|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Evaluation of the colorectal cancer risk conferred by rare UNC5C alleles显示文摘AIM:To evaluate the risk associated with variants of the UNC5C gene recently suspected to predispose to familial colorectal cancer(CRC).METHODS:We screened patients with familial CRC forms as well as patients with sporadic CRCs.In a first time,we analyzed exon 11 of the UNC5C gene in 120unrelated patients with suspected hereditary CRC,58patients with suspected Lynch-associated cancer or polyposis,and 132 index cases of Lynch syndrome families with a characterized mutation in a DNA mismatch repair(MMR).Next,1023 patients with sporadic CRC and1121 healthy individuals were screened for the variants identified in patients with familial cancer.RESULTS:Of 120 patients with familial CRC of unknown etiology,one carried the previously reported mis-sense mutation p.Arg603Cys(R603C)and another exhibited the unreported variant of unknown significance p.Thr617Ile(T617I).The p.Ala628Lys(A628K)mutation previously described as the main UNC5C risk variant for familial CRC was not detected in any cases of familial CRC of unknown etiology,but was present in a patient with familial gastric cancer and in two Lynch syndrome patients in co-occurrence with MMR mutations.A statistically non-significant increase in cancer risk was identified in familial CRC and/or other Lynchassociated cancers(1/178 patients vs 2/1121 healthy controls,OR=3.2,95%CI:0.29-35.05,P=0.348)and in sporadic CRCs(4/1023 patients vs 2/1121 healthy controls,OR=2.2,95%CI:0.40-12.02,P=0.364).CONCLUSION:We confirm that UNC5C mutations are very rare in familial and sporadic CRCs,but further investigations are needed to justify routine UNC5C testing for diagnostic purposes. | Sébastien Küry Céline Garrec Fabrice Airaud Flora Breheret Virginie Guibert Cécile Frenard Shuo Jiao Dominique Bonneau Pascaline Berthet Céline Bossard Olivier Ingster Estelle Cauchin Stéphane Bezieau | 2014 | World Journal of Gastroenterology2014，20，1： | 4 |
| 2 | 挪威Storgama小型源头集水区土壤和径流的天然可变性显示文摘为了提供挪威南部泰勒马克县Storgama的11个小型源头集水区(30~268 m^2)气候操控实验的基线数据,我们对位点特征和径流质量的天然可变性进行了分析。各位点径流中的年平均浓度的变异系数为26%~61%,其中总有机碳(TOC)和碳氮比(C/N)最小而无机氮(N)值最大。这些集水区的无机氮、TOC和总磷浓度比附近更大的Storgama集水区(0.6 km^2)高2~5倍。径流中的TOC和TON浓度随着土壤碳和氮含量以及集水区土壤体积而增加。对于径流中的硝酸盐(NO_3)和铵来说则相反。在潮湿年份,裸岩的比例是径流中年平均NO_3浓度的主要指示指标。 | Line Tau Strand Stle Haaland Φyvind Kaste Arne O.Stuanes 丁莉 | 2008 | AMBIO-人类环境杂志2008，37，1： | 3 |
| 3 | Aortic Stiffness Is an Independent Predictor of Fatal Stroke in Essential Hypertension显示文摘 | Stéphane Laurent Sandrine Katsahian Céline Fassot Anne-Isabelle Tropeano Isabelle Gautier Brigitte Laloux Pierre Boutouyrie | 2003 | Stroke: Journal of the American Heart Association2003，，5： | 2 |
| 4 | Plasma YKL-40 in patients with metastatic colorectal cancer treated with first line oxaliplatin-based regimen with or without cetuximab: results from the NORDIC Wl显示文摘 | Line ST Tormod KG Bengt G | 2014 | Plos One2014，9，2： | 1 |
| 5 | Syntheses of raspberrylike silica/polystyrene materials 显示文摘 | Céline Poncet-Legrand Serge Ravaine | 2002 | Chem Mater2002，14，： | 1 |
| 6 | Functional Toll-like receptors in primary first-trimester trophoblasts显示文摘 | Line H. Tanger?s Guro S. St?dle Guro D. Olsen Ann-Helen Leknes Astrid S. Gundersen Bente Skei Anne Jorunn Vikdal Liv Ryan Bj?rg Steinkjer Merete F. Myklebost Mette Langaas Rigmor Austgulen Ann-Charlotte Iversen | 2014 | Journal of Reproductive Immunology2014，，： | 1 |
| 7 | The resilience of the Indian economy to rising oil prices as a validation test for a global energy–environment–economy CGE model显示文摘 | Céline Guivarch Stéphane Hallegatte Renaud Crassous | 2009 | Energy Policy2009，，11： | 1 |
| 8 | A prospective study on radiation pneumonitis following conformal radiation therapy in non-small-cell lung cancer: clinical and dosimetric factors analysis显示文摘 | Line Claude David Pérol Chantal Ginestet Lionel Falchero Dominique Arpin Michel Vincent Isabelle Martel Stéphane Hominal Jean-Fran?ois Cordier Christian Carrie | 2004 | Radiotherapy and Oncology2004，，2： | 1 |
| 9 | Liver Steatosis Assessed by Controlled Attenuation Parameter (CAP) Measured with the XL Probe of the FibroScan: A Pilot Study Assessing Diagnostic Accuracy显示文摘 | Magali Sasso Stéphane Audière Astrid Kemgang Farid Gaouar Christophe Corpechot Olivier Chazouillères Céline Fournier Olivier Golsztejn Stéphane Prince Yves Menu Laurent Sandrin Véronique Miette | 2016 | Ultrasound in Medicine & Biology2016，，1： | 1 |
| 10 | Building SSPs for climate policy analysis: a scenario elicitation methodology to map the space of possible future challenges to mitigation and adaptation显示文摘 | Julie Rozenberg Céline Guivarch Robert Lempert Stéphane Hallegatte | 2014 | Climatic Change2014，，3： | 1 |
| 11 | Anatomical and electrophysiological plasticity of locomotor networks following spinal transection in the salamander显示文摘Recovery of locomotor behavior following spinal cord injury can occur spontaneously in some vertebrates, such as fish, urodele amphibians, and certain reptiles. This review provides an overview of the current status of our knowledge on the anatomical and electrophysiological changes occurring within the spinal cord that lead to, or are associated with the re-expression of locomotion in spinally-transected salamanders. A better understanding of these processes will help to devise strategies for restoring locomotor function in mammals, including humans. | Jean-Marie Cabelguen Stéphanie Chevallier Ianina Amontieva-Potapova Céline Philippe | 2013 | Neuroscience Bulletin2013，29，4： | 1 |
| 12 | Enteral Feeding and Early Outcomes of Patients Undergoing Allogeneic Stem Cell Transplantation Following Myeloablative Conditioning显示文摘 | David Seguy Céline Berthon Jean-Baptiste Micol Stéphane Darré Jean-Hugues Dalle Sylvain Neuville Francis Bauters Jean-Pierre Jouet Ibrahim Yakoub-Agha | 2006 | Transplantation2006，，6： | 1 |
| 13 | Schmallenberg virus experimental infection of sheep显示文摘 | Kerstin Wernike Bernd Hoffmann Emmanuel Bréard Anette B?tner Claire Ponsart Stéphan Zientara Louise Lohse Nathalie Pozzi Cyril Viarouge Pierre Sarradin Céline Leroux-Barc Mickael Riou Angele Breithaupt Martin Beer | 2013 | Veterinary Microbiology2013，，： | 1 |
| 14 | A prospective study on radiation pneumonitis following conformal radiation therapy in non-small-cell lung cancer: clinical and dosimetric factors analysis显示文摘 | Line Claude David Pérol Chantal Ginestet Lionel Falchero Dominique Arpin Michel Vincent Isabelle Martel Stéphane Hominal Jean-Fran?ois Cordier Christian Carrie | 2004 | Radiotherapy and Oncology2004，，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员