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| 1 | Transjugular intrahepatic portosystemic shunt for the management of acute variceal hemorrhage显示文摘Acute variceal hemorrhage,a life-threatening condition that requires a multidisciplinary approach for effective therapy,is defined as visible bleeding from an esophageal or gastric varix at the time of endoscopy,the presence of large esophageal varices with recent stigmata of bleeding,or fresh blood visible in the stomach with no other source of bleeding identified.Transfusion of blood products,pharmacological treatments and early endoscopic therapy are often effective;however,if primary hemostasis cannot be obtained or if uncontrollable early rebleeding occurs,transjugular intrahepatic portosystemic shunt(TIPS)is recommended as rescue treatment.The TIPS represents a major advance in the treatment of complications of portal hypertension.Acute variceal hemorrhage that is poorly controlled with endoscopic therapy is generally well controlled with TIPS,which has a 90%to 100%success rate.However,TIPS is associated with a mortality of 30%to 50%in such a setting.Emergency TIPS should be considered early in patients with refractory variceal bleeding once medical treatment and endoscopic sclerotherapy failure,before the clinical condition worsens.Furthermore,admission to specialized centers is mandatory in such a setting and regional protocols are essential to be organized effectively.This review article discusses initial management and then focuses on the specific role of TIPS as a primary therapy to control acute variceal hemorrhage,particularly as a rescue therapy following failure of endoscopic approaches. | Romaric Loffroy Louis Estivalet Violaine Cherblanc Sylvain Favelier Pierre Pottecher Samia Hamza Anne Minello Patrick Hillon Pierre Thouant Pierre-Henri Lefevre Denis Krausé Jean-Pierre Cercueil | 2013 | World Journal of Gastroenterology2013，19，37： | 25 |
| 2 | Endovascular management of visceral artery aneurysms: When to watch, when to intervene?显示文摘Visceral artery aneurysms(VAA) include splanchnic and renal artery aneurysms. They represent a rare clinical entity, although their detection is rising due to an increased use of cross-sectional imaging. Rupture is the most devastating complication, and is associated with a high morbidity and mortality. In addition, increased percutaneous endovascular interventions have raised the incidence of iatrogenic visceral artery pseudoaneurysms(VAPAs). For this reason, elective repair is preferable in the appropriately chosen patient. Controversy still exists regarding their treatment. Over the past decade, there has been steady increase in the utilization of minimally invasive, non-operative interventions, for vascular aneurysmal disease. All VAAs and VAPAs can technically be fixed by endovascular techniques but that does not mean they should. These catheter-based techniques constitute an excellent approach in the elective setting. However, in the emergent setting it may carry a higher morbidity and mortality. The decision for intervention has to take into account the size and the natural history of the lesion, the risk of rupture, which is high during pregnancy, and the relative risk of surgical or radiological intervention. For splanchnic artery aneurysms, we should recognize that we are not, in reality, well informed about their natural history. For most asymptomatic aneurysms, expectant treatment is acceptable. For large, symptomatic or aneurysms with a high risk of rupture, endovascular treatment has become the firstline therapy. Treatment of VAPAs is always mandatory because of the high risk of rupture. We present our point of view on interventional radiology in the splanchnic arteries, focusing on what has been achieved and the remaining challenges. | Romaric Loffroy Sylvain Favelier Pierre Pottecher Pierre-Yves Genson Louis Estivalet Sophie Gehin Jean-Pierre Cercueil Denis Krausé | 2015 | World Journal of Radiology2015，7，7： | 11 |
| 3 | Evaluation of Doppler-ultrasonography in the diagnosis of transjugular intrahepatic portosystemic shunt dysfunction: A prospective study显示文摘AIM To prospectively evaluate the performance of Dopplerultrasonography(US) for the detection of transjugular intrahepatic portosystemic shunt(TIPS) dysfunction within a multicenter cohort of cirrhotic patients.METHODS This study was conducted in 10 french teaching hospitals. After TIPS insertion, angiography and liver Doppler-US were carried out every six months to detect dysfunction(defined by a portosystemic gradient ≥ 12 mm Hg and/or a stent stenosis ≥ 50%). The association between ultrasonographic signs and dysfunction was studied by logistic random-effects models, and the diagnostic performance of each Doppler criterion was estimated by the bootstrap method. This study was approved by the ethics committee of Tours.RESULTS Two hundred and eighteen pairs of examinations performed on 87 cirrhotic patients were analyzed. Variables significantly associated with dysfunction were: The speed of flow in the portal vein(P = 0.008), the reversal of flow in the right(P = 0.038) and left(P = 0.049) portal branch, the loss of modulation of portal flow by the right atrium(P = 0.0005), ascites(P = 0.001) and the overall impression of the operator(P = 0.0001). The diagnostic performances of these variables were low; sensitivity was < 58% and negative predictive value was < 73%. Therefore, dysfunction cannot be ruled out from Doppler-US. CONCLUSION The performance of Doppler-US for the detection of TIPS dysfunction is poor compared to angiography. New tools are needed to improve diagnosis of TIPS dysfunction. | Charlotte Nicolas Amelie Le Gouge Louis d’Alteroche Jean Ayoub Monica Georgescu Vincent Vidal Denis Castaing Jean-Pierre Cercueil Patrick Chevallier Jerome Roumy Herve Trillaud Louis Boyer Vincent Le Pennec Christophe Perret Bruno Giraudeau Jean-Marc Perarnau STIC-TIPS group | 2017 | World Journal of Hepatology2017，9，27： | 6 |
| 4 | Management of BPH then 2000 and now 2016-From BPH to BPO显示文摘The diagnosis and treatment of benign prostatic obstruction(BPO)is based on a number of well-known lower urinary tract symptoms(LUTS)feared by all ageing males with functional testes.The ascent of modern urology turned this disease from lethal into an annoying but treatable health problem in the previous century.We are able to relieve the great majority of patients from their bothersome symptoms to a respectable quality of life by medication or removal of the obstructive part of the enlarged prostate.We can be proud of some progress made in the new millennium to reach a correct diagnosis and subsequent choice of treatment aiming for quality of life and cost-efficiency for public health.Still it remains symptomatic treatment and we expect the new generation of urologists to close some gaps in our knowledge on the regulation of prostatic growth to focus on prevention and elimination of the disease in the foreseeable future. | Johan Braeckman Louis Denis | 2017 | Asian Journal of Urology2017，4，3： | 2 |
| 5 | Predicting Recurrence and Progression in Individual Patients with Stage Ta T1 Bladder Cancer Using EORTC Risk Tables: A Combined Analysis of 2596 Patients from Seven EORTC Trials 显示文摘 | Richard J. Sylvester Adrian P.M. van der Meijden Willem Oosterlinck J. Alfred Witjes Christian Bouffioux Louis Denis Donald W.W. Newling Karlheinz Kurth | 2006 | European Urology2006，，3： | 2 |
| 6 | Hazard to man and the environment posed by the use of urban waste compost :A review 显示文摘 | ISABELLE DEPORTES JEAN LOUIS BENOIT GUYOD DENIS ZMIROU | 1995 | The Science of the Total Environment1995，172，： | 1 |
| 7 | Tricuspid valve replacement: an analysis of 25 years of experience at a single center显示文摘 | Michel Carrier Yves Hébert Michel Pellerin Denis Bouchard Louis P Perrault Raymond Cartier Arsène Basmajian Pierre Pagé Nancy C Poirier | 2003 | The Annals of Thoracic Surgery2003，，1： | 1 |
| 8 | Identification and characterization of a spinal muscular atrophy-determining gene显示文摘 | Suzie Lefebvre Lydie Bürglen Sophie Reboullet Olivier Clermont Philippe Burlet Louis Viollet Bernard Benichou Corinne Cruaud Philippe Millasseau Massimo Zeviani Denis Le Paslier Jean Frézal Daniel Cohen Jean Weissenbach Arnold Munnich Judith Melki | 1995 | Cell1995，，1： | 1 |
| 9 | Statin in Combination With β-Blocker Therapy Reduces Postoperative Stroke After Coronary Artery Bypass Graft Surgery显示文摘 | Denis Bouchard Michel Carrier Philippe Demers Raymond Cartier Michel Pellerin Louis P. Perrault Jean Lambert | 2011 | The Annals of Thoracic Surgery2011，，3： | 1 |
| 10 | Increased response of blood eosinophils to various chemotactic agents in quiescent Crohn disease显示文摘 | Denis MA Louis R Malaise M | 2001 | Scand J Gastroenterol2001，36，2： | 1 |
| 11 | Predicting Recurrence and Progression in Individual Patients with Stage Ta T1 Bladder Cancer Using EORTC Risk Tables: A Combined Analysis of 2596 Patients from Seven EORTC Trials 显示文摘 | Richard J. Sylvester Adrian P.M. van der Meijden Willem Oosterlinck J. Alfred Witjes Christian Bouffioux Louis Denis Donald W.W. Newling Karlheinz Kurth | 2006 | European Urology2006，，3： | 1 |
| 12 | Arterial Embolotherapy for Endoscopically Unmanageable Acute Gastroduodenal Hemorrhage: Predictors of Early Rebleeding显示文摘 | Romaric Loffroy Boris Guiu Philippe D'Athis Lise Mezzetta Alice Gagnaire Jean–Louis Jouve Pablo Ortega–Deballon Nicolas Cheynel Jean–Pierre Cercueil Denis Krausé | 2009 | Clinical Gastroenterology and Hepatology2009，，5： | 1 |
| 13 | On the safe use of long-rangelaser active imager in the near-infrared for homeland se- curity显示文摘 | DENI B SYLVIANE L LOUIS D | 2006 | SPIE2006，6406，： | 1 |
| 14 | Prosthetic valve thrombosis: twenty-year experience at the montreal heart institute显示文摘 | Nicolas Dürrleman Michel Pellerin Denis Bouchard Yves Hébert Raymond Cartier Louis P Perrault Arsène Basmadjian Michel Carrier | 2004 | The Journal of Thoracic and Cardiovascular Surgery2004，，： | 1 |
| 15 | Hazard to man and the environment posed by the use of urben waste compost: a review 显示文摘 | Isabelle Deportes Jean - Louis Benoit - Guyod Denis Zmirou | 1995 | Science of the Total Environment1995，，172： | 1 |
| 16 | Cabazitaxel for the treatment of prostate cancer显示文摘 | Dirk PJ Michielsen Johan G Braeckman Louis Denis | 2011 | Expert Opinion on Pharmacotherapy2011，，6： | 1 |
| 17 | Identification and characterization of a spinal muscular atrophy-determining gene显示文摘 | Suzie Lefebvre Lydie Bürglen Sophie Reboullet Olivier Clermont Philippe Burlet Louis Viollet Bernard Benichou Corinne Cruaud Philippe Millasseau Massimo Zeviani Denis Le Paslier Jean Frézal Daniel Cohen Jean Weissenbach Arnold Munnich Judith Melki | 1995 | Cell1995，，1： | 1 |
| 18 | The Computer Based Patient Record : A Strategic Issue in Process Innovation 显示文摘 | Claude Sicotte Jean Louis Denis Pascale Lehoux | 1998 | Journal of Medical Systems1998，22，6： | 1 |
| 19 | On the safe use of long-range laser active imager in the near-infrared for Homeland Security显示文摘 | Deni B Sylviane L Louis D | | 0，，： | 1 |
| 20 | Association of urinary 15 - F2t - isoprostane level with oxygen desaturation and carotidintima - media thickness in nonobese sleep apnea patients显示文摘 | Denis M Jean- Louis P Diane GR | 2010 | Free Radical Biology :Medicine2010，48，： | 1 |
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