induced diabetic rats and its potential active faction显示文摘 | Chongming Wu Yan Li Yan Chen Xinyuan Lao Linghui Sheng Rongji Dai Weiwei Meng Yulin Deng | 2010 | Phytomedicine2010，，4： | 1 |
| 12 | Lipid-lowering polyketides from a soft coral-derived fungus Cladosporium sp. TZP29显示文摘 | Meilin Zhu Huquan Gao Chongming Wu Tianjiao Zhu Qian Che Qianqun Gu Peng Guo Dehai Li | 2015 | Bioorganic & Medicinal Chemistry Letters2015，，17： | 1 |
| 13 | Unified constant frequency integration control of active power filters steady -state and dynamics显示文摘 | SMEDLEY K M ZHOU Luowei QIAO Chongming | 2001 | IEEE Trans on Power Electronics2001，16，3： | 1 |
| 14 | Three-phase unity- power-factor star-connected switch (VIENNA) rectifier with unified constant-frequency integration control 显示文摘 | Qiao Chongming Smedley K M | 2003 | IEEE Transactions on Power Electronics2003，18，4： | 1 |
| 15 | Unified Constant-Frequency Integration Control of Active Power Filter-Steady-State and Dynamics显示文摘 | Luowei Zhou Chongming Qiao | 2001 | IEEE Transactions on Power Electronics2001，16，3： | 1 |
| 16 | One-cycle control of three-phase active power filter with vector operation显示文摘 | QIAO Chongming JIN Taotao SMEDLEY K M | 2004 | IEEE Transactions on Industrial Electronics2004，51，2： | 1 |
| 17 | Unified constant-frequency integration control of active power filters-steady-state and dynamics显示文摘 | Luowei Zhou Chongming Qiao | 2001 | IEEE Transactions on Power Electronics2001，16，3： | 1 |
| 18 | A single-phase active power filter with one-cycle control under unipolar operation 显示文摘 | QIAO Chongming SMEDLEY K M MADDALENO F | 2004 | IEEE Transactions on Circuit and Systems2004，51，8： | 1 |
| 19 | Three-phase bi-polar mode active power filter显示文摘 | Qiao Chongming Smedley Keyue Ma | 2002 | IEEE Transaction on industry Application2002，38，2： | 1 |
| 20 | One-cycle control of three-phase active power filter with vector operation 显示文摘 | Qiao Chongming Jin Taotao Smedley K M | 2004 | IEEE Trans on Industrial Electronics2004，15，2： | 1 |
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