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| 1 | Identification of long non-coding RNA p34822 as a potential plasma biomarker for the diagnosis of hepatocellular carcinoma显示文摘Dear Editor,Hepatocellular carcinoma(HCC)is the third leading cause of cancer-related deaths worldwide(Li and Satomura,2015).Early diagnosis and treatment are vital for reducing mortality.Currently,biomarkers such as serum alpha fetoprotein(AFP),AFP-L2,and carcinoembryonic antigen are widely used tumor markers for managing HCC in patients(Shi et al.,2016).However,because of their low diagnostic sensitivity and specificity,novel biomarkers with high sensitivity and specificity for early HCC diagnosis are needed. | Cheng Wang Tianyu Ren Keyu Wang Shaogeng Zhang Shubin Liu Hu Chen Penghui Yang | 2017 | Science China(Life Sciences)2017，60，9： | 2 |
| 2 | Highly Sensitive Refractive Index Sensor Based on Polymer Long-Period Waveguide Grating With Liquid Cladding显示文摘We propose a novel structure and unique sensing mechanism bio-chemical sensor which is fabricated by a polymer long-period waveguide grating with the detection liquid directly as the waveguide cladding.Quantitative detection is realized from analyzing the output absorption spectrum and resonant wavelength shift related to the liquid detection concentration.The proposed polymer long-period waveguide grating based liquid refractive-index sensor is developed experimentally,the high sensitivity of 1.01×10^4nm/RIU is achieved,and the temperature stability coefficient is 1.47nm/℃.Theoretically and experimentally,this work has been demonstrated to have potential application in chemical and biological detections and may provide an important technical support for solving today's increasingly serious civil problems such as food safety and drug safety, which will also have the important scientific significance and application prospects. | Lingfang WANG Keyu REN Bao SUN Kaixin CHEN | 2019 | Photonic Sensors2019，9，1： | 1 |
| 3 | A multifunctional electrolyte with highly-coordinated solvation structure-in-nonsolvent for rechargeable lithium batteries显示文摘Rechargeable lithium-based battery is hailed as next-generation high-energy-density battery systems.However, growth of lithium dendrites, shuttle effect of lithium polysulfides intermediates and unstable interphase of high-voltage intercalation-type cathodes largely prevent their practical deployment.Herein, to fully conquer the three challenges via one strategy, a novel electrolyte with highlycoordinated solvation structure-in-nonsolvent is designed. On account of the particular electrolyte structure, the shuttle effect is completely suppressed by quasi-solid conversion of S species in Li-S batteries,with a stable cycle performance even at lean electrolyte(5μL mg^(-1)). Simultaneously, in-situ-formed highly-fluorinated interphases can not only lower Li+diffusion barrier to ensure uniform nucleation of Li but also improve stability of NCM cathodes, which enable excellent capacity retention of Lik LiNi(0.5)Co(0.2)Mn(0.3)O2 batteries under conditions toward practical applications(high loading of 2.7 m Ah cm^(-2) and lean electrolyte of 5 m L Ah^(-1)). Besides, the electrolyte is also nonflammable. This electrolyte structure offers useful guidelines for the design of novel organic electrolytes for practical lithium-based batteries. | Hui Zhao Jjinlei Gu Yuliang Gao Qian Hou Zengying Ren Yaqin Qi Kun Zhang Chao Shen Jun Zhang Keyu Xie | 2020 | Journal of Energy Chemistry2020，29，12： | 1 |
| 4 | (Ho_(0.25)Lu_(0.25)Yb_(0.25)Eu_(0.25))_(2)SiO_(5) high-entropy ceramic with low thermal conductivity,tunable thermal expansion coefficient,and excellent resistance to CMAS corrosion显示文摘Low thermal conductivity,compatible thermal expansion coefficient,and good calcium–magnesium–aluminosilicate(CMAS)corrosion resistance are critical requirements of environmental barrier coatings for silicon-based ceramics.Rare earth silicates have been recognized as one of the most promising environmental barrier coating candidates for good water vapor corrosion resistance.However,the relatively high thermal conductivity and high thermal expansion coefficient limit the practical application.Inspired by the high entropy effect,a novel rare earth monosilicate solid solution(Ho_(0.25)Lu_(0.25)Yb_(0.25)Eu_(0.25))_(2)SiO_(5)was designed to improve the overall performance.The as-synthesized(Ho_(0.25)Lu_(0.25)Yb_(0.25)Eu_(0.25))_(2)SiO_(5)shows very low thermal conductivity(1.07 W·m-1·K-1 at 600℃).Point defects including mass mismatch and oxygen vacancies mainly contribute to the good thermal insulation properties.The thermal expansion coefficient of(Ho_(0.25)Lu_(0.25)Yb_(0.25)Eu_(0.25))_(2)SiO_(5)can be decreased to(4.0–5.9)×10^(-6)K^(-1)due to severe lattice distortion and chemical bonding variation,which matches well with that of SiC((4.5–5.5)×10^(-6)K^(-1)).In addition,(Ho_(0.25)Lu_(0.25)Yb_(0.25)Eu_(0.25))_(2)SiO_(5)presents good resistance to CMAS corrosion.The improved performance of(Ho_(0.25)Lu_(0.25)Yb_(0.25)Eu_(0.25))_(2)SiO_(5)highlights it as a promising environmental barrier coating candidate. | Zhilin CHEN Zhilin TIAN Liya ZHENG Keyu MING Xiaomin REN Jingyang WANG Bin LI | 2022 | Journal of Advanced Ceramics2022，11，8： | 1 |
| 5 | Unveiling mitophagy-mediated molecular heterogeneity and development of a risk signature model for colorectal cancer by integrated scRNA-seq and bulk RNA-seq analysis显示文摘Background:Accumulating researchers have recognized mitophagy as a key player in tumors,but few studies have investigated its role in the tumor microenvironment(TME).Advances in the technology of single-cell RNA sequencing(scRNA-seq)have allowed unveiling the concealed features of the TME at cellular resolution.This study aimed to elucidate the role of mitophagy within the TME of colorectal cancer(CRC)and to establish a mitophagy-mediated risk model.Methods:We assessed mitophagy-related pathway activities at both single-cell and tissue levels.Subsequently,an unsupervised clustering algorithm was employed to identify mitophagy-mediated subtypes.Furthermore,we developed a mitophagy-mediated risk signature(MMRS)using least absolute shrinkage and selection operator(LASSO)Cox analysis and constructed a MMRS model incorporating the risk score and clinical variables.Subsequently,we used quantitative reverse transcription polymerase chain reaction analysis to verify the expression of the screened genes.Results:We retrieved and annotated a total of 14,719 cells from eight samples in the scRNA-seq GSE132465 data set.The activities of mitophagy-related pathways were uniformly upregulated in cancer cells.Integrating with bulk RNA-seq data,we identified two mitophagy-mediated clusters(C1 and C2)with distinct characteristics and prognoses.C2 was identified as a mitophagy-high cluster.Then,we developed a five-gene MMRS via LASSO Cox analysis in The Cancer Genome Atlas(TCGA)cohort.We utilized the GSE39582 cohort to validate the efficacy of our model.The expression of CX3CL1 and INHBB was upregulated in CRC tissues.Conclusions:The present study identified two mitophagy-mediated CRC subtypes with distinct features.Our MMRS may provide potential therapeutic strategies for CRC.The findings of our work offer novel insights into the involvement of mitophagy in CRC. | Han Gao Qi Zou Linyun Ma Keyu Cai Yi Sun Li Lu Donglin Ren Bang Hu | 2023 | Gastroenterology Report2023，11，1： | 0 |
| 6 | Regulating electrodeposition behavior through enhanced mass transfer for stable lithium metal anodes显示文摘Electrode process kinetics is a key part that determines the morphology of metal electrodeposition.However,the liquid-phase mass transfer process and its effect on lithium(Li)metal electrodeposition are still poorly understood.Herein,the effect of mass transfer on the electrodeposition behavior of Li metal is explored.Experiments and COMSOL Multiphysics simulations reveal that the enhanced mass transfer,which is induced by ultrasonic wave,can homogenize the ion flow on the surface of electrode to obtain uniform Li nucleation.Meanwhile,the rapid mass transfer of Li^(+)provides sufficient cations around the germinated Li to avoid preferential growth of Li in a specific direction.Based on the simultaneous regulation of nucleation and growth behavior,a smooth and compact Li deposits can be achieved,which exhibit a small polarization voltage during repeated Li plating/striping and a considerably enhanced cyclability.This work enriches the fundamental understanding of Li electrodeposition without dendrite structure and affords fresh guidance to develop dendrite-free metal anodes for metal-based batteries. | Yuliang Gao Fahong Qiao Jingyuan You Chao Shen Hui Zhao Jinlei Gu Zengying Ren Keyu Xie Bingqing Wei | 2021 | Journal of Energy Chemistry2021，30，4： | 0 |
| 7 | External rectal prolapse:abdominal or perineal repair for men?A retrospective cohort study显示文摘Background:External rectal prolapse is a relatively rare disease,in which male patients account for a minority.The selection of abdominal repair or perineal repair for male patients has rarely been investigated.Methods:Fifty-one male patients receiving abdominal repair(laparoscopic ventral rectopexy)or perineal repair(Delorme or Altemeier procedures)at the Sixth Affiliated Hospital of Sun Yat-sen University(Guangzhou,China)between March 2013 and September 2019 were retrospectively analysed.We compared the recurrence,complication rate,post-operative defecation disorder,length of stay,and quality of life between the abdominal and perineal groups.Results:Of the 51 patients,45 had a complete follow-up,with a median of 48.5 months(range,22.8–101.8 months).A total of 35 patients were under age 40 years.The complication rate associated with abdominal repair was less than that associated with perineal repair(0%vs 20.7%,P=0.031)and the recurrence rate was also lower(9.5%vs 41.7%,P=0.018).Multivariate analysis showed that perineal repair(odds ratio,9.827;95%confidence interval,1.296–74.50;P=0.027)might be a risk factor for recurrence.Moreover,only perineal repair significantly improved post-operative constipation status(preoperative vs post-operative,72.4%vs 25.0%,P=0.001).There was no reported mortality in either of the groups.No patient’s sexual function was affected by the surgery.Conclusions:Both surgical approaches were safe in men.Compared with perineal repair,the complication rate and recurrence rate for abdominal repair were lower.However,perineal repair was better able to correct constipation. | Bang Hu Qi Zou Zhenyu Xian Dan Su Chao Liu Li Lu Minyi Luo Zixu Chen Keyu Cai Han Gao Hui Peng Wuteng Cao Donglin Ren | 2022 | Gastroenterology Report2022，10，1： | 0 |
| 8 | Syn-rift to post-rift tectonic transition and drainage reorganization in continental rifting basins:Detrital zircon analysis from the Songliao Basin,NE China显示文摘Tectonic transition from a syn-rift stage to subsequent post-rift stage is an important mechanism in the evolution of extensional basins.The sedimentary infill records the crustal response to this process.We have obtained new detrital zircon U-Pb and Lu-Hf signatures from the Lower Cretaceous stratigraphic successions encompassing the commonly accepted syn-to post-rift transition boundary,the T4 unconformity,in the Songliao Basin,NE China.These constrain the Songliao Basin’s evolution from its center to distal margins,providing insights into the sediment provenance and dispersal pattern over the tectonic transition.Analysis of zircons from the syn-rift(the Shahezi and Yingcheng formations)and immediate post-rift(the Lower and Middle Denglouku Formation)stages reveals Phanerozoic age populations with positiveƐHf(t)values,which were derived from the proximal juvenile mantle-derived melt origin bedrocks of the Songliao Block.In contrast,the overlying samples from the Upper Denglouku Formation deposited in the subsequent post-rift stage contain exotic and ancient zircon populations with ages of 2.5 Ga&1.8 Ga and complex hafnium signatures,characteristic of a mixed origin.These are interpreted to be transported from distant cratonic terranes via larger drainage networks.It is obvious that the sediment dispersal pattern switched from being a local and hydrologically closed“intraregional”pattern to a“transcontinental”pattern during the transition.The time lag between the development of the T4 unconformity and the drainage reorganization also ensures a distinguishable3 Myr(106103 Ma,Late Albian)transition period of regional extent.During this transition stage,syn-rift faulting was replaced by postrift thermal subsidence,exhibiting a uniform sag configuration.Our new findings are important for understanding other continental rift basins during syn-to post-rift transition,which often demonstrates a complex interaction between the linkage and integration of sub-basins,and the reorganization of fluvial drainages and catchment systems. | Ying Song Jianye Ren Keyu Liu Dawei Lyu Xinjie Feng Yuan Liu Andrei Stepashko | 2022 | Geoscience Frontiers2022，13，3： | 0 |
| 9 | A self-healing liquid metal anode for lithium-ion batteries显示文摘The gallium-based liquid metal as one of the self-healing materials has gained wide attention, especially in the energy storage system. However, volume expansion with the ‘‘liquid-solid-liquid”transformation process still leads to un-controlled electrode failure, which stimulates the irreversibility of liquid metal and hinders their self-healing effect as the anode for lithium-ion batteries. Herein, the polypyrrole(PPy) with highly conductive and adhesive features is first introduced to fasten the liquid metal nanoparticles(gallium-tin alloy, EGaSn) in the integrated electrode and applied as the anode for lithium-ion batteries. A tightly PPy wrapped EGaSn nanoparticles structure is formed during the in-situ polymerization synthesis process, which effectively avoids the detachment of solid alloyed products. Based on the features of PPy, polyacrylic acid is added to facilitate strengthening the integrity of the electrode by constructing the hydrogen bond. The ‘‘dual-insurance” design endows the EGaSn to exhibit superior electrochemical kinetics and an astonishing self-healing effect. As a result, the customized anode displays superior cycling stability(499.8 mAh g^(-1) after 500 cycles at 1.0 A g^(-1))and rate capability(350 mAh g^(-1) at 2.0 A g^(-1)).This work enriches the electrode engineering technology of liquid metal nanoparticles and opens up a new way to customize the self-healing anode for lithium-ion batteries. | Yaqin Qi Chao Shen Qian Hou Zengying Ren Ting Jin Keyu Xie | 2022 | Journal of Energy Chemistry2022，31，9： | 0 |
| 10 | Gadolinium-doped mesoporous tungsten oxides:Rational synthesis,gas sensing performance,and mechanism investigation显示文摘As a typical family of volatile toxic compounds,benzene derivatives are massive emission in industrial production and the automobile field,causing serious threat to human and environment.The reliable and convenient detection of low concentration benzene derivatives based on intelligent gas sensor is urgent and of great significance for environmental protection.Herein,through heteroatomic doping engineering,rare-earth gadolinium(Gd)doped mesoporous WO_(3)with uniform mesopores(15.7–18.1 nm),tunable high specific surface area(52–55 m^(2)·g^(−1)),customized crystalline pore walls,was designed and utilized to fabricate highly sensitive gas sensors toward benzene derivatives,such as ethylbenzene.Thanks to the high-density oxygen vacancies(OV)and significantly increased defects(W^(5+))produced by Gd atoms doping into the lattice of WO_(3)octahedron,Gd-doped mesoporous WO_(3)exhibited excellent ethylbenzene sensing performance,including high response(237 vs.50 ppm),rapid response–recovery dynamic(13 s/25 s vs.50 ppm),extremely low theoretical detection limit of 24 ppb.The in-situ diffuse reflectance infrared Fourier transform and gas chromatograph-mass spectrometry results revealed the gas sensing process underwent a catalytic oxidation conversion of ethylbenzene into alcohol species,benzaldehyde,acetophenone,and carboxylate species along with the resistance change of the Gd-doped mesoporous WO_(3)based sensor.Moreover,a portable smart gas sensing module was fabricated and demonstrated for real-time detecting ethylbenzene,which provided new ideas to design heteroatom doped mesoporous materials for intelligent sensors. | Yanyan Li Keyu Chen Yan Liu Junhao Ma Yaozu Liao Haitao Yang Jinsheng Cheng Qin Yue Kaiping Yuan Yuan Ren Yidong Zou Yonghui Deng | 2023 | Nano Research2023，16，5： | 0 |
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