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| 1 | Decreased expression of Klotho in cardiac atria biopsy samples from patients at higher risk of atherosclerotic cardiovascular disease显示文摘BackgroundKlotho 蛋白质(α - 并且 β) 是基于膜的传播调整细胞新陈代谢的蛋白质,以及成纤维细胞生长因素(FGF ) 的 lifespan modulating 活动。最近的数据证明了更高的血浆传播 Klotho 层次减少心血管的风险,建议 Klotho 有在心血管的疾病的一个保护的角色。然而,尽管到目前为止它在各种各样的机关被识别了,它是未知的是否,并且高心血管的风险是否能影响 Klotho 的心脏的表示 cardiomyocytes 快车 Klotho 和 FGF , FGF 和另外的 molecules.MethodsWe 与心血管的疾病和 10 匹配年龄的控制使遭到,估计的10年的低风险经历的一名估计的10年的高动脉粥样硬化患者选择了 20 个病人为除冠的动脉以外的原因的心脏的外科绕过。在心肌的活体检视,我们由免疫组织化学评估了 Klotho 和 FGF 是否在 cardiomyocytes 被表示,并且更高心血管的风险是否影响涉及 endoplasmic 蜂窝胃应力的另外的分子的表示,氧化应力,发炎并且 fibrosis.ResultsOnly ,有更高心血管的风险的病人的 cardiomyocytes 显示出 Klotho 的更低的表示,但是 FGF 的更高的表情。而且,更高心血管的风险与增加的表示被联系氧化并且网状的应力,发炎和 fibrosis.ConclusionsThis 学习的 endoplasmic 第一次证明 Klotho 蛋白质在人的 cardiomyocytes 被表示, Klotho 的那心脏的表情在更高心血管的风险病人是下面调整的,当压力相关的分子的表示显著地被增加时。 | Giovanni Corsetti Evasio Pasini Tiziano M Scarabelli Claudia Romano Pratik R Agrawal Carol Chen-Scarabelli Richard Knight Louis Saravolatz Jagat Narula Mario Ferrari-Vivaldi Vincenzo Flati Deodato Assanelli Francesco S Dioguardi | 2016 | Journal of Geriatric Cardiology2016，13，8： | 7 |
| 2 | Toxoplasma gondii : from animals to humans显示文摘 | Astrid M Tenter Anja R Heckeroth Louis M Weiss | 2000 | International Journal for Parasitology2000，，12： | 4 |
| 3 | Role of endoscopic ultrasound in the molecular diagnosis of pancreatic cancer显示文摘Pancreatic ductal adenocarcinoma remains one of the most deadly types of tumor. Endoscopic ultrasoundguided fine-needle aspiration(EUS-FNA) is a safe, cost-effective, and accurate technique for evaluating and staging pancreatic tumors. However, EUS-FNA may be inconclusive or doubtful in up to 20% of cases. This review underlines the clinical interest of the molecular analysis of samples obtained by EUS-FNA in assessing diagnosis or prognosis of pancreatic cancer, especially in locally advanced tumors. On EUS-FNA materials DNA, mRNA and miRNA can be extracted, amplified, quantified and subjected to methylation assay. Kras mutation assay, improves diagnosis of pancreatic cancer. When facing to clinical and radiological presentations of pseudo-tumorous chronic pancreatitis, wildtype Kras is evocative of benignity. Conversely, in front of a pancreatic mass suspected of malignancy, a mutated Kras is highly evocative of pancreatic adenocarci-noma. This strategy can reduce false-negative diagnoses, avoids the delay of making decisions and reduces loss of surgical resectability. Similar approaches are conducted using analysis of miRNA expression as well as Mucin or markers of invasion(S100P, S100A6, PLAT or PLAU). Beyond the diagnosis approach, the prediction of response to treatment can be also investigated form biomarkers expression within EUS-FNA materials. | Barbara Bournet Marion Gayral Jérme Torrisani Janick Selves Pierre Cordelier Louis Buscail | 2014 | World Journal of Gastroenterology2014，20，31： | 3 |
| 4 | Fusion of the lumbar and sacral spine by internal fixation with screw plates 显示文摘 | Louis R | 1986 | Clin Orthop1986，203，： | 2 |
| 5 | Intracranial atherosclerosis显示文摘 | Adnan I Qureshi Louis R Caplan | 2014 | The Lancet . 2014 (9921)2014，，9921： | 2 |
| 6 | Selective RNA editing and subunit assembly of native glutamate receptors 显示文摘 | LOUIS J C BROSE N | 1994 | Neuron1994，13，1： | 1 |
| 7 | spectroscopic determination of dynamic plasma gradients in implosion cores显示文摘 | Golovkin I Mancini R Louis S | 2002 | Phys Rev Lett2002，88，04： | 1 |
| 8 | Pars intertarticularis reconstruction of spondylolysis using plates and screws with grafting without arthrodesis显示文摘 | Louis R | 1988 | Rev Chir Orthop reparatrice Appar Mot1988，74，6： | 1 |
| 9 | The relationship between air- ways inflammation and asthma severity显示文摘 | Louis R Lau LC Bron AO | 2000 | Am J Respir Crit Care Med2000，161，1： | 1 |
| 10 | Distinct immunopeptide maps of the sarcoplasmic reticulum Ca2+ release channel in malignant hyperthermia显示文摘 | Knudson C M Mickelson J R Louis C F | 1990 | Journal of Biological Chemistry1990，265，： | 1 |
| 11 | Virulence and molecular genotyping studies of Sporisorium reilianum isolates in sorghum显示文摘 | Louis K Prom Ramasamy Perumal Saradha R Erattaimuthu | 2011 | Plant Disease2011，95，5： | 1 |
| 12 | Restoring a sense of control during implementation 显示文摘 | Baronas A K Louis M R | 1988 | MIS Quarterly1988，12，1： | 1 |
| 13 | Urinary bisphenol A, phthalates, and couple fecundity: the Longitudinal Investigation of Fertility and the Environment (LIFE) Study显示文摘 | Louis GMB Sundaram R Sweeney AM | 2014 | Fertil Steril2014，101，： | 1 |
| 14 | Developmental abnormalities of the gonad and abnormal sex hormone concentrations in juvenile alligators from contaminated and control lakes in florida显示文摘 | LOUIS J GUILLETTE JR TIMOTHY S GROSS GREG R MASSON | 1994 | Environmental Health Perspectives1994，102，8： | 1 |
| 15 | Multisystemic production of interleukin 10 limits the severity of acute pancreatitis in mice显示文摘 | Van Laethem J-L Eskinazi R Louis H | 1998 | Gut1998，43，3： | 1 |
| 16 | Lung injury induced by sepsis: les- sons learned from large animal models and future directions for treatment 显示文摘 | Benjamin S Shreyas R Louis AG | 2011 | Expert Rev Anti infect Ther2011，9，12： | 1 |
| 17 | The migration of organizational functions to the work unit level: Buffering, spanning, and bringing up boundaries显示文摘 | YAN A LOUIS M R | 1999 | Human Relations1999，52，1： | 1 |
| 18 | Mechanism of deposition of gold precursors onto TiO2 during the preparation by cation adsorption and deposition-precipitation with NaOH and urea 显示文摘 | Zanella R Delannoy L Louis C | 2005 | Applied Catalysis A: General2005，291，12： | 1 |
| 19 | Spinal stability as defined by the three-columnspine concept显示文摘 | Louis R | 1985 | Anat Clin1985，7，1： | 1 |
| 20 | Pulse pressure and cardiovascular mortality in normotensive and hypertensive subjects显示文摘 | Annie R Michel S Louis G | 1998 | Hypertension1998，32，： | 1 |
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