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| 1 | Interaction between Rice stripe virus Disease- Specific Protein and Host PsbP Enhances Virus Symptoms显示文摘瑞斯条纹病毒(RSV ) 在许多东方亚洲国家在 Oryza sativa (米饭) 引起严重疾病。RSV 的疾病特定的蛋白质(SP ) 是非结构的蛋白质,它在米饭植物的 accumulationlevel 被显示决定 RSV 症状的严厉。这里,我们在米饭或 Nicotiana benthamiana 独自一个的 RSVSP 的那表情没生产可见症状的现在的证据。然而,在这二植物的 SP 的表示提高了 RSV- 或土豆病毒 X (PVX ) 导致了症状。通过酵母二混血儿的屏蔽, GST 下拉,和双分子的荧光互补试金,我们证明 RSV SP 与 PsbP 交往了, 23-kDa 演变氧的复杂蛋白质,在米饭和 N。benthamiana。而且,我们的调查证明在两植物的 PsbP 表示的 silencing 增加了疾病症状 severityand 病毒累积。共焦的显微镜学使用 N。benthamiana 原物证明 PsbP 在野类型的 N 在叶绿体主要积累了。benthamiana 房间。面对 RSV SP,大多数 PsbP 被招募进 assayed 房间的细胞质。另外, accumulationof SP 在 RSV 感染期间导致了叶绿体结构和功能的改变。我们的调查结果使位于 RSV 疾病症状 development.Key 词下面的 molecularmechanism 清楚些: | Lingfang Kong Jianxiang Wu Lina Lu Yi Xu Xueping Zhou | 2014 | Molecular Plant2014，7，4： | 13 |
| 2 | Geochemical Characteristics and Sources of Ore-forming Fluids of the Mayuan Pb-Zn Deposit,Nanzheng,Shaanxi,China显示文摘The Mayuan stratabound Pb-Zn deposit in Nanzheng,Shaanxi Province,is located in the northern margin of the Yangtze Plate,in the southern margin of the Beiba Arch.The orebodies are stratiform and hosted in breciated dolostone of the Sinian Dengying Formation.The ore minerals are primarily sphalerite and galena,and the gangue minerals comprise of dolomite,quartz,barite,calcite and solid bitumen.Fluid inclusions from ore-stage quartz and calcite have homogenization tempreatures from 98 to 337℃ and salinities from 7.7 wt%to 22.2 wt%(NaCl equiv.).The vapor phase of the inclusions is mainly composed of CH_4 with minor CO_2 and H_2S.The δD_(fluid) values of fluid inclusions in quartz and calcite display a range from-68‰ to-113‰(SMOW),and the δ^(18)O_(fluid)values calculated from δ^(18)O_(quartz) and δ^(18)O_(calcite) values range from 4.5‰ to 16.7‰(SMOW).These data suggest that the ore-forming fluids may have been derived from evaporitic sea water that had reacted with organic matter.The δ^(13)C_(CH4) values of CH_4 in fluid inclusions range from-37.2‰ to-21.0‰(PDB),suggesting that the CH_4 in the ore-forming fluids was mainly derived from organic matter.This,together with the abundance of solid bitumen in the ores,suggest that organic matter played an important role in mineralization,and that the thermochemical sulfate reduction(TSR) was the main mechanism of sulfide precipitation.The Mayuan Pb-Zn deposit is a carbonate-hosted epigenetic deposit that may be classified as a Mississippi Valley type(MVT) deposit. | LIU Shuwen LI Ronxi CHI Guoxiang ZENG Rong LIU Lingfang SHI Shun | 2015 | Acta Geologica Sinica(English Edition)2015，89，3： | 5 |
| 3 | Distinct Contributions of Replication and Transcription to Mutation Rate Variation of Human Genomes显示文摘Here, we evaluate the contribution of two major biological processes-DNA replication and transcription-to mutation rate variation in human genomes. Based on analysis of the public human tissue transcriptomics data, high-resolution replicating map of Hela cells and dbSNP data, we present significant correlations between expres-sion breadth, replication time in local regions and SNP density. SNP density of tissue-specific (TS) genes is sig-nificantly higher than that of housekeeping (HK) genes. TS genes tend to locate in late-replicating genomic re-gions and genes in such regions have a higher SNP density compared to those in early-replication regions. In addi-tion, SNP density is found to be positively correlated with expression level among HK genes. We conclude that the process of DNA replication generates stronger mutational pressure than transcription-associated biological processes do, resulting in an increase of mutation rate in TS genes while having weaker effects on HK genes. In contrast, transcription-associated processes are mainly responsible for the accumulation of mutations in highly-expressed HK genes. | Peng Cui Feng Ding Qiang Lin Lingfang Zhang Ang Li Zhang Zhang Songnian Hu Jun Yu | 2012 | Genomics, Proteomics & Bioinformatics2012，10，1： | 5 |
| 4 | 肝细胞中活化转录因子ATF6抑制SREBP1的转录活性显示文摘内质网膜定位的活化转录因子ATF6和SREBP1均是经过蛋白酶切水解激活,激活后的ATF6(N)和SREBP1(N)进入细胞核内,分别指导内质网膜未折叠蛋白聚集反应相关基因和脂肪酸合成相关基因的表达.研究发现,肝细胞内葡萄糖饥饿激活ATF6并抑制SREBP1的转录活性及其靶基因的表达.过表达ATF6(N)能够抑制SREBP1介导的转录及其下游基因的表达.免疫共沉淀实验显示,ATF6(N)在细胞核内结合SREBP1(N),这种结合在无糖状况下增强.不同功能区缺失分析表明,ATF6和SREBP1通过亮氨酸拉链(leucinezipper)功能区相互作用.在葡萄糖饥饿状况下,ATF6对SREBP1转录活性的抑制保证了细胞基本生命活动所需要的能量. | 李红玲 ZENG Lingfang 王保国 庞炜 朱毅 | 2005 | 中国生物化学与分子生物学报2005，21，4： | 4 |
| 5 | Multi-scale variability of the tropical Indian Ocean circulation system revealed by recent observations显示文摘The tropical Indian Ocean circulation system includes the equatorial and near-equatorial circulations, the marginal sea circulation, and eddies. The dynamic processes of these circulation systems show significant multi-scale variability associated with the Indian Monsoon and the Indian Ocean dipole. This paper summarizes the research progress over recent years on the tropical Indian Ocean circulation system based on the large-scale hydrological observations and numerical simulations by the South China Sea Institute of Oceanology(SCSIO), Chinese Academy of Sciences. Results show that:(1) the wind-driven Kelvin and Rossby waves and eastern boundary-reflected Rossby waves regulate the formation and evolution of the Equatorial Undercurrent and the Equatorial Intermediate Current;(2) the equatorial wind-driven dynamics are the main factor controlling the inter-annual variability of the thermocline in the eastern Indian Ocean upwelling;(3) the equatorial waves transport large amounts of energy into the Bay of Bengal in forms of coastal Kelvin and reflected free Rossby waves. Several unresolved issues within the tropical Indian Ocean are discussed:(i) the potential effects of the momentum balance and the basin resonance on the variability of the equatorial circulation system, and(ii) the potential contribution of wind-driven dynamics to the life cycle of the eastern Indian Ocean upwelling. This paper also briefly introduces the international Indian Ocean investigation project of the SCSIO, which will advance the study of the multi-scale variability of the tropical Indian Ocean circulation system, and provide a theoretical and data basis to support marine environmental security for the countries around the Maritime Silk Road. | Ke HUANG Dongxiao WANG Weiqiang WANG Qiang XIE Ju CHEN Lingfang CHEN Gengxin CHEN | 2018 | Science China Earth Sciences2018，61，6： | 4 |
| 6 | Dielectric Properties of Bi_4Ti_3O_(12) Ceramics by Impedance Spectroscopic Method显示文摘Various lead-free ceramics have been investigated in search for new high-temperature dielectrics. In particular, Bi_4Ti_3O_(12) is a type of ferroelectric ceramics, which is supposed to replace leadcontaining ceramics for its outstanding dielectric properties in the near future. Ferroelectric ceramics of Bi_4Ti_3O_(12) made by conventional mixed oxide route have been studied by impedance spectroscopy in a wide range of temperature. X-ray diffraction patterns show that Bi_4Ti_3O_(12) ceramics are a single-phase of ferroelectric Bi-layered perovskite structure whether it is calcined at 800 ℃ or after sintering production. This study focused on the effect of the grain size on the electric properties of BIT ceramics. The BIT ceramics with different grain sizes were prepared at different sintering temperatures. Grain becomes coarser with the sintering temperature increasing by 50 ℃, relative permittivity and dielectric loss also change a lot. When sintered at 1 100 ℃, r values peak can reach 205.40 at a frequency of 100 k Hz, the minimum dielectric losses of four different frequencies make no difference, all close to 0.027. The values of Ea range from 0.52 to 0.68 e V. The dielectric properties of the sample sintered at 1 100 ℃ are relatively better than those of the other samples by analyzing the relationship of the grain, the internal stresses, the homogeneity and the dielectric properties. SEM can better explain the results of the dielectric spectrum at different sintering temperatures. The results show that Bi_4Ti_3O_(12) ceramics are a kind of dielectrics. Thus, Bi_4Ti_3O_(12) can be used in high-temperature capacitors and microwave ceramics. | 陈勇 SU Huyin XUE Simin LI Zhaozhi ZHANG Cancan CHEN Qi XU Lingfang 曹万强 黄兆祥 | 2016 | Journal of Wuhan University of Technology(Materials Science)2016，31，5： | 3 |
| 7 | Health Inequalities during 20 Years of Rapid Economic Development in China (1980-2000):A Mortality Analysis显示文摘Objective To examine the influence of China's economic reforms on population health and regional mortality rates.Methods Longitudinal study measuring the mortality trends and their regional variations.Using data from the three most recent national censuses,we used the model life table to adjust the mortality levels within the population for each census,and to calculate life expectancy.We then examined the variation in patterns of mortality and population health by economic status,region and gender from 1980-2000.Results Life expectancy varied with economic status,province,and gender.Results showed that,although life expectancy in China had increased overall since the early 1980s,regional differences became more pronounced.Life expectancy for populations who live in the eastern coastal provinces are greater than those in the western regions.Conclusion Differences in life expectancy are primarily related to differences in regional economic development,which in turn exacerbate regional health inequalities.Therefore,it is necessary to improve economic development in less developed regions and to improve health policies and the public health system that address the needs of everyone. | ZHENG XiaoYing SONG XinMing CHEN Gong YOU YunZhong REN Qiang LIU JuFen ZHANG Lei TAN LingFang WEI JiHong CHEN QiuYuan | 2011 | Biomedical and Environmental Sciences2011，24，4： | 2 |
| 8 | 组蛋白去乙酰化酶与血管重建显示文摘病理性的血管重建是一类由多种因子和多种细胞参与的复杂过程,在动脉粥样硬化、高血压等心血管疾病中普遍存在。组蛋白去乙酰化酶(HDACs)作为一类重要的染色体结构调节酶类,几乎参与所有的细胞生化过程。传统的HDACs研究主要集中在其抗肿瘤的作用上,但近来有大量报道表明,HDACs在血管重建中也起到重要的作用。本综述总结了HDACs与新生血管形成的关系,包括其对内皮细胞的增殖、迁移、生存和分化的影响。此外,HDACs的抑制剂具有较明显的抑制新生血管形成的作用,是一种全新的肿瘤治疗和抗血管增生途径。因此,探讨HDACs参与血管重建的机制将为动脉粥样硬化、高血压等心血管疾病的治疗提供新的方向。 | 杨俊瑶 王前 Zeng Lingfang | 2014 | 中华高血压杂志2014，22，5： | 2 |
| 9 | Heat contribution of the Indonesian throughflow to the Indian Ocean显示文摘Based on the high-resolution Eulerian fields of an ocean general circulation model simulation, the heat contribution of the Indonesian throughflow(ITF) to the Indian Ocean is estimated by Lagrangian tracing method.The heat transport of each particle of ITF waters is calculated by tracing temperature change along the trajectory until the particle exits the Indian Ocean. The simulation reveals that the ITF waters flow westward and branch near Madagascar, further showing the ITF waters are redistributed in both northern and southern Indian Ocean.Heat budget analysis indicates that the ITF waters gain 0.41 PW(Petawatts, 1015 W) in the northern Indian Ocean and lose 0.56 PW in the southern Indian Ocean, respectively. As a result, the ITF waters warm the whole Indian Ocean basin with only 0.15 PW, which shows an 'insignificant' role of ITF on the Indian Ocean because of the heat exchange compensation between northern and southern Indian Ocean. Furthermore, the tracing pathways show that the ITF waters mainly flow out the Indian Ocean at both sides of the basin via Agulhas Current and Leeuwin Current. About 89% of the ITF waters leave along western boundary and the rest 11% along eastern boundary. Compared to seeding section, 0.10 PW and 0.05 PW are released to the Indian Ocean, respectively. | Tiecheng Zhang Weiqiang Wang Qiang Xie Lingfang Chen | 2019 | Acta Oceanologica Sinica2019，38，4： | 2 |
| 10 | Antioxidant activity of mangostin in cell-free system and its effect on K562 leukemia cell line in photodynamic therapy显示文摘Mangostin (军事顾问团) ,一种氧杂蒽酮广泛地在饮食和药使用了,有抗氧化剂,反煽动性,抗菌剂,和 anticancer 活动。由于它的抗氧化剂活动,军事顾问团可能保护从自由的基的房间在反应的氧种类生产在哪个期间被刺激期间在光力学的治疗(太平洋夏季时间) 损坏导致不可逆的肿瘤房间损害的癌症。在这研究,军事顾问团的抗氧化剂活动被调查,在 5-aminolevulinic 酸(翼) 的 K562 房间上的军事顾问团的影响基于太平洋夏季时间被表明。结果证明那个军事顾问团能清除氢氧根基, superoxide 阴离子,和氢过氧化物并且禁止 malondialdehyde (MDA ) 的形成,但是在没有房间的系统增加汗衫氧的数量。军事顾问团禁止房间增长并且在 K562 房间上在翼太平洋夏季时间提高房间 apoptosis,类脂化合物 peroxidation,和 DNA 损坏。NaN3,汗衫氧 quencher,压制导致军事顾问团的房间 apoptosis,类脂化合物 peroxidation,和 DNA 损坏。在结论,军事顾问团在 K562 房间和汗衫氧提高导致太平洋夏季时间的 cytotoxicity 涉及这个过程。这些结果暗示太平洋夏季时间力量上的抗氧化剂的效果由它汗衫氧的促进感受性能力是坚定的。 | Dan Sun Sujuan Zhang Yongfeng Wei Lingfang Yin | 2009 | Acta Biochimica et Biophysica Sinica2009，41，12： | 2 |
| 11 | Reputation, Trust, and Rebates: How Online Auction Markets Can Improve Their Feedback Mechanisms显示文摘 | Lingfang (Ivy)Li | 2010 | Journal of Economics & Management Strategy2010，，2： | 1 |
| 12 | Nesiritide fails to reduce the mortality of patients with acute decompensated heart failure: An updated systematic review and cumulative meta-analysis显示文摘 | Bin Yan Liyuan Peng Xiaojing Zhao HsingChun Chung Lijun Li Lingfang Zeng HeanYee Ong Gang Wang | 2014 | International Journal of Cardiology2014，，： | 1 |
| 13 | Programmed death ligand-1 regulates angiogenesis and metastasis by participating in the c-JUN/VEGFR2 signaling axis in ovarian cancer显示文摘Background:Although programmed cell death-ligand 1(PD-L1)plays a wellknown function in immune checkpoint response by interacting with programmed cell death-1(PD-1),the cell-intrinsic role of PD-L1 in tumors is still unclear.Here,we explored the molecular regulatory mechanism of PD-L1 in the progression and metastasis of ovarian cancer.Methods:Immunohistochemistry of benign tissues and ovarian cancer samples was performed,followed by migration,invasion,and angiogenesis assays in PDL1-knockdown ovarian cancer cells.Immunoprecipitation,mass spectrometry,and chromatin immunoprecipitation were conducted along with zebrafish and mouse experiments to explore the specific functions and mechanisms of PD-L1 in ovarian cancer.Results:Our results showed that PD-L1 induced angiogenesis,which further promoted cell migration and invasion in vitro and in vivo of ovarian cancer.Mechanistically,PD-L1 was identified to directly interact with vascular endothelial growth factor receptor-2(VEGFR2)and then activated the FAK/AKT pathway,which further induced angiogenesis and tumor progression,leading to poor prognosis of ovarian cancer patients.Meanwhile,PD-L1 was found to be regulated by the oncogenic transcription factor c-JUN at the transcriptional level,which enhanced the expression of PD-L1 in ovarian cancer.Furthermore,we demonstrated that PD-L1 inhibitor durvalumab,combined with the antiangiogenic drug,apatinib,could enhance the effect of anti-angiogenesis and the inhibition of cell migration and invasion.Conclusion:Our results demonstrated that PD-L1 promoted the angiogenesis and metastasis of ovarian cancer by participating in the c-JUN/VEGFR2 signaling axis,suggesting that the combination of PD-L1 inhibitor and antiangiogenic drugs may be considered as a potential therapeutic approach for ovarian cancer patients. | Yufei Yang Lingfang Xia Yong Wu Hongyu Zhou Xin Chen Haoran Li Midie Xu Zihao Qi Ziliang Wang Huizhen Sun Xi Cheng | 2021 | Cancer Communications2021，41，6： | 1 |
| 14 | The effect of citric acid to metal nitrates molar ratio on sol - gel combustion synthesis of nanocrystalline LaMnO3 powders显示文摘 | Li Yuanyuan Xue Lihong Fan Lingfang | 2009 | Journal of Alloys and Compounds2009，478，1： | 1 |
| 15 | Isolation of RNA of high quality and yield from Ginkgo biloba leaves显示文摘 | Tao Wang Nianhui Zhang Lingfang Du | 2005 | Biotechnology Letters2005，，9： | 1 |
| 16 | GCRV 096 VP6 protein and its impacts on GCRV replication with different genotypes in CIK cells显示文摘Grass carp reovirus(GCRV)is the causative agent of grass carp hemorrhagic disease,which has detrimental effects on the grass carp aquaculture industry.There are four known genotypes of GCRV and strains of different GCRV genotypes differ greatly.In this study,the diversity of the protein VP6 from different GCRV stains and the effect of genotype GCRV 096 on replication was investigated in CIK cells.Our results showed that the VP6 protein of GCRV 096(genotypeІ)exhibited limited homology to that of GCRV GD108(genotypeШ),with few residues conserved in predicted protein-protein interaction domains.GCRV 096 VP6 protein was expressed and purified and an antiserum against it was characterized.Addition of purified VP6 protein or antiserum to culture media of CIK cells inhibited the replication of GCRV 096 in these cells.In contrast,replication of GCRV GD108(genotypeШ)was not affected in CIK cells under the same condition.Overall,our results indicated that the protein VP6 and VP6 antiserum did not provide cross-protection against GCRV strains and this can be attributed to differences among GCRV genotypes.It will be important to consider multiple GCRV genotypes in the development of effective GCRV vaccines and other therapies against grass carp hemorrhagic disease.In addition,bioinformatics analysis also suggested that the protein VP6 may have a role in the process of GCRV infection.This study lays the foundation for the prevention of grass carp hemorrhagic disease and further detailed studies on the pathogenesis of GCRV. | Xiuying Yan Lingfang Xiong Jie Li Ya Wang Zaohe Wu Jichang Jian Yu Ding | 2018 | Aquaculture and Fisheries2018，3，5： | 1 |
| 17 | MCM-41-supported mercapto platinum complex as a highly efficient catalyst for the hydrosilylation of olefins with triethoxysilane显示文摘 | HU Ronghua ZHA Lingfang CAI Mingzhong | 2010 | Catal Commun2010，11，56： | 1 |
| 18 | Isolation of RNA of high quality and yield from Ginkgo biloba leaves显示文摘 | Tao Wang Nianhui Zhang Lingfang Du | 2005 | Biotechnology Letters2005，27，9： | 1 |
| 19 | Design of the solar automatic tracker of polar axis type显示文摘 | Duo Ning Na Yao Lingfang Song | 2014 | Ap plied Mechanics and Materials2014，455，8： | 1 |
| 20 | Fouling detection based on analysis of ultrasonic time-domain reflectometry using wavelet transform显示文摘 | Sun Lingfang Feng Guoliang Lu Wenxuan | | 0，，： | 1 |
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