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| 1 | A titanium dioxide nanorod array as a high-affinity nano-bio interface of a microfluidic device for efficient capture of circulating tumor cells显示文摘处理临床的问题的 Nanomaterials 表演答应机会(例如传播肿瘤房间的不够的俘获;CTC ) 经由为生物房间的高表面 area-to-volume 比率和高亲密关系。然而,怎么与高特性遗体为有效 CTC 俘获在一台 microfluidic 设备作为一个 nano 简历接口使用这些 nanomaterials 挑战。在现在的工作,我们首先发现那钛二氧化物(能方便地在底层的多重类型上被准备的 TiO 2) nanorod 数组为肿瘤房间有高亲密关系。然后, TiO 2 nanorod 数组在有经由热水的反应的六角形地有图案的 Si micropillars 的 microchannel 的表面上是垂直地成年的,层次地形成 micro-nano 3D 的一种新类型结构化的 microfluidic 设备。当这 3D 的一个敏感 nano 简历接口层次地组织了 microfluidic 设备,垂直地成年的 TiO 2 nanorod 数组被使用,哪个显示出 CTC 俘获的高效率(76.7% 潩獮 ? 畯 ? 牰灯獯摥栠杩 ? 数晲牯慭据 ? 潍 ? ??? 猯'T ￣楢獯湥潳獲挠湡搠瑥捥 ?? 卐? 潣据湥牴瑡潩吗?? | Jichuan Qiu Kun Zhao Linlin Li Xin Yu Weibo Guo Shu Wang Xiaodi Zhang Caofeng Pan Zhong Lin Wang Hong Liu | 2017 | Nano Research2017，10，3： | 3 |
| 2 | Colonization of periphytic ciliated protozoa on an artificial substrate in mariculture waters with notes on responses to environmental factors显示文摘Colonization of periphytic ciliates and their usefulness for monitoring water quality were evaluated using the glass slide method in two enclosed mariculture ponds used to culture crab larva and in a natural seawater reservoir.The results revealed that(1) the ciliate species composition and colonizing process differed between the culturing ponds and the natural reservoir and(2) the dominant ciliate species showed a greater distribution in terms of both the abundance and the occurrence frequency.This study also demonstrated that structural parameters were strongly related to water conditions.For example,the abundance was positively associated with NO3-N and soluble reactive phosphate(P < 0.05),whereas the species number,species diversity and evenness were negatively correlated with nutrients(e.g.NO3-N and NH3-N) and temperature(P < 0.05).These findings support the evidence that periphytic ciliates are useful bioindicators of water quality in enclosed mariculture ecosystems. | Jiqiu Li Henglong Xu Xiaofeng Lin Weibo Song | 2009 | Progress in Natural Science:Materials International2009，19，10： | 3 |
| 3 | The role of intraoperative electron radiotherapy in centrally located hepatocellular carcinomas treated with narrow-margin (<1 cm) hepatectomy: a prospective, phase 2 study显示文摘Background: Postoperative radiotherapy (RT) is known to play an important role in the treatment of hepatocellular carcinomas (HCCs), but the specific role of intraoperative electron radiotherapy (IOERT) in HCCs remains unclear. The aim of this study was to investigate the safety and efficacy of IOERT in centrally located HCCs treated with narrow-margin (<1 cm) hepatectomy. Methods: This was a single-center, phase 2, prospective non-randomized controlled study, including 268 patients with centrally located HCCs who underwent narrow-margin hepatectomy. The patients were subsequently allocated to the IOERT group (n=59) or to the control group (n=65). The primary outcome of the study was to compare recurrence-free survival (RFS) between the IOERT group and the control group, and the secondary outcome was to compare overall survival (OS) rate between the two groups. Results: Of 268 patients enrolled, a total of 124 were included in the study: 59 in IOERT group, 65 in control group. The 1-, 2-, 3-year RFS rates were 79.3%, 62.1% and 45.8% for patients in the IOERT group, and 47.6%, 28.6%, and 22.9% for patients in the control group, respectively (P=0.025). The 1-, 2-, and 3-year OS rates were 100.0%, 94.9%, and 83.7% for patients in the IOERT group, and 92.3%, 87.5%, and 79.4% for patients in the control group, respectively (P=0.314). Subgroup analysis of MVI (+) patients revealed that RFS and OS are significantly prolonged in the IOERT subgroup as compared to the control, whereas there was no significant difference of RFS and OS between the two groups in MVI (−) patients. Conclusions: IOERT for centrally located HCCs with concurrent narrow-margin hepatectomy was feasible and safe. Statistically better RFS rate was observed in the IOERT group compared to the control group. Subgroup analysis revealed that IOERT was more beneficial for postoperative survival of HCC patients with MVI. Trial Registration: ChiCTR-TRC-12002802;www.who.int/ictrp. | Liming Wang Yunhe Liu Weiqi Rong Fan Wu Weibo Yu Kan Liu Shengtao Lin Yiling Zheng Kai Zhang Tana Siqin Changcheng Tao Mei Liu Bo Chen Qinfu Feng Jianxiong Wu | 2022 | Hepatobiliary Surgery and Nutrition2022，11，4： | 2 |
| 4 | A Multicenter Application and Evaluation of the Oxford Classification of IgA Nephropathy in Adult Chinese Patients显示文摘 | Cai-Hong Zeng Weibo Le Zhaohui Ni Minfang Zhang Lining Miao Ping Luo Rong Wang Zhimei Lv Jianghua Chen Jiong Tian Nan Chen Xiaoxia Pan Ping Fu Zhangxue Hu Lining Wang Qiuling Fan Hongguang Zheng Dewei Zhang Yaping Wang Yanhong Huo Hongli Lin Shuni Chen Sh | 2012 | American Journal of Kidney Diseases2012，，5： | 2 |
| 5 | WHIRLY1 recruits the histone deacetylase HDA15 repressing leaf senescence and flowering in Arabidopsis显示文摘Leaf senescence is controlled by a complex regulatory network in which robustness is ensured by the activity of transcription factors and epigenetic regulators.However,how these coordinate the process of leaf senescence remains poorly understood.We found that WHIRLY1 interacts with Histone Deacetylase(HDA)15,a Reduced Potassium Dependence3(RPD3)/HDA1-type HDA,by using green fluorescent protein-nanotrap-mass spectrum assays.The development-dependent interaction between WHIRLY1 and HDA15 was further confirmed by bimolecular fluorescence complementation assays and co-immunoprecipitation assays in Arabidopsis.Multi-omics genome-wide transcriptome and H3K9 acetylome enrichment analysis showed that HDA15 delays leaf senescence and flowering by repressing the expression of the positive regulators of leaf senescence and flowering,such as LOX2 and LARP1 C,and reducing H3K9 ac levels at these loci;WHIRLY1 and HDA15 co-target to the region near the transcription start site of a subset of nutrient recycling-related genes(e.g.,Glutathione S-transferases 10,non-coding RNA,and photosystem II protein D1 synthesizer attenuator PDIL1-2),as well as WRKY53 and ELF4,and co-repress their expression by removing H3K9 acetylation.Our study revealed a key transcription regulatory node of nutrient recycling and senescence-associated genes involved in leaf senescence and flowering via the recruitment of HDA15 by the single-stranded DNA/RNA-binding protein WHIRLY1. | Dongmei Huang Wei Lan Weibo Ma Rulin Huang Wenfang Lin Mengsi Li Chia-Yang Chen Keqiang Wu Ying Miao | 2022 | Journal of Integrative Plant Biology2022，64，7： | 2 |
| 6 | Three-Dimensional Water Quality Model Based on FVCOM for Total Load Control Management in Guan River Estuary,Northern Jiangsu Province显示文摘Guan River Estuary and adjacent coastal area(GREC) suffer from serious pollution and eutrophicational problems over the recent years.Thus,reducing the land-based load through the national pollutant total load control program and developing hydrodynamic and water quality models that can simulate the complex circulation and water quality kinetics within the system,including longitudinal and lateral variations in nutrient and COD concentrations,is a matter of urgency.In this study,a three-dimensional,hydrodynamic,water quality model was developed in GREC,Northern Jiangsu Province.The complex three-dimensional hydrodynamics of GREC were modeled using the unstructured-grid,finite-volume,free-surface,primitive equation coastal ocean circulation model(FVCOM).The water quality model was adapted from the mesocosm nutrients dynamic model in the south Yellow Sea and considers eight compartments:dissolved inorganic nitrogen,soluble reactive phosphorus(SRP),phytoplankton,zooplankton,detritus,dissolved organic nitrogen(DON),dissolved organic phosphorus(DOP),and chemical oxygen demand.The hydrodynamic and water quality models were calibrated and confirmed for 2012 and 2013.A comparison of the model simulations with extensive dataset shows that the models accurately simulate the longitudinal distribution of the hydrodynamics and water quality.The model can be used for total load control management to improve water quality in this area. | ZHANG Li LIN Weibo LI Keqiang SHENG Jianming WEI Aihong LUO Feng WANG Yan WANG Xiulin ZHANG Longjun | 2016 | Journal of Ocean University of China2016，15，2： | 1 |
| 7 | New Researches and Application Progress of Commonly Used Optical Molecular Imaging Technology显示文摘 | Zhi-Yi Chen Yi-Xiang Wang Feng Yang Yan Lin Qiu-Lan Zhou Yang-Ying Liao Weibo Cai | 2014 | BioMed Research International2014，，： | 1 |
| 8 | Electroacupuncture at Zusanli (ST36) Prevents Intestinal Barrier and Remote Organ Dysfunction following Gut Ischemia through Activating the Cholinergic Anti-Inflammatory-Dependent Mechanism显示文摘 | Sen Hu Ming-Hua Du Hong-Min Luo Huan Wang Yi Lv Li Ma Zhi-Long Lin Xian Shi Ingrid Gaischek Lu Wang Gerhard Litscher Weibo Zhang | 2013 | Evidence-Based Complementary and Alternative Medicine2013，，： | 1 |
| 9 | The β6-integrin-ERK/MAP kinase pathway contributes to chemo resistance in colon cancer显示文摘 | Song Liu Jian Wang Weibo Niu Enyu Liu Jiayong Wang Cheng Peng Pengfei Lin Ben Wang Abdul Qadir Khan Huijie Gao Benjia Liang Muhammad Shahbaz Jun Niu | 2013 | Cancer Letters2013，，2： | 1 |
| 10 | Effects of 1-MCP and exogenous ethylene on fruit ripening and antioxidants in stored mango显示文摘 | Baogang Wang Jianhui Wang Xiaoyuan Feng Lin Lin Yumei Zhao Weibo Jiang | 2009 | Plant Growth Regulation2009，，2： | 1 |
| 11 | Phase-pure two-dimensional Fe_(X)GeTe_(2) magnets with near-room-temperature Tc显示文摘Two-dimensional(2D)ferromagnets with out-of-plane(OOP)magnetic anisotropy are potential candidates for realizing the next-generation memory devices with ultra-low power consumption and high storage density.However,a scalable approach to synthesize 2D magnets with OOP anisotropy directly on the complimentary metal-oxide semiconductor(CMOS)compatible substrates has not yet been mainly explored,which hinders the practical application of 2D magnets.This work demonstrates a cascaded space confined chemical vapor deposition(CS-CVD)technique to synthesize 2D FexGeTe_(2) ferromagnets.The weight fraction of iron(Fe)in the precursor controls the phase purity of the as-grown FexGeTe2.As a result,high-quality Fe_(3)GeTe_(2) and Fe_(5)GeTe_(2) flakes have been grown selectively using the CS-CVD technique.Curie temperature(Tc)of the as-grown FexGeTe2 can be up to-280 K,nearly room temperature.The thickness and temperature-dependent magnetic studies on the Fe_(5)GeTe_(2) reveal a 2D Ising to 3D XY behavior.Also,Terahertz spectroscopy experiments on Fe_(5)GeTe_(2) display the highest conductivity among other FexGeTe_(2) 2D magnets.The results of this work indicate a scalable pathway for the direct growth and integration of 2D ternary magnets on CMOS-based substrates to develop spintronic memory devices. | Govindan Kutty Rajendran Nair Zhaowei Zhang Fuchen Hou§ Ali Abdelaziem Xiaodong Xu Steve Wu Qing Yang Nan Zhang Weiqi Li Chao Zhu Yao Wu Heng Weiling Lixing Kang Teddy Salim Jiadong Zhou Lin Ke Junhao Lin Xingji Li Weibo Gao Zheng Liu | 2022 | Nano Research2022，15，1： | 0 |
| 12 | Natural scaffolds-inspired synthesis of CF_(3)-substituted macrolides enabled by Rh-catalyzed C–H alkylation macrocyclization显示文摘The development of innovative strategies and methods to provide natural product-like macrocycles not accessible by biosynthesis, but endowed with novel bioactivities and simplified structure, is highly desirable. Inspired by the key scaffolds of rapamycin and FR252921, herein, we report a Rh(III)-catalyzed C–H alkylation macrocyclization, which enables access to CF_(3)-substituted macrolides. DFT calculations reveal that the chemoselectivity between C–H alkylation and olefination macrocyclization was highly controllable. Moreover, the unique CF_(3)-substituted macrolides showed potent anti-inflammation activities against TNF-α, IL-6 and CCL2 m RNA expression. | Tongyu Bi Yi Xu Xin Xu Bixi Tang Qing Yang Yi Zang Zhenyang Lin Jia Li Weibo Yang | 2022 | Chinese Chemical Letters2022，33，4： | 0 |
| 13 | Flexible, Transparent and Conductive Metal Mesh Films with Ultra‑High FoM for Stretchable Heating and Electromagnetic Interference Shielding显示文摘Despite the growing demand for transparent conductive films in smart and wearable electronics for electromagnetic interference(EMI)shielding,achieving a flexible EMI shielding film,while maintaining a high transmittance remains a significant challenge.Herein,a flexible,transparent,and conductive copper(Cu)metal mesh film for EMI shielding is fabricated by self-forming crackle template method and electroplating technique.The Cu mesh film shows an ultra-low sheet resistance(0.18Ω□^(-1)),high transmittance(85.8%@550 nm),and ultra-high figure of merit(>13,000).It also has satisfactory stretchability and mechanical stability,with a resistance increases of only 1.3%after 1,000 bending cycles.As a stretchable heater(ε>30%),the saturation temperature of the film can reach over 110°C within 60 s at 1.00 V applied voltage.Moreover,the metal mesh film exhibits outstanding average EMI shielding effectiveness of 40.4 dB in the X-band at the thickness of 2.5μm.As a demonstration,it is used as a transparent window for shielding the wireless communication electromagnetic waves.Therefore,the flexible and transparent conductive Cu mesh film proposed in this work provides a promising candidate for the next-generation EMI shielding applications. | Zibo Chen Shaodian Yang Junhua Huang Yifan Gu Weibo Huang Shaoyong Liu Zhiqiang Lin Zhiping Zeng Yougen Hu Zimin Chen Boru Yang Xuchun Gui | 2024 | Nano-Micro Letters2024，16，5： | 0 |
| 14 | Phase Relationship in the Al-rich(Al+0.15at %V)-Mg-Zn System显示文摘Isothermal sections at room temperature and 450℃ for Al-rich(Al+0.15at%V)-Mg-Zn system have been determined bymeans of X-ray diffraction,microscopic observation and DTA methods.Comparing with Al-Mg-Zn system the α-phase regionof in isothermal sections room at temperature and 450℃ for the system with 0.15at%V is slightly narrowed and expandedrespectively.The solubilitiy limits of Zn and Mg in α-Al have been found to be 3.3at%(7.6wt%)and 5.5at%(5.0wt%)respectively at room temperature,and to be 6.0at%(13.4wt%)and 11.0at%(10.0wt%)at 450℃.The τ phase in this system is aternary intermetallic compound,which undergoes an allotropic transformation at about 427℃. | Tang, Junqi Li, Dexuan Lin, Weibo Zhuang, Yinghong | 1989 | Rare Metals1989，9，3： | 0 |
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