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| 1 | A study of preoperative methionine-depleting parenteral nutrition plus chemotherapy in gastric cancer patients显示文摘AIM To investigate the interference ofmethionine.free parenteral nutrition plus 5-Fu(-MetTPN+5-Fu)in gastric cancer cell kineticsand the side effects of the regimen.METHODS Fifteen patients with advancedgastric cancer were randomly divided into twogroups,7 patients were given preoperatively aseven-day course of standard parenteralnutrition in combination with a five-day courseof chemotherapy(sTPN+5-Fu),while the other8 patients were given methionine-deprivedparenteral nutrition and 5-Fu(-MetTPN+5-Fu).Cell cycles of gastric cancer and normal mucosawere studied by flow cytometry(FCM).Bloodsamples were taken to measure the serumprotein,methionine(Met)and cysteine(Cys)levels,and liver and kidney functions.RESULTS As compared with the resultsobtained before the treatment,the percentage ofG0/G1 tumor cells increased and that of S phasedecreased in the-MetTPN+5-Fu group,while thecontrary was observed in the sTPN+5-Fu group.Except that the ALT,AST and AKP levels wereslightly increased in a few cases receiving-MetTPN+5-Fu,all the other biochemicalparameters were within normal limits.Serum Cys level decreased slightly after the treatmentin both groups.Serum Met level of patientsreceiving sTPN+5-Fu was somewhat higher aftertreatment than that before treatment;however,no significant change occurred in the -MetTPN+5-Fu group,nor operative complications in bothgroups.CONCLUSION -MetTPN+5-Fu exerted asuppressive effect on cancer cell proliferation,probably through a double mechanism ofcreating a state of'Met starvation'adverse tothe tumor cell cycle,and by allowing 5-Fu to killspecifically cells in S phase.Preoperative short-term administration of -MetTPN+5-Fu had littleundesirable effect on host metabolism. | Cao WX Cheng QM Fei XF Li SF Yin HR Lin YZ | 2000 | World Journal of Gastroenterology2000，6，2： | 22 |
| 2 | 药物开发中与草药相互作用药物的鉴定显示文摘迄今为止,几种临床上重要的药物已被鉴定与常用的草药相互作用。这些药物包括华法林、咪达唑仑、地高辛、阿米替林、茚地那韦、环孢素A、他克莫司、伊立替康。重要的是这些药物大多治疗指数极窄,大部分是细胞色素P450(CYP)和(或)P糖-蛋白(P-gp)的底物。由于药物-草药相互作用能显著地影响药物的循环浓度,改变临床结果,因此与常用的草药相互作用的药物的鉴定在药物开发中具重要的意义。计算机模拟、体外、动物和人体研究经常用于鉴定药物和草药的相互作用。建议将药物-草药和草药-CYP相互作用研究纳入药物开发中。 | Zhou SF Zhou ZW Li CG 贾秀虹 | 2008 | 国际药学研究杂志2008，35，3： | 2 |
| 3 | Microgravimetric DNA sensor based on quartz crystal microbalance: comparison of oligonucleotide immobilization methods and the application in genetic diagnosis显示文摘 | Huang LQ Li SF | 2001 | Biosens Bioelectron2001，16，12： | 1 |
| 4 | identification of functionally important amino acid residues in the mitochondria targeting sequence of hepatitis B virus X protein显示文摘 | Li SK Ho SF Tsui KW | 2008 | Virology2008，381，1： | 1 |
| 5 | Effect of HPMC and carbopol on the release and floating properties of gastric floating drug delivery system using factorial design显示文摘 | Li SF Lin SS Dagg BP | 2003 | Int J Pharm2003，253，12： | 1 |
| 6 | Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance 显示文摘 | Cao X Cai SF Fehniger TA Song J Collins LI Piwnica-Worms DR | 2007 | Immunity2007，27，63： | 1 |
| 7 | Stepwise abnormality of sex steroid hormone receptors,tumoRsuppressoRgene products(p53 and Rb),and cyclin E in uterine endometrioid carcinoma显示文摘 | Li SF Shiozawa T Nakayama K | | 0，，： | 1 |
| 8 | The complex relation-ship of serum adiponectin to COPD outcomes COPD and adiponectin显示文摘 | Yoon HI Li Y Man SF | | 0，，04： | 1 |
| 9 | Microgravimetric DNA sensor based on quartz crystal microbalance: comparison of oligonucleotide immobilization methods and the application in genetic diagnosis显示文摘 | Huang LQ Li SF | 2001 | Biosens Bioelectron2001，16，12： | 1 |
| 10 | Location of extra renal tumor extension does not impact survival of patients with p33a renal cell carcinoma显示文摘 | Margulis V Taml~li P Matin SF | 2007 | J Um12007，178，： | 1 |
| 11 | Differential effects of concomitant use of vitamins C and E on trophoblast apoptosis and autophagy between normoxia and hypoxia-reoxygenation显示文摘 | Hung TH Chen SF Li Mj | 2010 | PloS One2010，5，12： | 1 |
| 12 | Axillary osmidrosis treated by partial removal of the skin and subcutaneous tissue enbloc and apocrine gland subcision显示文摘 | Fan YM Wu ZH Li SF | 2001 | Int J Dermatol2001，40，11： | 1 |
| 13 | Elevation of human t alpha t-defensins and S100 calcium binding protein A8 and A9 in tear fluid of pterygium patients 显示文摘 | Zhou L Beuerman RW Ang LP Chan CM Li SF Chew FT | 2009 | Invest Ophthalmol Vis Sci2009，50，5： | 1 |
| 14 | Axillary osmidrosis treated by partial removal of the skin and subcutaneous tissue en bloc and apocrine gland subcision显示文摘 | Fan YM Wu ZH Li SF | 2001 | Int J Dermatol2001，40，11： | 1 |
| 15 | A new simple method for isolation of microvascular endothelial cells avoiding both chemical and mechanical injuries显示文摘 | Chen SF Fei X Li SH | 1995 | Microvasc Res1995，50，1： | 1 |
| 16 | Sequence variation in ROP9 gene among Toxoplasma gondii strains from different hosts and geographical locations显示文摘 | Chen J Fang SF Li ZY | 2012 | J Anim Vet Adv2012，11，： | 1 |
| 17 | Interference RNA (RNAi)- based silencing of endogenous thrombopoietin receptor (Mpl) in Dami cells resulted in decreased hNUDC-mediated megakaryocyte proliferation and differentiation 显示文摘 | Pang SF Li XK Zhang Q | 2009 | Exp Cell Res2009，25，： | 1 |
| 18 | High frequency of epidermal growth factor receptor mutations with complex patterns in nonsmall cell lung cancers related to gefitinib responsiveness in Taiwan显示文摘 | Huang SF Liu HP Li LH | 2004 | Clin Cancer Res2004，10，24： | 1 |
| 19 | Stepwise abnormality of sex steroid bormone receotiram tynir syooressir gebe oridycts(p53 and Rb),and cyclin E in uterine endmettrioid carcinoma显示文摘 | Li SF Shiozawa T Nakayama K | 1996 | Cancer1996，77，2： | 1 |
| 20 | Polymorphisms in the vitamin D re ceptor gene and risk of autoimmune thyroid diseases:a meta anal ysis显示文摘 | Feng M Li H Chen SF ct al | 2013 | Endocrine2013，43，2： | 1 |
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