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| 1 | A half century (1961-2011) of applying microsurgery to experimental liver research显示文摘The development of microsurgery has been dependent on experimental animals. Microsurgery could be a very valuable technique to improve experimental models of liver diseases. Microdissection and microsutures are the two main microsurgical techniques that can be considered for classifying the experimental models developed for liver research in the rat. Partial portal vein ligation, extrahepatic cholestasis and hepatectomies are all models based on microdissection. On the other hand, in portacaval shunts, orthotopic liver transplantation and partial heterotopic liver transplantation, the microsuture techniques stand out. By reducing surgical complications, these microsurgical techniques allow for improving the resulting experimental models. If good experimental models for liver research are successfully developed, the results obtained from their study might be particularly useful in patients with liver disease. Therefore experimental liver microsurgery could be an invaluable way to translate laboratory data on liver research into new clinical diagnostic and therapeutic strategies. | Maria-Angeles Aller Natalia Arias Isabel Prieto Salvador Agudo Carlos Gilsanz Laureano Lorente Jorge-Luis Arias Jaime Arias | 2012 | World Journal of Hepatology2012，4，7： | 4 |
| 2 | Management of pancreatic cancer in the elderly显示文摘Currently, pancreatic adenocarcinoma mainly occurs after 60 years of age, and its prognosis remains poor despite modest improvements in recent decades. The aging of the population will result in a rise in the incidence of pancreatic adenocarcinoma within the next years. Thus, the management of pancreatic cancer in the elderly population is gaining increasing relevance. Older cancer patients represent a heterogeneous group with different biological, functional and psychosocial characteristics that can modify the usual management of this disease, including pharmacokinetic and pharmacodynamic changes, polypharmacy, performance status, comorbidities and organ dysfunction. However, the biological age, not the chronological age, of the patient should be the limiting factor in determining the most appropriate treatment for these patients. Unfortunately, despite the increased incidence of this pathology in older patients, there is an underrepresentation of these patients in clinical trials, and the management of older patients is thus determined by extrapolation from the results of studies performed in younger patients. In this review, the special characteristics of the elderly, the multidisciplinary management of localized and advanced ductal adenocarcinoma of the pancreas and the most recent advances in the management of this condition will be discussed, focusing on surgery, chemotherapy, radiation and palliative care. | Oliver Higuera Ismael Ghanem Rula Nasimi Isabel Prieto Laura Koren Jaime Feliu | 2016 | World Journal of Gastroenterology2016，22，2： | 2 |
| 3 | 低渗核黄素在圆锥角膜患者角膜交联术中的应用(英文)显示文摘目的:比较圆锥角膜患者角膜交联(CXL)、等渗(IR)和低渗核黄素(HR)的结果。方法:回顾性研究,包括29例29眼圆锥角膜患者行角膜交联术,IR组15眼,HR组14眼。参数分析包括(随访1a):最佳矫正视力(BCVA),球体和柱体,中央和较薄处角膜厚度,平均和最大角膜曲率(分别为Km和Kmax),并发症及进展。结果:观察到两组的BCVA提高:治疗前IR组为0.26±0.57,HR组为0.47±0.72。术后1a,IR组为0.13±0.79,HR组为0.29±1.52,IR组BCVA更高(P=0.018)。术后1mo,两组中央角膜厚度(μm)均减少,但在接下来的数月中增加:术前IR组为497±28μm,HR组为432±14μm;术后1a,IR组为480±31μm,HR组为424±15μm。较薄处角膜厚度也是如此,术前IR组为487±29μm,HR组为410±20μm;术后1a,IR组为468±33μm,HR组为413±13μm。两组中Km和Kmax均降低。每组6眼呈现短暂的混浊,无持续性混浊。结论:在中央角膜厚度<400μm的患者中,HR的使用似乎是一个有效的替代执行传统CXL的技术。 | Ana Sofia Lopes Diana Silva Susana Henriques Peter Pego Cristina Vendrell Isabel Prieto | 2020 | 国际眼科杂志2020，20，2： | 2 |
| 4 | αKLOTHO and sTGFβR2 treatment counteract the osteoarthritic phenotype developed in a rat model显示文摘Dear Editor,Homeostasis and repair are critical biological processes that allow for tissue and organ preservation and function in multicellular organisms.Their regulation and extension vary drastically across the animal kingdom,and mammals show limited tissue-specific regenerative capacity that declines with age.During aging,articular cartilage is one of the tissues that undergo substantial changes in the matrix structure,molecular composition,metabolic activity,and mechanical properties(Loeser et al.2016). | Paloma Martinez-Redondo Isabel Guillen-Guillen Noah Davidsohn Chao Wang Javier Prieto Masakazu Kurita Fumiyuki Hatanaka Cuiqing Zhong Reyna Hernandez-Benitez Tomoaki Hishida Takashi Lezaki Akihisa Sakamoto Amy NNemeth Yuriko Hishida Concepcion Rodriguez Esteban Kensaku Shojima Ling Huang Maxim Shokhirev Estrella Nunez-Delicado Josep MCampistol Isabel Guillen-Vicente Elena Rodriguez-Inigo Juan Manuel Lopez-Alcorocho Marta Guillen-Vicente George Church Pradeep Reddy Pedro Guillen-Garcia Guang-Hui Liu Juan Carlos Izpisua Belmonte | 2020 | Protein & Cell2020，11，3： | 2 |
| 5 | Building dynamic capabilities in product de- velopment: How do contextual antecedents matter? 显示文摘 | Isabel M Prieto Elena Revilla Beatriz Rodr?' guez- Prado | 2009 | Scandinavian Journal of Management2009，25，： | 1 |
| 6 | Building dynamic capabilities in product development: How do contextual antecedents matter?显示文摘 | Isabel Ma Prieto Elena Revilla Beatriz Rodríguez-Prado | 2009 | Scandinavian Journal of Management2009，，3： | 1 |
| 7 | Temporal localization of porcine reproductive and respiratory syndrome virus in reproductive tissues of experimentally infected boars 显示文摘 | Cinta Prieto Carlos Garcl'a Isabel Simarro | 2003 | Theriogenology2003，60，： | 1 |
| 8 | Toxic cyanobacterial cells containing microcystins induce oxidative stress in exposed tilapia fish ( Oreochromis sp.) under laboratory conditions显示文摘 | ángeles Jos Silvia Pichardo Ana I. Prieto Guillermo Repetto Carmen M. Vázquez Isabel Moreno Ana M. Cameán | 2005 | Aquatic Toxicology2005，，3： | 1 |
| 9 | Tumor Necrosis Factor-α, Interleukin-1β and Nitric Oxide: Induction of Liver Megamitochondria in Prehepatic Portal Hypertensive Rats显示文摘 | Isabel Prieto Ph.D. Fulgencio Jiménez M.D. Maria-Angeles Aller Ph.D. Maria-Paz Nava Ph.D. Elena Vara PhD. Cruz Garcia Ph.D. Jaime Arias Ph.D | 2005 | World Journal of Surgery2005，，7： | 1 |
| 10 | Posterior corneal astigmatism modifications after cataract surgery and its role on total corneal astigmatism显示文摘Background:In recent years posterior corneal astigmatism and its effect on total corneal astigmatism has been studied,with research showing that this can impact total astigmatism.This study aims to ascertain if there is significant change in the posterior corneal astigmatism after cataract surgery and its impact on the total astigmatism.Methods:Analysis of 76 eyes that underwent cataract surgery with monofocal intraocular lens implantation.Corneal topography was performed with Pentacam(OCULUS®)pre-and post-operatively.Total corneal astigmatism was calculated with the algorithm of vergence tracing.We compared preoperative and postoperative changes in the magnitude and axis differences of anterior corneal curvature astigmatism,posterior corneal curvature astigmatism and the calculated total corneal astigmatism.We calculated the correlation between the total preoperative astigmatism and the difference between total corneal astigmatism and anterior corneal astigmatism.Results:The mean preoperative and postoperative posterior astigmatism was 0.31±0.02 D,showing no significant differences before and after surgery(P=0.989).Statistically significant differences between the calculated total corneal astigmatism and anterior corneal astigmatism were registered preoperatively and postoperatively in the with-the-rule anterior(WTR)corneal astigmatism(P=0.004,P<0.0001);against-the-rule(ATR)anterior corneal astigmatism(P<0.0001,P<0.0001)and in the oblique(P=0.026,P=0.019)subgroups.The posterior corneal astigmatism and the total corneal astigmatism correlated positively with the differences between the total corneal and anterior corneal astigmatism(R=0.378,P=0.001).Conclusions:There were statistically significant differences between the magnitude of the total astigmatism and anterior corneal astigmatism,underlining the impact of posterior corneal astigmatism.A positive correlation between the preoperative posterior astigmatism and the difference between the total corneal and the anterior corneal astigmatism suggests a specially relevant role of posterior corneal astigmatism when evaluating patients with higher degrees of astigmatism. | Diana Silva Mafalda Mota Catarina Pedrosa Peter Pêgo Sara Pinto Cristina Vendrell Isabel Prieto | 2018 | Annals of Eye Science2018，，1： | 0 |
| 11 | Hematotesticular barrier is altered from early stages of liver cirrhosis:Effect of insulin-like growth factor 1显示文摘AIM: The pathogenesis of hypogonadism in liver cirrhosis is not well understood. Previous results from our laboratory showed that IGF-1 deficiency might play a pathogenetic role in hypogonadism of cirrhosis. The administration of IGF-1 for a short period of time reverted the testicular atrophy associated with advanced experimental cirrhosis.The aim of this study was to establish the historical progression of the described alterations in the testes,explore testicular morphology, histopathology, cellular proliferation, integrity of testicular barrier and hypophysogonadal axis in rats with no ascitic cirrhosis.METHODS: Male Wistar rats with histologically-proven cirrhosis induced with carbon tetrachloride (CC14) for 11 wk,were allocated into two groups (n = 12, each) to receive recombinant IGF-1 (2 μg/100 g·d, sc) for two weeks or vehicle. Healthy rats receiving vehicle were used as control group (n = 12).RESULTS: Compared to controls, rats with compensated cirrhosis showed a normal testicular size and weight and very few histopathological testicular abnormalities.However, these animals showed a significant diminution of cellular proliferation and a reduction of testicular transferrin expression. In addition, pituitary-gonadal axis was altered, with significant higher levels of FSH (P<0.001 vs controls) and increased levels of LH in untreated cirrhotic animals. Interestingly, IGF-1 treatment normalized testicular transferrin expression and cellular proliferation and reduced serum levels of LH (P = ns vs controls, and P | Inma Castilla-Cortázar Nieves Diez María García-Fernández Juan Enrique Puche Fernando Diez-Caballero Jorge Quiroga Matías Díaz-Sánchez Alberto Castilla Amelia Díaz Casares Isabel Varela-Nieto Jesǘs Prieto Salvador González-Barón | 2004 | World Journal of Gastroenterology2004，10，17： | 0 |
| 12 | 两个商品PRRSV欧洲型改良式活疫苗在妊娠母猪上的使用效果显示文摘1前言
猪繁殖呼吸综合征(PRRS)的典型症状是仔猪呼吸窘迫和母猪繁殖失败.PRRSV属于动脉炎病毒科(Arterividae)动脉炎病毒属.是一种小体形、被囊膜包裹的单股正链RNA病毒。PRRSV是一类病度异基因的病毒.根据基因型、抗原性和致病力,可将其划分为欧洲型和美洲型两种基因型。 | 于古月 Mariela Scorttil Cinta Prieto Francisco J.Martínez-Lobo Isabel Simarro José M.Castro | 2007 | 国外畜牧学(猪与禽)2007，，2： | 0 |
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