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| 1 | Honeysuckle-encoded atypical microRNA2911 directly Largets influenza A viruses显示文摘 | Zhen Zhou Xihan Li Jinxiong Liu Lei Dong Qun Chen Jialing Liu Huihui Kongt Qianyi Zhang Xian Qi Dongxia Hou Lin Zhang Guoquan Zhang Yuchen Liu Yujing Zhang Jing Li Jin Wang Xi Chen Hua Wang Junfeng Zhang Hualan Chen Ke Zen Chen-Yu Zhang | 2015 | Cell Research2015，25，1： | 104 |
| 2 | Up-regulation of Bcl-2 is required for the progression of prostate cancer cells from an androgen-dependent to an androgen-independent growth stage显示文摘Bcl-2 是 anti-apoptotic oncoprotein,它的蛋白质层次相反地在许多癌症与预后被相关。然而,在前列腺癌症的前进的 Bcl-2 的角色不是清楚的。这里,我们报导 Bcl-2 从一个雄激素依赖者为 LNCaP 前列腺癌症细胞的前进被要求到一个雄激素无关的生长阶段。Bcl-2 的信使 rna 和蛋白质层次显著地在雄激素无关的前列腺癌症被增加在雄激素无关的前列腺癌症房间的 Bcl-2 的调停 cells.shRNA 的基因 silencing 导致 promotesUV 的 apoptosis 并且压制前列腺肿瘤的生长体内。在在形成的雄激素剥夺条件结果下面的 Growingandrogen 依赖的房间 ofandrogen 独立的殖民地;并且到 androgen-independentgrowth 的从雄激素依赖者的转变被 Bcl-2 对手 Bax 或 Bcl-2 shRNA 的宫外的表示堵住。因此,我们的结果证明 Bcl-2 为 androgen-independentprostate 癌症细胞的幸存是批评的不仅,但是也为前列腺癌症细胞的前进被要求从对一个雄激素无关的生长阶段 anandrogen 依赖。 | Yuting Lin Junichi Fukuchi Richard A Hiipakka John M Kokontis Jialing Xiang | 2007 | Cell Research2007，17，6： | 5 |
| 3 | The BH3-only protein BAD mediates TNFα cytotoxicity despite concurrent activation of IKK and NF-κB in septic shock显示文摘煽动性的 cytokine TNF 在许多煽动性、传染的疾病的病理起一个关键作用。然而,在这些疾病位于 TNF cytotoxicity 下面的机制不完全地被理解。这里,我们报导 pro-apoptotic BCL-2 家庭成员坏调停尽管有在由由得到多重机关的织物损坏并且贡献死亡在在有教养的房间并且在 vivo 导致 apoptosis 的 vitro 的 IKK 和 NF-B 的并发的激活的 TNF cytotoxicity 腐败吃惊。在高剂量, TNF 显著地通过 Src-p190GAP 小径的激活使 RhoA 失去活性,导致巨大的肌动朊压力纤维 destabilization,从细胞骨架由实质的坏版本列在后面到 cytosol。在这个条件下面,激活 IKK 没有通过所有 cytosolic 到 phosphorylate 坏,允许对线粒体不适宜的 non-phosphorylated 的 translocation 触发 apoptosis。Polymicrobial 感染利用象高剂量的 TNF 的一样的机制得到多重机关的联系 apoptosis 的织物损坏。因而,损失坏或坏 pro-apoptotic 活动的消除保护老鼠免受多重机关和还原剂死亡率的织物损坏的伤害。我们的结果支持在的一个模型坏调停尽管有在有教养的哺乳动物的房间并且在的 IKK-NF-B 小径的并发的激活的 TNF cytotoxicity 腐败吃惊。 | Jie Yan Hao Zhang Jialing Xiang Yu Zhao Xiang Yuan Beicheng Sun Anning Lin | 2018 | Cell Research2018，28，7： | 2 |
| 4 | Development of solvent micro-extraction combined with derivatization显示文摘 | Huaqing Lin Jiale Wang Lingjie Zeng Gang Li Yunfei Sha Da Wu Baizhan Liu | 2013 | Journal of Chromatography A2013，，： | 1 |
| 5 | JNK Suppresses Apoptosis via Phosphorylation of the Proapoptotic Bcl-2 Family Protein BAD显示文摘 | Chenfei Yu Yuzuru Minemoto Jiyan Zhang Jing Liu Fangming Tang Truc N. Bui Jialing Xiang Anning Lin | 2004 | Molecular Cell2004，，3： | 1 |
| 6 | Synthesis of gold nanoparticles by Cacumen platycladi leaf extract and its simulated solution:toward the plant-mediated bi osynthetie mechanism显示文摘 | Zhan Guowu Huang Jiale Lin Liqin | 2011 | Journal of Nanoparticle Re- search2011，13，： | 1 |
| 7 | A lightweight genetic block- matching algorithm for video coding显示文摘 | Lin Chunhuang Wu Jialing | 1998 | IEEE Transactions on Circuits and System for Video Technology1998，18，4： | 1 |
| 8 | Embedded together: The life and death consequences of interaction of the Bcl-2 family with membranes显示文摘 | Brian Leber Jialing Lin David W. Andrews | 2007 | Apoptosis2007，，5： | 1 |
| 9 | Desorption of VOC from polymer adsorbent in multistage fluidized bed显示文摘The desorption process of volatile organic compounds(VOC)from a polymer adsorbent in counter-current multistage fluidized bed was studied.And a mathematical model considering the mass transfer dynamics was developed,which was validated from experiment data.The gaseous ethyl acetate mass transfer was discussed,and the limiting step is the intraparticle mass transfer of the desorption process.The value of intraparticle mass transfer coefficient is between 1.85×10-6 and 1.38×10-5 m·s-1 under temperature of 100–160°C.Experiments under different operating conditions were carried out.The effects of operating conditions such as gas–solid flow ratio,gas inlet temperature and total stage number of multistage fluidized bed on outlet VOCs concentration and desorption efficiency were discussed.The maximum outlet VOCs concentration and corresponding desorption efficiency of the multistage fluidized bed desorber was calculated under different gas inlet temperatures and total stage numbers. | Jiale Zheng Wenli Song Lin Du Lina Wang Songgeng Li | 2020 | Chinese Journal of Chemical Engineering2020，28，6： | 1 |
| 10 | Shen Qi Wan attenuates renal interstitial fibrosis through upregulating AQP1显示文摘Renal interstitial fibrosis(RIF)is the crucial pathway in chronic kidney disease(CKD)leading to the end-stage renal failure.However,the underlying mechanism of Shen Qi Wan(SQW)on RIF is not fully understood.In the current study,we investigated the role of Aquaporin 1(AQP1)in SQW on tubular epithelial-to-mesenchymal transition(EMT).A RIF mouse model induced by adenine and a TGF-β1-stimulated HK-2 cell model were etablished to explore the involvement of AQP 1 in the protective effect of SQW on EMT in vitro and in vivo.Subsequently,the molecular mechanism of SQW on EMT was explored in HK-2 cells with AQP1 knockdown.The results indicated that SQW alleviated kidney injury and renal collagen deposition in the kidneys of mice induced by adenine,increased the protein expression of E-cadherin and AQP1 expression,and decreased the expression of vimentin andα-smooth muscle actin(α-SMA).Similarly,treatmement with SQW-containing serum significantly halted EMT process in TGF-β1 stimulated HK-2 cells.The expression of snail and slug was significantly upregulated in HK-2 cells after knockdown of AQP1.AQP1 knockdown also increased the mRNA expression of vimentin andα-SMA,and decreased the expression of E-cadherin.The protein expression of vimentin increased,while the expression of E-cadherin and CK-18 significantly decreased after AQP1 knockdown in HK-2 cells.These results revealed that AQP1 knockdown promoted EMT.Furthermore,AQP1 knockdown abolished the protective effect of SQW-containing serum on EMT in HK-2 cells.In sum,SQW attentuates EMT process in RIF through upregulation of the expression of AQP1. | LIN Yiyou WEI Jiale ZHANG Yehui HUANG Junhao WANG Sichen LUO Qihan YU Hongxia JI Liting ZHOU Xiaojie LI Changyu | 2023 | Chinese Journal of Natural Medicines2023，21，5： | 1 |
| 11 | Solvothermal synthesis of carbon coated N-doped TiO 2 nanostructures with enhanced visible light catalytic activity显示文摘 | Xue-Min Yan Jialing Kang Lin Gao Lin Xiong Ping Mei | 2013 | Applied Surface Science2013，，： | 1 |
| 12 | Ge tinib as front-line treatment in Chinese patients with advanced non-small-cell lung cancer显示文摘 | Lin Weichun Chiu Chao-hua Liou Jialing | 2011 | Lung Cancer2011，71，3： | 1 |
| 13 | On residents' satisfaction with community health services after health care system reform in Shanghai,China,2011显示文摘 | Zhijian Li Jiale Hou Lin Lu | | 0，，01： | 1 |
| 14 | On residentsj sat- isfaction with community health ser- vices after health care system reform in Shanghai, China 显示文摘 | Li Zhijian Hou Jiale Lu Lin Tang Shenglan Ma Jin | 2012 | BMC Public Health2012，，12： | 1 |
| 15 | A lightweight genetic block-matching al- gorithm for video coding显示文摘 | Lin Chunhung Wu Jialing | 1998 | IEEE Trans on Circuits and Systems for Video Technology1998，8，4： | 1 |
| 16 | Development of Rural Tourism Industry under the Background of New Rural Construction : A Case Study of Henghe of Boluo County in Huizhou City显示文摘Henghe Town in Boluo County of Huizhou is taken as the research object for analysis.The research and analysis on the tourism industry in Henghe Town of Boluo County are conducted,and the basic situation of rural tourism construction in Henghe Town is sorted out.The forms of tourism industry in Henghe Town and the problems in rural tourism development are identified,and some targeted suggestions and countermeasures are proposed.It hopes to provide ideas and references for the construction of beautiful rural areas in mountainous areas of Guangdong Province,and theoretical reference and practical significance for the development of rural tourism in mountainous areas of Guangdong Province. | Jialing DENG Yanping ZHONG Xiulian LIN | 2024 | Asian Agricultural Research2024，16，3： | 0 |
| 17 | Skeleton Keypoints Extraction Method Combined with Object Detection显示文摘Big data is a comprehensive result of the development of the Internet of Things and information systems.Computer vision requires a lot of data as the basis for research.Because skeleton data can adapt well to dynamic environment and complex background,it is used in action recognition tasks.In recent years,skeleton-based action recognition has received more and more attention in the field of computer vision.Therefore,the keypoints of human skeletons are essential for describing the pose estimation of human and predicting the action recognition of the human.This paper proposes a skeleton point extraction method combined with object detection,which can focus on the extraction of skeleton keypoints.After a large number of experiments,our model can be combined with object detection for skeleton points extraction,and the detection efficiency is improved. | Jiabao Shi Zhao Qiu Tao Chen Jiale Lin Hancheng Huang Yunlong He d Yu Yang | 2022 | Journal of New Media2022，4，2： | 0 |
| 18 | Generation of inactivated IL2RG and RAG1 monkeys with severe combined immunodeficiency using base editing显示文摘Severe combined immunodeficiency(SCiD)encompasses a range of inherited disorders that lead to a profound deterioration of the immune system.Among the pivotal genes associated with SCID,RAG1 and IL2RG play crucial roles.IL2RG is essential for the development,differentiation,and functioning of T,B,and NK cells,while RAG1 critically contributes to adaptive immunity by facilitating V(D)J recombination during the maturation of lymphocytes.Animal models carrying mutations in these genes exhibit notable deficiencies in their immune systems. | Xiao Zheng Chunhui Huang Yingqi Lin Bofeng Han Yizhi Chen Caijuan Li Jiawei Li Yongyan Ding Xichen Song Wei Wang Weien Liang Jianhao Wu Jiaxi Wu Jiale Gao Chengxi Wei Xudong Zhang Zhuchi Tu Sen Yan | 2023 | Signal Transduction and Targeted Therapy2023，8，10： | 0 |
| 19 | Fraud detection on payment transaction networks via graph computing and visualization显示文摘With the fast development of Internet technology,more and more payments are fulfilled by mobile Apps in an electrical way which significantly saves time and efforts for payment.Such a change has benefited a large number of individual users as well as merchants,and a few major players for payment service have emerged in China.As a result,the payment service competition becomes even fierce,and various promotion activities have been launched for attracting more users by the payment service providers.In this paper,the problem focused on is fraud payment detection,which in fact has been a major concern for the providers who spend a significant amount of money to popularize their payment tools.This paper tries the graph computing-based visualization to the behavior of transactions occuring between the individual users and merchants.Specifically,a network analysisbased pipeline has been built.It consists of the following key components:transaction network building based on daily records aggregation;transaction network filtering based on edge and node removal;transaction network decomposition by community detection;detected transaction community visualization.The proposed approach is verified on the real-world dataset collected from the major player in the payment market in Asia and the qualitative results show the efficiency of the method. | 孙权 Tang Tao Zheng Jianbin Lin Jiale Zhao Jintao Liu Hongbao | 2020 | High Technology Letters2020，26，3： | 0 |
| 20 | Recent advances in the development of in vitro liver models for hepatotoxicity testing显示文摘Liver injury is a common cause of drug approval withdrawal during drug development,pre-clinical research,and clinical treatment.If not properly treated,patients with severe liver injury can suffer from acute liver failure or even death.Thus,utilization of the convenient in vitro hepatotoxicity assessment model for early detection of drug-induced hepatotoxicity is vital for drug development and safe personalized medication.Biomaterials(e.g.,hydrogels,nanofibers,decellularized liver matrix)and bioengineering technologies(e.g.,microarrays,micropatterns,3D printing,and microfluidics)have been applied for in vitro hepatotoxicity assessment models.This review summarizes the structure and functions of the liver as well as the components of in vitro hepatotoxicity assessment models.In addition,it highlights the latest advances in developing hepatotoxicity models with the ultimate goal of further clinical translation. | Siming Lu Jingwei Zhang Sha Lin Danfeng Zheng Yan Shen Jiale Qin Yangyang Li Shuqi Wang | 2021 | Bio-Design and Manufacturing2021，4，4： | 0 |
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