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| 1 | Prevalence and risk factors of infections by multiresistant bacteria in cirrhosis: A prospective study显示文摘 | Javier Fernández Juan Acevedo Miriam Castro Orlando Garcia Carlos Rodríguez de Lope Daria Roca Marco Pavesi Elsa Sola Leticia Moreira Anibal Silva Tiago Seva‐Pereira Francesco Corradi Jose Mensa Pere Ginès Vicente Arroyo | 2012 | Hepatology2012，，： | 4 |
| 2 | Proton nuclear magnetic resonance-based metabonomic models for non-invasive diagnosis of liver fibrosis in chronic hepatitis C:Optimizing the classification of intermediate fibrosis显示文摘AIM To develop metabonomic models(MMs), using 1 H nuclear magnetic resonance(NMR) spectra of serum, to predict significant liver fibrosis(SF: Metavir ≥ F2), advanced liver fibrosis(AF: METAVIR ≥ F3) and cirrhosis(C: METAVIR = F4 or clinical cirrhosis) in chronic hepatitis C(CHC) patients. Additionally, to compare the accuracy of the MMs with the aspartate aminotransferase to platelet ratio index(APRI) and fibrosis index based on four factors(FIB-4). METHODS Sixty-nine patients who had undergone biopsy in the previous 12 mo or had clinical cirrhosis were included. The presence of any other liver disease was a criterion for exclusion. The MMs, constructed using partial least squares discriminant analysis and linear discriminant analysis formalisms, were tested by cross-validation, considering SF, AF and C. RESULTS Results showed that forty-two patients(61%) presented SF, 28(40%) AF and 18(26%) C. The MMs showed sensitivity and specificity of 97.6% and 92.6% to predict SF; 96.4% and 95.1% to predict AF; and 100% and 98.0% to predict C. Besides that, the MMs correctly classified all 27(39.7%) and 25(38.8%) patients with intermediate values of APRI and FIB-4, respectively. CONCLUSION The metabonomic strategy performed excellently in predicting significant and advanced liver fibrosis in CHC patients, including those in the gray zone of APRI and FIB-4, which may contribute to reducing the need for these patients to undergo liver biopsy. | Andrea Dória Batista Carlos Jonnatan Pimentel Barros Tássia Brena Barroso Carneiro Costa Michele Maria Goncalves de Godoy Ronaldo Dionísio Silva Joelma Carvalho Santos Mariana Montenegro de Melo Lira Norma ThoméJucá Edmundo Pessoa de Almeida Lopes Ricardo Oliveira Silva | 2018 | World Journal of Hepatology2018，10，1： | 2 |
| 3 | Evaluation of biodegradable electric conductive tube-guides and mesenchymal stem cells显示文摘AIM: To study the therapeutic effect of three tubeguides with electrical conductivity associated to mesenchymal stem cells(MSCs) on neuro-muscular regeneration after neurotmesis.METHODS: Rats with 10-mm gap nerve injury were tested using polyvinyl alcohol(PVA), PVA-carbon nanotubes(CNTs) and MSCs, and PVA-polypyrrole(PPy). The regenerated nerves and tibialis anterior muscles were processed for stereological studies after 20 wk. The functional recovery was assessed serially for gait biomechanical analysis, by extensor postural thrust, sciatic functional index and static sciatic functionalindex(SSI), and by withdrawal reflex latency(WRL). In vitro studies included cytocompatibility, flow cytometry, reverse transcriptase polymerase chain reaction and karyotype analysis of the MSCs. Histopathology of lung, liver, kidneys, and regional lymph nodes ensured the biomaterials biocompatibility. RESULTS: SSI remained negative throughout and independently from treatment. Differences between treted groups in the severity of changes in WRL existed, showing a faster regeneration for PVA-CNTs-MSCs(P < 0.05). At toe-off, less acute ankle joint angles were seen for PVA-CNTs-MSCs group(P = 0.051) suggesting improved ankle muscles function during the push off phase of the gait cycle. In PVA-PPy and PVA-CNTs groups, there was a 25% and 42% increase of average fiber area and a 13% and 21% increase of the 'minimal Feret's diameter' respectively. Stereological analysis disclosed a significantly(P < 0.05) increased myelin thickness(M), ratio myelin thickness/axon diameter(M/d) and ratio axon diameter/fiber diameter(d/D; g-ratio) in PVA-CNT-MSCs group(P < 0.05). CONCLUSION: Results revealed that treatment with MSCs and PVA-CNTs tube-guides induced better nerve fiber regeneration. Functional and kinematics analysis revealed positive synergistic effects brought by MSCs and PVA-CNTs. The PVA-CNTs and PVA-PPy are promising scaffolds with electric conductive properties, bio- and cytocompatible that might prevent the secondary neurogenic muscular atrophy by improving the reestablishment of the neuro-muscular junction. | Jorge Ribeiro Tiago Pereira Ana Rita Caseiro Paulo Armada-da-Silva Isabel Pires Justina Prada Irina Amorim Sandra Amado Miguel Franca Carolina Goncalves Maria Ascensao Lopes Jose Domingos Santos Dina Morais Silva Stefano Geuna Ana Lúcia Luís Ana Colette Maurício | 2015 | World Journal of Stem Cells2015，7，6： | 2 |
| 4 | Extramedullary plasmocytoma associated with a massive deposit of amyloid in the duodenum显示文摘We report a rare case of extramedullary plasmocytoma associated with a massive deposit of amyloid in the duodenum.A 72-year-old Japanese man was admitted to our hospital presenting with a 3-mo history of epigastric pain, vomiting and weight loss.On computed tomography(CT) a wall thickening of the fourth part of the duodenum was observed.Multiple biopsies obtained from the lesion showed inflltration of plasma cells and lymphocytes, but they were not conclusive.The patient underwent resection of the lesion and, on histopathological examination, the lesion consisted of a dense and diffuse inflltrate of plasma cells and a few admixed lymphocytes with reactive follicles extending to the muscular propria.An extensive deposition of amyloid was also observed.Immunohistochemical stains revealed that a few plasmacytoid cells showed λ light chain staining, though most were κ light chain positive.These cells also were positive for CD138 and CD56 but negative for CD20 and CD79.The flndings were consistent with extramedullary plasmocytomaassociated with a massive deposit of amyloid in duodenum.A subsequent workup for multiple myeloma was completely negative.The patient showed no signs of local recurrence or dissemination of the disease after 12 mo follow-up.Because of the association of plasmocytoma and amyloidosis, the patient must be followed up because of the possible systemic involvement of the neoplasm and amyloidosis in future. | Fabiana Pirani Carneiro Maria de Nazareth Machado Sobreira Lívia Bravo Maia Alesso Cervantes Sartorelli Luiz Eduardo de Almeida Prado Franceschi Mauro Brito Brando Bárbara Wosnjuk Calaca Fernando Silva Lustosa Joo Vieira Lopes | 2009 | World Journal of Gastroenterology2009，15，28： | 2 |
| 5 | Tumor Regression Grades: Can They Influence Rectal Cancer Therapy Decision Tree?显示文摘 | Marisa D. Santos Cristina Silva Anabela Rocha Eduarda Matos Carlos Nogueira Carlos Lopes Frank A. Frizelle | 2013 | International Journal of Surgical Oncology2013，，： | 2 |
| 6 | 低渗核黄素在圆锥角膜患者角膜交联术中的应用(英文)显示文摘目的:比较圆锥角膜患者角膜交联(CXL)、等渗(IR)和低渗核黄素(HR)的结果。方法:回顾性研究,包括29例29眼圆锥角膜患者行角膜交联术,IR组15眼,HR组14眼。参数分析包括(随访1a):最佳矫正视力(BCVA),球体和柱体,中央和较薄处角膜厚度,平均和最大角膜曲率(分别为Km和Kmax),并发症及进展。结果:观察到两组的BCVA提高:治疗前IR组为0.26±0.57,HR组为0.47±0.72。术后1a,IR组为0.13±0.79,HR组为0.29±1.52,IR组BCVA更高(P=0.018)。术后1mo,两组中央角膜厚度(μm)均减少,但在接下来的数月中增加:术前IR组为497±28μm,HR组为432±14μm;术后1a,IR组为480±31μm,HR组为424±15μm。较薄处角膜厚度也是如此,术前IR组为487±29μm,HR组为410±20μm;术后1a,IR组为468±33μm,HR组为413±13μm。两组中Km和Kmax均降低。每组6眼呈现短暂的混浊,无持续性混浊。结论:在中央角膜厚度<400μm的患者中,HR的使用似乎是一个有效的替代执行传统CXL的技术。 | Ana Sofia Lopes Diana Silva Susana Henriques Peter Pego Cristina Vendrell Isabel Prieto | 2020 | 国际眼科杂志2020，20，2： | 2 |
| 7 | Prevalence of hepatitis C virus infection and HCV genotypes among hemophiliacs in the State of Bahia,Northeastern Brazil:analysis of serological and virological parameters显示文摘 | Silva LK Silva MB Lopes GB | 2005 | Rev Soc Bras Med Trop2005，38，6： | 1 |
| 8 | Characterization for enterotoxin production, virulence factors, and antibiotic susceptibility of Staphylococcus aureus isolates from various foods in Portugal显示文摘 | V. Pereira C. Lopes A. Castro J. Silva P. Gibbs P. Teixeira | 2009 | Food Microbiology2009，，3： | 1 |
| 9 | Aryltetralone lignans and 7,8-seco-lignans from Holostylis reniformis 显示文摘 | SILVA T LOPES L M X | 2004 | Phytochemistry2004，65，： | 1 |
| 10 | Gastrointestinal symptoms and nutritional status in women and men on maintenancehemodialysis显示文摘 | Silva LF Lopes OB Matos CM | 2012 | J Ren Nutr2012，22，3： | 1 |
| 11 | Influence of inoculum on performance of anaerobic reactors for treating municipal solid waste显示文摘 | Wilton Silva Lopes Valderi Duarte Leite Shiva Prasad | 2004 | Bioresource Technology2004，94，3： | 1 |
| 12 | FLT3 internal tandem duplication during myelodysplastic syndrome follow-up: a marker of transformation to acute myeloid leukemia显示文摘 | Ronald Feitosa Pinheiro Eloisa de Sá Moreira Maria Regina Régis Silva Fernando Lopes Alberto Maria de Lourdes L.F. Chauffaille | 2008 | Cancer Genetics and Cytogenetics2008，，2： | 1 |
| 13 | Copula, Marginal Distributions and Model Selection: A Bayesian Note 显示文摘 | Ralph dos Santos Silva Hedihert Freitas Lopes | 2008 | Statistics and Computing2008，118，3： | 1 |
| 14 | Screening of cata- lysts and effect of temperature for kinetic degradation studies of aro- matic compounds during wet oxidation 显示文摘 | Lopes R J G Silva A M T Quinta-Ferreira R M | 2007 | Applied Catalysis B: Environmental2007，73，12： | 1 |
| 15 | Epilepsies as dynamical diseases of brain systems:basic models of the transition between normal and epileptic activity显示文摘 | LOPES F H SILVA D BLANES W | 2003 | Epilepsia2003，44，12： | 1 |
| 16 | Studies on the encapsulation of diclofenac in small unilamellar liposomes of soya phosphatidylcholine显示文摘 | Lopes LB Scarpa MV Silva GV | 2004 | Colloids Surf B Biointerfaces2004，39，4： | 1 |
| 17 | Primary Ectopic Breast Cancer Presenting as a Vulvar Mass显示文摘 | Gilberto Lopes Teresa DeCesare Giselle Ghurani Vladimir Vincek Merce Jorda Stefan Glück Orlando Silva | 2006 | Clinical Breast Cancer2006，，3： | 1 |
| 18 | A Phase II trial of split, low-dose docetaxel and low-dose capecitabine: a tolerable and efficacious regimen in the first-line treatment of patients with HER2/neu-negative metastatic breast cancer显示文摘 | SILVA O LOPES G MORGENZSTERN D | 2008 | Clin Breast Cancer2008，8，2： | 1 |
| 19 | Evaluation of the 2-thiobarbituricacid method for the measurement of lipid oxidation inmechanicallydeboned gamma irradiated chicken meat 显示文摘 | HELIANA DE AZEVEDO GOMES EDIR NEPOMUCENODA SILVA MARCOS ROBERTO LOPES DONASCIMENTO | 2003 | Food Chemistry2003，，80： | 1 |
| 20 | On-line preconeentration system using a minicolumn of polyurethane foam loaded with Me-BTABr for zinc determination by flame atomic absorption spectrometry 显示文摘 | AZEVEDO LEMOS V LOPES DOS SANTOS W N SILVA SANTOS J | 2003 | Chem Acta2003，481，： | 1 |
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