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| 1 | Endothelial-specific m^6A modulates mouse hematopoietic stem and progenitor cell development via Notch signaling显示文摘 | Junhua Tv Yifan Zhang Suwei Gao Chunxia Zhang Yusheng Chen Wei Li Yun-Gui Yang Qi Zhou Feng Liu | 2018 | Cell Research2018，28，2： | 12 |
| 2 | Fetal liver: an ideal niche for hematopoietic stem cell expansion显示文摘Fetal liver(FL) is an intricate and highly vascularized hematopoietic organ, which can support the extensive expansion of hematopoietic stem cells(HSCs) without loss of stemness, as well as of the downstream lineages of HSCs. This powerful function of FL largely benefits from the niche(or microenvironment), which provides a residence for HSC expansion. Numerous studies have demonstrated that the FL niche consists of heterogeneous cell populations that associate with HSCs spatially and regulate HSCs functionally. At the molecular level, a complex of cell extrinsic and intrinsic signaling network within the FL niche cells maintains HSC expansion. Here, we summarize recent studies on the analysis of the FL HSCs and their niche, and specifically on the molecular regulatory network for HSC expansion. Based on these studies, we hypothesize a strategy to obtain a large number of functional HSCs via 3 D reconstruction of FL organoid ex vivo for clinical treatment in the future. | Suwei Gao Feng Liu | 2018 | Science China(Life Sciences)2018，61，8： | 6 |
| 3 | An atypical component of RNA-directed DNA methylation machinery has both DNA methylation-dependent and -independent roles in locus-specific transcriptional gene silencing显示文摘指导 RNA 的 DNA methylation (RdDM ) 是在植物的一条重要 de novo DNA methylation 小径。RdDM 调停许多内长的 genomic loci,其大多数是联系的 transposon 的 transcriptional silencing。一幅前面的遗传屏幕在 Arabidopsis 为 RdDM 作为一个新部件识别了 DTF1 (DNA 有约束力的抄写因素 1 ) 。在 DTF1 的 Loss-of-function 变化释放 RdDM 目标 loci 的 transcriptional silencing 并且减少 24-nt 的累积从一些目标的小介入 RNA (siRNAs ) 。在 dtf1 异种植物,有趣地,在 solo-LTR 的 transcriptional 基因 silencing 的版本被减少的 siRNA 累积然而并非由减少的 DNA methylation 伴随。这些结果建议 DTF1 是 RdDM 的一个不正常的部件并且在 transcriptional 基因 silencing 有 methylation 依赖的两 DNA 和独立角色。我们建议除 DNA methylation 以外, siRNAs 可以引起某另外的 uncharacterized 导致 transcriptional 基因 silencing 的 epigenetic 修正。 | Jun Liu Ge Bai Cuijun Zhang Wei Chen Jinxing Zhou Suwei Zhang Qing Chen Xin Deng Xin-Jian He Jian-Kang Zhu | 2011 | Cell Research2011，21，12： | 6 |
| 4 | Identification of HSC/MPP expansion units in fetal liver by single-cell spatiotemporal transcriptomics显示文摘Limited knowledge of cellular and molecular mechanisms underlying hematopoietic stem cell and multipotent progenitor(HSC/MPP)expansion within their native niche has impeded the application of stem cell-based therapies for hematological malignancies.Here,we constructed a spatiotemporal transcriptome map of mouse fetal liver(FL)as a platform for hypothesis generation and subsequent experimental validation of novel regulatory mechanisms.Single-cell transcriptomics revealed three transcriptionally heterogeneous HSC/MPP subsets,among which a CD93-enriched subset exhibited enhanced stem cell properties.Moreover,by employing integrative analysis of single-cell and spatial transcriptomics,we identified novel HSC/MPP‘pocket-like’units(HSC PLUS),composed of niche cells(hepatoblasts,stromal cells,endothelial cells,and macrophages)and enriched with growth factors.Unexpectedly,macrophages showed an 11-fold enrichment in the HSC PLUS.Functionally,macrophage-HSC/MPP co-culture assay and candidate molecule testing,respectively,validated the supportive role of macrophages and growth factors(MDK,PTN,and IGFBP5)in HSC/MPP expansion.Finally,cross-species analysis and functional validation showed conserved cell-cell interactions and expansion mechanisms but divergent transcriptome signatures between mouse and human FL HSCs/MPPs.Taken together,these results provide an essential resource for understanding HSC/MPP development in FL,and novel insight into functional HSC/MPP expansion ex vivo. | Suwei Gao Qiang Shi Yifan Zhang Guixian Liang Zhixin Kang Baofeng Huang Dongyuan Ma Lu Wang Jianwei Jiao Xiangdong Fang Cheng-Ran Xu Longqi Liu Xun Xu Berthold Gottgens Cheng Li Feng Liu | 2022 | Cell Research2022，32，1： | 4 |
| 5 | Recent advances in the preparation of Fmoc-SPPS-based peptide thioester and its surrogates for NCL-type reactions显示文摘Solid phase peptide synthesis(SPPS)based on Fmoc chemistry has become a commonly used technique in peptide chemistry,as it can be easily conducted using automated machine,and not requiring highly toxic HF in comparison to Boc-SPPS.With the fast development in the emerging field of protein chemical synthesis,many efforts have been endeavored aiming to find more efficient methods for preparing peptide fragments required in ligation reactions.This review briefly summarizes recent advances in the engineering and modification of Fmoc-SPPS-derived peptides,which can be used as the N-terminal fragments in a native chemical ligation(NCL)or NCL-type ligation reactions. | Hongxing Li Suwei Dong | 2017 | Science China Chemistry2017，60，2： | 3 |
| 6 | Particulate matter pollution in Kunshan High-Tech zone: Source apportionment with trace elements, plume evolution and its monitoring显示文摘Particulate matter(PM) in the Kunshan High-Tech zone is studied during a three-month campaign. PM and trace elements are measured by the online pollution monitoring, forecastwarning and source term retrieval system AS3. Hourly measured concentrations of PM_(10), PM_(2.5) and 16 trace elements in the PM_(2.5) section(Ca, Pb, Cu, Cl, V, Cr, Fe, Ti, Mn, Ni, Zn, Ga, As, Se, Sr, Ba)are focused. Source apportionment of trace elements by Positive Matrix Factorization modeling indicates that there are five major sources, including dust, industrial processing, traffic,combustion, and sea salt with contribution rate of 23.68%, 21.66%, 14.30%, 22.03%, and 6.89%,respectively. Prediction of plume dispersion from concrete plant and traffic emissions shows that PM_(10) pollution of concrete plant is three orders of magnitude more than that of the traffic. The influence range can extend to more than 3 km in 1 hr. Because the footprint of the industrial plumes is constantly moving according to the local meteorological conditions, the fixed monitoring sites scattered in a few hundred meters haven't captured the heaviest pollution plume at the local scale of a few km^2. As a more intensive monitoring network is not operationally possible, the use of online modeling gives accurate and quantitative information of plume location, which increases the spatial pollution monitoring capacity and improves the understanding of measurement data. These results indicate that the development of the AS3 system, which combines monitoring equipment and air pollution modeling systems, is beneficial to the real-time pollution monitoring in the industrial zone. | Suwei Zhang Qijie Zhang Armand Albergel Didier Buty Liangmin Yu Haiting Wang Wuxia Bi Peng Cheng Fu Chen Jun Fang Ruirui Hou Xudong Luan Changgan Shu Jingjing Su | 2018 | Journal of Environmental Sciences2018，30，9： | 3 |
| 7 | X-ray and Magnetoresistance Measurements of Electrodeposited Cu-Co Granular Films显示文摘Granular CoxCu1-x alloy films were prepared by electrodeposition at room temperature directly onto semiconducting Si substrate. X-ray diffraction (XRD) revealed that the as-deposited films formed single phase metastable fcc alloy structure. The fcc lattice parameter α was found to decrease linearly with increasing Co concentration x in the studied range. The giant magnetoresistance (GMR) of the films was improved after annealing. Pure Co fcc diffraction peaks were observed in the diffractogram of the annealed sample, indicating phase separation occurred upon annealing.The optimal annealing temperature was 450℃. The maximum of magnetoresistance (MR) ratio 8.21% was obtained for the Co20Cu80 thin film after annealing at 450℃ for 1 h. The saturation field decreased upon annealing in the MR curves of Co20Cu80 film. | Suwei YAO, Haixia WU, Weiguo ZHANG and Hongzhi WANG Sugiyama Laboratory of Surface Technology, Department of Applied Chemistry, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China | 2005 | Journal of Materials Science & Technology2005，21，3： | 2 |
| 8 | Steroids and triterpenoids of Antrodia cinnamomea-A fungi parqasitic on cinnamomum microranthum显示文摘 | Shen Yuanchu Chen Changhang | 1996 | Phytochemistry1996，41，5： | 1 |
| 9 | Facile Generation of Strained Peptidyl Thiolactones from Hydrazides and Its Application in Assembling MUC-1 VNTR OIigomers显示文摘An efficient method for the activation of C-terminal 4-mecaptoproline-or penicillamine-containing peptide hydrazides in ligation re-actions is reported herein.The corresp on ding peptide hydrazides can be readily prepared using solid-phase peptide synthesis,and subsequently activated by acetylacet one(acac)without exoge nous thiol additives.Strained peptidyl thiolactones could be the possible reactive in termediates that drastically accelerate the reacti on rates at the sterically demandi ng proline and valine sites.This developed protocol allows for sequential peptide ligations in a one-pot manner,and expedites the assembly of mucin 1(MUC-1)variable number tandem repeat(VNTR)trimers in various glycosylated forms. | Yuankun Dao Biao Wang Weidong Dong Jun Zhang Chao Zhong Zhili Zhang Suwei Dong | 2021 | Chinese Journal of Chemistry2021，39，9： | 1 |
| 10 | StudyonextractionofantioxidantmaterialfromLotusleafdietaryfiber[J]显示文摘 | CHENGang(陈钢) SUWei(苏伟) DUJiajing(杜佳善) etal | | 食品工业科技0，，： | 1 |
| 11 | Gradual Evolution from Fluvial Dominated to Tide Dominated Deltas and Channel Type Transformation: A Case Study of MPE3 Block in the Orinoco Heavy Oil Belt of the Eastern Venezuelan Basin显示文摘Based on the data of core description and sporopollen analysis,the gradual evolution of deltas in vertical direction and transition of channel types in the MPE3 block of the eastern Venezuela Basin have been surveyed by seismic phase and well logging facies interpretation.The results show that due to the great sea level rise,the sedimentary system of the Miocene Oficina Formation in the MPE3 block shifted from the distal-source sandy braided river delta to tide-affected delta,and eventually to tide-dominated delta.Vertically,during the early stage of sedimentation of Oficina Formation,the distributary channels of the delta were dominated by braided river channels.While in the later stage,as the tidal effect was gradually intensified,the channel changed from braided channel to meandering channel.On plane,as a result of differential transgression,sedimentary framework and distribution of sand bodies vary across the study area.Compared with the eastern part,the western part has more braided channels,larger channel bars,less developments of distributary bay and higher ratio of sand to mud.Whereas the braided channels in the south are larger than those in the north.It is the first time we pointed out the impact of marine transgression differences on the sedimentary facies distribution and river type transition in the study area.Factors like the structural and paleogeomorphological change,sea level variation,supply of sediments have strong influence on the evolution of sedimentary system and distribution of sandbodies.It is predicted that the major sandbody is more developed in the central south,which can guide the subsequent horizontal well development. | HUANG Wensong CHEN Heping XU Fang MENG Zheng ZHANG Fanqin WU Suwei | 2019 | Acta Geologica Sinica(English Edition)2019，93，6： | 1 |
| 12 | Electrochemical preparation and characterization of Ni/SiC gradient deposit 显示文摘 | Hongzhi Wang Suwei Yao Sowjun Matsumura | 2004 | Journal of Materials Processing Technology2004，145，： | 1 |
| 13 | Microstruc- ture and magnetic properties of electrodeposited Co/Cu muhilay- er nanowire arrays 显示文摘 | Song Zhenxing Xie Yujuan Yao Suwei | 2011 | Materials Letters2011，65，： | 1 |
| 14 | Disentangling the effect of hybrid interactions and of the constant effort hypothesis on ecological community stability显示文摘 | Suweis S Grilli J Maritan A | 2014 | Oikos2014，123，5： | 1 |
| 15 | Electrochemical preparation and characterization of Ni/SiC gradient deposit显示文摘 | Wang Hongzhi Yao Suwei Sowjun matsumura | 2004 | Materials Processing Technology2004，，145： | 1 |
| 16 | Electrodeposition and mechanical and corrosion resistance properties of Ni–W/SiC nanocomposite coatings显示文摘 | Yingwu Yao Suwei Yao Lu Zhang Hongzhi Wang | 2006 | Materials Letters2006，，1： | 1 |
| 17 | Role of reactive oxygen species and P53 in chromium (Ⅵ) - induced apoptosis显示文摘 | Jianping Ye Suwei Wang Stephen S | 1999 | The Journal of Biological Chemistry1999，274，34： | 1 |
| 18 | Preparation, characterization and the study of the thermal strain in Ni-W gradient deposits with nanostructure显示文摘 | Wang Hongzhi Yao Suwei Sowjun Matsumura | 2002 | Surface Coatings Technology2002，，157： | 1 |
| 19 | Preparation of Ti/ SiO2 catalysts by chemical vapor deposition method for olefin epoxidation with cumene hydroperoxide显示文摘 | Li Kuotseng Lin Pinghung Lin Suwei | 2006 | Applied Catalysis A: General2006，301，1： | 1 |
| 20 | Doxorubicin-induced apoptosis: Implications in cardiotoxicity显示文摘 | B. Kalyanaraman Joy Joseph Shashi Kalivendi Suwei Wang Eugene Konorev Srigiridhar Kotamraju | 2002 | Molecular and Cellular Biochemistry2002，，1： | 1 |
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