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| 1 | Human hepatic sinusoidal endothelial cells can be distinguished by expression of phenotypic markers related to their specialised functions in vivo显示文摘The hepatic sinusoids are lined by a unique population of hepatic sinusoidal endothelial cells (HSEC), which is one of the first hepatic cell populations to come into contact with blood components. However, HSEC are not simply barrier cells that restrict the access of blood- borne compounds to the parenchyma. They are func- tionally specialised endothelial cells that have complex roles, including not only receptor-mediated clearance of endotoxin, bacteria and other compounds, but also the regulation of inflammation, leukocyte recruitment and host immune responses to pathogens. Thus understand- ing the differentiation and function of HSEC is critical for the elucidation of liver biology and pathophysiology. This article reviews methods for isolating and studying human hepatic endothelial cell populations using in vitro models. We also discuss the expression and functions of phe- notypic markers, such as the presence of fenestrations and expression of VAP-1, Stabilin-1, L-SIGN, which can be used to identify sinusoidal endothelium and to permit discrimination from vascular and lymphatic endothelial cells. | PF Lalor SM Curbishley S Shetty DH Adams | 2006 | World Journal of Gastroenterology2006，12，34： | 11 |
| 2 | DSA analysis of hepatic arteriovenous fistula concurrent with hepatic cancer and its clinical significance显示文摘INTRODUCTIONIntervention therapy has become one of the maintherapies of hepatic cancer.Theintroduction of hepatic arterial perfusion andembolization has provided opportunities for asecondary operation on patients with intermediateand advanced cancer,thus | Guo WP Zhang HX Wang ZM Wang YQ Ni DH Li WX Guan Y | 2000 | World Journal of Gastroenterology2000，6，6： | 11 |
| 3 | Influence of gut bacteria on development and progression of non-alcoholic fatty liver disease显示文摘The intestine of the human contains a dynamic population of microbes that have a symbiotic relationship with the host. In addition, there is an effect of the intestinal microbiota on metabolism and digestion. Non-alcoholic fatty liver disease(NAFLD) is a common cause worldwideof hepatic pathology and is thought to be the hepatic manifestation of the metabolic syndrome. In this review we examine the effect of the human microbiome on the components and pathogenesis of the metabolic syndrome. We are now on the threshold of therapeutic interventions on the human microbiome in order to effect human disease including NAFLD. | Ali Abdul-Hai Ali Abdallah Stephen DH Malnick | 2015 | World Journal of Hepatology2015，7，12： | 7 |
| 4 | 受体靶向多肽载体抗肿瘤药物显示文摘常规化疗药物对癌细胞没有选择性,常常会导致严重的副作用。提高这些药物的靶向特异性已成为药物开发的热点方向之一。一些小分子多肽能够靶向作用于特定的受体,因而被用作癌症化疗药物的载体。化疗药物与多肽载体偶联构成新的多肽载体抗肿瘤药物。这些药物具有高特异性、高亲和力和肿瘤渗透力等优点,能够通过细胞表面的特定受体将药物送到靶向癌细胞内,提高抗癌效果、减少副作用和癌细胞的耐药性。多肽载体靶向药物被誉为新一代的靶向特异性的抗肿瘤药物之一。 | 孙立春 Coy DH | 2015 | 上海医药2015，36，1： | 5 |
| 5 | A Novel Electrocatalysis Method for Organic Pollutants Degradation显示文摘A novel electrocatalysis, ferrous ion catalyzed anodic-cathodic electrocatalysis (FACEC), was developed for organic pollutants degradation, which could promote the degradation by achieving synergetic effects of both anodic oxidation and cathodic indirect oxidation. The degradation rate of model pollutants phenol by FACEC could increase by nearly 30% comparing with that of anodic electrocatalysis, and the current efficiency could reach 67%. | Zhou, MH Wu, ZC Wang, DH | 2001 | Chinese Chemical Letters2001，12，10： | 5 |
| 6 | 凝血酶肽类对创面愈合及表皮细胞增生与移行的作用研究显示文摘目的探讨新合成的凝血酶受体激活肽 TP508对创面愈合及表皮细胞增生与移行的作用。方法SD大鼠 18只,麻醉下在每一大鼠背部作 4个直径 1.5 cm圆形皮肤切除创面。 TP508治疗组 9只大鼠,每 1创面用 TP508 0.1μg(40ml)治疗。对照组9只大鼠用40μl等渗盐水处理。用 JAVA Jandel和 IMAGE PRO图形处理软件计算创面面积。人表皮细胞NHEK945增生采用MTT测定法和细胞计数仪直接计数法。细胞移行实验采用48孔 Boyden细胞移行测定板进行,移行至滤膜下表面的细胞数以斑点密度表示。结果术后 7 d和 14 d,TP508处理组创面面积分别为盐水组的73.7%和45.4%(P<0.01)。凝血酶、TP508显著促进表皮细胞增生。培养液组细胞移行斑点密度为 76.6±13.8,添加 1μg/ml凝血酶和 10 μg/ml TP508,其斑点密度分别增至 104.4±12.2和109.4±14.6。结论凝血酶及TP508对大鼠皮肤切除创面愈合及人表皮细胞增生与移行均有显著作用,后者在一定程度上解释了TP508促进创面愈合的机理。 | 黄跃生 杨宗城 黎鳌 DH Carney | 2000 | 中华烧伤杂志2000，16，1： | 5 |
| 7 | Comparison of two remote sensing models for estimating evapotranspiration: algorithm evaluation and application in seasonally arid ecosystems in South Africa显示文摘Remote sensing tools are becoming increasingly important for providing spatial information on water use by different ecosystems. Despite significant advances in remote sensing based evapotranspiration(ET) models in recent years, important information gaps still exist on the accuracy of the models particularly in arid and semi-arid environments. In this study, we evaluated the Penman-Monteith based MOD16 and the modified Priestley-Taylor(PT-JPL) models at the daily time step against three measured ET datasets. We used data from two summer and one winter rainfall sites in South Africa. One site was dominated by native broad leaf and the other by fine leafed deciduous savanna tree species and C4 grasses. The third site was in the winter rainfall Cape region and had shrubby fynbos vegetation. Actual ET was measured using open-path eddy covariance systems at the summer rainfall sites while a surface energy balance system utilizing the large aperture boundary layer scintillometer was used in the Cape. Model performance varied between sites and between years with the worst estimates(R2<0.50 and RMSE>0.80 mm/d) observed during years with prolonged mid-summer dry spells in the summer rainfall areas. Sensitivity tests on MOD16 showed that the leaf area index, surface conductance and radiation budget parameters had the largest effect on simulated ET. MOD16 ET predictions were improved by:(1) reformulating the emissivity expressions in the net radiation equation;(2) incorporating representative surface conductance values;and(3) including a soil moisture stress function in the transpiration sub-model. Implementing these changes increased the accuracy of MOD16 daily ET predictions at all sites. However, similar adjustments to the PT-JPL model yielded minimal improvements. We conclude that the MOD16 ET model has the potential to accurately predict water use in arid environments provided soil water stress and accurate biome-specific parameters are incorporated. | Sebinasi DZIKITI Nebo Z JOVANOVIC Richard DH BUGAN Abel RAMOELO Nobuhle P MAJOZI Alecia NICKLESS Moses A CHO David C LE MAITRE Zanele NTSHIDI Harrison H PIENAAR | 2019 | Journal of Arid Land2019，11，4： | 4 |
| 8 | Topologic configuration of a graphoglyptid and its functional morphologic analysis显示文摘IN the course of investigating the electric current and voltage efficiency of a circuit, it is more important to study its topologic configuration than to Study its Euclidean geometric morphology. If two kinds of partial topologic variations take place in the tree-network circuit, its electric current and voltage efficiency will synchronously change, but the electric current and | Gong, YM Huang, DH | 1997 | Chinese Science Bulletin1997，42，16： | 4 |
| 9 | Behaviour of Hydrogen in Nano-transition Metals显示文摘Nanocrystalline transition metals were prepared with Ar+H2 arc plasma method. The hydrogenmust be used during preparation to get a special nanrvparticles. The hydrogen plays an importantrole in the structure and state of nanocrystalline transition metals. The state of hydrogen andthe change of the nanocrystalline metal structure caused by hydrogen are called the behaviour ofhydrogen in nano-transition metals which includes the ability and function of storing hydrogenin the metals. | Zhang, ZK Cui, ZL Chen, KZ Zuo, DH Dong, LF | 1996 | Journal of Materials Science & Technology1996，12，1： | 4 |
| 10 | 慢性乙型肝炎患者使用他汀类药物与肝细胞癌发生风险的关系显示文摘【据《Hepatology》2019年10月报道】题:慢性乙型肝炎患者使用他汀类药物与肝细胞癌发生风险的关系(作者Goh MJ等)他汀类药物具有多效性,包括化学预防作用。一些观察性研究表明他汀类药物可以预防肝细胞癌(HCC),但其在慢性乙型肝炎中与HCC的关系尚未得到充分研究。该研究旨在探索慢性乙型肝炎患者使用他汀类药物与HCC发生风险的关系。来自韩国首尔的Goh等进行了一项基于医院的回顾性队列研究,作者于2008年1月-2012年12月在韩国首尔单中心收集了7713例慢性乙型肝炎患者,主要研究结局为发生HCC。他汀类药物的使用依据世界卫生组织推荐的每日用药剂量(DDD),随访期间使用的任意种类的他汀类药物的累计每日用药剂量定义为cDDD。随访期间使用他汀类药物cDDD至少28次的患者,被定义为他汀类药物使用者(n=713),为探索他汀类药物的剂量效应关系,将他汀类药物使用剂量分成5组,分别为<28、28~365、366~730、731~1095、>1095。应用时间相关协变量的多变量Cox回归模型来分析使用他汀类药物与HCC发病率的关系。 | 周胜云 段志辉 GOH MJ SINN DH KIM S | 2020 | 临床肝胆病杂志2020，36，1： | 4 |
| 11 | Azithromycin:A review of its antimicrobial activity,pharmacokinetic properties and clinical efficiency 显示文摘 | Peters DH Friede HA Metwsh D | 1992 | Drugs1992，44，5： | 2 |
| 12 | Adrenal adenomas and nonadenomas: assessment of washout at delayed contrast-enhanced CT显示文摘 | Szolar DH Kammerhuber FH | 1998 | Radiology1998，207，： | 2 |
| 13 | Feeding artery pressure and venous drainage pattern are primary determinants of hemorrhage from cerebral arteriovenous malformations显示文摘 | Duong DH Young WL Vang MC | 1998 | Stroke1998，29，9： | 2 |
| 14 | Relationship between visual evoked potentials and intracranial pressure显示文摘 | York DH Pulliam MW Rosenfeld JG | 1981 | J Neurosurg1981，55，： | 2 |
| 15 | It's time to revise the definition of status epilepticus显示文摘 | Lowenstein DH Bleck TP Macdonald RL | 1999 | Epilepsia1999，40，1： | 2 |
| 16 | Rheological properties of contraceptive gels显示文摘 | Owen DH Peters JJ Katz DF | 2000 | Contraception2000，62，： | 2 |
| 17 | Coexisting epithelioid trophoblastic tumor and choriocarcinoma of the uterus following a chemoresistant hydatidiform mole 显示文摘 | Shen DH Khoo US Ngan HY | 2003 | Arch Pathol Lab Med2003，127，： | 2 |
| 18 | Synthesis and Characterization of Mixed Al+AlN Nanoparticles显示文摘Mixed Al+AlN nanoparticles were synthesized by an active plasma-metal reaction method. Mean particle size of the mixed Al+AlN nanoparticles is about 30-50 nm. Defects were found in some AlN particles. Moreover, the AlN ratio and its particle size in mixed Al+AIN nanoparticles obtained in different atmospheres (N2+Ar) increase with increasing N2 particle pressure, and the specific sudece areas of the mixed Al+AlN nanoparticles increase with the AlN ratio. The surface degradation of the Al+AlN exposed to air is estimated by the infrared absorption | Sun, XC Yang, MC Ye, F Sun, XK Wei, WD Yu, YD Ping, DH | 1997 | Journal of Materials Science & Technology1997，13，4： | 2 |
| 19 | Polymorphism in the TNFα and TNF-receptor genes in patients with coronary artery disease显示文摘 | Allen RA Lee EM Roberts DH | 2001 | Eur J Clin Invest2001，31，： | 2 |
| 20 | 光固化修复材料的吸水性对人工间隙的影响显示文摘目的 :本实验比较了两种光固化修复材料复合体 /复合树脂在 12周浸水实验后人工间隙的变化。方法 :选择 40个深 5mm ,内径 5 .5mm的玻璃圆柱体作为人工洞形 ,其内表面的 1/ 2进行喷砂 ,酸蚀 ,硅烷化 ,涂布一层牙本质粘接剂Primer&BondNT ,分别由光固化材料DyractAP(D)和SpectrumTPH(S)充填各 2 0个 ,这样在圆柱体的未粘接面形成人工间隙。每组中 10个样本浸泡在 37℃的去离子水中 (W) ,10个样本浸泡在 37℃的硅油 (O)中 ,通过光学显微镜放大 5 70倍测量 0 ,1,2 ,4,6 ,8,10 ,12周每个样本产生的最大间隙值 ,并进行统计分析 ,同时检测间隙减小的程度与储存时间的关系。结果 :统计分析得出不同时间测量的两种材料最大间隙值在浸水组有显著性差异 (P<0 .0 0 1) ,在浸油组却不存在 (P >0 .0 5 ) ,进一步分析D -W组在第六周后和S -W组在第四周后就无显著性差异 ;线性回归分析显示D -W和S -W这两组中的间隙宽度随时间以指数形式减少 ,从回归线的斜率可得出D -W组的间隙减少的速率比S -W组快 4.6倍。结论 :人工间隙的减小是由两种光固化材料的吸水性决定 ,而且在DyractAP组中间隙减小得更多、更快。 | 黄翠 郑智明 张顺彬 祈理海 韦汉贤 Pashley DH | 2002 | 口腔医学研究2002，18，3： | 2 |
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