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| 1 | Orbit determination and time synchronization for a GEO/IGSO satellite navigation constellation with regional tracking network显示文摘Aiming at regional services,the space segment of COMPASS (Phase I) satellite navigation system is a constellation of Geostationary Earth Orbit (GEO),Inclined Geostationary Earth Orbit (IGSO) and Medium Earth Orbit (MEO) satellites.Precise orbit determination (POD) for the satellites is limited by the geographic distribution of regional tracking stations.Independent time synchronization (TS) system is developed to supplement the regional tracking network,and satellite clock errors and orbit data may be obtained by simultaneously processing both tracking data and TS data.Consequently,inconsistency between tracking system and TS system caused by remaining instrumental errors not calibrated may decrease navigation accuracy.On the other hand,POD for the mixed constellation of GEO/IGSO/MEO with the regional tracking network leads to parameter estimations that are highly correlated.Notorious example of correlation is found between GEO's orbital elements and its clock errors.We estimate orbital elements and clock errors for a 3GEO+2IGSO constellation in this study using a multi-satellite precise orbit determination (MPOD) strategy,with which clock error elimination algorithm is applied to separate orbital and clock estimates to improve numerical efficiency.Satellite Laser Ranging (SLR) data are used to evaluate User Ranging Error (URE),which is the orbital error projected on a receiver's line-of-sight direction.Two-way radio-wave time transfer measurements are used to evaluate clock errors.Experimenting with data from the regional tracking network,we conclude that the fitting of code data is better than 1 m in terms of Root-Mean-Square (RMS),and fitting of carrier phase is better than 1 cm.For orbital evaluation,difference between computed receiver-satellite ranging based on estimated orbits and SLR measurements is better than 1 m (RMS).For clock estimates evaluation,2-hour linear-fitting shows that the satellite clock rates are about 1.E-10 s/s,while receiver clock rates are about 1×10 13-1×10 12 s/s.For the 72-hour POD experiment,the average differences between POD satellite clock rates estimates and clock measurements based on TS system are about 1×10 13 s/s,and for receiver clock rates,the differences are about 1×10 15 s/s. | ZHOU ShanShi HU XiaoGong WU Bin LIU Li QU WeiJing GUO Rui HE Feng CAO YueLing Wu XiaoLi ZHU LingFeng SHI Xin TAN HongLi | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，6： | 44 |
| 2 | Inflammatory response and neuronal necrosis in rats with cerebral ischemia显示文摘In the middle cerebral artery occlusion model of ischemic injury, inflammation primarily occurs in the infarct and peripheral zones. In the ischemic zone, neurons undergo necrosis and apoptosis, and a large number of reactive microglia are present. In the present study, we investigated the pathological changes in a rat model of middle cerebral artery occlusion. Neuronal necrosis appeared 12 hours after middle cerebral artery occlusion, and the peak of neuronal apoptosis appeared 4 to 6 days after middle cerebral artery occlusion. Inflammatory cytokines and microglia play a role in damage and repair after middle cerebral artery occlusion. Serum intercellular cell adhesion molecule-1 levels were positively correlated with the permeability of the blood-brain barrier. These findings indicate that intercellular cell adhesion molecule-1 may be involved in blood-brain barrier injury, microglial activation, and neuronal apoptosis. Inhibiting blood-brain barrier leakage may alleviate neuronal injury following ischemia. | Lingfeng Wu Kunnan Zhang Guozhu Hu Haiyu Yang Chen Xie Xiaomu Wu | 2014 | Neural Regeneration Research2014，9，19： | 19 |
| 3 | Kinematics and Dynamics Analysis of a Quadruped Walking Robot with Parallel Leg Mechanism显示文摘It is desired to require a walking robot for the elderly and the disabled to have large capacity,high stiffness,stability,etc.However,the existing walking robots cannot achieve these requirements because of the weight-payload ratio and simple function.Therefore,Improvement of enhancing capacity and functions of the walking robot is an important research issue.According to walking requirements and combining modularization and reconfigurable ideas,a quadruped/biped reconfigurable walking robot with parallel leg mechanism is proposed.The proposed robot can be used for both a biped and a quadruped walking robot.The kinematics and performance analysis of a 3-UPU parallel mechanism which is the basic leg mechanism of a quadruped walking robot are conducted and the structural parameters are optimized.The results show that performance of the walking robot is optimal when the circumradius R,r of the upper and lower platform of leg mechanism are 161.7 mm,57.7 mm,respectively.Based on the optimal results,the kinematics and dynamics of the quadruped walking robot in the static walking mode are derived with the application of parallel mechanism and influence coefficient theory,and the optimal coordination distribution of the dynamic load for the quadruped walking robot with over-determinate inputs is analyzed,which solves dynamic load coupling caused by the branches' constraint of the robot in the walk process.Besides laying a theoretical foundation for development of the prototype,the kinematics and dynamics studies on the quadruped walking robot also boost the theoretical research of the quadruped walking and the practical applications of parallel mechanism. | WANG Hongbo SANG Lingfeng HU Xing ZHANG Dianfan YU Hongnian | 2013 | Chinese Journal of Mechanical Engineering2013，26，5： | 12 |
| 4 | Transcriptome analysis and metabolic profiling reveal the key role of carotenoids in the petal coloration of Liriodendron tulipifera显示文摘Liriodendron tulipifera,also known as tuliptree,is a popular ornamental horticultural plant with extraordinary tulipshaped flowers characterized by an orange band near their base.The mechanisms underlying petal band-specific pigmentation during L.tulipifera flower development are unclear.Here,we combined nontargeted and targeted metabolomics and transcriptomics to identify a pathway cascade leading to carotenoid biosynthesis that is specifically activated in the petal band.The comparative analysis of carotenoid metabolites between L.tulipifera and Liriodendron hybrids indicates thatγ-carotene,a rare carotene in plants,is the most likely orange pigment responsible for the coloration of the petal band.Phenotypic and transcriptomic analyses of developing petals reveal that the band area is first predefined by the loss of green color.Later,the band is maintained by locally activating and repressing carotenoid and chlorophyll biosynthesis genes,respectively.Two rate-limiting genes of carotene biosynthesis,carotenoid isomerase(CRTISO)and epsilon lycopene cyclase(ε-LCY),encode the core enzymes responsible for petal band-specific orange pigmentation in L.tulipifera.In particular,a putative additionalε-LCY copy specific to L.tulipifera may contribute to the distinct petal coloration pattern,compared with L.chinense.Taken together,our work provides a first glimpse of the metabolome and transcriptome dynamics in tuliptree flower coloration and provides a valuable resource for flower breeding or metabolic engineering as well as for understanding flower evolution in an early woody angiosperm. | Zhaodong Hao Siqin Liu Lingfeng Hu Jisen Shi Jinhui Chen | 2020 | Horticulture Research2020，7，1： | 7 |
| 5 | Applications of two-way satellite time and frequency transfer in the BeiDou navigation satellite system显示文摘A two-way satellite time and frequency transfer(TWSTFT) device equipped in the BeiDou navigation satellite system(BDS)can calculate clock error between satellite and ground master clock. TWSTFT is a real-time method with high accuracy because most system errors such as orbital error, station position error, and tropospheric and ionospheric delay error can be eliminated by calculating the two-way pseudorange difference. Another method, the multi-satellite precision orbit determination(MPOD)method, can be applied to estimate satellite clock errors. By comparison with MPOD clock estimations, this paper discusses the applications of the BDS TWSTFT clock observations in satellite clock measurement, satellite clock prediction, navigation system time monitor, and satellite clock performance assessment in orbit. The results show that with TWSTFT clock observations, the accuracy of satellite clock prediction is higher than MPOD. Five continuous weeks of comparisons with three international GNSS Service(IGS) analysis centers(ACs) show that the reference time difference between BeiDou time(BDT) and golbal positoning system(GPS) time(GPST) realized IGS ACs is in the tens of nanoseconds. Applying the TWSTFT clock error observations may obtain more accurate satellite clock performance evaluation in the 104 s interval because the accuracy of the MPOD clock estimation is not sufficiently high. By comparing the BDS and GPS satellite clock performance, we found that the BDS clock stability at the 103 s interval is approximately 10.12, which is similar to the GPS IIR. | ShanShi Zhou XiaoGong Hu Li Liu Rui Guo LingFeng Zhu ZhiQiao Chang ChengPan Tang XiuQiang Gong Ran Li Yang Yu | 2016 | Science China(Physics,Mechanics & Astronomy)2016，59，10： | 6 |
| 6 | Temporal and spatial comparisons of angiosperm diversity between eastern Asia and North America显示文摘Comparative approaches that examine floras with similar environments, but different diversity patterns, provide good opportunities to elucidate how uneven distributions of biodiversity were assembled. Eastern Asia(EA) and North America north of Mexico(NA;see definitions of EA and NA in Fig. S1 A) share similar geographical environments with comparable latitude, land area and climate. | Haihua Hu Jianfei Ye Bing Liu Lingfeng Mao Stephen A.Smith Russell L.Barrett Pamela S.Soltis Douglas E.Soltis Zhiduan Chen Limin Lu | 2022 | National Science Review2022，9，6： | 3 |
| 7 | The role of γ-aminobutyric acid in aluminum stress tolerance in a woody plant, Liriodendron chinense×tulipifera显示文摘The aluminum(Al)cation Al^(3+)in acidic soil shows severe rhizotoxicity that inhibits plant growth and development.Most woody plants adapted to acidic soils have evolved specific strategies against Al^(3+)toxicity,but the underlying mechanism remains elusive.The four-carbon amino acid gamma-aminobutyric acid(GABA)has been well studied in mammals as an inhibitory neurotransmitter;GABA also controls many physiological responses during environmental or biotic stress.The woody plant hybrid Liriodendron(L.chinense×tulipifera)is widely cultivated in China as a horticultural tree and provides high-quality timber;studying its adaptation to high Al stress is important for harnessing its ecological and economic potential.Here,we performed quantitative iTRAQ(isobaric tags for relative and absolute quantification)to study how protein expression is altered in hybrid Liriodendron leaves subjected to Al stress.Hybrid Liriodendron shows differential accumulation of several proteins related to cell wall biosynthesis,sugar and proline metabolism,antioxidant activity,cell autophagy,protein ubiquitination degradation,and anion transport in response to Al damage.We observed that Al stress upregulated glutamate decarboxylase(GAD)and its activity,leading to increased GABA biosynthesis.Additional GABA synergistically increased Al-induced antioxidant enzyme activity to efficiently scavenge ROS,enhanced proline biosynthesis,and upregulated the expression of MATE1/2,which subsequently promoted the efflux of citrate for chelation of Al^(3+).We also showed similar effects of GABA on enhanced Al^(3+)tolerance in Arabidopsis.Thus,our findings suggest a function of GABA signaling in enhancing hybrid Liriodendron tolerance to Al stress through promoting organic acid transport and sustaining the cellular redox and osmotic balance. | Pengkai Wang Yini Dong Liming Zhu Zhaodong Hao LingFeng Hu Xiangyang Hu Guibin Wang Tielong Cheng Jisen Shi Jinhui Chen | 2021 | Horticulture Research2021，8，1： | 3 |
| 8 | PseudoRandom Bit Generator Based on Non-Stationary LogisticMaps 显示文摘 | Liu Lingfeng Miao Suoxiao Hu Hanping | 2016 | IET Information Security2016，10，2： | 1 |
| 9 | Decreased miRNA-148a is associated with lymph node metastasis and poorclinical outcomes and functions as a suppressor of tumor metastasis in non-smallcell lung cancer显示文摘 | Yong Chen Lingfeng Min Xizhi Zhang Suwei Hu Buhai Wang Wei Liu Rui Wang Xuewen Gu Weigan Shen Houning Lv Jing Zou Yuexiang Chen Xingxiang Xu Longbang Chen | 2013 | Oncology Reports2013，，4： | 1 |
| 10 | In situ reaction synthesis,electrical and thermal,and mechanical properties of Nb4AlC3显示文摘 | Hu Chunfeng Li Fangzhi He Lingfeng | 2008 | Journal of the American Ceramic Society2008，91，7： | 1 |
| 11 | Sulfonylurea in the treatment of neonatal diabetes mellitus children with heterogeneous genetic backgrounds显示文摘 | Miaoying Zhang Xiuli Chen Shuixian Shen Tang Li Linqi Chen Min Hu Lingfeng Cao Ruoqian Cheng Zhuhui Zhao Feihong Luo | 2015 | Journal of Pediatric Endocrinology and Metabolism . 2015 (7-8)2015，，7： | 1 |
| 12 | Pseudorandom sequence generator based on the Chen chaotic system显示文摘 | Hanping Hu LingFeng Liu NaiDa Ding | 2013 | Computer Physics Communications2013，184，3： | 1 |
| 13 | Counteracting the dynamical degradation of digital chaos via hybrid control显示文摘 | HU Hanping DENG Yashuang and LIU Lingfeng | 2014 | Communications in Nonlinear Science and Numerical Simulation2014，19，6： | 1 |
| 14 | Immunity-and-matrix-regulatory cells enhance cartilage regeneration for meniscus injuries: a phase I dose-escalation trial显示文摘Immunity-and-matrix-regulatory cells(IMRCs)derived from human embryonic stem cells have unique abilities in modulating immunity and regulating the extracellular matrix,which could be mass-produced with stable biological properties.Despite resemblance to mesenchymal stem cells(MSCs)in terms of self-renew and tri-lineage differentiation,the ability of IMRCs to repair the meniscus and the underlying mechanism remains undetermined.Here,we showed that IMRCs demonstrated stronger immunomodulatory and pro-regenerative potential than umbilical cord MSCs when stimulated by synovial fluid from patients with meniscus injury.Following injection into the knees of rabbits with meniscal injury,IMRCs enhanced endogenous fibrocartilage regeneration.In the dose-escalating phase I clinical trial(NCT03839238)with eighteen patients recruited,we found that intra-articular IMRCs injection in patients was safe over 12 months post-grafting.Furthermore,the effective results of magnetic resonance imaging(MRI)of meniscus repair and knee functional scores suggested that 5×107 cells are optimal for meniscus injury treatment.In summary,we present the first report of a phase I clinical trial using IMRCs to treat meniscus injury.Our results demonstrated that intra-articular injection of IMRCs is a safe and effective therapy by providing a permissive niche for cartilage regeneration. | Liangjiang Huang Song Zhang Jun Wu Baojie Guo Tingting Gao Sayed Zulfiqar Ali Shah Bo Huang Yajie Li Bo Zhu Jiaqi Fan Liu Wang Yani Xiao Wenjing Liu Yao Tian Zhengyu Fang Yingying Lv Lingfeng Xie Sheng Yao Gaotan Ke Xiaolin Huang Ying Huang Yujuan Li Yi Jia Zhongwen Li Guihai Feng Yan Huo Wei Li Qi Zhou Jie Hao Baoyang Hu Hong Chen | 2023 | Signal Transduction and Targeted Therapy2023，8，12： | 0 |
| 15 | Performance analysis of a photovoltaic/thermal system with lunar regolith-based thermal storage for the lunar base显示文摘Powering a moon base,especially keeping it warm during the long lunar night,is a big challenge.This paper introduces a photovoltaic/thermal(PV/T)system incorporating regolith thermal storage to solve the challenge of power and heat provision for the lunar base simultaneously.The vacuum of space around the moon helps this system by reducing heat loss.During the moon's daytime,the system not only generates electricity but also captures heat.This stored heat in the regolith is then used at night,reducing the amount of equipment we need to send from Earth.The spectrally selective PV/T panels are designed to absorb a wide range of sunlight(0.3–2.5μm)while minimizing heat loss in the infrared range(3–30μm).Simulation results of the hybrid solar energy system indicate the average value of the overall efficiency is 45.9%,which relatively elevates 56.1%compared to the PV system.The launch mass of the proposed PV/T system is only 8.4%of a traditional photovoltaic-lithium battery system with the same amount of energy storage.And the total specific energy of the proposed system is 7.3 kWh kg^(-1),while that of the photovoltaic-lithium battery system is about 0.3 kWh kg^(-1).In summary,this study proposes an alternative combined heat and electricity supply system for the lunar base,which can greatly reduce the launch mass and free up load for other scientific research equipment. | SUN WenGan ZHAO Bin PEI Yu SHI LingFeng HU MaoBin LI MuJun REN Xiao PEI Gang | 2024 | Science China(Technological Sciences)2024，67，4： | 0 |
| 16 | Experimental study of kidney protective effects of sanhuangshaoshangling on severe burn rats in shock stage显示文摘Objective:To observe the protective effects and mechanisms of topical Chinese medicine on kidneys of severe burns shock rats.Methods:Blood urea nitrogen(Bun),creatinine(Cr),myeloperoxidase(MPO),tumor necrosis factor-α(TNF-α)and inter-leukin(IL-6),were checked by the time points of 8,24,48 hours.Blood tests,ELISA and other methods were used for these texts.Results:Compared with the povidone-iodine group,the levels of Bun and Cr were declined apparently in the Sanhuang group,and the activity of MPO was decreased as well.Conclusions:Sanhuangshaoshangling,taking ointment as matrix,can be externally applied to wounds.It contains some ef-fective ingredients which can clear heat-toxicity and promote blood circulation for removing blood stasis,and prevents wounds from the stimulation of the air to nerve endings and the invasion of bacteria.It can also inhibit bacteria from parasitizing,grow-ing,reproducing on the wound.Sanhuangshaoshangling helps blood circulation and facilitates the growth of tissues to inactivate the toxicity or reduce toxin by changing the structure of endotoxin after uptake into tissues.It can protect viscera by reducing the release of endotoxin,facilitating the excretion of endotoxin and weakening or eliminating the effects of TNF-αand IL-6. | Guolin Hu Lingfeng Wang Bo Feng | 2016 | Discussion of Clinical Cases2016，3，3： | 0 |
| 17 | Morphological, phenological, and transcriptional analyses provide in sight into the diverse flowering traits of a mutant of the relic woody plant Liriodendron chinense显示文摘Flowering is crucial to plant reproduction and controlled by multiple factors.However,the mechanisms underlying the regulation of flowering in perennial plants are still largely unknown.Here,we first report a super long blooming 1(slbl)mutant of the relict tree Liriodendron chinense possessing a prolonged blooming period of more than 5 months,in contrast to the 1 month blooming period in the wild type(WT).Phenotypic characterization showed that earlier maturation of lateral shoots was caused by accelerated axillary bud fate,leading to the phenotype of continuous flowering in slbl mutants.The transcriptional activity of genes related to hormone signaling(auxin,cytokinin,and strigolactone),nutrient availability,and oxidative stress relief further indicated active outgrowth of lateral buds in slbl mutants.Interestingly,we discovered a unique FT splicing variant with intron retention specific to slbl mutants,representing a potential causal mutation in the slbl mutants.Surprisingly,most slbl inbred offspring flowered precociously with shorter juvenility(~4 months)than that(usually 8-10 years)required in WT plants,indicating heritable variation underlying continuous flowering in slbl mutants.This study reports an example of a perennial tree mutant that flowers continuously,providing a rare resource for both breeding and genetic research. | Yu Sheng Zhaodong Hao Ye Peng Siqin Liu Lingfeng Hu Yongbao Shen Jisen Shi Jinhui Chen | 2021 | Horticulture Research2021，8，1： | 0 |
| 18 | Overexpression of the LcPIN2 and LtPIN2 Gene in Arabidopsis thaliana Promotes Root Elongation显示文摘The auxin polar transporter,PIN-FORMED 2(PIN2)plays an important role in root development.However,it remains unclear whether PIN2 genes form two Liriodendron species,L.chinense(LcPIN2)and L.tulipifera(LtPIN2),are both involved in root development and whether and to what extent these two genes diverge in function.Here,we cloned and overexpressed LcPIN2 and LtPIN2 in Arabidopsis thaliana wild-type(WT)and Atpin2 mutant.Phylogenetic and sequence analysis showed a small degree of differentiation between these two Liriodendron PIN2 genes.Tissue-specific gene expression analysis indicated that both Liriodendron PIN2 genes were highly expressed in roots,implying a potential role in root development.Finally,heterologous overexpression of LcPIN2 and LtPIN2 in Arabidopsis both significantly increased the root length compared to wild-type and empty vector.Furthermore,the root length defect in Atpin2 was complemented both by LcPIN2 and LtPIN2.However,heterologous overexpression of LcPIN2 and LtPIN2 cannot rescue the defect in root gravitropism of Atpin2 mutants.Taken together,ourfindings unravel PIN2 genes from the magnoliids plant Liriodendron were functionally conserved with AtPIN2 in the dicotyledonous plant Arabidopsis in regard to the regulation of root length,but not root gravitropism.This study also provides a potential target for genetic improvement of the root system in these valuable forest trees Liriodendron. | Zijian Cao Guoxia Xue Lingfeng Hu Haoxian Qu Shuang Liang Jisen Shi Jinhui Chen Zhaodong Hao | 2023 | Phyton-International Journal of Experimental Botany2023，92，8： | 0 |
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