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| 1 | Up-regulation of PIK3CA promotes metastasis in gastric carcinoma显示文摘AIM:To explore expressions of PIK3CA in the progression of gastric cancer from primary to metastasis and its effects on activation of phosphatidylinositol 3-kinase(PI3K)/Akt pathway.METHODS:mRNA and protein levels of PIK3CA were assessed,respectively,by real-time quantitative polymerase chain reaction and immunohistochemistry in specimens of normal gastric mucosa,primary foci and lymph node and distant metastasis of gastric cancer.Akt and phosphorylated Akt protein were also examined by Western blotting in these tissues,in order to analyze the effect of PIK3CA expression level changes on the activation of PI3K/Akt signaling pathway.RESULTS:PIK3CA mRNA in lymph node metastasis were approximately 5 and 2 folds higher,respectively,than that in the corresponding normal gastric mucosa and primary gastric cancer tissues(P<0.05),while no statistical significance was found compared with distant metastasis.Immunohistochemically,PIK3CA protein expression was discovered in 7(35%)specimens of 20 primary foci vs 10(67%)of 15 of lymph node metastasis or 11(61%)of 18 of distant metastasis(35%vs 67%,P=0.015;35%vs 61%,P=0.044).With the increased level of PIK3CA expression,the total Akt protein expression remained almost unchanged,but p-Akt protein was upregulated markedly.CONCLUSION:Increased expression of PIK3CA is expected to be a promising indicator of metastasis in gastric cancer.Up-regulation of PIK3CA may promote the metastasis of gastric cancer through aberrant activation of PI3K/Akt signaling. | Liu JF Zhou XK Chen JH Yi G Chen HG Ba MC Lin SQ Qi YC. | 2010 | World Journal of Gastroenterology2010，16，39： | 20 |
| 2 | The Responsivity of the Bacteriorhodopsin Langmuir-Blodgett Film Intermittent Light显示文摘TheResponsivityoftheBacteriorhodopsinLangmuir-BlodgettFilmIntermittentLight￥GuangYuWANG;JianHuaYANG;ZhiGuangZHANG;ShuHuangLIN... | Wang, GY Yang, JH Zhang, ZG Lin, SH Lu, T Li, BF Jiang, L | 1996 | Chinese Chemical Letters1996，7，12： | 12 |
| 3 | 急性缺血性脑卒中后低脉压与不良预后相关显示文摘众所周知,脉压与心脏功能、动脉僵硬度、体液状态和血管事件有关。该研究旨在探讨基于中国台湾地区脑卒中登记资料的急性缺血性脑卒中(acute ischemic stroke,AIS)患者入院时脉压的预后作用。 | 刘莉 叶鹏 Tang SC Yin JH Liu CH Sun MH Lee JT Sun Y Hsu CS Sun MC Lin CH Chen CH Lien LM Muo CH Jeng JS Hsu CY | 2017 | 中华高血压杂志2017，25，7： | 5 |
| 4 | Effectiveness of second and third-generation immuneoassays for the detection of hepatitis C virus infection in pregnant women 显示文摘 | Lin HH Kao JH | 2000 | J Obstet Gynaecol Res2000，26，4： | 2 |
| 5 | Secondary structural formation of alpha-synuclein amyloids as revealed by g-factor of solid-state circular dichroism.显示文摘 | Lin XJ Zhang F Xie YY Bao WJ He JH Hu HY | 2006 | 中国生物学文摘2006，20，9： | 2 |
| 6 | KIAP,a novel member of the inhibitor of apoptosis protein family显示文摘 | Deng G Huang Q | 2000 | Biochem Biophys Res Commun2000，279，3： | 1 |
| 7 | Opportunities and risk factors for premalignant and malignant transformation of endometrial polyps: management strategies显示文摘 | WANG JH ZHAO J LIN J | 2010 | J Minim Invasive Gynecol2010，17，1： | 1 |
| 8 | Transitional cell carcinoma in dialysis patients显示文摘 | OU JH PAN CC LIN JS | 2000 | Eur Urol2000，37，1： | 1 |
| 9 | Analysis of three lupane type triter- penoids in Helieteres angustifolia by high - performance liquid chroma- tography显示文摘 | Chang YS Ku YR Lin JH | 2001 | J Pharm Biomed Anal2001，26，5： | 1 |
| 10 | Ferulic acid augments angiogenesis via VEGF,PDGF and HIF-1 alpha显示文摘 | Lin CM Chiu JH Wu IH | 2010 | J Nutr Biochem2010，21，7： | 1 |
| 11 | Human RPB5, a subunit shared by eukaryotic nuclear RNA polymerases, binds human hepatitis B virus X protein and may play a role in X trans- activation显示文摘 | Cheong JH Yi M Lin Y | 2005 | EMBOJ2005，14，1： | 1 |
| 12 | Connexin mediates gap junctionindependent resistance to cellular injury显示文摘 | Lin JH Yang J Liu S | 2003 | J Neurosci2003，23，2： | 1 |
| 13 | Predicting long-term care institution utilization among post-rehabilitation stroke patients in Taiwan:a medical centre-based study显示文摘 | Lin JH Hsieh CL Hsiao SF | 2001 | Disabil Rehabil2001，23，： | 1 |
| 14 | Enhanced immunity by NeuEDHSP70 DNA vaccine is needed to combat an aggressive spontaneous metastatic breast cancer显示文摘 | Kim JH Majumder N Lin H et at | 2005 | Mol Ther2005，11，6： | 1 |
| 15 | Optimum nitrogen use and reduced nitrogen loss for production of rice and wheat in the Yangtse Delta Region 显示文摘 | Wang DJ Liu Q Lin JH | 2004 | Environmental Geochemistry and Health2004，26，2： | 1 |
| 16 | Induction of VX2 carcinoma in rabbit liver: comparison of two inoculation methods 显示文摘 | Chen JH Lin YC I-Iuan YS | 2004 | Lab Anim2004，38，： | 1 |
| 17 | HIV-1 protease molecular dynamics of a wild-type and of the V82F/I84V mutant: Possible contributions to drug resistance and a potential new target site for drugs显示文摘 | Perryman AL Lin JH Mccammon JA | 2004 | Protein Sci2004，13，4： | 1 |
| 18 | KIAP, a novel member of the inhibitor of apoptosis protein family 显示文摘 | Lin JH Deng G Huang Q | 2000 | Biochem Biophys Res Commun2000，279，3： | 1 |
| 19 | Astrocytic gap junctions remain open during ischemic conditions 显示文摘 | Cotrina ML Kang J Lin JH | 1998 | J Neurosci1998，18，7： | 1 |
| 20 | Cotton leaf curl Multan virus newly reported to be associated with cotton leaf curl disease in China显示文摘 | Cai JH Xie K Lin L Qin BX Chen BS Meng JR Liu Y | | 0，，04： | 1 |
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