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| 1 | Inflammatory response and neuronal necrosis in rats with cerebral ischemia显示文摘In the middle cerebral artery occlusion model of ischemic injury, inflammation primarily occurs in the infarct and peripheral zones. In the ischemic zone, neurons undergo necrosis and apoptosis, and a large number of reactive microglia are present. In the present study, we investigated the pathological changes in a rat model of middle cerebral artery occlusion. Neuronal necrosis appeared 12 hours after middle cerebral artery occlusion, and the peak of neuronal apoptosis appeared 4 to 6 days after middle cerebral artery occlusion. Inflammatory cytokines and microglia play a role in damage and repair after middle cerebral artery occlusion. Serum intercellular cell adhesion molecule-1 levels were positively correlated with the permeability of the blood-brain barrier. These findings indicate that intercellular cell adhesion molecule-1 may be involved in blood-brain barrier injury, microglial activation, and neuronal apoptosis. Inhibiting blood-brain barrier leakage may alleviate neuronal injury following ischemia. | Lingfeng Wu Kunnan Zhang Guozhu Hu Haiyu Yang Chen Xie Xiaomu Wu | 2014 | Neural Regeneration Research2014，9，19： | 19 |
| 2 | Immunity-and-matrix-regulatory cells enhance cartilage regeneration for meniscus injuries: a phase I dose-escalation trial显示文摘Immunity-and-matrix-regulatory cells(IMRCs)derived from human embryonic stem cells have unique abilities in modulating immunity and regulating the extracellular matrix,which could be mass-produced with stable biological properties.Despite resemblance to mesenchymal stem cells(MSCs)in terms of self-renew and tri-lineage differentiation,the ability of IMRCs to repair the meniscus and the underlying mechanism remains undetermined.Here,we showed that IMRCs demonstrated stronger immunomodulatory and pro-regenerative potential than umbilical cord MSCs when stimulated by synovial fluid from patients with meniscus injury.Following injection into the knees of rabbits with meniscal injury,IMRCs enhanced endogenous fibrocartilage regeneration.In the dose-escalating phase I clinical trial(NCT03839238)with eighteen patients recruited,we found that intra-articular IMRCs injection in patients was safe over 12 months post-grafting.Furthermore,the effective results of magnetic resonance imaging(MRI)of meniscus repair and knee functional scores suggested that 5×107 cells are optimal for meniscus injury treatment.In summary,we present the first report of a phase I clinical trial using IMRCs to treat meniscus injury.Our results demonstrated that intra-articular injection of IMRCs is a safe and effective therapy by providing a permissive niche for cartilage regeneration. | Liangjiang Huang Song Zhang Jun Wu Baojie Guo Tingting Gao Sayed Zulfiqar Ali Shah Bo Huang Yajie Li Bo Zhu Jiaqi Fan Liu Wang Yani Xiao Wenjing Liu Yao Tian Zhengyu Fang Yingying Lv Lingfeng Xie Sheng Yao Gaotan Ke Xiaolin Huang Ying Huang Yujuan Li Yi Jia Zhongwen Li Guihai Feng Yan Huo Wei Li Qi Zhou Jie Hao Baoyang Hu Hong Chen | 2023 | Signal Transduction and Targeted Therapy2023，8，12： | 0 |
| 3 | (Ca,K)(Zn,Mn)_(2)As_(2):Ferromagnetic semiconductor induced by decoupled charge and spin doping in CaZn_(2)As_(2)显示文摘We have successfully synthesized a novel diluted magnetic semiconductor(Ca_(1−2x)K_(2x))(Zn_(1−x)Mn_(x))_(2)As_(2) with decoupled charge and spin doping.The substitutions of(Ca^(2+),K^(+))and(Zn^(2+),Mn^(2+))in the parent compound CaZn_(2)As_(2)(space group P m1(No.164))introduce carriers and magnetic moments,respectively.Doping only Mn into CaZn_(2)As_(2) does not induce any type of long range magnetic ordering.The ferromagnetic ordering arise can only when K^(+)and Mn^(2+)are simultaneously doped.The res-ulted maximum Curie temperature reaches~7 K,and the corresponding coercive field is~60 Oe.The transport measurements confirm that samples with K and Mn co-doping still behave like a semiconductor. | Jinou Dong Xueqin Zhao Licheng Fu Yilun Gu Rufei Zhang Qiaolin Yang Lingfeng Xie Fanlong Ning | 2022 | Journal of Semiconductors2022，43，7： | 0 |
| 4 | Trophic gauntlet effects on fisheries recovery:a case study in Sansha Bay,China显示文摘Low biological productivity causes ecosystem energy deficiency.Sansha Bay is an important spawning and nursery ground for migratory fish in the East China Sea(ECS).There is significant mariculture in this area,but stock enhancement programs and seasonal fishery closures have failed to recover populations of the commercially important species,Larimichthys crocea.We want to figure out the potential reason of unsuccessful L.crocea resource in recent 30 years.In this study,the trophic status of L.crocea,the food source proportions of L.crocea and zooplankton,and the food web structure and functioning of Sansha Bay was analyzed.A high nutrient low chlorophyll phenomenon was observed:this prevented harmful algal blooms,and phytoplankton growth was restrained by intensive macroalgal culture,resulting in a low abundance of zooplankton in Sansha Bay.Phytoplankton was the most important food source of zooplankton,and zooplankton was the greatest food source of juvenile L.crocea.Analyzed L.crocea suffered from starvation.Crucially,most of the phytoplankton was not used efficiently in the Sansha Bay ecosystem.This study suggests that trophic bottleneck,caused by food limitation,is a potential reason for unsuccessful fishery recovery in enclosed bay with macroalgal culture. | Bin Xie Cheng Huang Ya Wang Xijie Zhou Guogan Peng Yancheng Tao Jiaju Huang Xiaoqing Lin Lingfeng Huang | 2021 | Ecosystem Health and Sustainability2021，7，1： | 0 |
| 5 | (Ba_(1−x)Na_(x))F(Zn_(1−x)Mn_(x))Sb: A novel fluoride-antimonide magnetic semiconductor with decoupled charge and spin doping显示文摘We report the successful synthesis and characterization of a novel 1111-type magnetic semiconductor(Ba_(1−x)Na_(x))F(Zn_(1−x)Mn_(x))Sb(0.05≤x≤0.175)with tetragonal ZrSiCuAs-type structure,which is isostructural to the layered iron-based superconductor La(O,F)FeAs.Na substitutions for Ba and Mn substitutions for Zn introduce carriers and local magnetic moments,respectively.Ferromagnetic interaction is formed when Na and Mn are codoped,demonstrating that local magnetic moments are mediated by carriers.Iso-thermal magnetization shows that the coercive field is as large as-12000 Oe,which is also reflected in the large split between the temperature-dependent magnetization in zero-field-cooling and field-cooling condition.AC susceptibility under zero field demonstrates that samples evolve into spin-glass state below spin freezing temperature T_(f).The measurements of temperature-dependent resistivity indicate that(Ba_(1−x)Na_(x))F(Zn_(1−x)Mn_(x))Sb exhibits semiconducting behaviour. | Xueqin Zhao Jinou Dong Licheng Fu Yilun Gu Rufei Zhang Qiaolin Yang Lingfeng Xie Yinsong Tang Fanlong Ning | 2022 | Journal of Semiconductors2022，43，11： | 0 |
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