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| 1 | Dysfunction of PLA2G6 and CYP2C44-associated network signals imminent carcinogenesis from chronic inflammation to hepatocellular carcinoma显示文摘很少长期的发炎怎么贡献 hepatocellular 癌(HCC ) 的前进被知道,特别癌症的开始。揭开从长期的发炎的批评转变到在网络水平的 HCC 和分子的机制,我们用我们的动态网络 biomarker (DNB ) 分析了土拨鼠肝炎 virus/c-myc 鼠标和匹配年龄的 wt-C57BL/6 鼠标的时间系列 proteomic 数据模型。DNB 分析显示在转基因的老鼠的出生以后的第 5 月是癌症开始的批评时期,就在批评转变前,它与临床的症状一致。同时,联系 DNB 的网络在批评转变前后显示出蛋白质表示和 coexpression 层次的激烈的倒置。DNB, PLA2G6 和 CYP2C44 的二个成员,与他们的联系差别一起表示了蛋白质,被发现导致 arachidonic 酸新陈代谢的机能障碍,进一步通过短暂受体潜力隧道的煽动性的调停人规定激活煽动性的回答,并且最后导致肝 detoxification 和恶意的转变的缺陷到癌症。作为一个 c-Myc 目标, PLA2G6 断然在表示与 c-Myc 相关,显示出从减少到在 carcinogenesis 期间增加的一个趋势,与在批评转变的最小的点或付小费给的点。相应 PLA2G6 和 c-Myc 的如此的趋势也在人的 hepatocarcinogenesis 期间被观察,与在高级 dysplastic 小瘤(就在 carcinogenesis 前的一个阶段) 的最小的点。我们的学习暗示 PLA2G6 可能在 hepatocarcinogenesis 期间作为象著名 c-Myc 一样的 oncogene 工作,当 PLA2G6 和 c-Myc 的 downregulation 能是显示逼近的 carcinogenesis 的一个警告信号时。 | Meiyi Li Chen Li Wei-Xin Liu Conghui Liu Jingru Cui Qingrun Li Hong Ni Yingcheng Yang Chaochao Wu Chunlei Chen Xing Zhen Tao Zeng Mujun zhao Lei Chen Jiarui Wu Rong Zeng Luonan Chen | 2017 | Journal of Molecular Cell Biology2017，9，6： | 12 |
| 2 | Adenovirus-mediated delivery of siRNA targeting TM4SF4 attenuated liver cancer cell growth in vitro and in vivo显示文摘基因用短介入 RNA (siRNA ) 指向成为了普通策略因为它的突出的功效和特性,探索基因功能。人的 transmembrane 4 总科成员(TM4SF4 ) 4 原来作为一个房间在肠和肝被识别增长相关的基因。最近,它在 hepatocellular 癌(HCC ) 显示出增加的表情纸巾。在这研究,我们开发了怀有指向 TM4SF4 (AdSiTM4SF4 ) 的有效 siRNA 的 adenoviral 向量并且在肿瘤细胞生长的抑制识别了它的功能。TM4SF4 与它由西方的污点分析和 immunohistochemistry 的配对的非肿瘤纸巾相比是在 HCC 纸巾的 overexpressed,这被证实。显著地,它在 HCC 房间的房间表面上是更丰富的。在在血浆膜戏剧性地局部性的四根房间线的宫外地表示的 TM4SF4 的信号,稍微在里面细胞质,并且在原子核不在,表明那 TM4SF4 是膜蛋白质。成功地由 AdSiTM4SF4 指向 TM4SF4 施加了基因击倒的效果。感染 AdSiTM4SF4 显著地显示了的 QGY-7701 和 SMMC-7721 HCC 房间稀释了生长潜力。而且, AdSiTM4SF4 的 intratumoral 注射显著地用 SMMC-7721 hepatoma 细胞在一个异种皮移植老鼠模型压制了肿瘤生长。我们的结果显示那指向的 TM4SF4 可能是为 HCC 的抑制的一种有希望的形式。 | Leiming Wang Jian Feng Liang Da Ying Li Zaiping Li Mujun Zhao | 2013 | Acta Biochimica et Biophysica Sinica2013，45，3： | 4 |
| 3 | Hepatitis B virus X protein reduces starvation-induced cell death through activation of autophagy and inhibition of mitochondrial apoptotic pathway显示文摘 | Yi Mao Liang Da Hong Tang Jiali Yang Yinrui Lei Pierre Tiollais Tsaiping Li Mujun Zhao | 2011 | Biochemical and Biophysical Research Communications2011，，1： | 2 |
| 4 | Hepatitis B virus X protein sensitizes cells to starvation‐induced autophagy via up‐regulation of beclin 1 expression显示文摘 | Hong Tang Liang Da Yi Mao Ying Li Dong Li Zhenhua Xu Feng Li Yifei Wang Pierre Tiollais Tsaiping Li Mujun Zhao | 2008 | Hepatology2008，，1： | 2 |
| 5 | Human tetraspanin transmembrane 4 superfamily member 4 or intestinal and liver tetraspan membrane protein is overexpressed in hepatocellular carcinoma and accelerates tumor cell growth显示文摘人的 transmembrane 4 总科成员 4 或肠并且肝 tetraspan 膜蛋白质(TM4SF4/il-TMP ) 是原来被克隆一肠并且肝 tetraspan 膜蛋白质并且调停密度依赖者房间增长。TM4SF4 的老鼠相当或相同的事物被发现在在 TM4SF4 的三分之二 hepatectomy 和 overexpression 能提高 CCl4 导致的肝损害以后,改革肝起来调整。然而,在肝癌症的 TM4SF4/il-TMP 的表示和意义仍然保持未知。这里,我们报导 TM4SF4/il-TMP 经常并且显著地是在 hepatocellular 癌(HCC ) 的 overexpressed。实时量的反向的抄写聚合酶链反应(RT-PCR ) 和西方的污点分析证明 TM4SF4/il-TMP mRNA 和蛋白质层次在 80% HCC 纸巾是起来调整的。75 配对的 HCC 织物 microarray 的 Immunohistochemical 分析表明 TM4SF4/il-TMP 是显著地在 HCC 纸巾的 overexpressed (P < 0.001 ) ,并且 TM4SF4/il-TMP 的高 immunointensity 趋于与糟糕区分的肿瘤相比在 well-to-moderately 区分的 HCC。功能的研究通过显著地支持的 TM4SF4 表示 plasmid 的稳定的 transfection 在 QGY-7701 和 BEL-7404 HCC 房间线显示出 TM4SF4/il-TMP 的那 overexpression HCC 房间的房间生长和殖民地形成。在 QGY-7701 和 BEL-7404 房间由的 TM4SF4/il-TMP 表示的减小稳定地, transfecting TM4SF4 antisense plasmid 引起了房间增长的大抑制。我们的调查结果建议 TM4SF4/il-TMP 有潜力是在 HCC 的 biomarker 并且在癌症房间增长的提升起一个关键作用。 | Ying Li Leiming Wang Jie Qiu Liang Da Pierre Tiollais Zaiping Li Mujun Zhao | 2012 | Acta Biochimica et Biophysica Sinica2012，44，3： | 2 |
| 6 | Expression and function on embryonic development of lissencephaly-1 genes in zebrafish显示文摘Lissencephaly,严重疾病被大脑畸形性描绘。主要原因的基因 lissencephaly 是 LIS1。LIS1 的变化或删除在大脑开发导致增长和神经原的迁居缺乏。然而,很少在胚胎的开发对它的生物函数被知道。在这篇文章,我们识别了 zebrafish LIS1 基因的表达式模式并且在胚胎的开发调查了它的函数。我们证明 zebrafish 由二 LIS1 基因, LIS1a 和 LIS1b 组成了。生物信息学分析表明 LIS1 基因在蛋白质序列和 genomic 结构两个都在进化被保存。zebrafish LIS1a 和 LIS1b 的表示模式证明两个抄本无所不在地被表示根本胚胎的发展阶段并且在检验的成年纸巾。在蛋白质水平, LIS1 产品主要在由西方的弄污显示出分析的早阶段在大脑织物并且在胚胎存在。整个山的 immunostaining 数据证明 LIS1 蛋白质在整个从 1 房间舞台的胚胎是分布式的到 5 白天授精以后。通过 morpholino antisense oligonucleotides 的 LIS1 蛋白质表示击倒在 zebrafish,包括的大脑畸形性,发行量反常,和身体导致了许多发展缺乏卷屈。一起拿,我们的学习建议 zebrafish LIS1 在胚胎的开发起一个很重要的作用。 | Chengfu Sun Mafei Xu Zhen Xing Zhili Wu Yiping Li Tsaiping Li Mujun Zhao | 2009 | Acta Biochimica et Biophysica Sinica2009，41，8： | 1 |
| 7 | Performance analysis of a photovoltaic/thermal system with lunar regolith-based thermal storage for the lunar base显示文摘Powering a moon base,especially keeping it warm during the long lunar night,is a big challenge.This paper introduces a photovoltaic/thermal(PV/T)system incorporating regolith thermal storage to solve the challenge of power and heat provision for the lunar base simultaneously.The vacuum of space around the moon helps this system by reducing heat loss.During the moon's daytime,the system not only generates electricity but also captures heat.This stored heat in the regolith is then used at night,reducing the amount of equipment we need to send from Earth.The spectrally selective PV/T panels are designed to absorb a wide range of sunlight(0.3–2.5μm)while minimizing heat loss in the infrared range(3–30μm).Simulation results of the hybrid solar energy system indicate the average value of the overall efficiency is 45.9%,which relatively elevates 56.1%compared to the PV system.The launch mass of the proposed PV/T system is only 8.4%of a traditional photovoltaic-lithium battery system with the same amount of energy storage.And the total specific energy of the proposed system is 7.3 kWh kg^(-1),while that of the photovoltaic-lithium battery system is about 0.3 kWh kg^(-1).In summary,this study proposes an alternative combined heat and electricity supply system for the lunar base,which can greatly reduce the launch mass and free up load for other scientific research equipment. | SUN WenGan ZHAO Bin PEI Yu SHI LingFeng HU MaoBin LI MuJun REN Xiao PEI Gang | 2024 | Science China(Technological Sciences)2024，67，4： | 0 |
| 8 | Inhibition of ammonia-oxidizing bacteria promotes the growth of ammonia-oxidizing archaea in ammonium-rich alkaline soils显示文摘Disparities in the substrate affinity and tolerance threshold for ammonia have been believed to play a key role in driving niche differentiation between ammonia-oxidizing archaea (AOA) and bacteria (AOB);however, recent surveys argue that direct competition between AOA and AOB is also important in this phenomenon. Accordingly, it is reasonable to predict that diverse AOA lineages would grow in ammonium (NH_(4)^(+))-rich alkaline arable soils if AOB growth is suppressed. To test this hypothesis, a microcosm study was established using three different types of alkaline arable soils, in which a high NH_(4)^(+) concentration (200 μg N g^(-1) dry soil) was maintained by routinely replenishing urea and the activities of AOB were selectively inhibited by 1-octyne or 3,4-dimethylpyrazole phosphate (DMPP). Compared with amendment with urea alone, 1-octyne partially retarded AOB growth, while DMPP completely inhibited AOB. Both inhibitors accelerated the growth of AOA, with significantly higher ratios of abundance of AOA to AOB observed with DMPP amendment across soils. Nonmetric multidimensional scaling analysis (NMDS) indicated that different treatments significantly altered the community structures of both AOA and AOB and AOA OTUs enriched by high-NH_(4)^(+) amendment were taxonomically constrained across the soils tested and closely related to Nitrososphaera viennensis EN76 and N. garnensis. Given that these representative strains have been demonstrated to be sensitive to high ammonia concentrations, our results suggest that it is the competitiveness for ammonia, rather than disparities in substrate affinity and tolerance threshold for ammonia, that drives niche differentiation between these phylotypes and AOB in NH_(4)^(+)-rich alkaline soils. | Chang YIN Xiaoping FAN Hao CHEN Mujun YE Guochao YAN Tingqiang LI Hongyun PENG Shengzhe E Zongxian CHE Steven AWAKELIN Yongchao LIANG | 2022 | Pedosphere2022，32，4： | 0 |
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