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| 1 | Development and validation of an endoscopic images-based deep learning model for detection with nasopharyngeal malignancies显示文摘Background:Due to the occult anatomic location of the nasopharynx and frequent presence of adenoid hyperpla-sia,the positive rate for malignancy identification during biopsy is low,thus leading to delayed or missed diagnosis for nasopharyngeal malignancies upon initial attempt.Here,we aimed to develop an artificial intelligence tool to detect nasopharyngeal malignancies under endoscopic examination based on deep learning.Methods:An endoscopic images-based nasopharyngeal malignancy detection model(eNPM-DM)consisting of a fully convolutional network based on the inception architecture was developed and fine-tuned using separate training and validation sets for both classification and segmentation.Briefly,a total of 28,966 qualified images were collected.Among these images,27,536 biopsy-proven images from 7951 individuals obtained from January 1st,2008,to December 31st,2016,were split into the training,validation and test sets at a ratio of 7:1:2 using simple randomiza-tion.Additionally,1430 images obtained from January 1st,2017,to March 31st,2017,were used as a prospective test set to compare the performance of the established model against oncologist evaluation.The dice similarity coef-ficient(DSC)was used to evaluate the efficiency of eNPM-DM in automatic segmentation of malignant area from the background of nasopharyngeal endoscopic images,by comparing automatic segmentation with manual segmenta-tion performed by the experts.Results:All images were histopathologically confirmed,and included 5713(19.7%)normal control,19,107(66.0%)nasopharyngeal carcinoma(NPC),335(1.2%)NPC and 3811(13.2%)benign diseases.The eNPM-DM attained an overall accuracy of 88.7%(95%confidence interval(CI)87.8%-89.5%)in detecting malignancies in the test set.In the prospective comparison phase,eNPM-DM outperformed the experts:the overall accuracy was 88.0%(95%CI 86.1%-89.6%)vs.80.5%(95%CI 77.0%-84.0%).The eNPM-DM required less time(40 s vs.110.0±5.8 min)and exhibited encouraging performance in automatic segmentation of nasopharyngeal malignant area from the background,with an average DSC of 0.78±0.24 and 0.75±0.26 in the test and prospective test sets,respectively.Conclusions:The eNPM-DM outperformed oncologist evaluation in diagnostic classification of nasopharyngeal mass into benign versus malignant,and realized automatic segmentation of malignant area from the background of nasopharyngeal endoscopic images. | Chaofeng Li Bingzhong Jing Liangru Ke Bin Li Weixiong Xia Caisheng He Chaonan Qian Chong Zhao Haiqiang Mai Mingyuan Chen Kajia Cao Haoyuan Mo Ling Guo Qiuyan Chen Linquan Tang Wenze Qiu Yahui Yu Hu Liang Xinjun Huang Guoying Liu Wangzhong Li Lin Wang Rui Sun Xiong Zou Shanshan Guo Peiyu Huang Donghua Luo Fang Qiu Yishan Wu Yijun Hua Kuiyuan Liu Shuhui Lv Jingjing Miao Yanqun Xiang Ying Sun Xiang Guo Xing Lv | 2018 | Cancer Communications2018，38，1： | 9 |
| 2 | Development and Analysis of an Electrically Actuated Lower Extremity Assistive Exoskeleton显示文摘一架电子上激活的更低的极限皮骨骼被开发,在哪个当有弹性的元素连接的另外的关节消极地被激活时,仅仅膝关节活跃地被激活。这份报纸描述批评设计标准并且介绍设计的进程和使活动系统的计算。一台灵活物理 Human-Robot-Interaction (pHRI ) 测量设备被设计并且适用检测人的运动,它包括纳入连接手铐的内部表面的二个力量传感器和二个气囊。联机适应 pHRI 最小化控制策略被建议并且实现了驱使机器的皮骨骼系统跟随人的手足的运动轨道。测量 pHRI 信息被变化加权的一般水准(VWA ) 方法熔化。pHRI 和控制转矩的吝啬的方形的价值(MSV ) 被利用评估皮骨骼的表演。改进舒适水平和还原剂精力消费,当控制法律被设计时,严肃赔偿被考虑。最后,实际实验在健康用户上被执行。试验性的结果证明建议系统能帮助人走,构画出的控制策略有效、有效。 | Yi Long Zhijiang Du Chaofeng Chen Weidong Wang Long He Xiwang Mao Guoqiang Xu Guangyu Zhao Xiaoqi Li Wei Dong | 2017 | Journal of Bionic Engineering2017，14，2： | 7 |
| 3 | High-yield preparation of robust gold nanoshells on silica nanorattles with good biocompatiblity显示文摘Although gold nanoshells are widely considered as one of the promising photothermal nanomaterials used for biomedicine, the high cost, low yield and poor stability severely limit their potential application in clinical trials.Herein, robust gold nanoshells on silica nanorattles(GSNs)were easily prepared in a high yield by an improved seedmediated method employing polyvinylpyrrolidone(PVP) as a stabilizing and capping agent. The present method is very simple, effective and reproducible and can well control the growth process of gold nanoshells. The as-prepared GSNs have a narrow size distribution(<10 % in standard deviation). Furthermore, the utilization rate of Au in the solution used for the growth of gold nanoshells increases by 70 %than that in previous method. The resultant GSNs have a good structural stability after placing over 6 months due to the protection of PVP. More importantly, in vivo and in vitro toxic studies indicate that the GSNs have good biocompatibility. We believe that our preparation method will remarkably promote the use of gold nanoshells for biomedicine. | Changhui Fu Chaofeng He Longfei Tan Shunhao Wang Lu Shang Linlin Li Xianwei Meng Huiyu Liu | 2016 | Science Bulletin2016，61，4： | 5 |
| 4 | A comparison of summer precipitation structures over the South China Sea and the East China Sea based on tropical rainfall measurement mission显示文摘The three-dimensional structures of summer precipitation over the South China Sea(SCS)and the East China Sea(ECS)are investigated based on tropical rainfall measurement mission(TRMM).The primary results are as follows.First,both the convective and stratiform precipitation rates in the SCS are much higher than those of the ECS.The contribution of the convective cloud precipitation to the surface precipitation is primarily over the SCS and the ECS with a proportion of about 70%,but the contribution of convective cloud precipitation is slightly larger in the SCS than the ECS.The contribution of stratus precipitation is slightly larger in the ECS than that in the SCS.Second,the content of cloud particles and precipitation particles in the ECS in June was greater than that in the SCS,while in July and August,the content of cloud and precipitation particles in the ECS was less than that in the SCS.Third,the latent heat profile of the ECS is quite different from that of the SCS.In June,the peak values of evaporation and condensation latent heating rates in the ECS are greater than those in the SCS.In July and August,however,the peak values of evaporation and condensation latent heating rates in the ECS are about 0.05/h less than those in the SCS. | LI Jiangnan YANG Chaofeng LI Fangzhou HE Qihua LI Weibiao | 2013 | Acta Oceanologica Sinica2013，32，11： | 3 |
| 5 | Product-oriented review summarization and scoring显示文摘 | Rong ZHANG Wenzhe YU Chaofeng SHA Xiaofeng HE Aoying ZHOU | 2015 | Frontiers of Computer Science2015，9，2： | 1 |
| 6 | EarlyCretaceous adakitic granites in the Northern Dabie Complex,central China: Implications for partial melting anddelamination of thickened lower crust 显示文摘 | Wang Qiang Wyman D A Xu Jifeng Jian Ping ZhaoZhenhua Li Chaofeng Xu Wei Ma Jinlong He Bin | 2007 | GeochimCosmochim Acta2007，71，26： | 1 |
| 7 | Revisiting Rhenium-Osmium Isotopic Investigations of Petroleum Systems: From Geochemical Behaviours to Geological Interpretations显示文摘Recent decades have witnessed an increasing number of studies investigating petroleum systems with the application of rhenium-osmium(Re-Os) isotopic geochemistry. Here, we review the use of the 187 Re-187 Os geochronometer with respect to the geochemical behaviour of rhenium and osmium in hydrocarbon-related geological processes. The Re-Os budget in hydrocarbon source rock predominantly originates from natural water columns during its deposition. Open seawater tends to have a homogeneous Os isotopic composition because its residence time in seawater is longer than the time taken for ocean mixing. On the contrary, restricted water bodies(e.g., lakes) may have heterogeneous Os isotopic compositions due to the greater amount of terrigenous input. Hydrogenous Re and Os atoms are sequestered from the water body into sedimentary organic matter and transferred into crude oil through thermal maturation of organic matter. Thermal maturation likely does not significantly alter the Re-Os isotopic systematics of the source rock as a Re-Os isochron age of 442±21 Ma(2σ) is yielded in this study for over matured source rocks within the Silurian Longmaxi Formation from the Sichuan Basin. Re-Os atoms are mainly hosted by the highly polar/aggregating/aromatic asphaltenes in hydrocarbons, possibly chelating with organic complexes or occurring as metalloporphyrins. Resin and aromatic hydrocarbons also contribute to the Re-Os budget, but are 2 to 3 orders of magnitude lower than that of asphaltenes, whereas saturates do not contain appreciable Re-Os contents. The distribution of Re-Os atoms in hydrocarbons is heterogeneous because the duplicate analysis of pure single bitumen samples yields similar ^(187)Os/^(188)Os ratios whereas variable ^(187)Re/^(188)Os ratios. The Re-Os system in crude oils can be reset during transport away from the source rocks, with Os-rich organic fractions more readily expelled than Re-rich fractions. Contact with metal-rich fluids(e.g., hydrothermal fluid) or compositional changes related to asphaltene contents(e.g., deasphalting, biodegradation, thermal cracking and thermochemical sulphate reduction) are also likely to alter the Re-Os systematics in hydrocarbons. These geochemical features enable the ^(187)Re-^(187)Os isotopic system to have robust applicability for petroleum system investigations, which may use the Re-Os radiometric tool for:(1) stratigraphic correlation of source rocks,(2) dating geological events altering the asphaltene content in hydrocarbon such as hydrocarbon generation, thermochemical sulphate reduction, etc., and,(3) fingerprinting hydrocarbons. Regardless of the robustness of the ^(187)Re-^(187)Os geochronometer for petroleum system investigations, there are several pending questions such as partitioning between solid organic species or between organic matter and sulphide, chelating sites in hydrocarbons and Os isotopic equilibration between hydrocarbon subfractions. To improve the understanding of the Re-Os behaviour in petroleum systems, we underscore multi-proxies-based geochemistry(e.g., inorganic-organic geochemistry) and experimental studies(e.g., hydrous pyrolysis). | Shao-Jie Li Xuan-Ce Wang Simon A.Wilde Zhuyin Chu Chaofeng Li Sheng He Keyu Liu Xingzhi Ma Yuxiang Zhang | 2021 | Journal of Earth Science2021，32，5： | 1 |
| 8 | Influences of Environmental Motion Modes on the Efficiency of Ultrathin Flexible Piezoelec trie Energy Harvesters显示文摘Harvesting energy from ambient vibration sources with ultrathin flexible piezoelectric energy harvesters(PEHs)for battery-free electronics has received attention in recent years.However,the excitation modes in the environment and human body motion are more complicated than the ideal harmonic modes employed in previous theoretical analyses,and their influence on the efficiency of PEHs has received little attention.In this study,these environmental excitation modes are classified into three types,i.e.,the triangular,sinusoidal,and square wave modes,with varied duty ratios.We derived theoretically the output power of flexible PEHs under these excitation modes and establish a simple scaling law,in which the normalized output power depends only on two combined normalized parameters,i.e.,the intrinsic system parameter and the excitation mode.Results reveal that the output power of PEHs changes dramatically for different excitation modes with varied duty ratios even when all the other parameters including excitation ampli tude,excitation frequency,elec trical parameter,and geometrical and material parameters of the PEHs are identical.This paper may provide a systematic understanding in the effect of exc计ation modes on the output power of flexible PEHs and promote the realization of energy harvesting from the complex environmental and human body motions. | Chaofeng Lii Yangyang Zhang He Zhang Zhicheng Zhang Yisheng Chen | 2019 | Acta Mechanica Solida Sinica2019，32，5： | 0 |
| 9 | Leachate Lithium Characteristics of Loess-paleosol Sequences on the Chinese Loess Plateau and their Paleoclimatic Significance显示文摘The geochemical components of the leachate from loess-paleosol deposits can provide information about climaterelated post-depositional processes.For example,leachate lithium([Li]_(leachate))is a potential paleoclimate proxy because lithium is a typical lithophile element that is readily adsorbed by clay minerals during weathering and pedogenesis,and thus stratigraphic variations in[Li]leachatecan reflect these processes.We investigated the[Li]leachatevalues of two loess-paleosols profiles(the Luochuan and Weinan sections),on a north-south climatic gradient on the Chinese Loess Plateau.Independent paleoclimate information was provided by measurements of magnetic susceptibility,grain size,Rb/Sr ratios,and clay mineral content.During the last glacial-interglacial period,[Li]leachateincreased from 0.39 to 1.97μg/g at Luochuan and from 0.67 to 2.45μg/g at Weinan,mainly due to increasing pedogenesis.Based on these results we developed a conceptual model to explain the variations in[Li]leachate,Li^(+)within loess layers is mainly derived from dust input and the decomposition of primary minerals,influenced by the East Asian winter monsoon,while in paleosol layers Li is mainly derived from clay mineral adsorption during pedogenic processes,influenced by the East Asian summer monsoon. | JIA Peng FU Chaofeng HE Maoyong LIU Junfeng LIU Na LI Yulong YANG Kaiyuan | 2023 | Acta Geologica Sinica(English Edition)2023，97，6： | 0 |
| 10 | 基于内镜图像深度学习的鼻咽恶性肿瘤检测模型的建立与验证显示文摘背景与目的由于鼻咽部解剖位置隐匿且腺体增生频发,活检时恶性肿瘤的阳性率较低,从而导致初诊时鼻咽恶性肿瘤确诊延时或漏诊。本文旨在建立一种人工智能工具——基于深度学习的内镜检查,来检测鼻咽恶性肿瘤。方法建立了一种基于内镜图像的鼻咽恶性肿瘤检测模型(endoscopic imagesbased nasopharyngeal malignancies detection model,eNPM-DM),该模型由基于空间结构的全卷积网络构成,采用单独训练集和验证集对分类和分割进行微调。总共收集了28,966张合格图像。其中,自2008年1月1日至2016年12月31日,从7951例个体中获得了27,536张经活检证实的图像,按照7∶1∶2的比例随机分为训练、验证和测试集。此外,将2017年1月1日到2017年3月31日获得的1430张图像纳入预测集,用以对建立模型的性能与肿瘤专家的评价进行比较。以鼻咽镜图像为背景,对自动分割和专家手工分割进行比较,采用dice相似系数(dice similarity coefficient,DSC)评价eNPM-DM从鼻咽部内镜图像的背景中自动分割出恶性肿瘤区域的效率。结果所有图像经过病理组织学验证,包括正常对照5713(19.7%)例、鼻咽癌(nasopharyngeal carcinoma,NPC)19,107(66.0%)例、其他恶性肿瘤335(1.2%)例和3811(13.2%)例良性病变。在测试集中,eNPM-DM检测恶性肿瘤的总准确率达88.7%[95%置信区间(confidence interval,CI):87.8%–89.5%]。在预测比较阶段,eNPM-DM表现优于专家:总准确率分别为88.0%(95%CI:86.1%–89.6%)和80.5%(95%CI:77.0%–84.0%)。eNPM-DM耗时更短(40 s vs. 110.0±5.8 min),且从背景中自动分割出鼻咽恶性肿瘤区域方面表现优秀,测试集和预测集中的平均DSC分别为0.78±0.24和0.75±0.26。结论 eNPM-DM在鼻咽肿块良性/恶性诊断分类方面优于肿瘤学家评估,并且实现了从鼻咽内镜图像背景中对恶性区域自动分割。 | Chaofeng Li Bingzhong Jing Liangru Ke Bin Li Weixiong Xia Caisheng He Chaonan Qian Chong Zhao Haiqiang Mai Mingyuan Chen Kajia Cao Haoyuan Mo Ling Guo Qiuyan Chen Linquan Tang Wenze Qiu Yahui Yu Hu Liang Xinjun Huang Guoying Liu Wangzhong Li Lin Wang Rui Sun Xiong Zou Shanshan Guo Peiyu Huang Donghua Luo Fang Qiu Yishan Wu Yijun Hua Kuiyuan Liu Shuhui Lv Jingjing Miao Yanqun Xiang Ying Sun Xiang Guo Xing Lv | 2019 | 癌症2019，38，7： | 0 |
| 11 | Effects of Mn-doping on the structure and electrical properties of Sm-PMN-PT piezoceramics显示文摘MnO_(2)-modified Pb_(0.9625)Sm_(0.025)(Mg_(1/3)Nb_(2/3))_(0.71)Ti_(0.2)9O_(3) ceramics were prepared via a solid-state reaction approach.Results of detailed characterizations revealed that the addition of MnO_(2) has influence on the grain size,and all samples exhibit a pure perovskite structure.As the content of manganese increases,the volume of tetragonal phase increases.The ceramics with 1.5 mol.%MnO_(2) show a high electro-strain of 0.151%at 2 kV/mm.Therefore,this study provides a new insight into the role of MnO_(2) addition in tailoring the electrical properties of the Sm-PMN-PT ceramics by acceptor doping. | Chaofeng Wu Wen Gong Jinfeng Geng Jianye Cui Lipeng Mi Jingkai Nie Qiang He Jiajiu Li Fang-Zhou Yao | 2023 | Journal of Advanced Dielectrics2023，13，3： | 0 |
| 12 | Manipulating micro-electric field and coordination-saturated site configuration boosted activity and safety of frustrated single-atom Cu/O Lewis pair for acetylene hydrochlorination显示文摘Simultaneously boosting acetylene hydrochlorination activity and avoiding formation of explosive copper acetylide over Cu-based catalyst,which represented a promising alternative to Hg-based and noble metal catalysts,remained challenging.Herein,we fabricated a frustrated single-atom Cu/O Lewis pair catalyst(Cu/O-FLP)by coupling epoxide group(C-O-C)with atomdispersed Cu-cis-N_(2)C_(2)Cl center to address this challenge.The basic epoxy site modulated the electron-deficient state of Lewisacidic Cu center and paired with the Cu-cis-N_(2)C_(2)Cl moiety to preferentially break HCl into different electronegative Cu-Clδ-and C-O-H^(δ+)intermediates,which further induced both an extra localized electric field to polarize acetylene and a upshift of the dband center of catalyst,thereby promoting adsorption and enrichment of acetylene by enhancing the dipolar interaction between acetylene and active intermediates.Moreover,the generated Cu-Clδ-and C-O-H^(δ+)drastically reduced the energy barrier of ratelimiting step and made vinyl chloride easier to desorb from the Lewis-basic oxygen-atom site rather than traditional Lewis-acidic Cu center.These superiorities ensured a higher activity of Cu/O-FLP compared with its counterparts.Meanwhile,preferential dissociation of HCl endowed single-atom Cu with the coordination-saturated configuration,which impeded formation of explosive copper acetylide by avoiding the direct interaction between Cu and acetylene,ensuring the intrinsic safety during catalysis. | Junchen Peng Dandan Dong Zongyuan Wang Hong Yang Dongyang Qiao Qinqin Wang Wei Sun Minmin Liu Jiajun Wang Mingyuan Zhu Bin Dai Fei He Chaofeng Huang | 2023 | Nano Research2023，16，7： | 0 |
| 13 | Theoretical and technical progress in exploration practice of the deep-water large oil fields, Santos Basin, Brazil显示文摘The history and results of petroleum exploration in the Santos Basin, Brazil are reviewed. The regularity of hydrocarbon enrichment and the key exploration technologies are summarized and analyzed using the seismic, gravity, magnetic and drilling data. It is proposed that the Santos Basin had a structural pattern of two uplifts and three depressions and the Aram-Uirapuru uplift belt controlled the hydrocarbon accumulation. It is believed that the main hydrocarbon source kitchen in the rift period controlled the hydrocarbon-enriched zones, paleo-structures controlled the scale and quality of lacustrine carbonate reservoirs, and continuous thick salt rocks controlled the hydrocarbon formation and preservation. The process and mechanism of reservoirs being transformed by CO_(2)charging were revealed. Five key exploration technologies were developed,including the variable-velocity mapping for layer-controlled facies-controlled pre-salt structures, the prediction of lacustrine carbonate reservoirs, the prediction of intrusive/effusive rock distribution, the detection of hydrocarbons in lacustrine carbonates, and the logging identification of supercritical CO_(2)fluid. These theoretical recognitions and exploration technologies have contributed to the discovery of deep-water super-large reservoirs under CNODC projects in Brazil, and will guide the further exploration of deep-water large reservoirs in the Santos Basin and other similar regions. | HE Wenyuan SHI Buqing FAN Guozhang WANG Wangquan WANG Hongping WANG Jingchun ZUO Guoping WANG Chaofeng YANG Liu | 2023 | Petroleum Exploration and Development2023，50，2： | 0 |
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