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| 1 | Multi-scale variability of the tropical Indian Ocean circulation system revealed by recent observations显示文摘The tropical Indian Ocean circulation system includes the equatorial and near-equatorial circulations, the marginal sea circulation, and eddies. The dynamic processes of these circulation systems show significant multi-scale variability associated with the Indian Monsoon and the Indian Ocean dipole. This paper summarizes the research progress over recent years on the tropical Indian Ocean circulation system based on the large-scale hydrological observations and numerical simulations by the South China Sea Institute of Oceanology(SCSIO), Chinese Academy of Sciences. Results show that:(1) the wind-driven Kelvin and Rossby waves and eastern boundary-reflected Rossby waves regulate the formation and evolution of the Equatorial Undercurrent and the Equatorial Intermediate Current;(2) the equatorial wind-driven dynamics are the main factor controlling the inter-annual variability of the thermocline in the eastern Indian Ocean upwelling;(3) the equatorial waves transport large amounts of energy into the Bay of Bengal in forms of coastal Kelvin and reflected free Rossby waves. Several unresolved issues within the tropical Indian Ocean are discussed:(i) the potential effects of the momentum balance and the basin resonance on the variability of the equatorial circulation system, and(ii) the potential contribution of wind-driven dynamics to the life cycle of the eastern Indian Ocean upwelling. This paper also briefly introduces the international Indian Ocean investigation project of the SCSIO, which will advance the study of the multi-scale variability of the tropical Indian Ocean circulation system, and provide a theoretical and data basis to support marine environmental security for the countries around the Maritime Silk Road. | Ke HUANG Dongxiao WANG Weiqiang WANG Qiang XIE Ju CHEN Lingfang CHEN Gengxin CHEN | 2018 | Science China Earth Sciences2018，61，6： | 4 |
| 2 | Heat contribution of the Indonesian throughflow to the Indian Ocean显示文摘Based on the high-resolution Eulerian fields of an ocean general circulation model simulation, the heat contribution of the Indonesian throughflow(ITF) to the Indian Ocean is estimated by Lagrangian tracing method.The heat transport of each particle of ITF waters is calculated by tracing temperature change along the trajectory until the particle exits the Indian Ocean. The simulation reveals that the ITF waters flow westward and branch near Madagascar, further showing the ITF waters are redistributed in both northern and southern Indian Ocean.Heat budget analysis indicates that the ITF waters gain 0.41 PW(Petawatts, 1015 W) in the northern Indian Ocean and lose 0.56 PW in the southern Indian Ocean, respectively. As a result, the ITF waters warm the whole Indian Ocean basin with only 0.15 PW, which shows an 'insignificant' role of ITF on the Indian Ocean because of the heat exchange compensation between northern and southern Indian Ocean. Furthermore, the tracing pathways show that the ITF waters mainly flow out the Indian Ocean at both sides of the basin via Agulhas Current and Leeuwin Current. About 89% of the ITF waters leave along western boundary and the rest 11% along eastern boundary. Compared to seeding section, 0.10 PW and 0.05 PW are released to the Indian Ocean, respectively. | Tiecheng Zhang Weiqiang Wang Qiang Xie Lingfang Chen | 2019 | Acta Oceanologica Sinica2019，38，4： | 2 |
| 3 | Nesiritide fails to reduce the mortality of patients with acute decompensated heart failure: An updated systematic review and cumulative meta-analysis显示文摘 | Bin Yan Liyuan Peng Xiaojing Zhao HsingChun Chung Lijun Li Lingfang Zeng HeanYee Ong Gang Wang | 2014 | International Journal of Cardiology2014，，： | 1 |
| 4 | Programmed death ligand-1 regulates angiogenesis and metastasis by participating in the c-JUN/VEGFR2 signaling axis in ovarian cancer显示文摘Background:Although programmed cell death-ligand 1(PD-L1)plays a wellknown function in immune checkpoint response by interacting with programmed cell death-1(PD-1),the cell-intrinsic role of PD-L1 in tumors is still unclear.Here,we explored the molecular regulatory mechanism of PD-L1 in the progression and metastasis of ovarian cancer.Methods:Immunohistochemistry of benign tissues and ovarian cancer samples was performed,followed by migration,invasion,and angiogenesis assays in PDL1-knockdown ovarian cancer cells.Immunoprecipitation,mass spectrometry,and chromatin immunoprecipitation were conducted along with zebrafish and mouse experiments to explore the specific functions and mechanisms of PD-L1 in ovarian cancer.Results:Our results showed that PD-L1 induced angiogenesis,which further promoted cell migration and invasion in vitro and in vivo of ovarian cancer.Mechanistically,PD-L1 was identified to directly interact with vascular endothelial growth factor receptor-2(VEGFR2)and then activated the FAK/AKT pathway,which further induced angiogenesis and tumor progression,leading to poor prognosis of ovarian cancer patients.Meanwhile,PD-L1 was found to be regulated by the oncogenic transcription factor c-JUN at the transcriptional level,which enhanced the expression of PD-L1 in ovarian cancer.Furthermore,we demonstrated that PD-L1 inhibitor durvalumab,combined with the antiangiogenic drug,apatinib,could enhance the effect of anti-angiogenesis and the inhibition of cell migration and invasion.Conclusion:Our results demonstrated that PD-L1 promoted the angiogenesis and metastasis of ovarian cancer by participating in the c-JUN/VEGFR2 signaling axis,suggesting that the combination of PD-L1 inhibitor and antiangiogenic drugs may be considered as a potential therapeutic approach for ovarian cancer patients. | Yufei Yang Lingfang Xia Yong Wu Hongyu Zhou Xin Chen Haoran Li Midie Xu Zihao Qi Ziliang Wang Huizhen Sun Xi Cheng | 2021 | Cancer Communications2021，41，6： | 1 |
| 5 | Isolation of RNA of high quality and yield from Ginkgo biloba leaves显示文摘 | Tao Wang Nianhui Zhang Lingfang Du | 2005 | Biotechnology Letters2005，，9： | 1 |
| 6 | GCRV 096 VP6 protein and its impacts on GCRV replication with different genotypes in CIK cells显示文摘Grass carp reovirus(GCRV)is the causative agent of grass carp hemorrhagic disease,which has detrimental effects on the grass carp aquaculture industry.There are four known genotypes of GCRV and strains of different GCRV genotypes differ greatly.In this study,the diversity of the protein VP6 from different GCRV stains and the effect of genotype GCRV 096 on replication was investigated in CIK cells.Our results showed that the VP6 protein of GCRV 096(genotypeІ)exhibited limited homology to that of GCRV GD108(genotypeШ),with few residues conserved in predicted protein-protein interaction domains.GCRV 096 VP6 protein was expressed and purified and an antiserum against it was characterized.Addition of purified VP6 protein or antiserum to culture media of CIK cells inhibited the replication of GCRV 096 in these cells.In contrast,replication of GCRV GD108(genotypeШ)was not affected in CIK cells under the same condition.Overall,our results indicated that the protein VP6 and VP6 antiserum did not provide cross-protection against GCRV strains and this can be attributed to differences among GCRV genotypes.It will be important to consider multiple GCRV genotypes in the development of effective GCRV vaccines and other therapies against grass carp hemorrhagic disease.In addition,bioinformatics analysis also suggested that the protein VP6 may have a role in the process of GCRV infection.This study lays the foundation for the prevention of grass carp hemorrhagic disease and further detailed studies on the pathogenesis of GCRV. | Xiuying Yan Lingfang Xiong Jie Li Ya Wang Zaohe Wu Jichang Jian Yu Ding | 2018 | Aquaculture and Fisheries2018，3，5： | 1 |
| 7 | Isolation of RNA of high quality and yield from Ginkgo biloba leaves显示文摘 | Tao Wang Nianhui Zhang Lingfang Du | 2005 | Biotechnology Letters2005，27，9： | 1 |
| 8 | Highly Sensitive Refractive Index Sensor Based on Polymer Long-Period Waveguide Grating With Liquid Cladding显示文摘We propose a novel structure and unique sensing mechanism bio-chemical sensor which is fabricated by a polymer long-period waveguide grating with the detection liquid directly as the waveguide cladding.Quantitative detection is realized from analyzing the output absorption spectrum and resonant wavelength shift related to the liquid detection concentration.The proposed polymer long-period waveguide grating based liquid refractive-index sensor is developed experimentally,the high sensitivity of 1.01×10^4nm/RIU is achieved,and the temperature stability coefficient is 1.47nm/℃.Theoretically and experimentally,this work has been demonstrated to have potential application in chemical and biological detections and may provide an important technical support for solving today's increasingly serious civil problems such as food safety and drug safety, which will also have the important scientific significance and application prospects. | Lingfang WANG Keyu REN Bao SUN Kaixin CHEN | 2019 | Photonic Sensors2019，9，1： | 1 |
| 9 | A Domain Decomposition Chebyshev Spectral Collocation Method for Volterra Integral Equations显示文摘We develop a domain decomposition Chebyshev spectral collocationmethod for the second-kind linear and nonlinear Volterra integral equations with smooth kernel functions.The method is easy to implement and possesses high accuracy.In the convergence analysis,we derive the spectral convergence order under the L¥-norm without the Chebyshev weight function,and we also show numerical examples which coincide with the theoretical analysis. | Hua Wu Yunzhen Zhu Hailu Wang Lingfang Xu | 2018 | Journal of Mathematical Study2018，51，1： | 1 |
| 10 | Bioconversion of lignocellulosic biomass to hydrogen: Potential and challenges显示文摘 | Nanqi Ren Aijie Wang Guangli Cao Jifei Xu Lingfang Gao | 2009 | Biotechnology Advances2009，，6： | 1 |
| 11 | IMCI: an efficient fingerprint retrieval approach based on 3D stacked memory显示文摘Dear editor,Data deduplication (Dedup for short) as a type of redundant data elimination technology,can effectively reduce the impact of redundant data on storage costs,which consequently alleviates the problems and pressures caused by massive data storage,management,and backup. | Wen CHENG Ran CAI Lingfang ZENG Dan FENG Andre BRINKMANN Yang WANG | 2020 | Science China(Information Sciences)2020，63，7： | 1 |
| 12 | Balanciflg risk and cost in fuzzy economic dispatch including wind power penetration based on particle swarm optimization显示文摘 | Wang Lingfang Singh Chanan | 2008 | Electric Power Systems Research2008，78，8： | 1 |
| 13 | Effects of all-trans retinoic acid on proliferation of human aorta smooth muscle cells显示文摘The primary cultured human aorta smooth muscle cells(SMCs)were characterized and theeffects of all—trans retinoic acid(atRA)on these cells were analysed.It is found that atRA could slowdown the growth rate of SMCs,and decrease the expression Ievels of cyclinDl,CDK4,c-myc at39%。38%and 43.6%respectively,while atRA had no effects on the expression of c^-actin which isspecific for SMCs.Results demonstrated that atRA inhibited cell growth of SMCs but did not induce celIdifferentiation.These effects may be clue to the decreased translation Ievels of cyclinDl.CDK4 andtranscription Ievel of c-myc.The fact that ati tA inhibited SMCs proIiferation may become one of thetheoretic basis for the cIinicaI use of atRA in the trea㈣t of SMCs proliferative diseases such asatherosclerosis. | Guoxia Liu Cunxi Li Lingfang Zeng Yongchao Wang | 1999 | Chinese Science Bulletin1999，44，5： | 0 |
| 14 | 细菌六型分泌系统利用一个受氧化还原调节的双功能血红素转运蛋白获取锌显示文摘文章简介在病原细菌与宿主的斗争过程中,宿主可通过利用营养免疫机制限制入侵病原菌获取生长必需的铁、锌、锰等元素,从而抑制病原细菌生长;与之相对应,病原细菌也进化出一系列精细的手段对抗宿主的营养免疫而获取相应元素。 | Meiru Si Yao Wang Bing Zhang Chao Zhao Yiwen Kang Haonan Bai Dawei Wei Lingfang Zhu Lei Zhang Tao G.Dong 沈锡辉 | 2018 | 科学新闻2018，0，4： | 0 |
| 15 | YTHDF2-mediated regulations bifurcate BHPF-induced programmed cell deaths显示文摘N6-methyladenosine(m^(6)A)is a critical regulator in the fate of RNA,but whether and how m^(6)A executes its functions in different tissues remains largely obscure.Here we report downregulation of a crucial m^(6)A reader,YTHDF2,leading to tissue-specific programmed cell deaths(PCDs)upon fluorene-9-bisphenol(BHPF)exposure.Currently,Bisphenol A(BPA)substitutes are widely used in plastic manufacturing.Interrogating eight common BPA substitutes,we detected BHPF in 14%serum samples of pregnant participants.In a zebrafish model,BHPF caused tissue-specific PCDs triggering cardiac and vascular defects.Mechanistically,BHPF-mediated downregulation of YTHDF2 reduced YTHDF2-facilitated translation of m^(6)A-gch1 for cardiomyocyte ferroptosis,and decreased YTHDF2-mediated m^(6)A-sting1 decay for caudal vein plexus(CVP)apoptosis.The two distinct YTHDF2-mediated m^(6)A regulations and context-dependent co-expression patterns of gch1/ythdf2 and tnfrsf1a/ythdf2 contributed to YTHDF2-mediated tissue-specific PCDs,uncovering a new layer of PCD regulation.Since BHPF/YTHDF2-medaited PCD defects were also observed in mammals,BHPF exposure represents a potential health threat. | Jiebo Lin Guankai Zhan Jinfeng Liu Yasen Maimaitiyiming Zhiping Deng Baohua Li Kunhui Su Jiafeng Chen Siqi Sun Wanlin Zheng Xianghui Yu Feng He Xiaodong Cheng Lingfang Wang Bin Shen Ziqin Yao Xinquan Yang Jian Zhang Wentao He Hengyu Wu Hua Naranmandura Kao-Jung Chang Junxia Min Jun Ma Mikael Björklund Peng-Fei Xu Fudi Wang Chih-Hung Hsu | 2023 | National Science Review2023，10，12： | 0 |
| 16 | Fiber-specific increase of carotenoid content promotes cotton fiber elongation by increasing abscisic acid and ethylene biosynthesis显示文摘Cotton fiber is a raw material for the global textile industry and fiber quality is essential to its industrial application.Carotenoids are plant secondary metabolites that may serve as dietary components,regulate light harvesting,and scavenge reactive oxygen species.Although carotenoids accumulate predominantly in rapidly elongating cotton fibers,their roles in cotton fiber development remain poorly understood.In this study,a fiber-specific promoter proSCFP was applied to drive the expression of GhOR1Del,a positive regulator of carotenoid accumulation,to upregulate the carotenoid level in cotton fiber in planta.Fiber length,strength,and fineness were increased in proSCFP:GhOR1Del transgenic cotton and abscisic acid(ABA)and ethylene contents were increased in elongating fibers.The ABA downstream regulator GhbZIP27a stimulated the expression of the ethylene synthase gene GhACO3 by binding to its promoter,suggesting that ABA promoted fiber elongation by increasing ethylene production.These findings suggest the involvement of carotenoids and ABA signaling in promoting cotton fiber elongation and provide a strategy for improving cotton fiber quality. | Jianyan Zeng Dan Yao Ming Luo Lingli Ding Yi Wang Xingying Yan Shu’e Ye Chuannan Wang Yiping Wu Jingyi Zhang Yaohua Li Lingfang Ran Yonglu Dai Yang Chen Fanlong Wang Hanyan Lai Nian Liu Nianjuan Fang Yan Pei Yuehua Xiao | 2023 | The Crop Journal2023，11，3： | 0 |
| 17 | Low-Cost and Highly Sensitive Liquid Refractive Index Sensor Based on Polymer Horizontal Slot Waveguide显示文摘We analyze and explore the potential of using a polymer horizontal slot waveguide as light-analyte interactive region to implement a low-cost and highly sensitive liquid refractive index sensor.Numerical analysis shows that the optimized polymer horizontal slot waveguide is able to realize high waveguide sensitivity.With the optimized horizontal slot waveguide,polymer liquid refractive index sensors based on Mach-Zehnder interferometer(MZI)and microring resonator(MRR)are then investigated numerically,and the results show that the MZI-based sensor can achieve high sensitivity of 17024 nm/RIU and low limit of detection(LOD)of 1.76´10^(-6) RIU while the MRR-based sensor can achieve the sensitivity of 177 nm/RIU and the LOD of 1.69´10^(-4) RIU with a very small footprint.Compared with the sensors employing conventional silicon or silicon nitride vertical slot waveguide,the sensors employing polymer horizontal slot waveguide exhibit comparable performances but simpler and lower fabrication costs. | Xiaoxia MA Kaixin CHEN Jieyun WU Lingfang WANG | 2020 | Photonic Sensors2020，10，1： | 0 |
| 18 | H3‑T6SS of Pseudomonas aeruginosa PA14 contributes to environmental adaptation via secretion of a biofilm‑promoting effector显示文摘Microbial species often occur in complex communities and exhibit intricate synergistic and antagonistic interactions.To avoid predation and compete for favorable niches,bacteria have evolved specialized protein secretion systems.The type VI secretion system(T6SS)is a versatile secretion system widely distributed among Gram-negative bacteria that translocates effectors into target cells or the extracellular milieu via various physiological processes.Pseudomonas aeruginosa is an opportunistic pathogen responsible for many diseases,and it has three independent T6SSs(H1-,H2-,and H3-T6SS).In this study,we found that the H3-T6SS of highly virulent P.aeruginosa PA14 is negatively regulated by OxyR and OmpR,which are global regulatory proteins of bacterial oxidative and acid stress.In addition,we identified a H3-T6SS effector PA14_33970,which is located upstream of VgrG3.PA14_33970 interacted directly with VgrG3 and translocated into host cells.Moreover,we found that H3-T6SS and PA14_33970 play crucial roles in oxidative,acid,and osmotic stress resistance,as well as in motility and biofilm formation.PA14_33970 was identified as a new T6SS effec-tor promoting biofilm formation and thus named TepB.Furthermore,we found that TepB contributes to the virulence of P.aeruginosa PA14 toward Caenorhabditis elegans.Overall,our study indicates that H3-T6SS and its biofilm-promot-ing effector TepB are regulated by OxyR and OmpR,both of which are important for adaptation of P.aeruginosa PA14 to multiple stressors,providing insights into the regulatory mechanisms and roles of T6SSs in P.aeruginosa. | Yantao Yang Damin Pan Yanan Tang Jiali Li Kaixiang Zhu Zonglan Yu Lingfang Zhu Yao Wang Peng Chen Changfu Li | 2022 | Stress Biology2022，2，1： | 0 |
| 19 | Tunable Filters Based on Cascaded Long-Period Polymer Waveguide Gratings显示文摘Long-period waveguide grating based filters have attracted attention due to their flexible fabrication,a variety of materials and structures,low back reflection,low insertion loss,and excellent performance in the tuning range and temperature sensitivity.To our knowledge,for the first time,a two-segment polymer long-period waveguide grating was cascaded to implement a filter with a narrower bandwidth.Experimental results showed that the device had a maximum extinction ratio of 24 dB at 1577 nm,and the 12 dB bandwidth was 10 nm.The temperature sensitivity of the fabricated device was 1.79 nm/℃. | Xin SHI Rui CAO Lingfang WANG | 2022 | Photonic Sensors2022，12，4： | 0 |
| 20 | The influence of Bi content on dielectric properties of Bi_(4-x)Ti_(3)O_(12-1.5x) ceramics显示文摘A kind of lead-free dielectric materials,such as the bismuth layered perovskite-type structure of Bi4-xTi3O12-1.5x(x=0.04,0.02,0,-0.02,-0.04),was prepared by the conventional solid-state method at 800C and sintered at 1100C.The variation of structure and electrical properties with different Bi concentration was studied.All the Bi4-xTi3O12-1.5x(x=0.04,0.02,0,-0.02,-0.04)samples exhibited a single structured phase.SEM could be a better approach to present the microstructure of Bi4-xTi3O12-1.5x(x=0.04,0.02,0,-0.02,-0.04)ceramics.It could be found that the grain size of Bi4.02Ti3O12.03 sintered at 1100C was smaller than that of others among the five samples through grain size mechanics.Through impedance spectra analysis,we knew,when the Bi content was fixed,that the dielectric constant and the loss values increased with the decrease of frequency.The Curie temperature of the five samples was about 670C.In particular,while at the frequency of 100 kHz,the lowest loss was 0.001 when Bi content was 3.98.The Bi4.02Ti3O12.03 ceramics with the minimum grain size had highest dielectric constant and the relatively low loss.Due to its high Curie temperature,high permittivity and low loss,the Bi_(4)Ti_(3)O_(12)(BIT)ceramics have a broad application prospect in high density memory,generator,sensor,ferroelectric tunnel junctions and so on. | Hui Gong Xiying Ke Shuqin Yang Zhaozhi Li Huyin Su Cancan Zhang Qian Luo Qi Chen Lingfang Xu Yong Chen Wei Wang | 2017 | Journal of Advanced Dielectrics2017，7，3： | 0 |
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