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| 1 | 针刺与艾灸对气虚证心率变异性的不同影响:随机对照研究显示文摘目的:观察针刺与艾灸对气虚证患者症状的改善作用及对心率变异性指标的不同影响。方法:招募30例气虚证患者及15例健康受试者,将30例气虚证患者随机分为针刺组和艾灸组,每组15例;15例健康受试者作为健康对照组。针刺组与健康对照组接受针刺治疗,艾灸组接受艾灸治疗,所取穴位均为关元和足三里,隔日治疗1次,共10次。在患者治疗前、治疗4次及治疗结束后进行气虚证症状量化评分并检测受试者心率变异性。比较气虚证症状量化评分与心率变异性指标的相关性,比较治疗前、治疗4次及治疗结束后3组受试者心率变异性指标的变化。结果:针刺组与艾灸组气虚证症状量化评分在第4次治疗后和治疗结束后均较治疗前下降(均P<0.05),治疗结束后艾灸组气虚证评分低于针刺组(P<0.05);气虚证患者的心率变异性指标比健康对照组更低(均P<0.05),且相关系数更高;治疗结束后,艾灸组的平均心率较治疗前下降(P<0.05),心率变异性总功率、低频均较治疗前上升(均P<0.05),健康对照组平均心率较治疗前上升(P<0.05);针刺组各指标与治疗前比较差异均无统计学意义(均P>0.05)。结论:心率变异性总功率能一定程度上反映气虚证的严重程度,针刺与艾灸均能改善患者的气虚症状,艾灸作用更明显,原因可能与艾灸能够持续性地提高自主神经系统活性有关。 | 舒晴 孙丹红 王华 梁凤霞 Gerhard Litscher Daniela Litscher Ingrid Gaischek 陈丽 何文娟 王雅媛 | 2017 | 中国针灸2017，37，1： | 19 |
| 2 | 针灸关元、足三里对气虚证心率变异性即时效应的影响显示文摘目的:比较针刺与艾灸关元、足三里对气虚证心率变异性相关指标的即时效应。方法:将90例气虚证患者随机分为针刺组、艾灸组和非针灸组,每组30例。针刺组采用针刺治疗,穴取关元、足三里,留针15 min,仅治疗1次;艾灸组采用艾灸治疗,选穴、治疗时间同针刺组;非针灸组不予以任何干预。于治疗前后记录各组患者气虚证症状分级量化评分;于治疗前5 min,治疗5、10、15 min及治疗后5 min检测各组患者平均心率及心率变异性相关指标[总功率、低频(LF)、高频(HF)、低高频比值对数(log LF/HF)]。结果:针刺组及艾灸组治疗后气虚证症状分级量化评分均降低(P<0.05)。与治疗前比较,针刺组患者治疗5 min HF升高(P<0.05),治疗15 min及治疗后5 min HF均降低(P<0.05,P<0.01);治疗5、10 min及治疗后5 min log LF/HF均升高(P<0.01)。针刺组治疗前后5 min平均心率差值高于艾灸组、非针灸组(P<0.05),log LF/HF变化幅度高于艾灸组及非针灸组(P<0.01,P<0.05)。结论:针刺与艾灸疗法对气虚证心率变异性均具有一定即时作用,针刺组优于艾灸组,这可能与针刺对自主神经系统的良性调节有关。 | 宋燕娟 梁凤霞 王华 Gerhard Litscher 吴松 李佳 黄琪 李桐 滕汝枫 李悦 陈祥林 | 2020 | 中国针灸2020，40，10： | 9 |
| 3 | Acupotomy versus sodium hyaluronate for treatment of knee osteoarthritis in rabbits显示文摘OBJECTIVE: To investigate the possible advantages of acupotomy over sodium hyaluronate injection for the treatment of knee osteoarthritis(KOA).METHODS: Twenty rabbits were divided randomly into four groups(n = 5 in each): a control group,model group, acupotomy group, and sodium hyaluronate injection group. The model, acupotomy,and sodium hyaluronate groups underwent anterior cruciate ligament transection plus partial medial meniscectomy. Sodium hyaluronate injection and acupotomy were administered to the respective groups from weeks 5 to 8, and samples of the tibial plateau and medial condyle of the femur were collected in week 9. Vascular endothelial growth factor(VEGF) expression was assessed in cartilage and subchondral bone by immunohistochemical staining.RESULTS: Articular cartilage degeneration was less pronounced in the acupotomy compared with the model and sodium hyaluronate groups. VEGF expression levels in cartilage and subchondral bone were increased in the model group compared with the control group(P < 0.01), and acupotomy had a more pronounced therapeutic effect than sodium hyaluronate injection(P < 0.01).CONCLUSION: Acupotomy and sodium hyaluronate injection may both reduce degeneration in the cartilage and subchondral bone in KOA based on the results from a rabbit model, but acupotomy improved the histopathology and reduced the VEGF content more effectively than sodium hyaluronate injection, probably by reducing venous stasis and intraosseous pressure. Acupotomy may improve KOA by lowering VEGF. | Ding Yu Yuan Xueling Wang Yongcheng Wang Aiyuan Shi Xian Wang Lu Daniela Litscher Ingrid Gaischek Irmgard Th.Lippe Gerhard Litscher | 2017 | Journal of Traditional Chinese Medicine2017，37，3： | 8 |
| 4 | 利用MoorFLPI激光血流成像仪等观察不同针刺手法的效应显示文摘目的:观察单纯提插或捻转手法造成的穴位及相关部位皮肤表面微血管灌注量的变化、对受试者血压、心率及心率变异性的影响,同时记录受试者的针感。方法:选择20岁~35岁青年志愿者15人,平均年龄25.4岁±2.61岁。针刺右下肢足三里穴,采用MoorFLPI激光多普勒扫描仪散斑全帧实时扫描成像系统进行穴位及相关部位点状波形模式的实时扫描,扫描前后进行心电及血压监测。结果:提插及捻转手法操作均可有效降低血压及心率,改善HRV;提插与捻转手法对被观察点及对照点的皮肤微血管灌注量的影响有较大的差异;提插手法产生的针感明显强于捻转手法。结论:提插与捻转手法在上述所观察的各项指标均有差异,提示其对人体产生影响的机制有所不同,值得进一步研究。 | 黄涛 张维波 贾术永 田宇瑛 王广军 杨李健 王璐 Gerhard Litscher | 2012 | 中国中医基础医学杂志2012，18，11： | 7 |
| 5 | Comparison of the Effects of Traditional Box-Moxibustion and Eletrothermal Bian-Stone Moxibustion on Volume of Blood Flow in the Skin显示文摘Objective: To investigate and compare the effects of Electrothermal Bian-stone moxibustion and traditional box-moxibustion on capillary blood perfusion in the body surface. Methods: Twenty healthy subjects, 18 females and 2 males, aged averagely 36 years, were enrolled in this experiment. The traditional box-moxibustion and electrothermal Bian-stone moxibustion were respectively given on the hypogastrium around Guanyuan (CV 4), and the changes of local capillary blood perfusion in the body surface were investigated with Laser Doppler Perfusion Imaging (LDPI). Results:The traditional box-moxibustion was superior to the electrothermal Bian-stone moxibustion in the transient increasing effect in whole body and the long-term increasing effect in the local area of moxibustion on capillary blood perfusion; but for both methods, the increasing effect on the capillary blood perfusion in the local area of moxibustion was same. Conclusion: Electrothermal Bian-stone moxibustion can not completely take the place of the traditional box-moxibustion; but for some disorders with local pain, they possibly have the same effects. | 黄涛 王瑞红 黄鑫 田玉英 张维波 Hossein Ayali 王广军 张宇沁 Genhard Litscher 王璐 | 2011 | Journal of Traditional Chinese Medicine2011，31，1： | 7 |
| 6 | Auricular Acupuncture and Biomedical Research——A Promising Sino-Austrian Research Cooperation显示文摘Treatment by auricular acupuncture has a long history.Ear-acupoint research has been advancing step by step in China and also in Europe.Auricles are rich in nerves,therefore a close relationship with different functions of the human body has been proved by the research teams of the two main authors of this article from China and Austria.In recent years,great progress has been made in the research of regulating human body functions through electroacupuncture at the auricular branch of the vagus nerve,which is part of auricular acupuncture therapy.It is well known that the auricular branch of the vagus nerve is the only peripheral pathway to the cerebral cortex.Studies of the Chinese team on hypertension,diabetes,epilepsy and depression have shown that the mechanism of auricular vagus nerve stimulation(VNS) may be comparable with cervical VNS in terms of pathways.Auricular VNS has a broad clinical application prospect. | 荣培晶 赵敬军 李宇清 Daniela Litscher 李少源 Ingrid Gaischek 翟煦 WANG Lu 罗曼 Gerhard Litscher | 2015 | Chinese Journal of Integrative Medicine2015，21，12： | 6 |
| 7 | 针刺足三里、关元对气虚证患者心率变异性的影响——盲法随机对照研究显示文摘目的观察针刺足三里、关元穴对气虚证患者临床症状及心率变异性指标的影响,并探究穴位特异性。方法将90例气虚证患者随机分为足三里组、关元组、假针刺组,每组30例。足三里组针刺双侧足三里穴,同时假针刺关元穴;关元组针刺关元穴,同时假针刺双侧足三里穴;假针刺组同时假针刺双侧足三里穴和关元穴。各组均隔日治疗,共治疗10次。治疗前后进行气虚证症状量化评分并检测患者心率变异性指标,包括时域指标的平均心率(mean HR)、全部窦性心搏R-R间期的标准差(SDNN)、24h内相邻窦性R-R间期差值的均方根(r-MSSD)和频域指标的心率变异性总功率(HRV total)、低频(LF)、高频(HF)、极低频带(VLF)、低频高频比对数值[log(LF/HF)]。结果治疗后足三里组、关元组患者气虚证症状量化评分均较本组治疗前下降,且治疗后评分均低于假针刺组,而治疗后足三里组评分又低于关元组(P<0.05)。足三里组治疗后SDNN、r-MSSD、VLF、LF、HRV total均显著增高,关元组HRV total升高,差异有统计学意义(P<0.05)。足三里组治疗后SDNN、r-MSSD、VLF、LF、HRV total显著高于关元组(P<0.05)。结论针刺足三里、关元穴可改善气虚证患者临床症状,并调控心率变异性,两者作用有差异且针刺足三里对自主神经功能调节的作用优于针刺关元穴。 | 李桐 王华 吴松 陈丽 黄琪 王雅媛 李佳 宋燕娟 王文 韩颖 毛锡顺 Gerhard Litscher 梁凤霞 | 2022 | 中医杂志2022，63，12： | 5 |
| 8 | 电热砭石作用于大椎区域对脑动脉血流速度影响的研究显示文摘目的:使用多向超声多普勒血流测定仪,对10名健康受试者进行了电热砭石(9cm×10cm)作用于大椎穴后对脑动脉血流速度影响的观察。方法:观察了大脑中动脉(middle cerebral artery,MCA)和基底动脉(basilar artery,BA)的血流速度。结果:电热砭石对大脑中动脉影响不大,而对离大椎较近的基底动脉具有显著的影响(P<0.01)。结论:说明电热砭石对改善局部动脉血流、加强脑组织的供血有一定积极的作用。 | 黄涛 Gerhard Litscher 王璐 张维波 | 2012 | 中国中医基础医学杂志2012，18，3： | 5 |
| 9 | Influence of Acupuncture on Autonomic Balance in Adult Tinnitus Patients:An Exploratory Study显示文摘Acupuncture is an alternative therapy for tinnitus in clinical practice.The mechanism by which acupuncture can alleviate tinnitus is still unknown.Autonomic nervous system was reported to be responsible for tinnitus.The aim of this study was to explore the effect of acupuncture on autonomic balance in adult tinnitus patients.Thirty patients were randomly assigned into either the deep acupuncture(DA)group or the shallow acupuncture(SA)group.Each patient received 6 acupuncture sessions(a-f phase)over three weeks.Measures of heart rate variability and Tinnitus Handicap Inventory(THI)were obtained at baseline and after the sixth acupuncture session in all patients.The results showed that the low frequency/high frequency(LF/HF)pattern was increased at b-f phase until the sixth acupuncture session when compared with that at the first acupuncture session in DA group.However,it continuously increased at b-f phase in SA group even at the sixth acupuncture session,which was not significantly different from that at the first acupuncture session.The decrease in THI in DA group was greater than that in SA group after 3-week treatment(P=0.043).Our preliminary study suggests three-week deep acupuncture can improve tinnitus symptoms in adult tinnitus patients,which may be related to the regulation of autonomic nervous system balance. | Jian-feng TU Mirim Kim Jing-wen YANG Qian-qian LI Gerhard Litscher Lu WANG Guang-xia SHI Daniela Litscher Cun-zhi LIU | 2019 | Current Medical Science2019，39，6： | 2 |
| 10 | The Influence of Zusanli and Nonmeridian Acupuncture Points on the Survival Rate and Intestinal Tissue Features after Fatal Hemorrhagic Shock in Rats显示文摘 | Xian Shi Yuxian Zhong Jiarui Yao Sen Hu Lu Wang Gerhard Litscher Weibo Zhang | 2013 | Evidence-Based Complementary and Alternative Medicine2013，，： | 2 |
| 11 | Glycoprotein constituents of the vitelline coat of Phallusia mammillata (Ascidiacea)with fertilization inhibiting activity显示文摘 | Litscher E Honegger T G | 1991 | Developmental Biology1991，148，2： | 1 |
| 12 | Anesthesia and acupuncture显示文摘Using acupuncture instead of anesthetics to induce analgesia was performed in China many years ago in surgical anesthetization. Although many medical units in China's cities and rural areas are applying these techniques in operations, it should be pointed out that acupuncture anesthesia is still in the process of development and is of next to no practical and even less scientific value in the western world. However, acupuncture-assisted anesthesia can be useful also in countries other than China. | Gerhard Litscher Holger Simonis Wolfgang Kr?ll | 2015 | World Journal of Anesthesiology2015，4，1： | 1 |
| 13 | Characterization of a mouse ZP3-derived glycopeptide gp55, that exhibits sperm receptor and acrosome reaction-inducing activity in vitro 显示文摘 | Litscher E S Wassarman P M | 1996 | Biochemistry1996，35，： | 1 |
| 14 | Acupuncture using laser needles modulates brain function:first evidence from functional transcranial Doppler sonography and functional magnetic resonance imaging显示文摘 | Litscher G Rachbauer D Ropele S | 2004 | Lasers In Medical Science2004，19，1： | 1 |
| 15 | Ten years evidence-based high-tech acupuncture -A short review of peripherally measured effects (Part I)显示文摘 | Litscher G | 2009 | eCAM2009，6，： | 1 |
| 16 | Computer - based quantification of traditional Chinese -, ear and Korean hand acupuncture: needle induced changes of regional cerebral blood flow velocity显示文摘 | Litscher G | 2002 | Neurol Res2002，24，4： | 1 |
| 17 | Ten years evidence-based high-tech acupuncture -A short review of centrally measured effects (Part II)显示文摘 | Litscher G | 2009 | eCAM2009，6，： | 1 |
| 18 | 针灸现代化研究进展显示文摘中国传统医学,特别是针灸学,作为一种世界范围内广泛使用的治疗医学,有着重大的科学研究价值和应用前景。在充分发挥其治疗效果的基础上,通过多种高科技手段研究针灸的作用机理,将对针灸的国际化应用产生重大的推动和促进作用。在过去的十几年时间里,奥地利格拉兹医科大学中医科研中心对针灸的作用机理进行了广泛而深入的科学研究,利用多种高科技手段的检测,更直观的显示出了针灸的独特功效和相关机理,为针灸的量化及作用机制的进一步研究提供了新的思路。 | Gerhard Litscher | 2015 | 湖北中医药大学学报2015，17，3： | 1 |
| 19 | Computer based quantification of traditional Chinese-ear and Korean handacupuncture:needl-induced changes of regional cerebral blood flow velocity显示文摘 | Litscher G | 2002 | Neurological Research2002，24，4： | 1 |
| 20 | A profile of fertilization in mammals显示文摘 | Wassarman PM Jovine L Litscher ES | 2001 | Nature Cell Biol2001，3，2： | 1 |
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