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| 1 | Autoimmune hepatitis and anti-tumor necrosis factor alpha therapy:A single center report of 8 cases显示文摘This article describes cases of anti-tumor necrosis factor(TNF)-α-induced autoimmune hepatitis and evaluates the outcome of these patients in relation to their immunosuppressive strategy. A retrospective analysis of medical records was performed in our center, in order to detect cases of autoimmune hepatitis(AIH) associated with anti-TNF biologic agents. We describe and analyze eight cases of AIH following anti-TNF therapy, 7 with infliximab and 1 with adalimumab. A distinction should be made between induction of autoimmunity and clinically evident autoimmune disease. Liver biopsy is useful in detecting the role of the TNF-α antagonist in the development of AIH. The lack of relapse after discontinuing immunosuppressive therapy favors, as in this case series, an immune-mediated drug reaction as most patients with AIH have a relapse after treatment is suspended. Although AIH related to anti-TNF therapy is rare, a baseline immunological panel along with liver function tests should be performed in all patients with autoimmune disease before starting biologics. | Susana Rodrigues Susana Lopes Fernando Magro Hélder Cardoso Ana Maria Horta e Vale Margarida Marques Eva Mariz Miguel Bernardes Joanne Lopes Fátima Carneiro Guilherme Macedo | 2015 | World Journal of Gastroenterology2015，21，24： | 9 |
| 2 | 过瘤胃蛋氨酸、赖氨酸和组氨酸对泌乳奶牛生产性能的影响显示文摘试验旨在研究饲料中单独添加或综合添加过瘤胃(RP)蛋氨酸、赖氨酸和组氨酸及可代谢蛋白(MP)对泌乳后期奶牛生产性能的影响。试验选取72头荷斯坦奶牛,随机分为6组,试验期9周。奶牛随机分配到6个试验组中,2周作为1个变量周期:MPA组,根据美国国家科学研究委员会(2001)标准,在饲料中添加调节MP到243 g·d-1;MPD组,不添加MP,MP含量低于标准量54 g·d-1;MPDM组,在MPD组的基础上加入RP蛋氨酸;MPDL组,在MPD组的基础上加入RP赖氨酸;MPDH组,在MPD组的基础上加入组氨酸;MPDMLH组,在MPD组的基础上加入RP蛋氨酸、RP赖氨酸和RP组氨酸。试验结果表明,与MPA组对比,MPD组的干物质采食量(DMI)、产奶量、乳成分(乳脂肪、乳蛋白和乳糖)及能量校正的牛乳(ECM)、ECM饲料利用效率、牛奶和血浆中的N均降低。在MPD基础上补充RP赖氨酸可使乳蛋白率、血浆中葡萄糖浓度增加,且牛奶中N元素含量有增加的趋势;补充RP组氨酸可使DMI、牛奶浓缩蛋白增加,且乳脂肪、乳蛋白和ECM显著增加;补充3种RP氨基酸时,增加了乳蛋白率,使DMI和乳脂率有增加趋势,也提高了乳脂肪、乳蛋白含量和ECM及ECM饲料利用效率。与MPA相比,MPD组牛奶中N的含量有降低趋势,且血浆中必需氨基酸(除赖氨酸和蛋氨酸)浓度均降低。补充RP赖氨酸、RP蛋氨酸和RP组氨酸提高了血浆中蛋氨酸(除MPDM组)、赖氨酸和组氨酸浓度。饲喂MPD的奶牛血红蛋白浓度降低,血浆生长素含量高于MPA组。MPD组牛奶中总饱和脂肪酸浓度有高于MPA和MPDMLH组的趋势。MPD组的多元不饱和脂肪、牛奶中奇链与支链脂肪酸含量与MPA组相比,有降低趋势。试验结果表明,对于饲料中缺乏MP的奶牛,在饲料中添加组氨酸和添加3种RP氨基酸(赖氨酸、蛋氨酸和组氨酸)均有提高牛奶产量和牛奶组分含量的可能性。 | Giallongo F Harper M T Oh J Lopes J C Lapierre H Patton R A Parys C Shinzato I Hristov A N | 2016 | 饲料博览2016，0，7： | 4 |
| 3 | Contribution of intraopertive electrical stimulations in surgery of low grade gliomas: a comparative study between two series without (1985-96) and with (1996-2003) functional mapping in the same institution显示文摘 | Duffau H Lopes M Arthuis F | 2005 | I Neurol Neurosurg Psychiatry2005，76，6： | 1 |
| 4 | Event-related EEG/MEG synchronization and desychronization: basic principles 显示文摘 | Pfurtscheller G Lopes da Silva F H | 1999 | Clinical Neurophysiology1999，110，11： | 1 |
| 5 | Retrogression and re-aging of 7075 aluminium alloy: Microstructural characterization显示文摘 | VIANA F PINTO A M P SANTO H M C LOPES A B | 1999 | Materials Processing Technology1999，9293，： | 1 |
| 6 | Contribution of intraoperative electrical stimulations in surgery of low grade gliomas:a comparative study between two series without(1985-96)and with(1996-2003)functional mapping in the same institution显示文摘 | Duffau H Lopes M Arthuis F | 2005 | J Neurol Neurosurg Psychiatry2005，76，6： | 1 |
| 7 | Model of brain rhythmic activity显示文摘 | Lopes da Silva F H Hoeks A Smits H | 1974 | Biological Cybernetics1974，15，1： | 1 |
| 8 | The nucleus accumbens as a complex of functionally distinct neuronal ensembles:an integr-ation of behavioral,electrophysioligical and anatomical data显示文摘 | Pennartz C M Groenewegen H J Lopes da Sliva F H | 1994 | Prog Neurobiol1994，42，6： | 1 |
| 9 | Event-related EEG/MEG synchronization and desynchronization: Basic principles显示文摘 | Pfurtscheller G Lopes da Silva F H | 1999 | Clinical Neurophysiology1999，110，11： | 1 |
| 10 | Adenosine deminase and tuberculous meningitis-a systematic review with meta-analysis 显示文摘 | TUON F F HIGASHINO H R LOPES M I LITVOC M N ATOMIYA A N ANTONANGELO L | 2010 | Scand J Infect Dis2010，42，： | 1 |
| 11 | Eventrelated EEG/MEG synchronization and desynchronization:Basic principles显示文摘 | PFURTSCHELLER G LOPES DA SILVA F H | 1999 | Clinical neurophysiology:1999，110，11： | 1 |
| 12 | Apoptosis underlies immunopathogenic mechanisms in acute silicosis 显示文摘 | BORGES V M LOPES M F FALCAO H | 2002 | Am J Respir Cell Mol Biol2002，27，1： | 1 |
| 13 | Epilepsies as dynamical diseases of brain systems:basic models of the transition between normal and epileptic activity显示文摘 | LOPES F H SILVA D BLANES W | 2003 | Epilepsia2003，44，12： | 1 |
| 14 | Bayesian model uncertainty in Smooth Transition Autoregression显示文摘 | Lopes H F Salazar E | 2006 | Journal of Time series Analy- sis2006，27，1： | 1 |
| 15 | Contribution of intraoperative electrical stimulations in surgery of low grade gliomas:a comparative study between two series without(1985-96)and with(1996-2003)functional mapping in the same institution显示文摘 | Duffau H Lopes M Arthuis F | 2005 | J Neurol Neur Psych2005，76，6： | 1 |
| 16 | Event-related EEG/MEG synchronization and desynchronizaiton: basic principles 显示文摘 | Pfurstcheller G Lopes da Silva F H | 1999 | Clinical Neurophysiology1999，110，11： | 1 |
| 17 | Quality grading of cork planks with classification models based on defect characterization显示文摘 | GONZALEZ-ADRADOS J R LOPES F PEREIRA H | 2000 | Holz als Roh-und Werkstoff2000，58，12： | 1 |
| 18 | Adenosine deaminase and tuberculous meningitis--a systematic review with meta-analysis显示文摘 | TUON F F HIGASHINO H R LOPES M I | | 0，，03： | 1 |
| 19 | Heavy metals behavior during mono-eombustion and co-combustion of sewage sludge显示文摘 | LOPES M H ABELHA P SANTOS OLIVEIRA J F eta/ | 2005 | Environmen- tal Engineering Science2005，22，2： | 1 |
| 20 | Model of brain rhythmic activity显示文摘 | LOPES F H HOEKS A SMITS H | 1974 | Kybernetik1974，15，1： | 1 |
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