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| 1 | Role of autophagy in the pathophysiology of nonalcoholic fatty liver disease:A controversial issue显示文摘Autophagy is a mechanism involved in cellular homeostasis under basal and stressed conditions delivering cytoplasmic content to the lysosomes for degradation to macronutrients.The potential role of autophagy in disease is increasingly recognised and investigated in the last decade.Nowadays it is commonly accepted that autophagy plays a role in the hepatic lipid metabolism.Hence,dysfunction of autophagy may be an underlying cause of non-alcoholic fatty liver disease.However,controversy of the exact role of autophagy in the lipid metabolism exists:some publications report a lipolytic function of autophagy,whereas others claim a lipogenic function.This review aims to give an update of the present knowledge on autophagy in the hepatic lipid metabolism,hepatic insulin resistance,steatohepatitis and hepatic fibrogenesis. | Wilhelmus J Kwanten Wim Martinet Peter P Michielsen Sven M Francque | 2014 | World Journal of Gastroenterology2014，20，23： | 17 |
| 2 | Circulating predictive and diagnostic biomarkers for hepatitis B virus-associated hepatocellular carcinoma显示文摘Chronic hepatitis B virus(HBV) infected patients have an almost 100-fold increased risk to develop hepatocellular carcinoma(HCC). HCC is the fifth most common and third most deadly cancer worldwide. Up to 50% of newly diagnosed HCC cases are attributed to HBV infection. Early detection improves survival and can be achieved through regular screening. Six-monthly abdominal ultrasound, either alone or in combination with alphafetoprotein serum levels, has been widely endorsed for this purpose. Both techniques however yield limited diagnostic accuracy, which is not improved when they are combined. Alternative circulating or histological markers to predict or diagnose HCC are therefore urgently needed. Recent advances in systems biology technologies have enabled the identification of several new putative circulating biomarkers. Although results from studies assessing combinations of these biomarkers are promising, evidence for their clinical utility remains low. In addition, most of the studies conducted so far show limitations in design. Attention must be paid for instance to different ethnicities and different etiologies when studying biomarkers for hepatocellular carcinoma. This review provides an overview on the current understandings and recent progress in the field of diagnostic and predictive circulating biomarkers for hepatocellular carcinoma in chronically infected HBV patients and discusses the future prospects. | Stijn Van Hees Peter Michielsen Thomas Vanwolleghem | 2016 | World Journal of Gastroenterology2016，22，37： | 13 |
| 3 | Early prediction of major depression in chronic hepatitis C patients during peg-interferon α-2b treatment by assessment of vegetative-depressive symptoms after four weeks显示文摘AIM: To study the predictive value of the vegetative- depressive symptoms of the Zung Depression Rating Scale for the occurrence of depression during treatment with peg-interferon α-2b of chronic hepatitis C (CHC) patients. METHODS: The predictive value of vegetative- depressive symptoms at 4 wk of treatment for the occurrence of a subsequent diagnosis of major depressive disorder (MDD) was studied in CHC patients infected after substance use in a prospective, multi- center treatment trial in Belgium. The presence of vegetative-depressive symptoms was assessed using the Zung Scale before and 4 wk after the start of antiviral treatment. RESULTS: Out of 49 eligible patients, 19 (39%) developed MDD. The area under the ROC curve of the vegetative Zung subscale was 0.73, P = 0.004. The sensitivity at a cut-point of > 15/35 was 95% (95% CI: 74-100). The positive predictive value equalled 44% (95% CI: 29-60). CONCLUSION: In this group of Belgian CHC patients infected after substance use, antiviral treatment caused a considerable risk of depression. Seven vegetativedepressive symptoms of the Zung scale at wk 4 of treatment predicted 95% of all emerging depressions, at a price of 56% false positive test results. | Geert Robaeys Jozef De Bie Marieke C Wichers Liesbeth Bruckers Frederik Nevens Peter Michielsen Marc Van Ranst Frank Buntinx | 2007 | World Journal of Gastroenterology2007，13，43： | 4 |
| 4 | Reference population and mara- thon runner sera assessed by highly sensitive cardiac troponln T and commercial cardiac troponin T and I assays显示文摘 | ingels A Jacobs L Michielsen E | 2009 | Clinical Chemistry2009，，01： | 1 |
| 5 | Crystallization behavior of elastomeric block copolymers: Thermoplastic polyurethane and polyether-block-amide显示文摘 | AsliBegenir Stephen Michielsen BehnamPourdeyhimi | 2009 | Journal of Applied Polymer Scienee2009，111，： | 1 |
| 6 | The role of nireic oxide in portal hypertensive systemic and portal vascular pathology 显示文摘 | Harthb M Michielsen PP Dxiurkowska - Marek A | 1997 | Acta Gastroenterol Velg1997，，60： | 1 |
| 7 | Integral-geometry morphological image analysis显示文摘 | Michielsen K De Raedt H | 2001 | Physics Reports2001，347，6： | 1 |
| 8 | Viral hepatitis and pregnancy 显示文摘 | MICHIELSEN PP VAN DAMME P | 1999 | Acta Gastroenterol Belg1999，62，1： | 1 |
| 9 | Viral hepatitis and hepatocellular carcinoma显示文摘 | Michielsen PP Francque SM Dongen JL | 2005 | Wor J Sur Oncol2005，3，27： | 1 |
| 10 | Viral hepatitis and pregnan- cy显示文摘 | Michielsen PP Van Damme P | 1998 | Acta gastro enterologica Belgica1998，62，1： | 1 |
| 11 | Assessment of fatigue among working people: a comparison of six questionnaires显示文摘 | DE V J MICHIELSEN H J VAN H G | 2003 | Occup Environ Med2003，，： | 1 |
| 12 | Release kinetics of intact and degraded troponin I and T after irreversible cell damage显示文摘 | HESSEL M H M MICHIELSEN E C H J ATSMA D E | 2008 | Exp Mol Pathol2008，，85： | 1 |
| 13 | Reference Population and Marathon Runner Sera Assessed by Highly Sensitive Cardiac Troponin T and Commercial Cardiac Troponin T and I Assays 显示文摘 | Mingels A Jacobs L Michielsen E | 2009 | Clin Chem2009，55，1： | 1 |
| 14 | Melt-blowing Thermoplastic Polyurethane and Polyether-block-amide Elastomers : Effect of Processing Conditions and Crystallization on Web Properties 显示文摘 | Begenir A Michielsen S Pourdeyhimi B | 2009 | Polym Eng Sci2009，49，7： | 1 |
| 15 | Subretinal neovascular membranes associated with chronic membranoproliferative glomerulonephritis type II显示文摘 | Leys A Michielsen B Leys M | 1990 | Graefes Arch Clin Exp Ophthalmol1990，228，： | 1 |
| 16 | Solute - solvent interactions in cryosolutions : a study of halothane - ammonia complexes 显示文摘 | Michielsen B Dom JJ van der Veken B J | 2012 | Phys Chem Chem Phys2012，14，18： | 1 |
| 17 | :Reference population and marathon runner sera assessed by highly sensitive cardiae tro ponin T and commercial cardiac troponin T and I assays显示文摘 | Mingels A Jaeohs L Michielsen E | 2009 | Clin Chem2009，55，1： | 1 |
| 18 | Design of a Superhydrophobic surface using woven structures显示文摘 | STEPHEN MICHIELSEN HOON J LEE | 2007 | Langmuir2007，23，11： | 1 |
| 19 | Meltblowing thermoplastic polyurethane and polyether-block- amide elastomers:Effect of processing conditions and crystallization on web properties显示文摘 | BEGENIR A MICHIELSEN S POURDEYHIMI B | 2009 | Polymer Engineering and Science2009，49，7： | 1 |
| 20 | Prevalence of attention-deficit hyperactivity disorder in older adults in the Netherlands显示文摘 | Michielsen M Semeijn E Comijs HC van de Ven P Beekman AT Deeg DJ | 2012 | Br J Psychiatry2012，201，4： | 1 |
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