|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A study of preoperative methionine-depleting parenteral nutrition plus chemotherapy in gastric cancer patients显示文摘AIM To investigate the interference ofmethionine.free parenteral nutrition plus 5-Fu(-MetTPN+5-Fu)in gastric cancer cell kineticsand the side effects of the regimen.METHODS Fifteen patients with advancedgastric cancer were randomly divided into twogroups,7 patients were given preoperatively aseven-day course of standard parenteralnutrition in combination with a five-day courseof chemotherapy(sTPN+5-Fu),while the other8 patients were given methionine-deprivedparenteral nutrition and 5-Fu(-MetTPN+5-Fu).Cell cycles of gastric cancer and normal mucosawere studied by flow cytometry(FCM).Bloodsamples were taken to measure the serumprotein,methionine(Met)and cysteine(Cys)levels,and liver and kidney functions.RESULTS As compared with the resultsobtained before the treatment,the percentage ofG0/G1 tumor cells increased and that of S phasedecreased in the-MetTPN+5-Fu group,while thecontrary was observed in the sTPN+5-Fu group.Except that the ALT,AST and AKP levels wereslightly increased in a few cases receiving-MetTPN+5-Fu,all the other biochemicalparameters were within normal limits.Serum Cys level decreased slightly after the treatmentin both groups.Serum Met level of patientsreceiving sTPN+5-Fu was somewhat higher aftertreatment than that before treatment;however,no significant change occurred in the -MetTPN+5-Fu group,nor operative complications in bothgroups.CONCLUSION -MetTPN+5-Fu exerted asuppressive effect on cancer cell proliferation,probably through a double mechanism ofcreating a state of'Met starvation'adverse tothe tumor cell cycle,and by allowing 5-Fu to killspecifically cells in S phase.Preoperative short-term administration of -MetTPN+5-Fu had littleundesirable effect on host metabolism. | Cao WX Cheng QM Fei XF Li SF Yin HR Lin YZ | 2000 | World Journal of Gastroenterology2000，6，2： | 22 |
| 2 | Sedation and safety of propofol for therapeutic endoscopic retrograde cholangiopancreatography显示文摘Endoscopic retrograde cholangiopancrea tography(ERCP) is the most complex gastrointestinal procedure,which needs patients’ cooperation. The aim of this study was to observe the quality and safey of sedation with propofol in patients undergoing therapeutic ERCP. METHODS:Seventy patients who had undergone therapeutic ERCP were randomly divided into two groups.One group, given intravenously propofol, and the other sedated with routine method, served as the control. Blood pressure, heart rate,oxygen saturation were monitored and cardiorespiratory event was observed. Patient cooperation,performance, recovery time and amnesia served as variables postoperation. RESULTS:Blood pressure elevated in four patients in the propofol group, less than in the control group(P<0.01). Seven patients showed decreased blood pressure after administration of propofol,but none in the control group (P<0.01). Twelve patients in the control group showed mild or significant resistance, but none in the propofol group (P<0.01). The time for performance in the propofol group(P<0.05) was shorter than in the control group. Patient recovery was quicker in the propofol group than in the control group (P<0.01). The degree of amnesia better in the propofol group than in the control group ( P<0.01). The degree of amnesia was also better in the propofol group than in the control group (P<0.01). CONCLUSIONS:Propofol proves to be an excellent sedative for therapeutic ERCP. Being effective and safe, it shows a shorter ERCP duration but quick recovery and better amnesia. It is better than other routine sedatives. | Digestive Department (Chen WX, Lin HJ, Gu Q, Zhong XQ, Yu CH, Li YM and Gu ZY) and Department of Intensive Care Unit (Zhang WF), First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003 , China | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 10 |
| 3 | Distribution of sorbed phenanthreneand pyrene in different humic fractions of soils andimportance of humin显示文摘 | Pan B Xing BS Liu WX Tao S Lin XM Zhang YX XiaoY Dai HC Yuan HS | 2006 | Environmental Pollution2006，143，3： | 1 |
| 4 | Analysis of DAX1 (NROB1) and steroidogenic factor-1 (NR5A1) in children and adults with primary adrenal failure: ten years' experience 显示文摘 | Lin L Gu WX Ozisik G | 2006 | J Clin Endocrinol Metab2006，91，8： | 1 |
| 5 | Association of serum levels of glycated albumin, C-reactive protein and tumor necrosis factor- α with the severity of coronary artery disease and renal impalrment in patients with type 2 diabetes mellitus显示文摘 | LIN L LI JP XUE WX | 2007 | Clinical Biochcmistry2007，40，11： | 1 |
| 6 | Proteomic approach formolecular physiological mechanism on consecutive monoculture problems of Rehmanniaglutinosa显示文摘 | Lin WX Fang CX Wu LK | 2011 | Journal of Integrated Omics2011，1，2： | 1 |
| 7 | Rice allelopathic potential and its modes of action on barnyard grass Echinochloa crusgalli 显示文摘 | Lin WX Kim KU | 2000 | Allelopathy J2000，7，2： | 1 |
| 8 | Rice allelopathic potential and its modes of action on barnyardgrass(Echinochloa crus-galli)显示文摘 | LIN WX KIM KU SHIN DH | 2000 | Allelopathy Journal2000，7，2： | 1 |
| 9 | Analysis of DAX1 ( NROB1 ) and steroidogenic factor-1 ( NR5A1 ) in children and adults with pri- mary adrenal failure : ten years experience 显示文摘 | Lin L Gu WX Ozisik G | 2006 | J Clin Endocrinol Metab2006，324，91： | 1 |
| 10 | Methane production potential and methanogenic archaea community dynamics along the Spartina alterniflora invasion chrono- sequence in a coastal salt marsh显示文摘 | Yuan JJ Ding WX Liu DY Xiang J Lin YX | 2014 | Applied Microbiology and Biotechnology2014，98，4： | 1 |
| 11 | The beta identity of class I PtdIns3K:A positive role of p110β in autophagy revealed显示文摘 | Dou Z Pan JA Lin RZ Zong WX | 2011 | Autophagy2011，7，2： | 1 |
| 12 | Bactericidal activity of isothiocyanate against pathogens on fresh produce显示文摘 | Lin CM Kim J Du WX | 2000 | Journal of Food Protection2000，63，： | 1 |
| 13 | Notch signaling pathway and human placenta 显示文摘 | Zhao WX Lin JH | 2012 | Int JMedSci2012，9，6： | 1 |
| 14 | Analysis of DAXI(NROBI) and steroidogenic factor-1 (NRSAI) in children and adults with primary adrenal failure: ten years' experience 显示文摘 | Lin L Gu WX Ozisik G | 2006 | J Clin Endocrinol Metab2006，91，8： | 1 |
| 15 | SLC25A13 gene analysis in citrin deficiency:sixteen novel mutations in East Asian patients,and the mu-tation distribution in a large pediatric cohort in China 显示文摘 | Song YZ Zhang ZH Lin WX | 2013 | PLoS One2013，8，74： | 1 |
| 16 | Clinical,molecular and functional investigation on an infant with neonatal intrahepatic cholestasis caused by citrin deficiency(NICCD)显示文摘 | Zhang ZH Lin WX Deng M | 2014 | PLoS One2014，9，89： | 1 |
| 17 | Comparison of the efficacy and safety of EFGR tyrosine kinase inhibitor monotherapy with standard second-line chemotherapy in previously treated advanced non-small-cell lung cancer:A systematic review and meta-analysis 显示文摘 | Qi WX Shen Z Lin F | 2012 | Asian Pac J Cancer Prev2012，13，10： | 1 |
| 18 | Cytokine network and mechanism of traditional Chinese medicine显示文摘 | Shen WX Lin YM | 2000 | World Sci Teach-Mod Tradit Chin Med2000，2，6： | 1 |
| 19 | Rice allelopathic potential and its modes of action on bamyardgrass (Echinochloa crusgalli)显示文摘 | Lin WX Kim KU Smin DH | | 0，，02： | 1 |
| 20 | Distributions and assemblages of microbial communities along a sediment core retrieved from a potential hydrate-bearing region offshore southwestern Taiwan 显示文摘 | Lin LH Wu LW Cheng TW Tu WX Lin JR Yang TF Chen PC Wang YS Wang PL | 2014 | J Asian Earth Sci2014，92，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员