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| 1 | Near-infrared fluorescence guided esophageal reconstructive surgery: A systematic review显示文摘BACKGROUND After an esophagectomy, the stomach is most commonly used to restore continuity of the upper gastrointestinal tract. These esophago-gastric anastomoses are prone to serious complications such as leakage associated with high morbidity and mortality. Graft perfusion is considered to be an important predictor for anastomotic integrity. Based on the current literature we believe Indocyanine green fluorescence angiography(ICGA) is an easy assessment tool for gastric tube(GT) perfusion, and it might predict anastomotic leakage(AL).AIM To evaluate feasibility and effectiveness of ICGA in GT perfusion assessment and as a predictor of AL.METHODS This study was designed according to the PRISMA guidelines and registered in the PROSPERO database. PubMed and EMBASE were independently searched by 2 reviewers for studies presenting data on intraoperative ICGA GT perfusion assessment during esophago-gastric reconstruction after esophagectomy.Relevant outcomes such as feasibility, complications, intraoperative surgical changes based on ICGA findings, quantification attempts, anatomical data and the impact of ICGA on postoperative anastomotic complications, were collected by 2 independent researchers. The quality of the included articles was assessed based on the Methodological Index for Non-Randomized Studies. The 19 included studies presented data on 1192 esophagectomy patients, in 758 patients ICGA was used perioperative to guide esophageal reconstruction.RESULTS The 19 included studies for qualitative analyses all described ICGA as a safe and easy method to evaluate gastric graft perfusion. AL occurred in 13.8% of the entire cohort, 10% in the ICG guided group and 20.6% in the control group(P <0.001). When poorly perfused cases are excluded from the analyses, the difference in AL was even larger(AL well-perfused group 6.3% vs control group 20.5%, P <0.001). The AL rate in the group with an altered surgical plan based on the ICG image was 6.5%, similar to the well perfused group(6.3%) and significantly less than the poorly perfused group(47.8%)(P < 0.001), suggesting that the technique is able to identify and alter a potential bad outcome.CONCLUSION ICGA is a safe, feasible and promising method for perfusion assessment. The lower AL rate in the well perfused group suggest that a good fluorescent signal predicts a good outcome. | Elke Van Daele Yves Van Nieuwenhove Wim Ceelen Christian Vanhove Bart P Braeckman Anne Hoorens Jurgen Van Limmen Oswald Varin Dirk Van de Putte Wouter Willaert Piet Pattyn | 2019 | World Journal of Gastrointestinal Oncology2019，11，3： | 3 |
| 2 | Management of BPH then 2000 and now 2016-From BPH to BPO显示文摘The diagnosis and treatment of benign prostatic obstruction(BPO)is based on a number of well-known lower urinary tract symptoms(LUTS)feared by all ageing males with functional testes.The ascent of modern urology turned this disease from lethal into an annoying but treatable health problem in the previous century.We are able to relieve the great majority of patients from their bothersome symptoms to a respectable quality of life by medication or removal of the obstructive part of the enlarged prostate.We can be proud of some progress made in the new millennium to reach a correct diagnosis and subsequent choice of treatment aiming for quality of life and cost-efficiency for public health.Still it remains symptomatic treatment and we expect the new generation of urologists to close some gaps in our knowledge on the regulation of prostatic growth to focus on prevention and elimination of the disease in the foreseeable future. | Johan Braeckman Louis Denis | 2017 | Asian Journal of Urology2017，4，3： | 2 |
| 3 | Long-term survival in an adult metastaticrenal peripheral primitive neuroectodermal tumor (pPNET) with multimodality treatment including high-dose chemotherapy显示文摘 | Fontaine C Schots R Braeckman J | 1997 | Ann Oncol1997，8，7： | 1 |
| 4 | Eicosapentaenoic Acid Ethyl Ester (AMR101) Therapy in Patients With Very High Triglyceride Levels (from the Multi-center, plAcebo-controlled, Randomized, double-blINd, 12-week study with an open-label Extension [MARINE] Trial)显示文摘 | Harold E. Bays Christie M. Ballantyne John J. Kastelein Jonathan L. Isaacsohn Rene A. Braeckman Paresh N. Soni | 2011 | The American Journal of Cardiology2011，，5： | 1 |
| 5 | Swelling pressure observations on degrading dex-HEMA hydrogels 显示文摘 | Stubbe B G Braeckmans K Horkay F Hennink W E De Smedt S C Demeester J | 2002 | Maeromolecules2002，35，： | 1 |
| 6 | Differential contribution of testosterone and estradiol in the determination of cholesterol and lipoprotein profile in healthy middle-aged men显示文摘 | Van Pottelbergh I Braeckman L De Bacquer D el al | 2003 | Atherosclerosis2003，166，1： | 1 |
| 7 | Prevalence of rotavirus antibodies in breast milk and inhibitory effects to rotavirus vaccines显示文摘 | Trang NV Braeckman T Lernout T | 2014 | Hum Vaccin Immunother2014，10，12： | 1 |
| 8 | Life extension via dietary restriction is independent of the Ins/IGF-1 signaling pathway in Caenorhabditis elegans显示文摘 | Houthoofd K Braeckman BP Johnson TE | 2003 | Exp Gerontol2003，38，9： | 1 |
| 9 | Vitreous:a barrier to nonviral ocular gene therapy显示文摘 | Peeters L Sanders NN Braeckmans K Boussery K Johan Voorde VD Smedt SC | | 0，，10： | 1 |
| 10 | Testing the rate-of-living/oxidative damage theory of aging in the nematode model Caenorhabditis elegans显示文摘 | Brys K Vanfleteren JR Braeckman BP | 2007 | Exp Gerontology2007，42，9： | 1 |
| 11 | The hunt for the record life span in Caenorhsbditis elegans 显示文摘 | Houthoofd K Braeckman B P Vanfleteren J R | 2004 | The Journals of Gerontology Series A: Biological and Medical Sciences2004，59，5： | 1 |
| 12 | A web-and case-based learning program for postgraduate students in occupational medicine显示文摘 | Braeckman LA FieuwAM Van Bogaert HJ | 2008 | International Journal of Occupational and Environmental Health2008，14，1： | 1 |
| 13 | Swelling pressure observations on degrading dex- HEMA hydrogels显示文摘 | Stubbe B G Braeckmans K Horkay F Hennink W E De Smedt S C Demeester J | 2002 | Maeromolecules2002，35，： | 1 |
| 14 | Influence of combined IR-grilling and hot air cooking conditions on moisture and fat content,texture and colour attributes of meat patties显示文摘 | Braeckman L Ronsse F Hidalgo P C | 2009 | Journal of Food Engineering2009，93，4： | 1 |
| 15 | Computer - aided ul- trasonography (HistoScanning) : a novel technology for locating and characterizing prostate cancer 显示文摘 | Braeckman J Autier P Garbar C | 2008 | BJU hat2008，101，3： | 1 |
| 16 | Two decades of hepatitis B vaccination in mentally retarded patients:ef- fectiveness ,antibody persistence and duration of immune memory显示文摘 | Braeckman TL Herck K Jilg W | 2012 | Vaccine2012，30，32： | 1 |
| 17 | Influence of free chains on the swell- ing pressure of PEG HEMA and dex HEMA hydrogels显示文摘 | Van Thienen T G Horkay F Braeckmans K Stubbe B G De- meester J De Smedt S C | 2007 | IntJ Pharm2007，337，： | 1 |
| 18 | Epidemiological Study of the Hematological Effects of Carbon Disulfide显示文摘 | Tan X Vanhorne M Braeckman L | 1996 | Occup Med Environ Health1996，3，： | 1 |
| 19 | Intestinal absorption screening of mixtures from combinatorial libraries in the Caco-2 model 显示文摘 | Taylor EW Gibbons JA Braeckman RA | 1997 | Pharm Res1997，14，： | 1 |
| 20 | Polysaccharide-based nucleic acid nanoformulations显示文摘 | Raemdonck K Martens T F Braeckmans K | 2013 | Advanced Drug Delivery Reviews2013，65，9： | 1 |
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