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| 1 | Research on the application of 4-weighted fractional Fourier transform in communication system显示文摘The paper reveals the relationship between the weighting coefficients and weighted functions via the research of coefficients matrix and based on the original definition of 4-weighted fractional Fourier transform(4-WFRFT).The multi-parameters expression of weighting coefficients are given.Moreover, the 4-WFRFT of discrete sequences is defined by introducing DFT into it, which makes it suitable for digital communication systems.After analyzing the properties of WFRFT, a typical scheme for modulation/demodulation is proposed, which could make the statistics properties of the real and image part on both of the time and frequency domain and the phase properties have a significant variation.Such a variation could be controlled by the adjustment of transform parameters.If the WFRFT of multi-parameters is implemented, it will be more difficult to intercept and capture the modulated signals than normal. | MEI Lin SHA XueJun RAN QinWen ZHANG NaiTong | 2010 | Science China(Information Sciences)2010，53，6： | 25 |
| 2 | Single-cell RNA-seq uncovers dynamic processes and critical regulators in mouse spermatogenesis显示文摘 | Yao Chen Yuxuan Zheng Yun Gao Zhen Lin Suming Yang Tongtong Wang Qiu Wang Nannan Xie Rong Hua Mingxi Liu Jiahao Sha Michael D. Griswold Jinsong Li Fuchou Tang Ming-Han Tong | 2018 | Cell Research2018，28，9： | 26 |
| 3 | Guaranteeing Wireless Communication Secrecy via a WFRFT-Based Cooperative System显示文摘In this paper, a weighted fractional Fourier transform(WFRFT) based cooperative overlay system, aiming to guarantee physical layer(PHY) security, is proposed. The paper elaborates how WFRFT and physical layer properties of the wireless medium are collaborated to guarantee the secrecy of wireless transmissions. In the proposed system, WFRFT is first preform on the secret data, such that the transmitted signal is distorted and can only be neutralized by inverse-WFRFT with the same parameter. And then two streams of the transformed sequences that bearing different messages are cooperatively and simultaneously transmitted to two legitimate receivers via a beamforming-liked method, respectively. In general, both the rapid spatial decorrelation property and the inherent security features of WFRFT are leveraged, such that only the eavesdropper's is degraded, and hence, the wireless communication secrecy is reliably guaranteed. Numerical simulations are conducted to evaluate the performance of the proposed system in terms of the average bit error rate and the secrecy capacity. | Fang Xiaojie Sha Xuejun Mei Lin | 2015 | China Communications2015，12，9： | 18 |
| 4 | Roux-en-Y gastric bypass promotes expression of PDX-1 and regeneration of β-cells in Goto-Kakizaki rats显示文摘AIM:To study the effects of Roux-en-Y gastric bypass(RYGB) on the expression of pancreatic duodenal homeobox-1(PDX-1) and pancreatic β-cell regeneration/neogenesis,and their possible mechanisms in diabetics.METHODS:Three groups of randomly selected nonobese diabetic Goto-Kakizaki(GK) rats were subjected to RYGB,sham-RYGB and sham-operation(sham-op) surgery,respectively.The rats were euthanized at postoperative 1,2,4 and 12 wk.Their pancreases were resected and analyzed using reverse transcription polymerase chain reaction to detect the mRNA of PDX-1.Anti-PDX-1 immunohistochemical(IHC) staining and Western blotting were used to detect the protein of PDX-1.Double IHC staining of anti-Brdu and-insulin was performed to detect regenerated β-cells.The index of double Brdu and insulin positive cells was calculated.RESULTS:In comparison with sham-RYGB and sham-op groups,a significant increase in the expressions of PDX-1 mRNA in RYGB group was observed at all experimental time points(1 wk:0.378 ± 0.013 vs 0.120 ± 0.010,0.100 ± 0.010,F = 727.717,P < 0.001;2 wk:0.318 ± 0.013 vs 0.110 ± 0.010,0.143 ± 0.015,F = 301.509,P < 0.001;4 wk:0.172 ± 0.011 vs 0.107 ± 0.012,0.090 ± 0.010,F = 64.297,P < 0.001;12 wk:0.140 ± 0.007 vs 0.120 ± 0.010,0.097 ± 0.015,F = 16.392,P < 0.001);PDX-1 protein in RYGB group was also increased significantly(1 wk:0.61 ± 0.01 vs 0.21 ± 0.01,0.15 ± 0.01,F = 3031.127,P < 0.001;2 wk:0.55 ± 0.00 vs 0.15 ± 0.01,0.17 ± 0.01,F = 3426.455,P < 0.001;4 wk:0.39 ± 0.01 vs 0.18 ± 0.01,0.22 ± 0.01,F = 882.909,P < 0.001;12 wk:0.41 ± 0.01 vs 0.20 ± 0.01,0.18 ± 0.01,F = 515.833,P < 0.001).PDX-1 mRNA and PDX-1 protein production showed no statistical significance between the two sham groups.Many PDX-1 positive cells could be found in the pancreatic islets of the rats in RYGB group at all time points.In addition,the percentage of Brdu-insulin double staining positive cells was higher in RYGB group than in the other two groups(1 wk:0.22 ± 0.13 vs 0.03 ± 0.06,0.03 ± 0.06,P < 0.05;2 wk:0.28 ± 0.08 vs 0.00 ± 0.00,0.03 ± 0.06,P < 0.05;4 wk:0.24 ± 0.11 vs 0.07 ± 0.06,0.00 ± 0.00,P < 0.001;12 wk:0.20 ± 0.07 vs 0.03 ± 0.06,0.00 ± 0.00,P < 0.05).CONCLUSION:RYGB can increase the expression of pancreatic PDX-1 and induce the regeneration of β-cells in GK rats.The associated regeneration of islet cells may be a possible mechanism that how RYGB could improve type 2 diabetes mellitus. | Zhen Li,Dong-Fei Li,Jing-Xing Dai,Yu Bai,Lin Yuan,Southern Medical University,Institute of Basic Medical Anatomy National Key Disciplines,Guangzhou 510515,Guangdong Province,China Hong-Ya Zhang,Lu-Xian Lv,Wen-Qiang Li,Second Affiliated Hospital,Xinxiang Medical College,Henan Province Key Laboratory of Biological Psychiatry,Xinxiang 453002,Henan Province,China Ou Sha,Department of Anatomy,Faculty of Medicine,Shenzhen University,Shenzhen 518060,Guangdong Province,China | 2010 | World Journal of Gastroenterology2010，16，18： | 14 |
| 5 | Overexpression of interleukin-17 in tumor-associated macrophages is correlated with the differentiation and angiogenesis of laryngeal squamous cell carcinoma显示文摘 | MENG Cui-da ZHU Dong-dong JIANG Xiao-dan LI Lin SHA Ji-chao DONG Zhen KONG Hong | 2012 | Chinese Medical Journal2012，，9： | 14 |
| 6 | Advances and development trends in eco-friendly pavements显示文摘The major contemporary in road pavement engineering is related to the creation of green and sustainable infrastructures,e.g.,reduction of environmental impacts,increase in traffic safety,and transportation efficiency,etc.This review presents the recent trends in research and the technical solutions developed so far to address these challenges.After the analysis of research status in the past decades,a novel technology system of eco-friendly pavements is proposed considering two solutions,materials modification and structure improvement.The construction of an eco-friendly pavement can be achieved thanks to several different technologies ensuring permeable,noise-reducing,self-luminous,and exhaust-decomposing properties as well as apporting lower heat absorbing and enhanced anti-/de-icing characteristics.A systematic review of these technologies is presented pivoting on four main aspects:technical principle,material and structural composition,performance evaluation,and engineering application.The current trend in road engineering is combining the pavement infrastructure with various eco-friendly functions,e.g.,water permeability,noise reduction,low heat absorption,exhaust gas decomposition,and anti-/de-icing.Finally,the review lists the drawbacks of the existing technologies,including high cost,single function,etc.,and depicts the future developing direction and architecture of the next generation of eco-friendly pavements in which the road infrastructure should have more environmentally friendly functions than the existing technology. | Aimin Sha Zhuangzhuang Liu Wei Jiang Lin Qi Liqun Hu Wenxiu Jiao Diego Maria Barbieri | 2021 | Journal of Road Engineering2021，1，1： | 9 |
| 7 | Gene functional research using polyethylenimine-mediated in vivo gene transfection into mouse spermatogenic cells显示文摘瞄准:为了学习 polyethylenimine (PEI ) ,调停了在活体内基因 transfection 进睾丸房间和用这个方法的精子发生的的房间特定的基因 NYD-SP12 的初步的功能的研究。方法:PEI/DNA 建筑群用睾丸内注射被介绍进老鼠睾丸的细精管。Transfection 效率和专业与荧光灯的显微镜学并且苏木精染色在 transfection 的第三天被分析。GFP-NYD-SP12 熔化蛋白质和它的潜水艇的长持续的表示在在不同阶段的 spermatogenic 的细胞的本地化与染色的荧光灯的显微镜学和 propidium 碘化物被分析。结果:与 PEI 的调停, GFP-NYD-SP12 熔化基因高效地在生殖细胞被转移并且表示(特别在主要 spermatocytes ) 。进 Sertoli 房间的 Transfection 没被观察。GFP-NYD-SP2 熔化蛋白质的细胞的本地化在精子发生期间在不同阶段在 spermatogenic 看了动态移动的潜水艇。结论:PEI 能高效地调停基因转移进 spermatocytes。因此,它可能为象 NYD-SP12 基因那样的 spermatogenic 房间 specific 基因的功能的研究是有用的。在我们的学习, NYD-SP12 蛋白质被设想并且在精子发生期间涉及顶体的形成。我们的研究将在 spermatocytes 继续进 NYD-SP12 的详细功能。 | Li Lu Min Lin Min Xu Zuo-Min Zhou Jia-Hao Sha | 2006 | Asian Journal of Andrology2006，8，1： | 9 |
| 8 | MiR-98 promotes chondrocyte apoptosis by decreasing Bcl-2 expression in a rat model of osteoarthritis显示文摘 | Jing Wang Lingqiang Chen Song Jin Jun Lin Hongmei Zheng Hong Zhang Hongtao Fan Fang He Sha Ma Qin Li | 2016 | Acta Biochimica et Biophysica Sinica2016，48，10： | 8 |
| 9 | Three-dimensional dynamic contrast-enhanced MR angiography for evaluating recipient vessels in orthotopic liver transplantation显示文摘BACKGROUND:With the improvement of MR technology, three-dimensional dynamic contrast-enhanced MR angiography(3D-DCE-MRA)may be the optimal vascular imaging method for preoperative evaluation of liver transplantation candidates.This study was undertaken to determine the value of 3D-DCE-MRA in the assessment of recipient vessels in orthotopic liver transplantation(OLT). METHODS:The surgical and pathological records were taken as the'gold standards'.Eighteen cases of OLT were retrospectively analyzed to assess the image quality of MRA,including the signal-to-noise ratio(SNR)in arteries and veins,depiction of vascular variation and vessel disease, and the accuracy of vascular diameter measurement. RESULTS:3D-DCE-MRA of 34 cases was carried out before OLT.The rates(excellent and good)showing hepatic arteries and portal vein for 3D-DCE-MRA were 94.1%(32/34)and 88.2%(30/34),respectively.The SNRs of the celiac axis and portal vein measurements from 3D-DCE-MRA were 20.58±3.74 and 13.43±4.12, and the mean diameters were 3.4±0.3 mm and 13.1±3.2 mm,respectively.There were 5 cases of vessel variation according to the Michel's classification.Of the 34 patients, 18 were compared radiologically and pathologically.The accuracy of depiction of the hepatic artery and portal vein with 3D-DCE-MRA was 100%for both;3D-DCE-MRA precisely assessed 4 cases of more than moderate stenosis in hepatic arteries,2 cases of small-caliber hepatic artery 3 cases of venous stenosis at the second porta hepatis, 6 cases of collateral vasculature,1 case of portal vein thrombosis and 1 case of portal vein aneurysm;all were confirmed pathologically.CONCLUSION:3D-DCE-MRA may be the first choice for recipient vascular assessment before OLT. | Bian, Jie Sha, Lin Yang, Chao Sun, Chuan-Shu | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，5： | 8 |
| 10 | Research progress on microstructure evolution of semi-solid aluminum alloys in ultrasonic field and their rheocasting显示文摘The effects of ultrasonic vibration(UV)treatment on microstructure of semi-solid aluminum alloys and the application of UV in rheocasting process are reviewed.Good semi-solid slurry can be produced by high-intensity UV process for aluminum alloys.The microstructures of Al-Si,Al-Mg and Al-Cu alloys produced by rheocasting assisted with UV are compact and with fine grains.The mechanical properties of the UV treated alloys are increased by about 20%-30%.Grain refinement of the alloys is generally considered because of cavitation and acoustic streaming caused by UV.Apart from these mechanisms,a hypothesis of the fuse of dendrite root caused by capillary infiltration in the ultrasonic field,as well as a mechanism of crystallites falling off from the mould-wall and crystal multiplication by mechanical vibration effect in indirect ultrasonic vibration are proposed to explain the microstructure evolution of the alloys. | Wu Shusen Lin Chong Lü Shulin Sha Meng | 2014 | China Foundry2014，11，4： | 7 |
| 11 | GENISTEIN INHIBITS PROLIFERATION OF HUMAN ENDOMETRIAL ENDOTHELIAL CELL IN VITRO显示文摘Objective To explore the effect of genistein on proliferation of human endometrial endothelial cells(HEECs)and glandular epithelium.Methods In vitro HEECs and human endometrial cancer-1B cell(HEC-1B)were cultured with 0,1,10,50,100,and 200 μmol/L of genistein alone or indicated concentrations of genistein combined with 0.2 or 1 nmol/L 17β-estradiol(17β-E2).Cell proliferation was determined by[3H]-thymidine incorporation and cell cycle was measured by flow cytometry.Results After 96 hours of treatment,genistein inhibited the proliferation of HEECs in a dose-dependent manner.The stimulation index reduced from 100%(without genistein treatment)to about 1%(200 μmol/L genistein).HEECs were arrested at G1/0 and G2/M phase when treated with genistein for 96 hours.When the concentration of genistein was 200 μmol/L,the percentages of HEECs at G1/0,G2/M,and S phase were 96.0%,2.1%,and 1.9%,respectively.However,when HEECs were treated without genistein,the percentages of HEECs at G1/0,G2/M,and S phase were 76.7%,8.5%,and 14.7%,respectively.17β-E2 could not influence the effects of genistein on the proliferation of HEECs.Meanwhile,genistein could suppress the proliferation of HEC-1B.If the stimulation index of HEC-1B was defined as 100% when HEC-1B was treated with different doses of 17β-E2(without genistein),it was 67%,19%,as well as 32% when cell was supplemented with 200 μmol/L genistein combined with 0,0.2,or 1 nmol/L 17β-E2,respectively.Conclusion Genistein at the concentration of 200 μmol/L can sufficiently inhibit the proliferation of HEECs and endometrial glandular epithelium simultaneously in vitro. | Gui-hua Sha Shou-qing Lin | 2008 | Chinese Medical Sciences Journal2008，23，1： | 6 |
| 12 | miR-486 sustains NF-KB activity by disrupting multiple NF-KB-negative feedback loops显示文摘 | Libing Song Chuyong Lin Hul Gong Chanjuan Wang Liping Liu Jueheng Wu Sha Tao Bo Hu Shi-Yuan Cheng Mengfeng Li Jun Li | 2013 | Cell Research2013，23，2： | 6 |
| 13 | PIV EXPERIMENTAL RESEARCH OF INSTANTANEOUS FLOW CHARACTERISTICS OF CIRCULAR ORIFICE SYNTHETIC JET显示文摘The instantaneous flow characteristics of circular orifice synthetic jet was experimentally studied by a phase-locked Particle Image Velocimetry (PIV) system. The instantaneous flowfields, including the forming, developing and breaking down of the vortex for the jet were clearly shown by the PIV experimental results. As the basis of the study of the instantaneous flow, 36 images were taken and phase-averaged for each condition. The PIV experiment was mainly focused on the time evolution of the vortex pairs formed in the push cycle, the saddle point existing in the suck cycle, the variation of the centerline velocity in the whole cycle and the cross-stream velocity profiles and their self-similarity. Finally, the orifice depth was changed from 1.5 mm to 2 mm and 3.5 mm in order to study the effect of different orifice depths on the flow structure, which shows that at all stream wise sections, the peak of the mass flux and momentum flux increases as the orifice depth increases. Furthermore, the nondimensional distance of the mass flux from the exit is the maximum, while the nondimensional distance of the centerline velocity peak from the exit is the minimum, and nondimensional distance of the momentum flux from the exit section is between them. | XU Jing-lei SHA Jiang LIN Chun-feng ZHANG Kun-yuan | 2007 | Journal of Hydrodynamics2007，19，4： | 6 |
| 14 | Lipoprotein(a) as a Marker for Predicting the Presence and Severity of Coronary Artery Disease in Untreated Chinese Patients Undergoing Coronary Angiography显示文摘Objective Low-density lipoprotein cholesterol(LDL-C) has been well known as the risk factor of coronary artery disease(CAD). However, the role of lipoprotein(a) [Lp(a)] in the development of CAD is of great interest but still controversial. Thus, we aim to explore the effect of Lp(a) on predicting the presence and severity of CAD in Chinese untreated patients, especially in combination with LDL-C. Methods We consecutively recruited 1,980 non-treated patients undergoing coronary angiography, among which 1,162 patients were diagnosed with CAD. Gensini score(GS) was used to assess the severity of CAD. Lp(a) was measured by immunoturbidimetric method. Results Patients with CAD had higher level of LDL-C and Lp(a) compared with non-CAD(P < 0.05). Multivariable logistic regression revealed that Lp(a) > 205 mg/L(highest tertile) predicted 1.437-fold risk for CAD(95% CI: 1.108-1.865, P = 0.006) and 1.480-fold risk for high GS(95% CI: 1.090-2.009, P = 0.012) respectively. Interestingly, concomitant elevated level of Lp(a) and LDL-C conferred the highest risk for both presence [OR = 1.845, 95% CI: 1.339-2.541, P < 0.001] and severity [OR = 1.736, 95% CI: 1.188-2.538, P = 0.004] of CAD. Conclusion Lipoprotein(a) is a useful marker for predicting the presence and severity of CAD, especially combined with LDL-C. | SUN Di ZHAO Xi LI Sha ZHANG Yan WU Na Qiong ZHU Cheng Gang GUO Yuan Lin GAO Ying QING Ping LIU Geng DONG Qian LI Jian Jun | 2018 | Biomedical and Environmental Sciences2018，31，4： | 6 |
| 15 | A fully automatic registration approach based on contour and SIFT for HJ-1 images显示文摘To achieve a fully automatic registration between HJ-1 CCD images and HJ-1 infrared images is a difficult task as it must deal with the varying illuminations and resolutions of the images,different perspectives,and the local deformations within the images.In this paper,aimed at those registration issues,a fully automatic registration approach based on contour and SIFT is proposed.The registration technique performs a pre-registration process using contour feature matching algorithm that decides the overlapping region between a reference image and an input image.Once the coarse regions are obtained,it performs a fine registration process based on SIFT detector and a local adaptive matching strategy.In the fine registration process,image blocking theory is used,which not only speeds up the features extraction and matching,but also makes the matching point pairs distributed uniformly in images,and further improves the accuracy of input image rectification.Experiments with visible images and infrared images from HJ-1A/B demonstrate the efficiency and the accuracy of the proposed technique for multisource remote sensing images registration. | NI XiLiang CAO ChunXiang DING Lin JIANG Tao ZHANG Hao JIA HuiCong LI GuangHe ZHAO Jian CHEN Wei JI Wei XU Min GAO MengXu ZHENG Sheng TIAN Rong LIU Cheng LI Sha | 2012 | Science China Earth Sciences2012，55，10： | 5 |
| 16 | Circulating MicroRNAs as Novel Diagnostic Biomarkers for Very Early-onset(≤40 years) Coronary Artery Disease显示文摘Objective Very early-onset coronary artery disease(CAD) is a great challenge in cardiovascular medicine throughout the world,especially regarding its early diagnosis.This study explored whether circulating micro RNAs(mi RNAs) could be used as potential biomarkers for patients with very early-onset CAD.Methods We performed an initial screening of mi RNA expression using RNA isolated from 20 patients with angiographically documented very early-onset CAD and 20 age-and sex-matched normal controls.For further confirmation,we prospectively examined the mi RNAs selected from 40 patients with very early-onset CAD and 40 angiography-normal controls.Results A total of 22 overexpressed mi RNAs and 22 underexpressed mi RNAs were detected in the initial screening.RT-q PCR analysis of the mi RNAs obtained from the initial screening revealed that four mi RNAs including mi R-196-5p,mi R-3163-3p,mi R-145-3p,and mi R-190a-5p exhibited significantly decreased expression in patients compared with that in controls(P<0.05).The areas under the receiver operating characteristic curve for these mi RNAs were 0.824(95% CI,0.731-0.917;P<0.001),0.758(95% CI,0.651-0.864;P<0.001),0.753(95% CI,0.643-0.863;P<0.001),and 0.782(95% CI,0.680-0.884;P<0.001),respectively,in the validation set.Conclusion To our knowledge,this is an advanced study to report about four serum mi RNAs(mi R-196-5p,mi R-3163-3p,mi R-145-3p,and mi R-190a-5p) that could be used as novel biomarkers for the diagnosis of very early-onset CAD. | DU Ying YANG Sheng Hua LI Sha CUI Chuan Jue ZHANG Yan ZHU Cheng Gang GUO Yuan Lin WU Na Qiong GAO Ying SUN Jing DONG Qian LIU Geng LI Jian Jun | 2016 | Biomedical and Environmental Sciences2016，29，8： | 5 |
| 17 | BER analysis of STBC hybrid carrier system based on WFRFT with frequency domain equalization显示文摘The inherent characteristic of hybrid carrier(HC) scheme based on the weighted-type fractional Fourier transform(WFRFT) is revealed. The proposed linear combination of single carrier(SC) and multicarrier's(MC) characteristics is helpful to balance the conflicting requirements and achieve the comparative analysis of SC/MC. As an example, analytical SER/BER expressions of HC system with zero forcing(ZF)and minimum mean square error(MMSE) equalization are derived. In addition, the derived BER expressions are extended to multi-input systems. A unified framework of space time block code(STBC) HC scheme is proposed with two WFRFT modules at the transmitter or receiver, where STBC-SC and STBC-MC systems are the special cases of the novel structure. | Zhenduo WANG Lin MEI Xuejun SHA Naitong ZHANG | 2018 | Science China(Information Sciences)2018，61，8： | 5 |
| 18 | TsCl-promoted sulfonylation of quinoline N-oxides with sodium sulfinates in water显示文摘An eco-friendly protocol for the synthesis of various 2-sulfonyl quinolines/pyridines through sulfonylation of heteroaromatic N-oxides with sodium sulfinates in water at ambient temperature under metal-and oxidant-free conditions has been developed.The mild reaction conditions,high reaction efficiency,operational simplicity,short reaction time and remarkable functional-group compatibility make the developed protocol very attractive for the preparation of 2-sulfonyl N-heteroaromatic compounds. | Sha Peng Yan-Xi Song Jun-Yi He Shan-Shan Tang Jia-Xi Tan Zhong Cao Ying-Wu Lin Wei-Min He | 2019 | Chinese Chemical Letters2019，30，12： | 5 |
| 19 | The role of ezrin-associated protein network in human sperm capacitation显示文摘在精子房间的膜修正在精子 capacitation 代表关键步;然而,这些修正的分子的基础充分没被理解。Ezrin 是 ezrin/radixin/merlin 家庭的学习最好的成员。作为在外皮的细胞骨架和血浆膜蛋白质之间的 cross-linker, ezrin 贡献膜表面结构改变。而且,激活 ezrin 和 Rho 分离禁止者, RhoGDI,通过 Rho 激活支持外皮的 cytoskeleton-polymerized 肌动朊的形成。因此, ezrin,肌动朊, RhoGDI, Rho 和血浆膜蛋白质在 vivo 形成一个复杂网络,它贡献膜表面的结构的集会。以前,我们证明 ezrin 和 RhoGDI1 在人的睾丸被表示。因此,我们寻求了决定 ezrin 鈥揜h oGDI1 鈥揳c 听鈥搈e mbrane 蛋白质网络是否在人的精子 capacitation 有一个角色。我们由西方的污点的结果显示 ezrin 被 threonine567 残余的 phosphorylation 在 capacitation 期间激活。Co-immunoprecipitation 研究表明在精子 capacitation 期间,在 ezrin 和 RhoGDI1 之间的相互作用增加,并且二维的电气泳动胶化的 phosphostaining 证明 RhoGDI1 是 phosphorylated,建议 RhoGDI1 从 RhoA 分裂并且导致精子头上的肌动朊聚合。我们推测那激活的 ezrin 在 capacitation 以后与 polymerized 肌动朊和 glycosylated 膜蛋白质 cd44 交往。用 ezrin 特定或肌动朊特定的 monoclonal 抗体堵住精子 capacitation 减少他们的 acrosome 反应(AR ) 率,但是没独自在 AR 上有效果。一起拿,我们的结果证明由 ezrin, RhoGDI1, RhoA, F 肌动朊和膜蛋白质组成的一个网络工作影响在人的精子 capacitation 期间发生在精子头的膜上的修正。 | Lei Wang Wen Chen Chun Zhao Ran Huo Xue-Jiang Guo Min Lin Xiao-Yan Huang Yun-Dong Mao Zuo-Min Zhou Jia-Hao Sha | 2010 | Asian Journal of Andrology2010，12，5： | 4 |
| 20 | A Teosinte-derived Allele of a MYB Transcription Repressor Confers Multiple Disease Resistance in Maize.显示文摘Natural alleles controlling multiple disease resistances (MDR) are valuable for crop breeding. However, only one MDR gene have been cloned in maize, and molecular mechanisms of MDR are not clear. By map-based cloning, we have cloned a teosinte-derived allele of a resistance gene, Mexicana lesion mimic 1 (ZmMM1), which has a lesion mimic phenotype and confers resistance to northern leaf blight (NLB), gray leaf spot (GLS) and southern corn rust (SCR). Strong MDR conferred by the teosinte allele is linked with the polymorphisms in the 3' untranslated region of the ZmMM1 gene that cause increased accumulation of ZmMM1 protein. ZmMM1 acts as a transcription repressor and negatively regulates transcription of specific target genes including ZmMM1-target gene 3 (ZmMT3), which functions as a negative regulator of plant immunity and associated cell death. The successful isolation of the ZmMM1 resistance gene will help not only in developing broad-spectrum and durable disease resistance but also in understanding the molecular mechanisms underlying MDR. | Hongze Wang Jiabao Hou Pei Ye Long Hu Junshi Huang Zhikang Dai Bao Zhang Sha Dai Jiamin Que Haoxuan Min Gengshen Chen Yanbo Wang Min Jiang Yan Liang Lin Li Xuecai Zhang Zhibing Lai | 2021 | Molecular Plant2021，14，11： | 4 |
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