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| 1 | Dendritic cell-based vaccination with lentiviral vectors encoding ubiquitinated hepatitis B core antigen enhances hepatitis B virus-specific immune responses in vivo显示文摘肝炎 B 病毒(HBV ) 的活动特定的细胞毒素的 T 淋巴细胞(CTL ) 戏在 HBV 的清理的一个占优势的角色。树枝状的房间(DC ) 是关键介绍抗原的房间并且在有免疫力的回答的开始起一个重要作用。我们以前验证了有效地编码 ubiquitinated 肝炎 B 核心抗原(LV-Ub-HBcAg ) 的那 lentiviral 向量导致成熟的 transduced DC,和成熟 DC 高效地导致了 T 房间极化到 Th1 并且产生了 HBcAg 特定的 CTL 前 vivo。在这研究,在 BALB/c 老鼠的 LV-Ub-HBcAg 的 HBV 特定的有免疫力的回答(H-2K d ) 被评估。LV-Ub-HBcAg 的直接注射增加了 cytokines IL-2 和 IFN- 的生产,这被显示出,得到了强壮的抗体回答,并且显著地产生了 IFN-+ 有在 BALB/c 老鼠的 HBV 特定的 CTL 回答的 CD8 + T 房间。另外, LV-Ub-HBcAg 的直接注射导致了有势力 anti-HBV 免疫者回答,类似于得到由的那些在 vitro-transduced DC。在结论,基于 DC 的治疗学的疫苗的 LV-Ub-HBcAg 得到了特定的抗体免疫者回答并且在 vivo 导致了柔韧的特定的 CTL 活动。 | Shenglan Dai Meng Zhuo Linlin Song Xiaohua Chen Yongsheng Yu Zhenghao Tang Guoqing Zang | 2015 | Acta Biochimica et Biophysica Sinica2015，47，11： | 9 |
| 2 | High-yield preparation of robust gold nanoshells on silica nanorattles with good biocompatiblity显示文摘Although gold nanoshells are widely considered as one of the promising photothermal nanomaterials used for biomedicine, the high cost, low yield and poor stability severely limit their potential application in clinical trials.Herein, robust gold nanoshells on silica nanorattles(GSNs)were easily prepared in a high yield by an improved seedmediated method employing polyvinylpyrrolidone(PVP) as a stabilizing and capping agent. The present method is very simple, effective and reproducible and can well control the growth process of gold nanoshells. The as-prepared GSNs have a narrow size distribution(<10 % in standard deviation). Furthermore, the utilization rate of Au in the solution used for the growth of gold nanoshells increases by 70 %than that in previous method. The resultant GSNs have a good structural stability after placing over 6 months due to the protection of PVP. More importantly, in vivo and in vitro toxic studies indicate that the GSNs have good biocompatibility. We believe that our preparation method will remarkably promote the use of gold nanoshells for biomedicine. | Changhui Fu Chaofeng He Longfei Tan Shunhao Wang Lu Shang Linlin Li Xianwei Meng Huiyu Liu | 2016 | Science Bulletin2016，61，4： | 5 |
| 3 | Exosome-mediated cellular crosstalk within the tumor microenvironment upon irradiation显示文摘Radiotherapy is one of the most effective treatment methods for various solid tumors.Bidirectional signal transduction between cancer cells and stromal cells within the irradiated microenvironment is important in cancer development and treatment responsiveness.Exosomes,initially considered as'garbage bins'for unwanted from cells,are now understood to perform a variety of functions in interactions within the tumor microenvironment.Exosome-mediated regulation processes are rebuilt under the irradiation stimuli,because the exosome production,uptake,and contents are markedly modified by irradiation.In turn,irradiation-modified exosomes may modulate the cell response to irradiation through feedback regulation.Here,we review current knowledge and discuss the roles of exosome-mediated interactions between cells under radiotherapy conditions. | Chuanshi He Ling Li Linlin Wang Wanrong Meng Yaying Hao Guiquan Zhu | 2021 | Cancer Biology & Medicine2021，18，1： | 3 |
| 4 | Tension-Torsion High-Cycle Fatigue Life Prediction of 2A12-T4 Aluminium Alloy by Considering the Anisotropic Damage:Model, Parameter Identification, and Numerical Implementation显示文摘To consider the anisotropic damage in fatigue, an improved boom-panel model is presented to simulate a representative volume element(RVE) in the framework of continuum damage mechanics. The anisotropic damage state of the RVE is described by the continuity extents of booms and panels, whose damage evolutions are assumed to be isotropic. The numerical implementation is proposed on the basis of damage mechanics and the finite element method. Finally,the approach is applied to the fatigue life prediction of 2A12-T4 aluminium alloy specimen under cyclic loading of tension-torsion. The results indicate a good agreement with the experimental data. | Linlin Sun Miao Zhang Weiping Hu Qingchun Meng | 2016 | Acta Mechanica Solida Sinica2016，29，4： | 2 |
| 5 | miR-7/TGF-β2 axis sustains acidic tumor microenvironment-induced lung cancer metastasis显示文摘Acidosis,regardless of hypoxia involvement,is recognized as a chronic and harsh tumor microenvironment(TME)that educates malignant cells to thrive and metastasize.Although overwhelming evidence supports an acidic environment as a driver or ubiquitous hallmark of cancer progression,the unrevealed core mechanisms underlying the direct effect of acidification on tumorigenesis have hindered the discovery of novel therapeutic targets and clinical therapy.Here,chemical-induced and transgenic mouse models for colon,liver and lung cancer were established,respectively.miR-7 and TGF-β2 expressions were examined in clinical tissues(n=184).RNA-seq,miRNA-seq,proteomics,biosynthesis analyses and functional studies were performed to validate the mechanisms involved in the acidic TME-induced lung cancer metastasis.Our data show that lung cancer is sensitive to the increased acidification of TME,and acidic TME-induced lung cancer metastasis via inhibition of miR-7-5 p.TGF-β2 is a direct target of miR-7-5 p.The reduced expression of miR-7-5 p subsequently increases the expression of TGF-β2 which enhances the metastatic potential of the lung cancer.Indeed,overexpression of miR-7-5 p reduces the acidic p H-enhanced lung cancer metastasis.Furthermore,the human lung tumor samples also show a reduced miR-7-5 p expression but an elevated level of activated TGF-β2;the expressions of both miR-7-5 p and TGF-β2 are correlated with patients’survival.We are the first to identify the role of the miR-7/TGF-β2 axis in acidic p H-enhanced lung cancer metastasis.Our study not only delineates how acidification directly affects tumorigenesis,but also suggests miR-7 is a novel reliable biomarker for acidic TME and a novel therapeutic target for non-small cell lung cancer(NSCLC)treatment.Our study opens an avenue to explore the p H-sensitive subcellular components as novel therapeutic targets for cancer treatment. | Tao Su Suchao Huang Yanmin Zhang Yajuan Guo Shuwei Zhang Jiaji Guan Mingjing Meng Linxin Liu Caiyan Wang Dihua Yu Hiu-Yee Kwan Zhiying Huang Qiuju Huang Elaine Lai-Han Leung Ming Hu Ying Wang Zhongqiu Liu Linlin Lu | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 2 |
| 6 | Query Translation on the Fly in Deep Web Integration显示文摘To facilitate users to access the desired information,many researches have dedicated to the Deep Web(i.e. Web data-bases) integration. We focus on query translation which is an im-portant part of the Deep Web integration. Our aim is to construct automatically a set of constraints mapping rules so that the system can translate the query from the integrated interface to the Web database interfaces based on them. We construct a concept hierar-chy for the attributes of the query interfaces,especially,store the synonyms and the types(e.g. Number,Text,etc.) for every concept. At the same time,we construct the data hierarchies for some con-cepts if necessary. Then we present an algorithm to generate the constraint mapping rules based on these hierarchies. The approach is suitable for the scalability of such application and can be ex-tended easily from one domain to another for its domain inde-pendent feature. The results of experiment show its effectiveness and efficiency. | JIANG Fangjiao JIA Linlin MENG Xiaofeng | 2007 | Wuhan University Journal of Natural Sciences2007，12，5： | 2 |
| 7 | Postzygotic single-nucleotide mosaicisms in whole-genome sequences of clinically unremarkable individuals显示文摘 | August Y Huang Xiaojing Xu Adam Y Ye Qixi Wu Linlin Yan Boxun Zhao Xiaoxu Yang Yao He Sheng Wang Zheng Zhang Bowen Gu Han-Qing Zhao Meng Wang Hua Gao Ge Gao Zhichao Zhang Xiaoling Yang Xiru Wu Yuehua Zhang Liping Wei | 2014 | Cell Research2014，24，11： | 2 |
| 8 | Analysis of the temporal and spatial distribution of water quality in China's major river basins, and trends between 2005 and 2010显示文摘 | Jinjian LI Xiaojie MENG Yan ZHANG Juan LI Linlin XIA Hongmei ZHENG | 2015 | Frontiers of Earth Science2015，9，3： | 1 |
| 9 | Small-dose naloxone combined with epinephrine improves the resuscitation of cardiopulmonary arrest显示文摘 | Yong Wang Linlin Gao Lingxin Meng | 2008 | American Journal of Emergency Medicine2008，，8： | 1 |
| 10 | Synthesis of Aqueous CdTe/CdS/ZnS Core/shell/shell Quantum Dots by a Chemical Aerosol Flow Method显示文摘 | Chuanmiao Yan Fangqiong Tang Linlin Li Hongbo Li Xinglu Huang Dong Chen Xianwei Meng Jun Ren | 2010 | Nanoscale Research Letters2010，，1： | 1 |
| 11 | Dynamic landscape mapping of humoral immunity to SARS-CoY-2 identifies non-structural protein antibodies associated with the survival of critical COVID-19 patients显示文摘A comprehensive analysis of the humoral immune response to the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is essential in understanding COVID-19 pathogenesis and developing antibody-based diagnostics and therapy.In this work,we performed a longitudinal analysis of antibody responses to SARS-CoV-2 proteins in 104 serum samples from 49 critical COVID-19 patients using a peptide-based SARS-CoV-2 proteome microarray.Our data show that the binding epitopes of IgM and IgG antibodies differ across SARS-CoV-2 proteins and even within the same protein. | Linlin Cheng Xiaomei Zhang Yu Chen Dan Wang Dong Zhang Songxin Yan Hongye Wang Meng Xiao Te Liang Haolong Li Meng Xu Xin Hou jiayu Dai Xian Wu Mingyuan Li Minya Lu Dong Wu Ran Tian Jing Zhao Yan Zhang Wei Cao Jinglan Wang Xiaowei Yan Xiang Zhou Zhengyin Liu Yingchun Xu Fuchu He Yongzhe Li Xiaobo Yu Shuyang Zhang | 2021 | Signal Transduction and Targeted Therapy2021，6，9： | 1 |
| 12 | The research on effect of ambient light on soft proofing 显示文摘 | Linlin Meng Jinglian Zhang Haoxue Liu | 2011 | Advanced Materials Research2011，174，： | 1 |
| 13 | An effective Building Neighborhood Green Index model for measuring urban green space显示文摘Urban green space forms an integral part of urban ecosystems.Quantifying urban green space is of substantial importance for urban planning and development.Considering the drawbacks of previous urban green space index models,which established either through a grid method or green distribution,and the difficulty of the validation process of earlier urban green space index models,this study exploits the advantages of multisource high-resolution remote sensing data to establish a Building Neighborhood Green Index(BNGI)model.The model which analyzes the spatial configuration of built-up areas and the vegetation is based on the building-oriented method and considers four parameters–Green Index(GI),proximity to green,building sparsity,and building height.Comparing BNGI with GI in different types of characteristic building regions,it was found that BNGI evaluates urban green space more sensitively.It was also found that high-rise low-sparsity area has a lower mean value of BNGI(0.56)as compared with that of low-rise low-sparsity neighborhood(0.62),whereas mean GI(0.24)is equal for both neighborhoods.Taking characteristics of urban building and green types into consideration,BNGI model can be effectively used in many fields such as land suitability analysis and urban planning. | Yuqin Liu Qingyan Meng Jiahui Zhang Linlin Zhang Tamas Jancso Rumiana Vatseva | 2016 | International Journal of Digital Earth2016，9，4： | 1 |
| 14 | Novel injectable biomimetic hydrogels with carbon nanofibers and self assembled rosette nanotubes for myocardial applications显示文摘 | Xiangling Meng David A. Stout Linlin Sun Rachel L. Beingessner Hicham Fenniri Thomas J. Webster | 2012 | J Biomed Mater Res2012，，4： | 1 |
| 15 | NPRC deletion mitigated atherosclerosis by inhibiting oxidative stress, inflammation and apoptosis in ApoE knockout mice显示文摘Previous studies suggested a beneficial effect of natriuretic peptides in animal models of cardiovascular disease,but the role of natriuretic peptide receptor C(NPRC)in the pathogenesis of atherosclerosis(AS)remains unknown.This study was designed to test the hypothesis that NPRC may promote AS lesion formation and instability by enhancing oxidative stress,inflammation,and apoptosis via protein kinase A(PKA)signaling.ApoE^(−/−)mice were fed chow or Western diet for 12 weeks and NPRC expression was significantly increased in the aortic tissues of Western diet-fed mice.Systemic NPRC knockout mice were crossed with ApoE^(−/−)mice to generate ApoE^(−/−)NPRC^(−/−)mice,and NPRC deletion resulted in a significant decrease in the size and instability of aortic atherosclerotic lesions in ApoE^(−/−)NPRC^(−/−)versus ApoE^(−/−)mice.In addition,endothelial cell-specific NPRC knockout attenuated atherosclerotic lesions in mice.In contrast,endothelial cell overexpression of NPRC aggravated the size and instability of atherosclerotic aortic lesions in mice.Experiments in vitro showed that NPRC knockdown in human aortic endothelial cells(HAECs)inhibited ROS production,pro-inflammatory cytokine expression and endothelial cell apoptosis,and increased eNOS expression.Furthermore,NPRC knockdown in HAECs suppressed macrophage migration,cytokine expression,and phagocytosis via its effects on endothelial cells.On the contrary,NPRC overexpression in endothelial cells resulted in opposite effects.Mechanistically,the anti-inflammation and anti-atherosclerosis effects of NPRC deletion involved activation of cAMP/PKA pathway,leading to downstream upregulated AKT1 pathway and downregulated NF-κB pathway.In conclusion,NPRC deletion reduced the size and instability of atherosclerotic lesions in ApoE^(−/−)mice via attenuating inflammation and endothelial cell apoptosis and increasing eNOS expression by modulating cAMP/PKA-AKT1 and NF-κB pathways.Thus,targeting NPRC may provide a promising approach to the prevention and treatment of atherosclerosis. | Cheng Cheng Jie Zhang Xiaodong Li Fei Xue Lei Cao Linlin Meng Wenhai Sui Meng Zhang Yuxia Zhao Bo Xi Xiao Yu Feng Xu Jianmin Yang Yun Zhang Cheng Zhang | 2023 | Signal Transduction and Targeted Therapy2023，8，9： | 0 |
| 16 | Correction: NPRC deletion mitigated atherosclerosis by inhibiting oxidative stress, inflammation and apoptosis in ApoE knockout mice显示文摘After online publication of the article,the authors noticed one inadvertent mistake in Fig.2b.The image of Sirus Red Dark in ApoE^(-/-)NPRC^(-/-)group Was mistakenly inserted as the image of Sirus Red Bright in ApoE^(-/-)group,during the final revision process.The correct figure was provided as follows. | Cheng Cheng Jie Zhang Xiaodong Li Fei Xue Lei Cao Linlin Meng Wenhai Sui Meng Zhang Yuxia Zhao Bo Xi Xiao Yu Feng Xu Jianmin Yang Yun Zhang Cheng Zhang | 2023 | Signal Transduction and Targeted Therapy2023，8，10： | 0 |
| 17 | New Understanding of Lithium Isotopic Evolution from Source to Deposit——A Case Study of the Qaidam Basin显示文摘Objective The lithium-rich deep brine of the western Qaidam Basin is the successor of the lithium-rich salt lake on the surface.The identification of the lithium source has been a topic of intense interest among geologists.The dissolved lithium in lithium-rich protoliths transported to the basin through surface river water is considered as an important source of lithium in deep brine.The geochemical characteristics of lithium isotopes as they move from | WANG Linlin ZHANG Yongsheng XING Enyuan MENG Qingqiang YU Dongdong | 2018 | Acta Geologica Sinica(English Edition)2018，92，5： | 0 |
| 18 | Template Protection Based on Chaotic Map for Face Recognition显示文摘With the widespread deployment of biometric recognition,personal data security and privacy are attracted more and more attentions.A crucial privacy issue is how to ensure the security of user template.This paper proposes a novel template protection algorithm for face recognition based on chaotic map.Each face template is corresponding to different chaotic sequence produced by system master key and user identification number.The order of chaotic sequence controls the substitution index of face template.Experiment results on facial FERET database show that our algorithm can significantly improve the recognition performance and ensure the security of face template. | Jinjin Dong Xiao Meng Meng Chen Zhifang Wang Linlin Tang | 2017 | 国际计算机前沿大会会议论文集2017，，1： | 0 |
| 19 | IKKβ mediates homeostatic function in inflammation via competitively phosphorylating AMPK and IκBα显示文摘Inhibitor of nuclear factor kappa-B kinase subunit beta(IKKβ)is one of important kinases in inflammation to phosphorylate inhibitor of nuclear factor kappa-B(IκBα)and then activate nuclear factor kappa-B(NF-κB).Inhibition of IKKβhas been a therapeutic strategy for inflammatory and autoimmune diseases.Here we report that IKKβis constitutively activated in healthy donors and healthy Ikkβ^(C46A)(cysteine 46 mutated to alanine)knock-in mice although they possess intensive IKKβ-IκBα-NF-κB signaling activation.These indicate that IKKβactivation probably plays homeostatic role instead of causing inflammation.Compared to IkkβWTlittermates,lipopolysaccharides(LPS)could induce high mortality rate in Ikkβ^(C46A) mice which is correlated to breaking the homeostasis by intensively activating p-IκBα-NF-κB signaling and inhibiting phosphorylation of 5’adenosine monophosphate-activated protein kinase(p-AMPK)expression.We then demonstrated that IKKβkinase domain(KD)phosphorylates AMPKa1 via interacting with residues Thr183,Ser184,and Thr388,while IKKβhelix-loop-helix motifs is essential to phosphorylate IκBαaccording to the previous reports.Kinase assay further demonstrated that IKKβsimultaneously catalyzes phosphorylation of AMPK and IκBαto mediate homeostasis.Accordingly,activation of AMPK rather than inhibition of IKKβcould substantially rescue LPS-induced mortality in Ikkβ^(C46A) mice by rebuilding the homeostasis.We conclude that IKKβactivates AMPK to restrict inflammation and IKKβmediates homeostatic function in inflammation via competitively phosphorylating AMPK and IκBα. | Juan Liu Yuxin Zhuang Jianlin Wu Qiang Wu Meixian Liu Yue Zhao Zhongqiu Liu Caiyan Wang Linlin Lu Yingjiao Meng Kawai Lei Xiaojuan Li Qibiao Wu Elaine Lai-Han Leung Zhengyang Guo Liang Liu Ting Li | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 0 |
| 20 | Micro/nano needles for advanced drug delivery显示文摘Along with the boost of drugs' exploitation, drug delivery has been a common concern among researchers and patients. As an emerging strategy, the micro-and nano-needle(MNN) is a single or an array of micro/nanoneedles,and promises to be a robust technology for efficient, noninvasive and convenient drug delivery. Compared with the conventional injection, MNN can pierce the bio-membranes to transfer cargos without any damage of tissue or nerves. And regarding the topical drug release, MNN is more efficient than oral administration and topical cream.More specifically, microneedle, a powerful technique, has been widely applied in different diseases such as diabetes, anti-obesity and contraception through skin and ocular surface. Correspondingly, many novel microneedles and optimization methods have been developed recently to improve the drug delivery efficacy. Nanoneedle, much smaller than microneedle, can minimize the skin damages caused by the repeated use of microneedles.Nanoneedles with nanoscaled size are usually used to penetrate the cell membrane. And recently many stimulusaided methods like electrical and magnetic force have been invented to deepen penetration and improve transfer effects. The aim of this review is to introduce the recent advances of MNN-based drug delivery, including their types, application locations and diseases, optimization of delivery strategies and future development prospects. | Xiangchun Meng Zeyu Zhan Linlin Li | 2020 | Progress in Natural Science:Materials International2020，30，5： | 0 |
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