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| 1 | Major reactive species of ambient volatile organic compounds (VOCs) and their sources in Beijing显示文摘Volatile organic compounds (VOCs) are important precursors of atmospheric chemical processes. As a whole mixture, the ambient VOCs show very strong chemical reactivity. Based on OH radical loss rates in the air, the chemical reactivity of VOCs in Beijing was calculated. The results revealed that alkenes, accounting for only about 15% in the mixing ratio of VOCs, provide nearly 75% of the reactivity of ambient VOCs and the C4 to C5 alkenes were the major reactive species among the alkenes. The study of emission characteristics of various VOCs sources indicated that these alkenes are mainly from vehicle exhaust and gasoline evaporation. The reduction of alkene species in these two sources will be effective in photochemical pollution control in Beijing. | SHAO Min FU Linlin LIU Ying LU Sihua ZHANG Yuanhang TANG Xiaoyan | 2005 | Science China Earth Sciences2005，48，z2： | 7 |
| 2 | Inducible regulation of GDNF expression in human neural stem cells显示文摘Glial cell derived neurotrophic factor (GDNF) holds promises for treating neurodegenerative diseases such as Parkinson's disease. Human neural stem cells (hNSCs) have proved to be a suitable cell delivery vehicle for the safe and efficient introduction of GDNF into the brain. In this study, we used hNSCs-infected with a lentivirus encoding GDNF and the hygromycin resistance gene as such vehicles. A modified tetracycline operator 7 (tetO7) was inserted into a region upstream of the EF1- promoter to drive GDNF expression. After hygromycin selection, hNSCs were infected with a lentivirus encoding a KRAB-tetracycline repressor fusion protein (TTS). TTS bound to tetO7 and suppressed the expression of GDNF in hNSCs. Upon administration of doxycycline (Dox) the TTS-tetO7 complex separated and the expression of GDNF resumed. The hNSCs infected with GDNF expressed the neural stem cell specific markers, nestin and sox2, and exhibited no significant change in proliferation rate. However, the rate of apoptosis in hNSCs expressing GDNF was lower compared with normal NSCs in response to actinomycin treatment. Furthermore, a higher percentage of Tuj-1 positive cells were obtained from GDNF-producing NSCs under conditions that induced differentiation compared to control NSCs. The inducible expression of GDNF in hNSCs may provide a system for the controllable delivery of GDNF in patients with neurodegenerative diseases. | WANG ShuYan REN Ping GUAN YunQian ZOU ChunLin FU LinLin ZHANG Yu | 2013 | Science China(Life Sciences)2013，56，1： | 5 |
| 3 | High-yield preparation of robust gold nanoshells on silica nanorattles with good biocompatiblity显示文摘Although gold nanoshells are widely considered as one of the promising photothermal nanomaterials used for biomedicine, the high cost, low yield and poor stability severely limit their potential application in clinical trials.Herein, robust gold nanoshells on silica nanorattles(GSNs)were easily prepared in a high yield by an improved seedmediated method employing polyvinylpyrrolidone(PVP) as a stabilizing and capping agent. The present method is very simple, effective and reproducible and can well control the growth process of gold nanoshells. The as-prepared GSNs have a narrow size distribution(<10 % in standard deviation). Furthermore, the utilization rate of Au in the solution used for the growth of gold nanoshells increases by 70 %than that in previous method. The resultant GSNs have a good structural stability after placing over 6 months due to the protection of PVP. More importantly, in vivo and in vitro toxic studies indicate that the GSNs have good biocompatibility. We believe that our preparation method will remarkably promote the use of gold nanoshells for biomedicine. | Changhui Fu Chaofeng He Longfei Tan Shunhao Wang Lu Shang Linlin Li Xianwei Meng Huiyu Liu | 2016 | Science Bulletin2016，61，4： | 5 |
| 4 | Targeting slug-mediated non-canonical activation of c-Met to overcome chemo-resistance in metastatic ovarian cancer cells显示文摘Metastasis-associated drug resistance accounts for high mortality in ovarian cancer and remains to be a major barrier for effective treatment. In this study, SKOV3/T4, a metastatic subpopulation of ovarian cancer SKOV3 cells, was enriched to explore potential interventions against metastaticassociated drug resistance. Quantitative genomic and functional analyses were performed and found that slug was significantly increased in the SKOV3/T4 subpopulation and contributed to the high resistance of SKOV3/T4. Further studies showed that slug activated c-Met in a ligand-independent manner due to elevated levels of fibronectin and provoked integrin α V function, which was confirmed by the significant correlation of slug and p-Met levels in 121 ovarian cancer patient samples. Intriguingly,c-Met inhibitor(s) exhibited greatly enhanced anti-cancer effects in slug-positive ovarian cancer models both in vitro and in vivo. Additionally, IHC analyses revealed that slug levels were highly correlated with reduced survival of ovarian cancer patients. Taken together, this study not only uncovers the critical roles of slug in drug resistance in ovarian cancer but also highlights a promising therapeutic strategy by targeting the noncanonical activation of c-Met in slug-positive ovarian cancer patients with poor prognosis. | Linlin Chang Yan Hu Yingying Fu Tianyi Zhou Jun You Jiamin Du Lin Zheng Ji Cao Meidan Ying Xiaoyang Dai Dan Su Qiaojun He Hong Zhu Bo Yang | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 3 |
| 5 | SOD1^(G93A) Induces a Unique PSAP-Dependent Mitochondrial Apoptosis Pathway via Bax-Bak Interaction显示文摘Amyotrophic lateral syndrome(ALS)is a progressive degenerative disorder characterized by motor neuron death and axon degeneration.Mitochondrial dysfunction plays a key role in the pathogenesis of ALS,the mechanism of which remains poorly understood.The B-cell lymphoma-2(Bcl-2)family of proteins that control and mediate mitochondrial function and apoptosis,including the pro-apoptotic members Bcl2-Associated X(Bax),are involved in ALS development.The death receptor 6(DR6)regulates motor neuron death in ALS,and DR6 antibodies can prevent axon degeneration and motor neuron damage by blocking DR6.Previous studies demonstrated that PSAP localized to mitochondria and was required for DR6-induced apoptosis.In this study,SOD1^(G93A) was transfected into the motor neuron cell line NSC-34 to serve as an ALS cell model in vitro.The data assessed the role of PSAP in SOD1^(G93A)induced apoptosis and demonstrated that the overexpression of SOD1^(G93A),but not wtSOD1,induced PARP cleavage,caspase-3 activation,cytochrome c release,and Bax translocation.PSAP,Bax,and Bak were necessary for SOD1^(G93A)induced apoptosis,as silencing PSAP inhibited SOD1^(G93A)-mediated cell death that was dependent on Bax-Bak interaction. | HAN NIU XIN CHEN XUEQI FU JINGTIAN ZHANG GUODONG LI YUXIANG WANG JIAYUE SONG XUETING MA CHEN HU XUEMIN XU FUQIANG ZHANG LINLIN ZENG | 2021 | BIOCELL2021，45，4： | 2 |
| 6 | Source profiles of volatile organic compounds (VOCs) measured in China: Part I显示文摘 | Ying Liu Min Shao Linlin Fu Sihua Lu Limin Zeng Dagang Tang | 2008 | Atmospheric Environment2008，，25： | 2 |
| 7 | Source profiles of volatile organic compounds (VOCs) measured in China: Part I显示文摘 | Ying Liu Min Shao Linlin Fu Sihua Lu Limin Zeng Dagang Tang | 2008 | Atmospheric Environment2008，，25： | 2 |
| 8 | Research on the EHect of Aerial Aircraft Flight Attitude on Exterior Orientation Ele- ments显示文摘 | Xin Lijun Fu Haiqiang Tang Linlin | 2010 | Technological Development of Enterprise2010，29，009： | 1 |
| 9 | Bioaugmentation of Bromoamine Acid Degradation with Sphingomonas xenophaga QYY and DNA Fingerprint Analysis of Augmented Systems显示文摘 | Yuanyuan Qu Jiti Zhou Jing Wang Zhiyong Song Linlin Xing Xiang Fu | 2006 | Biodegradation2006，，1： | 1 |
| 10 | NaLa(MoO4 ) 2 : REa + (RE3+ = Eu3+ , Sm3+ , Er3+/Yb3+ ) mierospheres : the synthesis and optical properties 显示文摘 | Gao Zhiyi Wang Zhiying Fu Linlin | 2015 | Materials Research Bulletin2015，70，： | 1 |
| 11 | Source profiles of vola- tile organic compounds (VOCs) measured in China part I 显示文摘 | LIU Yin SHAO Min FU Linlin | 2008 | Atmospheric Environment2008，42，25： | 1 |
| 12 | Source apportionment of ambient volatile organic compounds in the Pearl River Delta, China: Part II显示文摘 | Ying Liu Min Shao Sihua Lu Chih-Chung Chang Jia-Lin Wang Linlin Fu | 2008 | Atmospheric Environment2008，，25： | 1 |
| 13 | Source profiles of volatile organic compounds (VOCs) measured in China: Part I显示文摘 | Ying Liu Min Shao Linlin Fu Sihua Lu Limin Zeng Dagang Tang | 2008 | Atmospheric Environment2008，，25： | 1 |
| 14 | Structural and functional analysis of a potent human neutralizing antibody against enterovirus A71显示文摘Enterovirus A71(EV-A71) causes major outbreaks of hand,foot,and mouth disease(HFMD) in many countries,most frequently affecting children,and a small proportion of cases may lead to death.Currently,no vaccine is available in most endemic regions,and no licenced treatments for EV-A71 infection are available.Here,we characterize a human monoclonal antibody(Hu MAb),E1,by screening a Fab antibody phage library derived from patients who recovered from EV-A71 infection.E1 exhibits strong neutralizing activity against EV-A71 virus in cells.The cryo-electron microscopy(cryo-EM) structures of the EV-A71 virion in complex with E1 Fab fragments demonstrated that E1 recognized an epitope formed by residues in the BC and HI loops of VP1.In a mouse model,E1 effectively protected against lethal EV-A71 challenge in both prophylactic and therapeutic treatment.In particular,E1 significantly reduces virus titers and muscle damage.E1 might represent a potential adjunct to EV-A71 treatment. | Zhe Chen Linlin Bao Bin Zhu Hua Fu Shuangli Zhu Tianjiao Ji Ying Xue Chuan Liu Xurong Wang Fengdi Li Qi Lv Feifei Qi Pin Yu Wei Deng Wenbo Xu Chuan Qin Hongrong Liu Qi Jin | 2022 | Science China(Life Sciences)2022，65，12： | 0 |
| 15 | Exploring exosomes to provide evidence for the treatment and prediction of Alzheimer’s disease显示文摘Exosomes are extracellular vesicles with a 30–150 nm diameter originating from endosomes.In recent years,scientists have regarded exosomes as an ideal small molecule carrier for the targeted treatment of Alzheimer’s disease(AD)across the blood-brain barrier due to their nanoscale size and low immunogenicity.A large amount of evidence shows that exosomes are rich in biomarkers,and it has been found that the changes in biomarker content in blood,cerebrospinal fluid,and urine are often associated with the onset of AD patients.In this paper,some recent advances in the use of exosomes in the treatment of AD are reviewed,and various exosome markers and some latest detection methods are summarized to provide some evidence for the detection or treatment of AD by exosomes. | XIANGYU QUAN XUETING MA GUODONG LI XUEQI FU JIANGTAO LI LINLIN ZENG | 2023 | BIOCELL2023，47，10： | 0 |
| 16 | New proof of continuity of Lyapunov exponents for a class of smooth Schrödinger cocycles with weak Liouville frequencies显示文摘We reconsider the continuity of the Lyapunov exponents for a class of smooth Schrödinger cocycles with a C2 cos-type potential and a weak Liouville frequency.We propose a new method to prove that the Lyapunov exponent is continuous in energies.In particular,a large deviation theorem is not needed in the proof. | Linlin FU Jiahao XU Fan WU | 2020 | Frontiers of Mathematics in China2020，15，3： | 0 |
| 17 | On the Stability of Orthogonal Additivity in β-Homogeneous F-Spaces显示文摘In this paper,we study the stability of the orthogonal equation,which is closely related to the results by W.Fechner and J.Sikorska in 2010.There are some differences that we consider the target space with theβ-homogeneous norm and quasi-norm.Overcoming theβ-homogeneous norm and quasi-norm bottlenecks,we get some new results. | Qi LIU Linlin FU Yongjin LI | 2022 | Journal of Mathematical Research with Applications2022，42，3： | 0 |
| 18 | Phenotypic and Genetic Characteristics of a Bordetella hinzii Isolated from a Rex Rabbit显示文摘A Bordetella hinzii strain,isolated from the lung of a dead breast-feeding infant rex rabbit with a respiratory infection,was used as study object to investigate its phenotypic and genetic characteristics. The strain could grow on Mac Conkey agar and was gram-negative,oxidase-positive,catalase-positive,short rodshaped,and it can produce alkali from malonate. Its 6S rRNA sequence was partially identical with B. hinzii( AF177667). Animal experiments revealed nasal mucous hyperemia,tracheal congestion and bronchopneumonia in 28-day old rex rabbits. To sum up,this Bordetella hinzii isolate was deemed as a novel causative agent of respiratory disease in rex rabbit. | Li Shuguang Shen Zhiqiang Qu Guanggang Guan Yu Fu Shijun Hu Linlin Wang Yumao | 2015 | Animal Husbandry and Feed Science2015，7，3： | 0 |
| 19 | Improvement of Poplar Bark Extract on Physiological Characters of Lactococcus lactis in Intestine of White Feather Broilers显示文摘[Objective]The paper was to study the improvement of poplar bark extract on intestinal Lactococcus lactis of white feather broilers.[Method]Totally 450 Ross 308 white-feather broilers were randomly divided into five groups:control group,low dose group,medium dose group,high dose group,and antibiotic group(oxytetracycline hydrochloride).The feeding duration was 45 d.The probiotics were screened and isolated through homology,and the physiological and biochemical characteristics of chicken intestinal bacteria in different groups were compared to determine the properties of bacterial strain.The drug resistance,antibacterial ability,proliferation ability,acid resistance and bile salt resistance of isolated strain were tested,and a strain of L.lactis was obtained.[Result]The isolated L.lactis was sensitive to other drugs except natural tetracyclines,and there was no significant difference among the four groups except oxytetracycline group;as the concentration of extract increased,the inhibition of L.lactis against Salmonella sp.increased;the medium dose extract had the largest increase in the ability to tolerate the proliferation of L.lactis.[Conclusion]Feeding poplar bark extract will produce positive effects on the physiological characters of intestinal L.lactis in broiler chicken,which will provide potential probiotic strain for chicken production. | Liu Guofang Zheng Guangyao He Pengfei Song Chunlei Yan Linlin Chen Ming Luo Guilan Liu Fu'an Zhu Haoyuan Qin Dongyu | 2020 | Animal Husbandry and Feed Science2020，12，3： | 0 |
| 20 | Iodine-catalyzed amination of benzothiazoles with KSeCN in water to access primary 2-aminobenzothiazoles显示文摘A facile and sustainable approach for the amination of benzothiazoles with KSe CN using iodine as the catalyst in water has been disclosed under transition-metal free conditions. The reaction proceeded smoothly to afford various primary 2-amino benzothiazoles in up to 96% yield. A series of control experiments were performed, suggesting a ring-opening mechanism was involved via a radical process. This protocol provides efficient synthesis of primary 2-aminobenzothiazoles. | Yu-Shen Zhu Linlin Shi Lianrong Fu Xiran Chen Xinju Zhu Xin-Qi Hao Mao-Ping Song | 2022 | Chinese Chemical Letters2022，33，3： | 0 |
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