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| 1 | Functional characterization of the NF-kB binding site in the human NOD2 promoter显示文摘Nucleotide-binding and oligomerization domain 2(NOD2),a member of the NOD protein family,plays an important role in innate immunity.In response to pathogen attack,NOD2 stimulates cytokine and defensin production by activating nuclear factor(NF)-kB,a key transcription factor responsible for mediating downstream reactions.However,the mechanism linking NOD2 regulation and NF-kB activation is poorly understood.Using bioinformatics,we found a completely preserved canonical NF-kB binding site in the NOD2 core promoter(216 to 225 bp)in both humans and chimpanzees.The functional role of this NF-kB binding site was investigated using the enhanced green fluorescent protein(EGFP)reporter system,site-directed mutagenesis,the NF-kB activation inhibitor(JSH-23)and the chromatin immunoprecipitation(ChIP)assay.The results show that the NF-kB binding site is critical for regulation of the NOD2 gene.Either deletion of the NF-kB binding elements within the NOD2 promoter or treatment with an NF-kB activation inhibitor could lead to a significant loss of NOD2 promoter activity as detected by reporter gene assay.The canonical NF-kB binding site was bound by NF-kB as determined by the ChIP method.Based on these results,we suggest a positive feedback regulation between NF-kB and NOD2,which may represent an efficient mechanism in response to pathogen invasion. | Chaofeng Hu Liping Sun Yiling Hu Daxiang Lu Huadong Wang Suisheng Tang | 2010 | Cellular & Molecular Immunology2010，7，4： | 3 |
| 2 | Safety of endovascular therapy for symptomatic intracranial artery stenosis:a national prospective registry显示文摘Introduction The safety outcomes of endovascular therapy for intracranial artery stenosis in a real-world stetting are largely unknown.The Clinical Registration Trial of Intracranial Stenting for Patients with Symptomatic Intracranial Artery Stenosis(CRTICAS)was a prospective,multicentre,real-world registry designed to assess these outcomes and the impact of centre experience.Methods 1140 severe,symptomatic intracranial arterial stenosis(ICAS)patients treated with endovascular therapy were included from 26 centres,further divided into three groups according to the annual centre volume of intracranial angioplasty and stent placement procedures over 2 years:(1)high volume for≥25 cases/year;(2)moderate volume for 10–25 cases/year and(3)low volume for<10 cases/year.Results The rate of 30-day stroke,transient ischaemic attack or death was 9.7%(111),with 5.4%,21.1%and 9.7%in high-volume,moderate-volume and low-volume centres,respectively(p<0.05).Multivariable logistic regression confirmed high-volume centres had a significantly lower primary endpoint compared with moderate-volume centres(OR=0.187,95%CI:0.056 to 0.627;p≤0.0001),while moderate-volume and low-volume centres showed no significant difference(p=0.8456).Conclusion Compared with the preceding randomised controlled trials,this real-world,prospective,multicentre registry shows a lower complication rate of endovascular treatment for symptomatic ICAS.Non-uniform utilisation in endovascular technology,institutional experience and patient selection in different volumes of centres may have an impact on overall safety of this treatment. | Yabing Wang Tao Wang Adam Andrew Dmytriw Kun Yang Liqun Jiao Huaizhang Shi Jie Lu Tianxiao Li Yujie Huang Zhenwei Zhao Wei Wu Jieqing Wan Qinjian Sun Bo Hong Yongli Li Liyong Zhang Jianfeng Chu Qiong Cheng Yiling Cai Pengfei Wang Qi Luo Hua Yang Baijing Dong Yang Zhang Jun Zhao Zuoquan Chen Wei Li Xiaoxin Bai Weiwen He Xueli Cai Maimai Ti Osama O Zaidat | 2022 | Stroke & Vascular Neurology2022，7，2： | 3 |
| 3 | Interaction between the interstitial fluid and the extracellular matrix in confined indentation显示文摘 | Lu Yiling Wang Wen | 2008 | J Biomech Eng2008，130，41： | 1 |
| 4 | 查看详情显示文摘 | Lu Shixiang Chen Yiling Xu Wenguo | | 0，，20： | 1 |
| 5 | Comparison of hepatic gene expression profiles between three mouse models of Nonalcoholic Fatty Liver Disease显示文摘Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver disorder worldwide. Murine models of NAFLD have been widely used to explore its pathogenesis. In this study, we performed a systematic evaluation of hepatic genome-wide mRNA expression by RNA-Sequencing using three mouse models of NAFLD: leptin receptor deficient db/db mice, high-fat high-sugar diet (HSHF)-induced obese mice, and dexamethasone (DEX)-induced NAFLD mice. As a result, we found both distinct and common pathways in the regulation of lipid metabolism from transcriptomes of three mouse models. Moreover, only a total of 12 differentially expressed genes (DEGs) were commonly detected among all three mouse groups, indicating very little overlap among all three models. Therefore, our results suggest that NAFLD is a heterogeneous disease with highly variable molecular mechanisms. | Liping Xiang Yang Jiao Yiling Qian Yao Li Fei Mao Yan Lu | 2022 | Genes & Diseases2022，9，1： | 1 |
| 6 | Synthesis and Spectral Properties of Novel Water-soluble Indocyanine Dyes as Fluorescent Dyes for Proteins Detection显示文摘二新奇水溶性的 indocyanine 染料被综合。他们的化学结构被 1H NMR,红外, MS 和紫外力的技术证实。在不同溶剂的准备染料的吸收被测量。二染料展出了否定 solvatochromism,与吸收和排放最大值在的蓝移动(牛的浆液白朊) protonic 溶剂相对非 protonic 溶剂。处于免费状态和 BSA 的染料的荧光性质被调查。为 Dye2 的荧光紧张的重要改进面对 BSA 被观察。Dye2 能作为荧光灯被建议为在水的答案的 BSA 察觉的染料。 | Fu, Yile Wang, Lanying Zhang, Xianghan Lu, Tianqin Xie, Qianjie Shi, Zhen | 2011 | Chinese Journal of Chemistry2011，29，3： | 1 |
| 7 | NIR-II driven plasmon-enhanced cascade reaction for tumor microenvironment-regulated catalytic therapy based on bio-breakable Au-Ag nanozyme显示文摘Emerging nanozymes with natural enzyme-mimicking catalytic activities have inspired extensive research interests due to their high stability,low cost,and simple preparation,especially in the field of catalytic tumor therapy.Here,bio-breakable nanozymes based on glucose-oxidase(GOx)-loaded biomimetic Au–Ag hollow nanotriangles(Au–Ag–GOx HTNs)are designed,and they trigger an near-infrared(NIR)-II-driven plasmon-enhanced cascade catalytic reaction through regulating tumor microenvironment(TME)for highly efficient tumor therapy.Firstly,GOx can effectively trigger the generation of gluconic acid(H+)and hydrogen peroxide(H2O2),thus depleting nutrients in the tumor cells as well as modifying TME to provide conditions for subsequent peroxidase(POD)-like activity.Secondly,NIR-II induced surface plasmon resonance can induce hot electrons to enhance the catalytic activity of Au–Ag–GOx HTNs,eventually boosting the generation of hydroxyl radicals(•OH).Interestingly,the generated H2O2 and H+can simultaneously induce the degradation of Ag nanoprisms to break the intact triangle nanostructure,thus promoting the excretion of Au–Ag–GOx HTNs to avoid the potential risks of drug metabolism.Overall,the NIR-II driven plasmon-enhanced catalytic mechanism of this bio-breakable nanozyme provides a promising approach for the development of nanozymes in tumor therapy. | Min Xu Qianglan Lu Yiling Song Lifang Yang Chuchu Ren Wen Li Ping Liu Yule Wang Yan Zhu Nan Li | 2020 | Nano Research2020，13，8： | 1 |
| 8 | Controlled growth of superhydrophobic films by sol–gel method on aluminum substrate显示文摘 | Shixiang Lu Yiling Chen Wenguo Xu Wei Liu | 2010 | Applied Surface Science2010，，20： | 1 |
| 9 | Left Atrial Wall Stress Distribution and Its Relationship to Electrophysiologic Remodeling in Persistent Atrial Fibrillation显示文摘 | Ross J. Hunter Yankai Liu Yiling Lu Wen Wang Richard J. Schilling | 2012 | Circulation: Arrhythmia and Electrophysiology2012，，2： | 1 |
| 10 | Comprehensive Genomic Characterization of Long Non-coding RNAs across Human Cancers显示文摘 | Xiaohui Yan Zhongyi Hu Yi Feng Xiaowen Hu Jiao Yuan Sihai D. Zhao Youyou Zhang Lu Yang Weiwei Shan Qun He Lingling Fan Lana E. Kandalaft Janos L. Tanyi Chunsheng Li Chao-Xing Yuan Dongmei Zhang Huiqing Yuan Keqin Hua Yiling Lu Dionyssios Katsaros Qihong H | 2015 | Cancer Cell2015，，4： | 1 |
| 11 | The mechanism of different cyanobacterial responses to glyphosate显示文摘Glyphosate, the most extensively used herbicide globally, has raised ecotoxicological concerns because it can be transported into the aquatic environment and cause adverse effects on the aquatic system. However, the functional mechanism of glyphosate on cyanobacteria are not completely disentangled. In this study, we selected six common cyanobacteria to evaluate glyphosate effects on cyanobacterial growth in monoculture experiment. Results showed that the growth of five tested cyanobacterial species were promoted under different degrees, and only Pseudanabaena was inhibited by glyphosate. In the phylogenetic tree based on gene sequences of 5-enol-pyruvylshikimate-3-phosphate synthase(EPSPS),a target for glyphosate, we found that the position of Pseudanabaena is the closest to plant,which was sensitive to glyphosate, thereby explaining the inhibitory effect of Pseudanabaena following glyphosate exposure. The primary degraded metabolites or analogs did not induce cyanobacterial growth, laterally demonstrating that glyphosate was used as a source of phosphorus to accelerate cyanobacterial growth because phosphorus levels increased in the medium of glyphosate treatment. Overall, this study provides a better understanding of the influence of glyphosate on the composition of aquatic microbiota and explains the mechanism of cyanobacterial response to glyphosate. | Wei Lin Zhenyan Zhang Yiling Chen Qi Zhang Mingjing Ke Tao Lu Haifeng Qian | 2023 | Journal of Environmental Sciences2023，，3： | 0 |
| 12 | Modulated illumination localization microscopy-enabled sub-10 nm resolution显示文摘Optical microscopy is an essential tool for exploring the structures and activities of cells and tissues.To break the limit of resolution caused by diffraction,researchers have made continuous advances and innovations to improve the resolution of optical microscopy since the 1990s.These contributions,however,still make sub-10nm imaging an obstacle.Here,we name a series of technologies as modulated illumination localization microscopy(MILM),which makes ultra-high-resolution imaging practical.Besides,we review the recent progress since 2017 when MINFLUX was proposed and became the inspiration and foundation for the follow-up devel-opment of MILM.This review divides MILM into two types:point-scanning and wide-field.The schematics,principles and future research directions of MILM are discussed elaborately. | Yile Sun Lu Yin Mingxuan Cai Hanmeng Wu Xiang Hao Cuifang Kuang Xu Liu | 2022 | Journal of Innovative Optical Health Sciences2022，15，2： | 0 |
| 13 | Targeting LncRNA LLNLR-299G3.1 with antisense oligonucleotide inhibits malignancy of esophageal squamous cell carcinoma cells in vitro and in vivo显示文摘Accumulating evidence has indicated that long non-coding RNAs(lncRNAs)play critical roles in the development and progression of cancers,including esophageal squamous cell carcinoma(ESCC).However,the mechanisms of lncRNAs in ESCC are still incompletely understood and therapeutic attempts for in vivo targeting cancer-associated lncRNA remain a challenge.By RNA-sequencing analysis,we identified that LLNLR-299G3.1 was a novel ESCC-associated lncRNA.LLNLR-299G3.1 was up-regulated in ESCC tissues and cells and promoted ESCC cell proliferation and invasion.Silencing of LLNLR-299G3.1 with ASO(antisense oligonucleotide)resulted in opposite effects.Mechanistically,LLNLR-299G3.1 bound to cancerassociated RNA binding proteins and regulated the expression of cancer-related genes,including OSM,TNFRSF4,HRH3,and SSTR3.ChIRP-seq(chromatin isolation by RNA purification and sequencing)revealed that these genes contained enriched chromatin binding sites for LLNLR-299G3.1.Rescue experiments confirmed that the effects of LLNLR-299G3.1 on ESCC cell proliferation were dependent on interaction with HRH3 and TNFRSF4.Therapeutically,intravenous delivery of placental chondroitin sulfate A binding peptide-coated nanoparticles containing antisense oligonucleotide(pICSA-BP-ANPs)strongly inhibited ESCC tumor growth and significantly improved animal survival in vivo.Overall,our results suggest that LLNLR-299G3.1 promotes ESCC malignancy through regulating gene-chromatin interactions and targeting ESCC by pICSA-BP-ANPs may be an effective strategy for the treatment of lncRNA-associated ESCC. | LI TIAN YONGYI HUANG BAOZHEN ZHANG YI SONG LIN YANG QIANQIAN CHEN ZHENG WANG YILING WANG QIHAN HE WENHAN YANG SHUYONG YU TIANYU LU ZICHEN LIU KAIPING GAO XIUJUN FAN JIAN SONG RIHONG ZHAI | 2023 | Oncology Research2023，31，4： | 0 |
| 14 | Status Quo of Maker Spaces in Main Urban Area of Chengdu显示文摘This paper, based on the literature review and field investigation, studied the status quo of maker spaces in main urban district of Chengdu at a time when the development of the maker spaces has received strong support from national and local governments. In addition to introducing the related concepts and policy support of the maker space, it summarized its distribution characteristics, audience characteristics, and status quo as well as problems and presented the direction for the development of the maker space in main urban area of Chengdu grounded on a survey of the status quo of national maker spaces in main urban area of Chengdu. | GAO Wei LIU Pan LIANG Zihan HOU Junzheng LUO Tianze LU Baorong WANG Xufei YU Xinyu FENG Yajin REN Zijie DU Jinqiang BAI Yile WANG Kejie SUN Zhentong | 2017 | Journal of Landscape Research2017，9，4： | 0 |
| 15 | Adjuvant chemotherapy versus adjuvant concurrent chemoradiotherapy after radical surgery for early-stage cervical cancer:a randomized,non-inferiority,multicenter trial显示文摘We conducted a prospective study to assess the non-inferiority of adjuvant chemotherapy alone versus adjuvant concurrent chemoradiotherapy (CCRT) as an alternative strategy for patients with early-stage (FIGO 2009 stage IB–IIA) cervical cancer having risk factors after surgery. The condition was assessed in terms of prognosis, adverse effects, and quality of life. This randomized trial involved nine centers across China. Eligible patients were randomized to receive adjuvant chemotherapy or CCRT after surgery. The primary end-point was progression-free survival (PFS). From December 2012 to December 2014, 337 patients were subjected to randomization. Final analysis included 329 patients, including 165 in the adjuvant chemotherapy group and 164 in the adjuvant CCRT group. The median follow-up was 72.1 months. The three-year PFS rates were both 91.9%, and the five-year OS was 90.6% versus 90.0% in adjuvant chemotherapy and CCRT groups, respectively. No significant differences were observed in the PFS or OS between groups. The adjusted HR for PFS was 0.854 (95% confidence interval 0.415–1.757;P = 0.667) favoring adjuvant chemotherapy, excluding the predefined non-inferiority boundary of 1.9. The chemotherapy group showed a tendency toward good quality of life. In comparison with post-operative adjuvant CCRT, adjuvant chemotherapy treatment showed non-inferior efficacy in patients with early-stage cervical cancer having pathological risk factors. Adjuvant chemotherapy alone is a favorable alternative post-operative treatment. | Danhui Weng Huihua Xiong Changkun Zhu Xiaoyun Wan Yaxia Chen Xinyu Wang Youzhong Zhang Jie Jiang Xi Zhang Qinglei Gao Gang Chen Hui Xing Changyu Wang Kezhen Li Yaheng Chen Yuyan Mao Dongxiao Hu Zimin Pan Qingqin Chen Baoxia Cui Kun Song Cunjian Yi Guangcai Peng Xiaobing Han Ruifang An Liangsheng Fan Wei Wang Tingchuan Xiong Yile Chen Zhenzi Tang Lin Li Xingsheng Yang Xiaodong Cheng Weiguo Lu Hui Wang Beihua Kong Xing Xie Ding Ma | 2023 | Frontiers of Medicine2023，17，1： | 0 |
| 16 | What can we learn from quality assurance badges in open-source software?显示文摘In the development of open-source software(OSS),many developers use badges to give an overview of the software and share some key features/metrics conveniently.Among various badges,quality assurance(QA)badges make up a large proportion and are the most prevalent because QA is of vital importance in software development,and ineffective QA may lead to anomalies or defects.In this paper,we focus on QA badges in open-source projects,which present quality assurance information directly and instantly,and aim to produce some interesting findings and provide practical implications.We collect and analyze 100000 projects written in popular programming languages from GitHub and conduct a comprehensive empirical study both inside and outside QA badges.Inside QA badges,we build a category classification for all QA badges based on the properties they focus on,which shows the types of QA badges developers use.Then,we analyze the frequency of the properties that QA badges focus on,and property combinations,too,which present their use status.We find that QA badges focus on various properties while developers give different preferences to different properties.The use status also differs between different programming languages.For example,projects written in C focus on Security to a great extent.Our findings also provide implications for developers and badge providers.Outside QA badges,we conduct a correlation analysis between QA badges and some software metrics that have potential relationships with code quality,contribution quality,and popularity.We find that QA badges have statistically significant correlations with various software metrics. | Feng LI Yiling LOU Xin TAN Zhenpeng CHEN Jinhao DONG Yang LI Xuanzhi WANG Dan HAO Lu ZHANG | 2024 | Science China(Information Sciences)2024，67，4： | 0 |
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