|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The Tartary Buckwheat Genome Provides Insights into Rutin Biosynthesis and Abiotic Stress Tolerance显示文摘 | Zhang, Lijun Li, Xiuxiu Ma, Bin Gao, Qiang Du, Huilong Han, Yuanhuai Li, Yan Cao, Yinghao Qi, Ming Zhu, Yaxin Lu, Hongwei Ma, Mingchuan Liu, Longlong Zhou, Jianping Nan, Chenghu Qin, Yongjun Wang, Jun Cui, Lin Liu, Huimin Liang, Chengzhi Qiao, Zhijun | 2017 | Molecular Plant2017，10，9： | 53 |
| 2 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 3 | A huge oceanic-type UHP metamorphic belt in southwestern Tianshan, China: Peak metamorphic age and P-T path显示文摘Recent progress in the study of the UHP metamorphic belt in southwestern Tianshan,China,is summarized in this paper.This about 80-km-long and over 10-km-wide UHP belt has been recognized by the discovery of coesite,coesite pseudomorphs and other UHP minerals.It is the largest oceanic-type UHP metamorphic belt reported so far.It has formed due to northward subduction of the Tianshan Paleo-Ocean.U-Pb dating of metamorphic rims of zircons from a coesite-bearing garnet-phengite schist yields a peak UHP metamorphic ages of 320±3.7 Ma.Combined with ages of 233–226 Ma obtained from rims of zircons from retrograded eclogites,a long retrograde metamorphic evolution(>70 Ma)has been revealed.According to phase equilibria modeling,the P-T paths of both coesite-bearing eclogites and garnet-phengite schists are characterized by thermal relaxation,i.e.,the metamorphic temperature peak lags behind the pressure peak,indicating that the UHP rocks experienced slow and long heating and decompression during exhumation in the subduction channel.On the basis of the field observation that a small amount of eclogite lenses is wrapped in large volumes of metapelites,and the similar P-T paths of both rock types,we propose that the exhumation of the UHP eclogites from southwestern Tianshan,China,may have resulted from the exhumation of large volumes of low-density metapelites,which carried the denser eclogites to the Earth’s surface. | ZHANG LiFei DU JinXue Lü Zeng YANG Xin GOU LongLong XIA Bin CHEN ZhenYu WEI ChunJing SONG ShuGuang | 2013 | Chinese Science Bulletin2013，58，35： | 19 |
| 4 | Testing method and distribution characteristics of spatial pesticide spraying deposition quality balance for unmanned aerial vehicle显示文摘In order to explore the spatial pesticide spraying deposition distribution,the downwash flow field characteristics for unmanned aerial vehicle(UAV)pesticide application with accurate flight height and velocity and the relationship of these two aspects,a novel measurement method was proposed in this paper.A model‘3WQF80-10’single-rotor diesel UAV was tested using this method in wheat field and the effects of flight direction,flight parameters and crosswind on the distribution of spatial spraying deposition quality balance(SSDQB)and the downwash flow field distribution were researched.A cuboid aluminum sampling frame of spatial spraying deposition quality balance(SFSSDQB)with monofilament wires was made for collecting the droplets in four directions,and a set of multi-channel micro-meteorology measurement system(MMMS)was applied for measuring the downwash wind speed in three directions.Besides,BeiDou Navigation Satellite System(BNSS)was used for controlling and recording the working height,velocity and track of this model of single-rotor UAV.The results showed the distribution of the spatial spray deposition and the downwash flow field of UAV could be measured effectively at exact flight height and velocity via this method.When the average wind speed was 0.9 m/s,the average temperature was 31.5℃ and the average relative humidity was 34.1%,and the average distribution ratios of spraying deposition for model‘3WQF80-10’UAV on the upwind part,the top part,the downwind part and the bottom part were 4.4%,2.3%,50.4%and 43.7%,respectively.The flight directions of forward and backward had an impact on droplet deposition distribution and the working effect of flying backwards,with 60%of deposition ratio of the bottom part of the SFSSDQB,was better than flying forward.There was a linear negative correlation between the coefficient of variation(CV)of the bottom part and the flight height and the coefficient of determination was 0.9178,which means that the deposition distribution becomes more uniform with the increase of height.Additionally,there was a linear positive correlation between weighted mean deposition rate and crosswind speed and the coefficient of determination was 0.9684,which shows the deposition distribution gets more concentrated towards the downwind part with the rise of crosswind speed.Therefore,according to the results of tests of downwash airflow speed,it is shown that regardless of the flight direction and height and the crosswind,all these factors influence the droplet deposition distribution via weakening the intensity of the downwash airflow field in the direction perpendicular to the ground.The results can provide valuable information for the research of UAV pesticide application techniques and the establishment of the standard of spraying deposition and drift tests of UAV in crop field. | Changling Wang Xiongkui He Xiaonan Wang Zhichong Wang Shilin Wang Longlong Li Jane Bonds Andreas Herbst Zhiguo Wang | 2018 | International Journal of Agricultural and Biological Engineering2018，11，2： | 14 |
| 5 | Efficient production of ethyl levulinate from cassava over Al2(SO4)3 catalyst in ethanol–water system显示文摘One-pot achievement of ethyl levulinate from cassava was conducted in ethanol-water system over several simple sulfate salt catalysts.Al_2(SO_4)_3 catalyst had the best performance in synthesizing ethyl levulinate comparing with those of a series of sulfate salts.The highest yields of ethyl levulinate was up to39.27%as well as 7.78%levulinate acid when cassava was catalyzed in ethanol medium by adding 10 wt%water.^(13)C and ~1H NMR spectroscopic investigations confirmed that isomerization of glucose to fructose over Al_2(SO_4)_3 catalyst is an important step in producing ethyl levulinate and levulinate acid.Due to aggregations of Al^(3+) under hydrothermal conditions,tiny amount of Al^(3+) were detected in filtrate at the percentage of 0.32%even if in absolute water.Bronsted and Lewis acids could improve the yield of ethyl levulinate and levulinate acid by synergistic effect.All results suggested that A1_2(SO_4)_3 was a simple and efficient catalyst for ethyl levulinate and levulinate acid production. | Jin Tan Qiying Liu Lungang Chen Tiejun Wang Longlong Ma Guanyi Chen | 2017 | Journal of Energy Chemistry2017，26，1： | 11 |
| 6 | Two-dimensional metal-organic-framework as a unique theranostic nano-platform for nuclear imaging and chemo-photodynamic cancer therapy显示文摘Nanoscale metal organic frameworks (NMOFs) with porous structure and inherent biodegradability are attractive nanomedicine platforms.In addition to conventional particulate NMOFs,two-dimensional (2D) NMOFs are emerging as a unique type of NMOFs which however have been relatively less explored for nanomedicine applications.Herein,2D NMOFs composed of Zn2+ and tetrakis(4-carboxyphenyl) porphyrin (TCPP) are fabricated and functionalized with polyethylene glycol (PEG).Compared to their particulate counterpart,such 2D NMOFs show greatly increased drug loading capacity and enhanced light-triggered singlet oxygen production,promising for chemotherapy and photodynamic therapy (PDT),respectively.Utilizing the porphyrin structure of TCPP,our 2D NMOFs could be labeled with a diagnostic radioisotope,99mTc,for single photon emission computer tomography (SPECT) imaging,which reveals efficient tumor homing of those 2D NMOFs upon intravenous injection.While offering a remarkable synergistic in vivo antitumor effect for the combined chemo-PDT,such 2D NMOFs show efficient biodegradation and rapid renal clearance.Our work presents the great promise of 2D NMOFs for nanomedicine applications. | Wenjun Zhu Yu Yang Qiutong Jin Yu Chao Longlong Tian Jingjing Liu Ziliang Dong Zhuang Liu | 2019 | Nano Research2019，12，6： | 9 |
| 7 | Design and experiment of variable rate orchard sprayer based on laser scanning sensor显示文摘During different growth periods,canopy size and density in orchards are variable,which need application conditions(flow rate and air flow)to be adjusted to match the canopy’s characteristics.In order to improve orchard sprayer’s automatic operating performance,an automatic variable-rate orchard sprayer(VARS)fixed with 40 electromagnetic valves and 8 brushless fans was developed based on the canopy’s spatial dimensions.Each solenoid valve and brushless motor can be individually adjusted in real-time through pulse width modulation(PWM)signals emitted by a control system to adjust each nozzle’s spout and fan rotation speed.A high-precision laser scanning sensor(light detecting and ranging,LIDAR)was adopted as the detector to measure the canopy volume using the variable rate algorithm principle.Field experiments were conducted in an apple orchard,and conventional air blast sprayer(CABS)and directed air-jet sprayer(DAJS)were tested as a comparison.Results showed that on average,46%less spraying solution was applied compared to conventional applications,while penetration rate was similar to DAJS.Normalized deposition in the canopy with variable application was higher than that of conventional applications,indicating that electronic sprayers are more efficient than conventional sprayers.It was also observed that VARS could significantly reduce off-target loss.The field experiment showed that the newly developed variable-rate sprayer can greatly reduce pesticide use and protect the environment for the orchard fruit production,and also provide a reference for design and performance optimization for plant protection machinery. | Longlong Li Xiongkui He Jianli Song Yajia Liu Aijun Zeng Liu Yang Chaohui Liu Zhixiong Liu | 2018 | International Journal of Agricultural and Biological Engineering2018，11，1： | 8 |
| 8 | An isoflavone derivative potently inhibits the angiogenesis and progression of triple-negative breast cancer by targeting the MTA2/SerRS/VEGFA pathway显示文摘Objective:Angiogenesis plays a vital role in tumor growth and metastasis.Here,we aimed to find novel efficient antiangiogenic molecules targeting vascular endothelial growth factor A(VEGFA)at the transcriptional level to treat triple-negative breast cancer(TNBC).Methods:We used a cell-based seryl tRNA synthetase(SerRS)promoter-driven dual-luciferase reporter system to screen an in-house library of 384 naturally occurring small molecules and their derivatives to find candidate molecules that could upregulate the expression of SerRS,a potent transcriptional repressor of VEGFA.The levels of SerRS and VEGFA were examined by quantitative RT-PCR(qRT-PCR),western blotting,and/or ELISAs in TNBC cells after candidate molecule administration.Zebrafish,the Matrigel plug angiogenesis assay in mice,the TNBC allograft,and xenograft mouse models were used to evaluate thein vivoanti-angiogenic and anti-cancer activities.Furthermore,the potential direct targets of the candidates were identified by proteomics and biochemical studies.Results:We found the most active compound was 3-(4-methoxyphenyl)quinolin-4(1H)-one(MEQ),an isoflavone derivative.In TNBC cells,MEQ treatment resulted in increased SerRS mRNA(P<0.001)and protein levels and downregulated VEGFA production.Both the vascular development of zebrafish and Matrigel plug angiogenesis in mice were inhibited by MEQ.MEQ also suppressed the angiogenesis in TNBC allografts and xenografts in mice,resulting in inhibited tumor growth and prolonged overall survival(P<0.05).Finally,we found that MEQ regulated SerRS transcription by interacting with MTA2(Metastasis Associated 1 Family Member 2).Conclusions:Our findings suggested that the MTA2/SerRS/VEGFA axis is a drug-treatable anti-angiogenic target,and MEQ is a promising anti-tumor molecule that merits further investigation for clinical applications. | Xiaotong Zhang Gengyi Zou Xiyang Li Lun Wang Tianyu Xie Jin Zhao Longlong Wang Shunchang Jiao Rong Xiang Haoyu Ye Yi Shi | 2020 | Cancer Biology & Medicine2020，17，3： | 6 |
| 9 | Transition-Metal-Free Defluorosilylation of Fluoroalkenes with Silylboronates显示文摘Silylated fluoroalkenes are important synthetic intermediates with complementary reactivity,which play a key role in the construction of natural products,pharmaceuticals,and manmade materials.Converting the normally highly stable fiuoroalkenes into silylated fluoroalkenes by selective defluorosilylation is a challenging task.Herein,we report a simple,inexpensive and robust defluorosilylation of a variety of fluoroalkenes with silylboronates in the presence of alkoxy base to directly synthesize various silylated fluoroalkenes.The protocol features mild and safe reaction conditions that avoid a catalyst,a transition metal,a ligand,and high reaction temperature and tolerates a wide scope of fluoroalkene substrates without compromising the efficiency.Density functional theory calculations show that transient silyl anion complex undergoes an SN2,or SNv substitution,which is responsible for this base-mediated defluorosilylation. | Pan Gao Guoqiang Wang Longlong Xi Minyan Wang Shuhua Li Zhuangzhi Shi | 2019 | Chinese Journal of Chemistry2019，37，10： | 5 |
| 10 | Petrological evidence for isobaric cooling of ultrahightemperature pelitic granulites from the Khondalite Belt,North China Craton显示文摘The ultrahigh-temperature(UHT) pelitic granulites from the Khondalite Belt, North China Craton(NCC), contain ilmenite in the matrix, which has been partially replaced by rutile. Based on this observation and the growth of biotite by garnet-consuming reaction, the UHT rocks are inferred to have recorded three metamorphic stages: the peak metamorphic stage(M1) and two retrograde metamorphic stages(M2 and M3). The M1 stage is represented by the assemblage of perthite+sillimanite+ ilmenite in the matrix, and quartz inclusions bearing(in the cores) garnet porphyroblasts. The M2 stage is defined by rutile-replacing ilmenite and growth of garnet mantles and rims containing acicular sillimanite inclusions, with the garnet+ perthite+ sillimanite+rutile+ ilmenite+ quartz assemblage. The M3 stage is recorded by the growth of biotite in the matrix, with the garnet+ biotite+ perthite+ sillimanite+rutile+ilmenite+quartz assemblage. Based on phase equilibrium modeling, an isobaric cooling path is reconstructed, which is consistent with the idea that mantle-derived magma provided the heat for the UHT metamorphism in the Khondalite Belt, NCC. | Longlong Gou Chengli Zhang Quan Wang | 2015 | Science Bulletin2015，60，17： | 5 |
| 11 | Integrative analysis of DNA methylation and gene expression identified cervical cancer-specific diagnostic biomarkers显示文摘Cervical cancer is the leading cause of death among women with cancer worldwide.Here,we performed an integrative analysis of Illumina HumanMethylation450K and RNA-seq data from TCGA to identify cervical cancer-specific DNA methylation markers.We first identified differentially methylated and expressed genes and examined the correlation between DNA methylation and gene expression.The DNA methylation profiles of 12 types of cancers,including cervical cancer,were used to generate a candidate set,and machine-learning techniques were adopted to define the final cervical cancer-specific markers in the candidate set.Then,we assessed the protein levels of marker genes by immunohistochemistry by using tissue arrays containing 93 human cervical squamous cell carcinoma samples and cancer-adjacent normal tissues.Promoter methylation was negatively correlated with the local regulation of gene expression.In the distant regulation of gene expression,the methylation of hypermethylated genes was more likely to be negatively correlated with gene expression,while the methylation of hypomethylated genes was more likely to be positively correlated with gene expression.Moreover,we identified four cervical cancer-specific methylation markers,cg07211381(RAB3C),cg12205729(GABRA2),cg20708961(ZNF257),and cg26490054(SLC5A8),with 96.2%sensitivity and 95.2%specificity by using the tenfold cross-validation of TCGA data.The four markers could distinguish tumors from normal tissues with a 94.2,100,100,and 100%AUC in four independent validation sets from the GEO database.Overall,our study demonstrates the potential use of methylation markers in cervical cancer diagnosis and may boost the development of new epigenetic therapies. | Wanxue Xu Mengyao Xu Longlong Wang Wei Zhou Rong Xiang Yi Shi Yunshan Zhang Yongjun Piao | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 4 |
| 12 | Precipitation of rutile needles in garnet from sillimanite-bearing pelitic granulite from the Khondalite Belt, North China Craton显示文摘Pelitic granulite from the Khondalite Belt,North China Craton,is composed of garnet,sillimanite,perthite,biotite and quartz.Oriented rutile needles in garnet are reported for the first time from the granulite.The rutile needles have been identified by optical microscopy and confirmed by in situ Raman spectroscopy,where they show the characteristic bands at 446–448 and 610 cm-1.Because of their very strong shape preferred orientation in3–4 easily observable directions,these rutile needles are interpreted to have formed by precipitation during exhumation and cooling following peak metamorphism.The ternary feldspar geothermometer gives a peak metamorphic temperature of*980°C at 10 kbar.The presence of oriented rutile needles in garnet is suggested to be a valuable indicator of ultrahigh-temperature(UHT)metamorphism in the Khondalite Belt and therefore likely in other UHT terrains. | Longlong Gou Chengli Zhang Lifei Zhang Quan Wang | 2014 | Chinese Science Bulletin2014，59，32： | 4 |
| 13 | Advances in graphene reinforced metal matrix nanocomposites:Mechanisms,processing,modelling,properties and applications显示文摘Graphene has been extensively explored to enhance functional and mechanical properties of metalmatrix nanocomposites for wide-range applications due to their superior mechanical,electrical and thermal properties.This article discusses recent advances of key mechanisms,synthesis,manufacture,modelling and applications of graphene metal matrix nanocomposites.The main strengthening mechanisms include load transfer,Orowan cycle,thermal mismatch,and refinement strengthening.Synthesis technologies are discussed including some conventional methods(such as liquid metallurgy,powdermetallurgy,thermal spraying and deposition technology)and some advanced processing methods(such as molecular-level mixing and friction stir processing).Analytical modelling(including phenomenological models,semi-empirical models,homogenization models,and self-consistent model)and numerical simulations(including finite elements method,finite difference method,and boundary element method)have been discussed for understanding the interface bonding and performance characteristics between graphene and different metal matrices(Al,Cu,Mg,Ni).Key challenges in applying graphene as a reinforcing component for the metal matrix composites and the potential solutions as well as prospectives of future development and opportunities are highlighted. | Wenge Chen Tao Yang Longlong Dong Ahmed Elmasry Jiulong Song Nan Deng Ahmed Elmarakbi Terence Liu Hai Bao Lv Yong Qing Fu | 2020 | Nanotechnology and Precision Engineering2020，3，4： | 4 |
| 14 | Selective hydrogenolysis of 5-hydroxymethylfurfural to 2,5-dimethylfuran over Co_3O_4 catalyst by controlled reduction显示文摘2,5-dimethyfuran(DMF), which is produced from 5-hydroxymethyfurfural(HMF) by hydrodeoxygenation(HDO), is a high quality fuel due to the high heating value, the high octane number and the suitable boiling point. Selective hydrogenation of HMF into liquid fuel DMF has been widely researched. In this paper, Co_3O_4 catalyst was prepared by co-precipitation and was reduced at different temperatures to form Co–CoO_x catalysts. The characterization of catalysts was tested by XRD, TEM, XPS, TPR, BET and NH3-TPD.Co–CoO_x possessed a high amount of Co metal and CoO_x acidic sites, wherein Co worked as the active hydrogenation sites and CoO_x acted as the acid promoter to facilitate the selective HDO of HMF to DMF.The synergistic effect of Co–CoO_x is the key for HDO of HMF, obtaining 83.3% of DMF yield at 170 °C, 12 h and the reduction temperature of 400 °C. This method not only saves the catalyst cost, but also promotes the utilization of biomass energy. | Dan Li Qiying Liu Changhui Zhu Haiyong Wang Chunhua Cui Chenguang Wang Longlong Ma | 2019 | Journal of Energy Chemistry2019，28，3： | 4 |
| 15 | Flexoelectric materials and their related applications: A focused review显示文摘Flexoelectricity refers to the mechanical-electro coupling between strain gradient and electric polarization, and conversely, the electro-mechanical coupling between electric field gradient and mechanical stress. This unique effect shows a promising size effect which is usually large as the material dimension is shrunk down. Moreover, it could break the limitation of centrosymmetry, and has been found in numerous kinds of materials which cover insulators, liquid crystals, biological materials, and semiconductors. In this review, we will give a brief report about the recent discoveries in flexoelectricity, focusing on the flexoelectric materials and their applications. The theoretical developments in this field are also addressed. In the end, the perspective of flexoelectricity and some open questions which still remain unsolved are commented upon. | Longlong SHU Renhong LIANG Zhenggang RAO Linfeng FEI Shanming KE Yu WANG | 2019 | Journal of Advanced Ceramics2019，8，2： | 4 |
| 16 | Geochemistry and zircon U-Pb geochronology of the rhyolitic tuff on Port Island, Hong Kong: Implications for early Cretaceous tectonic setting显示文摘Early Cretaceous rhyolitic tuffs,widely distributed on Port Island,provide insights into the volcanism and tectonic setting of Hong Kong.In this paper we present petrological,geochronological and geochemical data of the rhyolitic tuff to constrain the diagenesis age and petrogenesis of the rocks,tectonic setting and early Cretaceous volcanism of Hong Kong.The first geochronological data show that the zircons in the volcanic rocks have U-Pb age of 141.1-139.5 Ma,which reveals that the rhyolitic tuff on Port Island was formed in the early Cretaceous(K_1).Geochemically,these acid rocks,which are enriched in large ion lithophile elements(LILEs) and light rare earth elements(LREEs),and depleted in high field strength elements(HFSEs),belong to the high K calc-alkaline to shoshonite series with strongly-peraluminous characteristic.The geochemical analyses suggest that the volcanic rocks were derived from deep melting in the continental crust caused by basaltic magma underplating.Based on the geochemical analysis and previous studies,we concluded that the rhyolitic tuffs on Port Island were formed in a backarc extension setting in response to the subduction of the Paleo-Pacific Plate beneath the Eurasian Plate. | Longlong Zhao Lulin Wang Mingzhong Tian Fadong Wu | 2017 | Geoscience Frontiers2017，8，3： | 4 |
| 17 | Selection and characterization of the novel anti-human PD-1 FV78 antibody from a targeted epitope mammalian cell-displayed antibody library显示文摘Currently,display-based methods are well established and widely used in antibody engineering for affinity maturation and structural stability improvement.We obtained a novel anti-human programmed death 1(PD-1)antibody using computer-aided design and a mammalian cell display technology platform.We used computer-aided modeling and distance geometry methods to predict and assign the key residues that contributed to the binding of human PD-L1 to PD-1.Then,we analyzed the sequence of nivolumab(an anti-human PD-1 antibody,referred to as MIL75 in the article)to determine the template for antibody design and library construction.We identified a series of potential substitutions on the obtained template and constructed a virtual epitope-targeted antibody library based on the physicochemical properties and each possible location of the assigned key residues.The virtual antibody libraries were displayed on the surface of mammalian cells as the antigen-binding fragments of full-length immunoglobulin G.Then,we used flow cytometry and sequencing approaches to sort and screen the candidates.Finally,we obtained a novel anti-human PD-1 antibody named FV78.FV78 competitively recognized the PD-1 epitopes that interacted with MIL75 and possessed an affinity comparable to MIL75.Our results implied that FV78 possessed equivalent bioactivity in vitro and in vivo compared with MIL75,which highlighted the probability and prospect of FV78 becoming a new potential antibody therapy. | Longlong Luo Shi Wang Xiaoling Lang Tingting Zhou Jing Geng Xinying Li Chunxia Qiao Jiannan Feng Beifen Shen Ming Lv Yan Li | 2018 | Cellular & Molecular Immunology2018，15，2： | 4 |
| 18 | Dependence of magnetic properties on microstructure and composition of Ce-Fe-B sintered magnets显示文摘In this paper,dependence of magnetic properties on microstructure and composition of Ce-Fe-B sintered magnets with Cu-doped Ce-rich alloy addition was investigated.It shows that the maximum energy product(BH)(max)and coercivity H(cj)of Ce-Fe-B sintered magnet are improved from 6.76 to 9.13 MGOe by 35.1%,and from 1.44 to 1.67 kOe by 16.0%,respectively,via adding 5 wt%liquid phase alloy of Ce(35.58)Fe(57.47)Cu6 B(0.95)(at%).Compared with the magnet without Cerich alloy addition,the volume fraction of the grain-boundary phase with low melting point increases in the magnet with Ce-rich alloy additio n,which is be ne ficial to imp roving the microstructure and promoting the coercivity enhancement of the magnet.In the Ce-Fe-B magnet with Ce-rich alloy addition,Cu and Ce enrich in the grain boundaries of the magnet after annealing,therefore the as-annealed magnet has a higher coercivity than the as-sintered magnet.A distinct Fe-rich layer with the average thickness of 60 nm is found in the grain boundaries in the magnet without Ce-rich alloy addition,but it seems that Fe-rich phase disappears in the magnet with Ce-rich alloy addition.The present work suggests that the further improvement of coercivity in the Ce-Fe-B sintered magnets is expectable by designing the composition and structure of added liquid phase alloys. | Longlong Xi Anhua Li Haibo Feng Min Tan Wei Sun Minggang Zhu Wei Li | 2019 | Journal of Rare Earths2019，37，8： | 4 |
| 19 | Modification of Mn on corrosion and mechanical behavior of biodegradable Mg(88)Y4Zn2Li5 alloy with long-period stacking ordered structure显示文摘The biological corrosion behavior and mechanical properties of Mg(89-x)Y4 Zn2 Li5 Mnx(x=0,0.5,1,1.5 and2 at.%) alloy with long-period stacking ordered(LPSO) structure were investigated in this work.The magnesium matrix and the eutectic phase of Mg(88)Y4 Zn2 Li5 Mn1 alloy are effectively refined by the grain boundary segregation of Mn,and the average size of matrix and the eutectic phase decreased by 66%and 74%,respectively.The ultimate tensile strength(UTS) and elongation enhanced by 36% and 55%,respectively.The corrosion rates obtained by weight loss and hydrogen evolution of Mg(88)Y4 Zn2 Li5 Mn1 alloy were 79% and 84% lower than that of Mg(88)Y4 Zn2 Li5 alloy.Additionally,Mg(88)Y4 Zn2 Li5 Mn1 alloy also presents superior corrosion behavior in electrochemical test.It is verified that Mn plays a positive role in both corrosion and mechanical properties of the Mg(88)Y4 Zn2 Li5 Mn1 alloy,which provides a reference for further experimental work. | Jiaxin Zhang Jinshan Zhang Fuyin Han Wei Liu Longlong Zhang Rui Zhao Chunxiang Xu Jing Dou | 2020 | Journal of Materials Science & Technology2020，42，7： | 4 |
| 20 | Slope stability prediction using ensemble learning techniques: A case study in Yunyang County, Chongqing, China显示文摘Slope stability prediction plays a significant role in landslide disaster prevention and mitigation.This study develops an ensemble learning-based method to predict the slope stability by introducing the random forest(RF)and extreme gradient boosting(XGBoost).As an illustration,the proposed approach is applied to the stability prediction of 786 landslide cases in Yunyang County,Chongqing,China.For comparison,the predictive performance of RF,XGBoost,support vector machine(SVM),and logistic regression(LR)is systematically investigated based on the well-established confusion matrix,which contains the known indices of recall rate,precision,and accuracy.Furthermore,the feature importance of the 12 influencing variables is also explored.Results show that the accuracy of the XGBoost and RF for both the training and testing data is superior to that of SVM and LR,revealing the superiority of the ensemble learning models(i.e.XGBoost and RF)in the slope stability prediction of Yunyang County.Among the 12 influencing factors,the profile shape is the most important one.The proposed ensemble learning-based method offers a promising way to rationally capture the slope status.It can be extended to the prediction of slope stability of other landslide-prone areas of interest. | Wengang Zhang Hongrui Li Liang Han Longlong Chen Lin Wang | 2022 | Journal of Rock Mechanics and Geotechnical Engineering2022，14，4： | 4 |
您所在的机构暂未开通此部分的功能，请联系管理员