|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities显示文摘Aim:To clarify the mechanism of the therapeutic action of icariin on erectlile dysfunction(ED).Methods:PDE5 was isolated from the human platelet and PDE4 form the rat liver tissue using the FPLC system (Pharmacia,Milton Keynes,UK)and the Mono Q column.The inhibitory effects of icariin on PDE5 and PDE4 activities were investigated by the two-step radioisotope procedure with [^3H]-c GMP/[^3H]-cAMP.Papaverine served as the control drug.Results:Icariin and papaverine showed dose-dependent inhibitory effects on PDE5 and PDE4 activities.The IC50 of Icariin and papaverine on PDE5 were 0.432μ mol/L and 0.680μmol/L,respectively and those on PDE4,73.50μmol/L and 3.07μmol/L,respectively.The potencies of selectivity of icariin and papaverine on PDE5(PDE4/PDE5 of IC50)were 167.67 times and 4.54 times,respectively.Conclusion:Icariin is a cGMP-specific PDE5 inhibitor that may be developed into an oral effective agent for the treatment of ED. | ZC Xin EK Kim CS Lin WJ Liu L Tian YM Yuan J Fu | 2003 | Asian Journal of Andrology2003，5，1： | 38 |
| 2 | Sedation and safety of propofol for therapeutic endoscopic retrograde cholangiopancreatography显示文摘Endoscopic retrograde cholangiopancrea tography(ERCP) is the most complex gastrointestinal procedure,which needs patients’ cooperation. The aim of this study was to observe the quality and safey of sedation with propofol in patients undergoing therapeutic ERCP. METHODS:Seventy patients who had undergone therapeutic ERCP were randomly divided into two groups.One group, given intravenously propofol, and the other sedated with routine method, served as the control. Blood pressure, heart rate,oxygen saturation were monitored and cardiorespiratory event was observed. Patient cooperation,performance, recovery time and amnesia served as variables postoperation. RESULTS:Blood pressure elevated in four patients in the propofol group, less than in the control group(P<0.01). Seven patients showed decreased blood pressure after administration of propofol,but none in the control group (P<0.01). Twelve patients in the control group showed mild or significant resistance, but none in the propofol group (P<0.01). The time for performance in the propofol group(P<0.05) was shorter than in the control group. Patient recovery was quicker in the propofol group than in the control group (P<0.01). The degree of amnesia better in the propofol group than in the control group ( P<0.01). The degree of amnesia was also better in the propofol group than in the control group (P<0.01). CONCLUSIONS:Propofol proves to be an excellent sedative for therapeutic ERCP. Being effective and safe, it shows a shorter ERCP duration but quick recovery and better amnesia. It is better than other routine sedatives. | Digestive Department (Chen WX, Lin HJ, Gu Q, Zhong XQ, Yu CH, Li YM and Gu ZY) and Department of Intensive Care Unit (Zhang WF), First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003 , China | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 10 |
| 3 | Staffing levels and patient needs in the intensive care Unit显示文摘 | Wu LC Chen YM Lin YW | 1993 | Kao Hsiung I Hsueh Ko Hsueh Tsa Chin1993，9，6： | 1 |
| 4 | Effects of different magnitudes of mechanical strain on Osteoblasts in vitro显示文摘 | Tang L Lin Z Li YM | 2006 | Biochem Biophys Res Commun2006，344，1： | 1 |
| 5 | Components of Hedyotis diffusa Wild显示文摘 | Tai D F Lin YM Chen F C | 1979 | Hua Hsueh1979，，3： | 1 |
| 6 | Evaluation of methods and timing in nail dynamisation for treating delayed healing femoral shaft fractures 显示文摘 | Huang KC Tong KM Lin YM | 2012 | Injury2012，43，10： | 1 |
| 7 | Three LactobaciUus strains from healthy infant stool inhibit enterotoxigenic Escherichia coli grown in vitro显示文摘 | Tsai CC Lin PP Hsieh YM | 2008 | Anaerobe2008，14，2： | 1 |
| 8 | Expression and functional analysis of pituitary tumor transforming gene - 1 in uterine leiomyomas 显示文摘 | Tsai SJ Lin SJ Cheng YM | 2005 | J Clin Endocrinol Metab2005，90，： | 1 |
| 9 | The organic precursors affecting the formation of disinfection by-products with chlorine dioxide显示文摘 | Chomg CY Hsieh YH Lin YM | 2001 | Chemosphere2001，44，： | 1 |
| 10 | Roux-en-Y reconstruc-tion after distal gastrectomy to reduce enterogastric reflux and Helicobacter pylori infection 显示文摘 | Chan DC Fan YM Lin CK etal | 2007 | J GastrointestSurg2007，，12： | 1 |
| 11 | Structural basis for the identification f the N terminal domain of coronavirus nucleo- capsid protein as an antiviral target 显示文摘 | Lin SY Liu CL Chang YM | 2014 | Med Chem2014，57，6： | 1 |
| 12 | Mechanisms controlling the effects of bevacizumab(Avastin) on the inhibition of early but not late formed cor-neal neovascularization显示文摘 | CHEN WL CHEN YM CHU HS LIN CT CHOW LP CHENCT | 2014 | PLoS One2014，9，94： | 1 |
| 13 | Ultrahigh-pressure (4.5-5.5 GPa) experimental research on pyroxene-garnet transition and its significance显示文摘Al-PYROXENE in nature may be regarded as garnet solid solution in Al-free pyroxene. The transition from Al-pyroxene to garnet + Al-poor pyroxen can be carried out under high-pressure conditions. Ultrahigh-pressure experiment on pyroxene-garnet transition was carried out in this work using natural soecimens to exolain the genesis of garnet peridotite. | Fan, QC Liu, RX Xie, HS Zhang, YM Lin, ZR | 1997 | Chinese Science Bulletin1997，42，17： | 1 |
| 14 | AZFa candidate gene deletions in Taiwanese patients with spermatogenic failure显示文摘 | Lin YM Teng YN Lee PC | 2001 | J Formos Med Assoc2001，100，9： | 1 |
| 15 | A pilot study of threedimensional conformal radiotherapy in unresectabl hepatocellular carcinsioma显示文摘 | Lin YM Chuang VP | 1999 | J Gastroenterol Hepatol1999，14，： | 1 |
| 16 | Short-term versus long-term intermittent hypobaric hypoxia on cardiac fibrosis and Fas death receptor dependent apoptotic pathway in rat hearts 显示文摘 | Lin YM Huang SK Wang HF | 2008 | Chin J Physiol2008，51，5： | 1 |
| 17 | Dose escalation using twice-taily radio- therapy for nasopharyngeal carcinoma: dose heavier dosing result in a happier ending?显示文摘 | Jen YM Lin YS Su WF | 2002 | Int J Radiat Oncol Biol Phys2002，54，1： | 1 |
| 18 | Occult hepatitis B virus infection in hepatitis B vaccinated children in Taiwan显示文摘 | Mu SC Lin YM Jow GM | 2009 | J Hepatol2009，50，2： | 1 |
| 19 | Tumor necrosis factor-α stimulates fractalkine production by mesangial cells and regulates monocyte transmigration:down-regulation by camp显示文摘 | Chen YM Lin SL Chen CW | 2003 | Kidney Int2003，63，2： | 1 |
| 20 | Susceptibility to esophageal cancer and genetic polymorphisms in glutathione S-transferases T1,P1,and M1 and cytochrome P450 2E1 显示文摘 | Lin DX Tang YM Peng Q | 1998 | Cancer Epidemiol Biomarkers Prey1998，7，11： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员