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| 1 | Antibody drug conjugate:the“biological missile”for targeted cancer therapy显示文摘Antibody–drug conjugate(ADC)is typically composed of a monoclonal antibody(mAbs)covalently attached to a cytotoxic drug via a chemical linker.It combines both the advantages of highly specific targeting ability and highly potent killing effect to achieve accurate and efficient elimination of cancer cells,which has become one of the hotspots for the research and development of anticancer drugs.Since the first ADC,Mylotarg®(gemtuzumab ozogamicin),was approved in 2000 by the US Food and Drug Administration(FDA),there have been 14 ADCs received market approval so far worldwide.Moreover,over 100 ADC candidates have been investigated in clinical stages at present.This kind of new anti-cancer drugs,known as“biological missiles”,is leading a new era of targeted cancer therapy.Herein,we conducted a review of the history and general mechanism of action of ADCs,and then briefly discussed the molecular aspects of key components of ADCs and the mechanisms by which these key factors influence the activities of ADCs.Moreover,we also reviewed the approved ADCs and other promising candidates in phase-3 clinical trials and discuss the current challenges and future perspectives for the development of next generations,which provide insights for the research and development of novel cancer therapeutics using ADCs. | Zhiwen Fu Shijun Li Sifei Han Chen Shi Yu Zhang | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 5 |
| 2 | Research Progress of Active Ingredients and Pharmacological Action of Honeysuckle显示文摘Honeysuckle,the dry flower bud or with open flower of Lonicera japonica in caprifoliaceae,has been touted as a cure-all for heat-clearing and detoxifying effect.Honeysuckle contains abundant components such as volatile oil,flavonoids and organic acids,playing the role of antibiosis,antivirus,antiphlogosis,immunopotentiation and antioxidation.The active ingredients and pharmacological action of honeysuckle are reviewed in the paper,so as to lay the foundation for further application of honeysuckle in veterinary clinic. | Zhang Zhimei Guo Shijin Fu Shijun Xu Qianqian Yang Limei Zhang Ying Wang Yanping Ma Li Wang Jianjun Shen Zhiqiang | 2014 | Animal Husbandry and Feed Science2014，6，1： | 4 |
| 3 | Application Progresses of Glucose Oxidase(GOD)in Feed显示文摘Glucose oxidase( GOD) is a new pollution-free enzyme preparation which can improve morphological structure and micro ecological balance of intestine in livestock and poultry,perfect intestinal environment,and increase feed digestibility,growth performance and disease resistance. This paper summarizes the physical and chemical properties and biological function of GOD and its application status in feed. | Huo Fang Wang yan Fu Shijun | 2015 | Animal Husbandry and Feed Science2015，7，5： | 3 |
| 4 | Effects of Root Zone Temperature on Growth and Photosynthetic Parameters of Grafted Cucumber显示文摘Taking Cucurbita maxima and Cucurbita moschata as root stocks,and‘Jinyou No 3'cucumber as scion,the effects of different root zone temperature conditions optimal temperature( CK)( 18-20 ℃),suboptimal temperature( 13-15 ℃) and low temperature( 8-10 ℃) on the growth and photosynthesis indexes were studied. The results showed that,compared with optimal temperature( CK),suboptimal temperature and low temperature produced a significant inhibition of growth on cucumbers. The plant height,stem diameter,leaf area,number of leaves and dry weight of aboveground part were all reduced,dry weight of underground part and root shoot ratio all increased,while the inhibition was more significant at low temperature. Low and suboptimal temperature conditions also reduced SPAD value,net photosynthetic rate,transpiration rate,intercellular CO_2 concentration and stomatal conductance of the grafted cucumber. And there were differences between different grafted seedlings,and seedlings with‘black seeds' as stock performed better than those with‘white seeds' as stock at low temperature. | shijun sun shimao cui yang song chongyi fu lihong ye yu gao | 2018 | Agricultural Biotechnology2018，7，2： | 2 |
| 5 | Determination of Berberine Hydrochloride Content in Qingwen Baidu Granule by HPLC显示文摘The paper was to establish a simple and sensitive HPLC method for determination of berberine hydrochloride content in Qingwen Baidu granule.The HPLC system consisted of Stable Bond- C18 column(4.6×150 mm,5μm) and with a mobile phase of acetonitrile- 0.05mol / L potassium dihydrogen phosphate solution(50∶50,v∶v) mixture.Berberine hydrochloride was detected at the wavelength of 345 nm,with a flow rate of 1.0 mL / min and a column temperature of30 ℃.The excipients and solvents in the granule could be well separated from the drug under such a designated chromatogram condition and did not interfere with the assay.A good linear relationship was found between peak area and the concentration of berberine hydrochloride in the range of 16.0- 48.0 μg / mL.The average recovery of berberine hydrochloride was 99.09%.The established approach was specific,accurate,reliable,prompt,sensitive and applicable,and could be used to control the quality of Qingwen Baidu granule. | Guo Shijin Wang Yanping Fu Shijun Zhang Zhimei Xu Qianqian Shen Zhiqiang | 2014 | Animal Husbandry and Feed Science2014，6，1： | 2 |
| 6 | Multi-objective optimization of frequency and damping of vertical stabilizer skin structure placed with variable-angle tows显示文摘The vibration characteristics of composite vertical stabilizer skin structures play a critical role in damping effects designed for overcoming the air disturbances experienced by aircraft structural components during flight.The first-order fundamental frequencies and their corresponding damping characteristics of the vertical stabilizer skin structure tow-steered by automatic fiber placement technique were optimized with the parameterized trajectories and plies as design variables.Firstly,the vibration and damping numerical models were derived based on Kirchhoff laminate theory,the Rayleigh-Ritz method,and the Strain Energy Method.Then the optimization model was developed by adopting the self-adaptive Differential Evolution Multi-objective optimization algorithm and incorporating the solution method of Pareto Front.The constraints of this optimization model considered the experimentally obtained minimum turning radius of prepregs tow-steered in automatic fiber placement process obtained from experimental tests.Finally,the comparison of numerical simulation results was conducted for the optimized trajectories and the conventional straight trajectories under various boundary conditions,and the numerical results were partially validated through damping and frequency tests.The results indicate the vibration characteristics of the composite vertical stabilizer skin structure can be enhanced to a large extent by optimizing fiber trajectories,and the enhancement percentage is affected by the boundary conditions of the actual structure. | Lei ZU Xianzhao XIA Qian ZHANG Guiming ZHANG Shijun CHEN Jianhui FU Lichuan ZHOU Huabi WANG Debao LI Liqing ZOU | 2023 | Chinese Journal of Aeronautics2023，36，1： | 1 |
| 7 | Advance in Effect of Veterinary Drug Residues on Ecological Environment显示文摘Thousands of tons of pharmaceutically active substances are used in veterinary medicines in intensive livestock and poultry production,but most of the drugs are poorly absorbed by animals and excreted with the animal feces. The veterinary medicines can cause various kinds of harmful impact to the environment.Now the relevant research has been a hot all over the world. With the feces excreted to the environment,the veterinary medicines can be accumulated in the soil and water,and produce all sorts of reaction. Some medicines can cause toxic effect to animals,plants and microorganisms. The article summarized the residue,the environmental impact,the transformation and the development direction of the veterinary medicine in the environment to supply frame of reference for further research. | Zhang Zhimei Fu Shijun Guo Shijin Zhang Ying Ma Li Yang Limei Wang Jianjun Shen Zhiqiang | 2015 | Animal Husbandry and Feed Science2015，7，3： | 1 |
| 8 | Bacillus phytases: present scenario and future perspectives显示文摘 | FU Shijun SUN Jianyi QIAN Lichun | 2008 | Appl Biochem Biotechnol2008，151，1： | 1 |
| 9 | Detection of Patulin in Dairy Products by ELISA显示文摘The content of patulin in dairy products was detected by rapid ELISA assay.The pretreatment of samples was simple,with wide range of application.The standard product showed good linear relationship with the range of 0-5.4 μg/kg,and the linear relationship reached 0.999 3,with high sensitivity.It took shorter time,with a total time-consumption of 1 h.Moreover,it had good repeatability for analytical requirements. | Tang Shiyun Shen Zhiqiang Fu Shijun Wu Yuxiang Li Jinlin | 2018 | Animal Husbandry and Feed Science2018，10，2： | 1 |
| 10 | Simultaneous Determination of Sulfamonomethoxine Sodium and Trimethoprim in Compound Sulfamonomethoxine Sodium Propolis Solution by High Performance Liquid Chromatography(HPLC)显示文摘[Objective] The paper aimed to provide a basis for quality control of compound sulfamonomethoxine sodium propolis solution. [Method] High performance liquid chromatography( HPLC) method was used to determine the contents of sulfamonomethoxine sodium and trimethoprim simultaneously in compound sulfamonomethoxine sodium propolis solution. [Result]Sulfamonomethoxine sodium and trimethoprim showed a linear relationship within the concentration of 10-500 μg / m L under the following chromatographic conditions: Kromasil C18column( 250 mm × 4. 6 mm,5 μm),mobile phase 0. 02 mol / L phosphoric acid solutionmethanol( 80∶20,V / V),detection wavelength 270 nm,flow rate 1. 0 m L / min,and column temperature 30℃. The average recoveries were 99. 3% and 99. 4%,respectively. [Conclusion] The method is accurate and feasible,and can determine sulfamonomethoxine sodium and trimethoprim simultaneously in compound sulfamonomethoxine sodium propolis solution. | Guo Shijin Zhang Zhimei Fu Shijun Tang Shiyun Shen Zhiqiang | 2015 | Animal Husbandry and Feed Science2015，7，4： | 1 |
| 11 | Bacillus phytases: present scenario and future perspectives显示文摘 | FU Shijun SUN Jianyi QIAN Lichun | 2008 | Appl Biochem Biotechnol2008，151，1： | 1 |
| 12 | Dynamic MicroRNA Expression Programs During Cardiac Differentiation of Human Embryonic Stem Cells: Role for miR-499显示文摘 | Kitchener D. Wilson Shijun Hu Shivkumar Venkatasubrahmanyam Ji-Dong Fu Ning Sun Oscar J. Abilez Joshua J.A. Baugh Fangjun Jia Zhumur Ghosh Ronald A. Li Atul J. Butte Joseph C. Wu | 2010 | Circulation: Cardiovascular Genetics2010，，： | 1 |
| 13 | Applications of loop- mediated isothermal DNA amplification显示文摘 | FU Shijun QU Guanggang GUO Shijin | 2011 | Applied Biochemistry and Biotechnology2011，163，： | 1 |
| 14 | A motivating mitigation mechanism for generators on condition of coordinated regulation of emission and electricity market显示文摘 | Fu Shijun Ren Yulong | 2011 | International Journal of Electrical Power & Energy Systems2011，33，5： | 1 |
| 15 | Research Advances in Detection Techniques of High Performance Liquid Chromatography-Refractive Index Detector显示文摘As a highly sensitive and stable detector,refractive index detector is usually used for quantitative detection of substances such as polymer,sugar and organic acid. The research reviewed the application of HPLC-RID in the fields of quantitative determination of medicine and food,in order to lay a foundation for wider use of RID. | Huo Fang Zhang Zhimei Wang Jianjun Guo Shijin Zhou Chunfeng Fu Shijun | 2014 | Animal Husbandry and Feed Science2014，6，2： | 1 |
| 16 | Harms of Mycotoxins to Animals and Research Progress of Detection Methods显示文摘Mycotoxin is widely distributed in various feedstuffs and feeds of animals.Mycotoxin not only causes feed deterioration,but also leads to various diseases of animals,or even results in acute toxic death,causing great harm to the breeding industry.In this paper,the harm of mycotoxin to animals and its detection methods in feed and animals are summarized and analyzed,so as to provide the reference basis for further improving the detection methods of mycotoxin and reducing the harm of mycotoxin to breeding industry. | Guo Shijin Zhang Zhimei Tang Shiyun Fu Shijun Li Ling Shen Zhiqiang | 2022 | Animal Husbandry and Feed Science2022，14，4： | 0 |
| 17 | Application Research Progress of Amino Acid Chelated Iron in Pig Nutrition显示文摘As an essential trace element for pigs,iron is very important for pig production,and plays an important role in sow performance,growth and development of piglets,metabolic process and physiological defense[1-3].Iron is a cofactor of catalase in the body’s anti-oxidation system,which plays an important role in preventing lipid oxidation and maintaining meat flavor.Iron is an indispensable activator of enzymes involved in redox reaction,such as superoxide dismutase(SOD). | Guo Shijin Zhang Zhimei Fu Shijun Wang Jianjun Tang Shiyun Shen Zhiqiang | 2022 | Animal Husbandry and Feed Science2022，14，4： | 0 |
| 18 | Research Advances of Detection Methods of Mycotoxins显示文摘Mycotoxins are widely distributed in various feed ingredients and animal feed. Feed contamination by mycotoxin leads to deteriorated feed,various diseases of animals and even acute death,bringing great loss to breeding industry. The article summarized the harm of mycotoxin to animal and detection methods in feed and animal,in order to provide a reference for further improving mycotoxin detection methods and reducing the harm of mycotoxin to breeding industry. | Zhang Zhimei Fu Shijun Guo Shijin Song Daozhen Huo Fang Shen Zhiqiang | 2016 | Animal Husbandry and Feed Science2016，8，4： | 0 |
| 19 | Mutation Breeding of Lactobacillus and Its Application in Yoghurt显示文摘With the gradual improvement of the quality of people’s life, the disorder of lipid metabolism caused by high-fat diet has become the main reason that affects the health of our people. Hyperlipidemia, hypertension and hyperglycemia have the effect of causing a large number of serious complications, and are also the main factors of cardiovascular disease. Lactic acid bacteria can avoid hyperlipidemia by inhibiting the excessive growth of harmful intestinal bacteria, maintaining the balance of intestinal microecology, absorbing intestinal cholesterol and regulating lipid metabolism. Therefore, this paper focused on the mutation and breeding of Lactobacillus, and analyzed its application in yoghurt, aiming to provide reference for relevant researchers. | Xin LI Shiyun TANG Fengrong TIAN Bing ZHANG Shijun FU Shijin GUO | 2023 | Agricultural Biotechnology2023，12，1： | 0 |
| 20 | Identification of Gardenoside and Sarsasapogenin from Qingwen Baidu Granules by TLC显示文摘[Objective] We aimed to establish the identification method of gardenoside and sarsasapogenin in Qingwen baidu granules. [Method]With ethyl acetate-acetone-formic acid-water( 10∶7∶2∶0. 5) as the developer and 10% sulfuric acid ethanol solution as the chromogenic reagent,the samples were heated at 100 ℃until the spots were clearly visible,and the existence of gardenoside was checked under natural light. With toluene-acetone( 9∶1) as the developer and 5% vanillin sulfuric acid solution as the chromogenic reagent,the samples were heated at 105 ℃ until the spots were clearly visible,and the existence of sarsasapogenin was checked under natural light. [Result] Qingwen baidu granules had the same spots with gardenoside and sarsasapogenin at the same Rf value under natural light.[Conclusion]A TLC method detecting gardenoside and sarsasapogenin in Qingwen baidu granules was established,which had good specificity and repeatability,suitable for rapid detection of gardenoside and sarsasapogenin. | Guo Shijin Wang Yanping Zhang Zhimei Fu shijun Xu Qianqian Zhang Ying Shen Zhiqiang | 2016 | Animal Husbandry and Feed Science2016，8，2： | 0 |
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