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| 1 | Association of PINK1 and DJ-1 confers digenic inheritance of early-onset Parkinson's disease显示文摘 | Tang B Xiong H Sun P Zhang Y Wang D Hu Z Zhu Z Ma H Pan Q Xia JH Xia K Zhang Z | 2006 | 中国生物学文摘2006，20，8： | 30 |
| 2 | Gender and racial differences in nonalcoholic fatty liver disease显示文摘Due to the worldwide epidemic of obesity, nonalcoholic fatty liver disease(NAFLD) has become the most com-mon cause of elevated liver enzymes. NAFLD represents a spectrum of liver injury ranging from simple steato-sis to nonalcoholic steatohepatitis(NASH) which may progress to advanced fibrosis and cirrhosis. Individuals with NAFLD, especially those with metabolic syndrome, have higher overall mortality, cardiovascular mortality, and liver-related mortality compared with the general population. According to the population-based studies, NAFLD and NASH are more prevalent in males and in Hispanics. Both the gender and racial ethnic differences in NAFLD and NASH are likely attributed to interaction between environmental, behavioral, and genetic fac-tors. Using genome-wide association studies, several genetic variants have been identified to be associated with NAFLD/NASH. However, these variants account for only a small amount of variation in hepatic steatosis among ethnic groups and may serve as modifiers of the natural history of NAFLD. Alternatively, these variants may not be the causative variants but simply markers representing a larger body of genetic variations. In this article, we provide a concise review of the gender and racial differences in the prevalence of NAFLD and NASHin adults. We also discuss the possible mechanisms for these disparities. | Jen-Jung Pan Michael B Fallon | 2014 | World Journal of Hepatology2014，6，5： | 10 |
| 3 | Monitoring the impact of climate change and human activities on grassland vegetation dynamics in the northeastern Qinghai-Tibet Plateau of China during 2000–2015显示文摘Climate change and human activities can influence vegetation net primary productivity(NPP), a key component of natural ecosystems. The Qinghai-Tibet Plateau of China, in spite of its significant natural and cultural values, is one of the most susceptible regions to climate change and human disturbances in the world. To assess the impact of climate change and human activities on vegetation dynamics in the grassland ecosystems of the northeastern Qinghai-Tibet Plateau, we applied a time-series trend analysis to normalized difference vegetation index(NDVI) datasets from 2000 to 2015 and compared these spatiotemporal variations with trends in climatic variables over the same time period. The constrained ordination approach(redundancy analysis) was used to determine which climatic variables or human-related factors mostly influenced the variation of NDVI. Furthermore, in order to determine whether current conservation measures and programs are effective in ecological protection and reconstruction, we divided the northeastern Qinghai-Tibet Plateau into two parts: the Three-River Headwater conservation area(TRH zone) in the south and the non-conservation area(NTRH zone) in the north. The results indicated an overall(73.32%) increasing trend of vegetation NPP in grasslands throughout the study area. During the period 2000–2015, NDVI in the TRH and NTRH zones increased at the rates of 0.0015/a and 0.0020/a, respectively. Specifically, precipitation accounted for 9.2% of the total variation in NDVI, while temperature accounted for 13.4%. In addition, variation in vegetation NPP of grasslands responded not only to long-and short-term changes in climate, as conceptualized in non-equilibrium theory, but also to the impact of human activities and their associated perturbations. The redundancy analysis successfully separated the relative contributions of climate change and human activities, of which village population and agricultural gross domestic product were the two most important contributors to the NDVI changes, explaining 17.8% and 17.1% of the total variation of NDVI(with the total contribution >30.0%), respectively. The total contribution percentages of climate change and human activities to the NDVI variation were 27.5% and 34.9%, respectively, in the northeastern Qinghai-Tibet Plateau. Finally, our study shows that the grassland restoration in the study area was enhanced by protection measures and programs in the TRH zone, which explained 7.6% of the total variation in NDVI. | XIONG Qinli XIAO Yang Marwa Waseem A HALMY Mohammed A DAKHIL LIANG Pinghan LIU Chenggang ZHANG Lin Bikram PANDEY PAN Kaiwen Sameh B EL KAFRAWAY CHEN Jun | 2019 | Journal of Arid Land2019，11，5： | 10 |
| 4 | Linkage of microbiota and osteoporosis:A mini literature review显示文摘The gut microbiota(GM) has become a recent topic of interest in the role of many disease states. Assessing patients with osteoporosis(OP), there is a strong correlation between gut microbe dysregulation and decreased bone density. Gut dysbiosis may lead to inflammation, dysregulation of nutrient and calcium transport across the intestine into circulation and systemic inflammation.Investigation of microbial profile relative to normal gut microbiomes, assessment of inflammatory markers such as interleukin-1(IL-1), IL-6, and tumor necrosis factor-alpha. Therapies to normalize GM in patients with OP or prevent occurrence of OP to be investigated include: High fiber prebiotic diets to promote growth of normal gut bacteria and short chain fatty acid production, Probiotics to encourage growth of normal gut microbes, and antibiotic treatment followed by fecal matter transplant. | David Yatsonsky Ⅱ Karen Pan Vithal B Shendge Jiayong Liu Nabil A Ebraheim | 2019 | World Journal of Orthopedics2019，10，3： | 7 |
| 5 | Effect of Sr on microstructure and aging behavior of Mg-14Li alloys | Bin Jiang a,b,c,Ying Zeng b,Hengmei Yin a,b,Ruihong Li a,b,Fusheng Pan a,b a National Engineering Research Center for Magnesium Alloys,Chongqing University,Chongqing 400030,China b College of Materials Science and Engineering,Chongqing University,Chongqing 400030,China c New Materials Center,Chongqing Academy of Science and Technology,Chongqing 401123,China | 2012 | Progress in Natural Science:Materials International2012，22，2： | 3 |
| 6 | 透析前后血压水平与全因死亡风险的关系:一项剂量-效应关系的荟萃分析显示文摘血液透析人群的血压管理是一个巨大挑战。该研究旨在通过剂量-效应关系的荟萃分析,评估血液透析人群中透析前后血压水平与全因死亡风险之间关联的定量特征和潜在阈值。研究人员搜索了2017年3月18日之前发表的、关于透析前后血压水平与全因死亡率风险关联的所有前瞻性队列研究资料,共纳入来自8项研究的229688例普通血液透析患者。 | 刘莉 叶鹏 Han YC Tu Y Zhou LT Pan MM Wang B Liu H Tang RN Liu BC | 2018 | 中华高血压杂志2018，26，11： | 2 |
| 7 | Effect of physical forms of soil organic matter on phenanthrene sorption 显示文摘 | Pan B Xing B Tao S | 2007 | Chemosphere2007，68，： | 1 |
| 8 | Microtia: ear reconstruction using tissue expander and autogenous costal cartilage 显示文摘 | PAN B JIANG H GUO D | 2008 | J Plast Reconstr Aesthet Surg2008，61，： | 1 |
| 9 | Adsorption - Dessorption of phosphate on airborne dust and riverbone particulates in east medcterranean seawater显示文摘 | G Pan M D Krom B Herut | 2002 | Environ Sci Technol2002，36，： | 1 |
| 10 | A Novel Differential Evolution Algorithm for Bi-criteria No-wait Flow Shop Scheduling Problems显示文摘 | PAN Q K WANG L QIAN B | 2009 | Computers and Operations Research2009，36，8： | 1 |
| 11 | Fabrication of threedimensional cartilaginous framework in auricular reconstruction显示文摘 | Jiang H Pan B Lin L | 2008 | J Plast Reconstr Aesthetic Surg2008，61，1： | 1 |
| 12 | Effect of green tea polyphenols on dopamine uptake and on MPP ^+ -induced dopamine neuron injury显示文摘 | Pan T H Fei J Zhou X B | 2003 | Life Sci2003，72，： | 1 |
| 13 | Modulation of iron homeostasis in macrophages by bacterial intracellular pathogens显示文摘 | Pan X Tamilselvam B Hansen EJ | 2010 | BMC Microbiol2010，1064，： | 1 |
| 14 | Derivatiration/Solid - phase Microextraction: New Approach to Polar Analytes显示文摘 | Pan L Pawliazyn J B | 1977 | Anal Chem1977，，69： | 1 |
| 15 | Plant miemRNA:A small regulatory molecule with big impact显示文摘 | Zhang B H Pan X Cobb GP | 2006 | Dev Bio12006，289，： | 1 |
| 16 | Resistance to ammonia stress of Penaeus monodon Fabricius Juvenile fed diets supplemented with astaxanthin 显示文摘 | PAN C H CHIEN Y H HUNTER B T | 2003 | J Exp Marine Biol Ecol2003，297，1： | 1 |
| 17 | MicroRNAs as oncogenes and tumor suppressors显示文摘 | Zhang B Pan X Cobb G P | 2007 | Dev Biol2007，302，1： | 1 |
| 18 | Downregulation and abromal expression of E-cadherin and β-catenin in nasopharyngeal carcinoma:close association with advanced disease stage and lymph node metastasis显示文摘 | Zheng Z Pan J Chu B | 1999 | Hum Pathol1999，30，4： | 1 |
| 19 | Random-peptide librar-ies and antigen-fragment libraries for epitope mappingand the development of vaccines and diagnostics显示文摘 | Irving M B Pan O Scott J K | 2001 | Curr Opin Chem Biol2001，5，3： | 1 |
| 20 | Selective removal of Cu(Ⅱ) ions by using cation-exchange resin-supported polyethyleneimine (PEI)nanoclusters显示文摘 | Chen Y L Pan B C Li H Y | 2010 | Environmental Science and Technology2010，44，： | 1 |
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