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| 1 | PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1-Parkin-mediated mitophagy显示文摘Mitophagy 是为损坏线粒体的特定的消除的选择 autophagy 的一种重要类型。(PINK1 )导致 PTEN 的通常认为的 kinase 蛋白质 1 催化 ubiquitin (Ub ) 的 phosphorylation 在 PINK1-Parkin-mediated mitophagy 的发作起一个关键作用。(PTEN-L ) 磷酸酶和 tensin 相当或相同的事物(PTEN ) 长是 PTEN 的最新识别的 isoform,与到它的 N 终点的 173 氨基酸的增加。这里,我们报导 PTEN-L 是经由它对 phosphorylated ubiquitin 的蛋白质磷酸酶活动的 mitophagy 的一个新奇否定管理者。我们发现 PTEN-L 在外部 mitochondrial 膜(OMM ) 本地化,而 PTEN-L 的删除支持, PTEN-L 的 overexpression 禁止, mitophagy 由各种各样的损坏线粒体的代理人导致了。机械学地, PTEN-L 能够有效地阻止 Parkin mitochondrial translocation,减少 Parkin phosphorylation,维持它的关上的不活跃的符合构造,并且禁止它的 E3 ligase 活动。更重要地, PTEN-L 在 vivo 减少 phosphorylated ubiquitin (pSer65-Ub ) 的水平,并且在 vitro,磷酸酶试金经由它的蛋白质磷酸酶活动证实那 PTEN-L dephosphorylates pSer65-Ub,独立于它的类脂化合物磷酸酶功能。一起拿,我们的调查结果为 ubiquitin 作为蛋白质磷酸酶表明 PTEN-L 的新奇功能,它抵抗在 mitophagy 正式就职和 mitophagy 的最终的抑制导致前馈控制机制的阻塞的调停 PINK1 的 ubiquitin phosphorylation。因此,理解 PTEN-L 的这新奇功能在控制 mitophagy 的分子的难题提供一关键错过片,在包括象 Parkinsons 那样的 neurodegenerative 混乱的许多重要人的疾病的一个批评过程疾病。 | Liming Wang Yik-Lam Cho Yancheng Tang Jigang Wang Jung-Eun Park Yajun Wu Chunxin Wang Yan Tong Ritu Chawla Jianbin Zhang Yin Shi Shuo Deng Guang Lu Yihua Wu Hayden Weng-Siong Tan Pornteera Pawijit Grace Gui-Yin Lim Hui-Ying Chan Jingzi Zhang Lei Fang Hanry Yu Yih-Cherng Liou Mallilankaraman Karthik Boon-Huat Bay Kah-Leong Lim Siu-Kwan Sze Celestial T. Yap Han-Ming Shen | 2018 | Cell Research2018，28，8： | 25 |
| 2 | Gas desorption characteristics of the high-rank intact coal and fractured coal显示文摘The objective of this work is to study the gas desorption characteristics of the high-rank intact coal and fractured coal.The gas adsorption,mercury porosimetry and gas desorption experiments were carried out in this study.Then,the theories of thermodynamics,diffusion mechanism and desorption kinetics were used to estimate the gas desorption characteristics.The results of gas adsorption experiments show that the initial isosteric adsorption heat of the intact coal is greater than that of the fractured coal,indicating that the gas molecules desorb more easily from fractured coal than intact coal.Using the mercury porosimetry,we find that the diffusion channels of fractured coal are more developed than those of intact coal.The difficult diffusion form dominates in the intact coal during the gas diffusing,while the easy diffusion form dominates in the fractured coal.The results of gas desorption experiments show that the initial gas desorption volume and velocity of the fractured coal are both greater than those of the intact coal.Using the Fick diffusion law,the study calculates the gas diffusion coefficients of the intact coal and fractured coal.The diffusion coefficients of the fractured coal are 2 times and 10 times greater than those of the intact coal at the time of 0-120 and 0-10 min,respectively. | Lu Shouqing Cheng Yuanping Qin Liming Li Wei Zhou Hongxing Guo Haijun | 2015 | International Journal of Mining Science and Technology2015，25，5： | 15 |
| 3 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 4 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 5 | Relationship between endothelial cell protein C receptor gene 6936A/G polymorphisms and deep venous thrombosis显示文摘背景深静脉的血栓(DVT ) 能导致肺的栓塞,从进肺的手足由于血块(血栓) 的赶出和运动的致命的复杂并发症。与 DVT 开发有关的基因风险因素在凝结蛋白质包括变化,特别 endothelial 蛋白质 C 受体(EPCR ) , anticoaguiation 蛋白质 C (PC ) 小径的一个部件。现在的学习的目的是在 EPCR 基因和这研究包含了的 DVT.Methods 的出现分析在 6936A/G 多型性之间的关系有 DVT 和 71 匹配年龄、匹配性的健康控制的 65 个病人。外部血样品从所有题目被收集。可溶的 EPCR (sEPCR ) 的血浆层次被连接酶的 immunosorbent 试金测量。 Genomic DNA 被提取, EPCR 基因产品被一个标准 PCR reaction.Gene 产品放大乐队们被定序在控制组,识别 EPCR 基因 polymorphisms.Results 在有 6936AG 遗传型的题目的 sEPCR 的水平在有 6936AA 遗传型的题目比那显著地高(( 0.97ic ( OR:1.270 , P=0.044 )并且非糖尿病(或:1.369, P=0.011 ) 在为传统的风险因素调整以后的病人。在 CC 遗传型和在糖尿病患者(P=0.019 ) ,然而并非在非糖尿病患者(P=0.126 ) 的 diseased 容器的数字之间有一个协会。在糖尿病的病人之中, CC 遗传型搬运人有早发作的 CAD 的增加的风险(或: 。2.367, P=0.008 ) 并且更大的累积动脉粥样硬化患者负担与 non-CC 遗传型搬运人相比(Gensini 分数: 31.80 ????????挠潨敬瑳牥汯吮敨????????????????????????????映獡楴杮?????倠??‵??湯汣獵潩?????????????????????????僚?瀠汯浹牯桰獩?潈敷敶??????????????????????? | CHEN Xu-dong TIAN Lu LIMing JIN Wei ZHANG Hong-kun ZHENG Cheng-fei | 2011 | Chinese Medical Journal2011，，1： | 10 |
| 6 | Synergistic effects of elevated homocysteine level and abnormal blood lipids on the onset of stroke显示文摘Hyperhomocysteinemia and abnormal blood lipids are independent risk factors for stroke.However,whether both factors exert a synergistic effect in the onset of stroke remains unclear.The present study is a retrospective analysis of 2 089 cases of stroke and 2 089 control cases of simple intervertebral disk protrusion using a paired multivariate logistic regression method.Adjusting for known confounding variables including the patients’age,gender,smoking status,alcohol consumption status,patient and family medical history,and clinical biochemical indices,elevated homocysteine level was related to the onset of stroke.Patients with elevated homocysteine levels and abnormal blood lipids showed a 40.9%increase in the risk for stroke compared to patients with normal homocysteine levels and blood lipids(odds ratio 1.409;95%confidence interval1.127–1.761).These results indicate that elevated homocysteine and abnormal blood lipids exert synergistic effects in the onset of stroke.Patients with elevated homocysteine levels and abnormal blood lipids are predisposed to stroke. | Lu Hao Liming Chen Xiaoyong Sai Zhefeng Liu Guang Yang Rongzeng Yan Lili Wang Caiyun Fu Xuan Xu Zhenzhen Cheng Qiang Wu Shuzhang Li | 2013 | Neural Regeneration Research2013，8，31： | 9 |
| 7 | Endovascular treatment of blood blister-like aneurysms in the internal carotid artery using a Willis covered stent显示文摘Background Despite the current availability of flow diverter devices(FDD), problems remains regarding optimal endovascular treatment(EVT) for blood blister-like aneurysms(BBAs) of the internal carotid artery(ICA). Objective To evaluate the safety and efficacy of EVT of BBAs in the ICA with a Willis covered stent. Methods 20 consecutive patients(5 men and 15 women) with ruptured BBAs underwent EVT using a Willis covered stent in two institutions from March 2013 to March 2018. Clinical observations, angiographic characteristics, and procedural and follow-up outcomes were retrospectively evaluated. Results 20 consecutive patients(5 men and 15 women) with ruptured BBAs underwent EVT using a Willis covered stent in two institutions from March 2013 to March 2018. Clinical observations, angiographic characteristics, and procedural and follow-up outcomes were retrospectively evaluated. Conclusion Our initial results demonstrate that reconstructive EVT using a Willis covered stent provides a viable approach to treat ICA BBAs. However, an expanded clinical evaluation and larger cohort are needed to confirm the results. | Yi Gu Binxian Gu Yongdong Li Yueqi Zhu Haitao Lu Liming Wei Mo Chen Minhua Li Jieqing Wan Wu Wang | 2018 | Journal of Interventional Medicine2018，1，3： | 8 |
| 8 | High-Resolution Genome-wide Association Study Identifies Genomic Regions and Candidate Genes for Important Agronomic Traits in Wheat显示文摘Wheat(Triticum aestivum)is a major staple food crop worldwide.Genetic dissection of important agronomic traits is essential for continuous improvement of wheat yield to meet the demand of the world's growing population.We conducted a large-scale genome-wide association study(GWAS)using a panel of 768 wheat cultivars that were genotyped with 327609 single-nucleotide polymorphisms generated by genotyping-by-sequencing and detected 395 quantitative trait loci(QTLs)for 12 traits under 7 environments.Among them,273 QTLs were delimited to≤1.0-Mb intervals and 7 of them are either known genes(Rht-D,Vrn-B1,and Vrn-D1)that have been cloned or known QTLs(TaGA2ox8,APO1,TaSus1-7B,and Rht12)that were previously mapped.Eight putative candidate genes were identified for three QTLs that enhance spike seed setting and grain size using gene expression data and were validated in three bi-parental populations.Protein sequence analysis identified 33 putative wheat orthologs that have high identity with rice genes in QTLs affecting similar traits.Large r^2 values for additive effects observed among the QTLs for most traits indicated that the phenotypes of these identified QTLs were highly predictable.Results from this study demonstrated that significantly increasing GWAS population size and marker density greatly improves detection and identification of candidate genes underlying a QTL,solidifying the foundation for large-scale QTL fine mapping,candidate gene validation,and developing functional markers for genomics-based breeding in wheat. | Yunlong Pang Chunxia Liu Danfeng Wang Paul St.Amand Amy Bernardo Wenhui Li Fang He Linzhi Li Liming Wang Xiufang Yuan Lei Dong Yu Su Huirui Zhang Meng Zhao Yunlong Liangi Hongze Jia Xitong Shen Yue Lu Hongming Jiang Yuye Wu Anfei Li Honggang Wang Lingrang Kong Guihua Bai Shubing Liu | 2020 | Molecular Plant2020，13，9： | 8 |
| 9 | Magnetic resonance imaging of artificial lumbar disks: safety and metal artifacts显示文摘这研究是调查二的安全的背景商业地可得到的腰部的人工的磁盘打字( CHARITE 和 PRODISC -L)在磁性的回声成像( MRI )期间在一个1.5泰斯拉先生系统的过程,并且为不同 sequences.Methods 想象在 MR 上评估金属人工制品的尺寸 A 1.5泰斯拉临床的先生成像系统被使用。二个人工的磁盘的终板的偏转的度被一台角度测量仪器在 MRI 扫描仪的门评估。收音机频率(RF ) 的加热效果磁场被在在 L5/S1 intervertebral 圆盘地点与一个人工的腰部的磁盘植入的一具人的死尸上使用“最坏”的成像序列评估。邻近 implant 的织物,并且 L4/L5 intervertebral 圆盘的温度(用作控制) 分别地,在 MRI 扫描顺序前后用一个数字探查温度计被测量。一个矩形的水幽灵被设计在在静态的先生域下面的 implants 的终板的最大的偏转角度是的不同先生成像 sequences.Results 下面评估这二个人工的磁盘的金属人工制品 7.5 和 6.0 度,为 CHARITE 和 PRODISC -L, 分别地。邻近人工的磁盘的二种类型的织物的温度上升和 L4/L5 控制地点的温度上升之间的差别分别地是 0.4 和 0.6。 TSE ( T1/T2-weighted )的图象上的金属人工制品的尺寸,搅动并且涡轮黑暗液体序列是相对不到那些 TSE 脂肪浸透,闪光和 SE (T1加权) sequences.Conclusions CHARITE 和人工的圆盘不介绍的 PRODISC -L 另外的危险或风险到用与 1.5T 的一个静态的磁场操作的一台扫描仪经历一个 MRI 过程的一个病人或更低。如果兴趣的解剖区域在或在在哪儿的区域附近,从 implants 的图象人工制品可以导致问题这些植入被定位(例如,在影响片断的脊椎的运河) 。 | YANG Chang-wei LIU Liu WANG Jian DONG Ai-sheng LU Jian-ping HE Shi-sheng LIMing | 2009 | Chinese Medical Journal2009，，8： | 6 |
| 10 | The Medium Energy X-ray telescope (ME) onboard the Insight-HXMT astronomy satellite显示文摘The Medium Energy X-ray telescope(ME) is one of the three main telescopes on board the Insight hard X-ray modulation telescope(Insight-HXMT) astronomy satellite. ME contains 1728 pixels of Si-PIN detectors sensitive in 5-30 ke V with a total geometrical area of 952 cm^2. The application specific integrated circuit(ASIC) chip, VA32TA6, is used to achieve low power consumption and low readout noise. The collimators define three kinds of field of views(FOVs) for the telescope, 1°×4°, 4°×4°,and blocked ones. Combination of such FOVs can be used to estimate the in-orbit X-ray and particle background components.The energy resolution of ME is ~3 ke V at 17.8 ke V(FWHM) and the time resolution is 255 μs. In this paper, we introduce the design and performance of ME. | XueLei Cao WeiChun Jiang Bin Meng WanChang Zhang Tao Luo Sheng Yang ChunLei Zhang YuDong Gu Liang Sun XiaoJing Liu JiaWei Yang Xian Li Ying Tan ShaoZhen Liu YuanYuan Du FangJun Lu YuPeng Xu Ju Guan ShuangNan Zhang HuanYu Wang TiPei Li ChengMo Zhang XiangYang Wen JinLu Qu LiMing Song XiaoBo Li MingYu Ge YuPeng Zhou ShaoLin Xiong Shu Zhang YongJie Zhang ZeHao Cheng Fei Zhang MaoShun Li XiaoHua Liang Min Gao EnBo Yang XiaoHang Liu HongWei Liu YiJung Yang Fan Zhang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 5 |
| 11 | Ability of lower teardrop edge to restore anatomical hip center height in total hip arthroplasty显示文摘 | Lu Yufeng Cheng Liming Guo Wanshou Yu Qingsheng Gao Fuqiang Zhang Qidong Liu Zhaohui Sun Wei Shi Zhencai | 2014 | Chinese Medical Journal2014，，22： | 5 |
| 12 | Determining the fluorescent components in drilling fluid by using NMR method显示文摘Fluorescent additives can reduce drilling operation risks, especially during high angle deviated well drilling and when managing stuck pipe problems. However, they can affect oil discovery and there is a need to reduce the level of fluorescents or change the drilling fluids to prevent loss of drilling velocity and efficiency. In this paper, based on the analysis of drilling fluids by NMR with high sensitivity, solid and liquid additives have been analyzed under conditions with different fluorescent levels and temperatures. The results show that all of the solid additives have no NMR signal, and therefore cannot affect oil discovery during drilling. For the liquid additives with different oil products, the characterizations can be quantified and evaluated through a T2 cumulated spectrum, oil peak(T2g), and oil content of the drilling fluids. NMR can improve the application of florescent additives and help us to enhance oil exploration benefits and improve drilling operations and efficiency. | Wang Zhizhan Qin Liming Lu Huangsheng Li Xin Cai Qing | 2015 | Chinese Journal Of Geochemistry2015，34，3： | 5 |
| 13 | Transformation of organic matters in fresh leachate during anaerobic degradation under long hydraulic retention time显示文摘This study investigated the biodegradability of fresh leachate from a young municipal solid waste landfill at the inoculum to substrate ratios(V/V) of 10/100,25/100,50/100 and 100/100,as well as the transformation of organic matters in leachate under prolonged hydraulic retention time(HRT) of 50 d.Fresh leachate showed a good biodegradability,with chemical oxygen demand(COD) removal effciency as high as 87%-92%and cumulative methane yield close to theoretical value(0.35 L CH4/g CODdeg) .Methane production and COD depletion presented biphasic characteristics associated with the successive utilization of two major intermediates,acetate and propionate.The biphasic degradation of fresh leachate was resulted from the different hydrolysis rates of diverse substrates and the changes in microorganism community structure.After 50 d,the effuents were dominated by high-MW organic compounds(MW>10 kDa) at each inoculum ratio,which might be refractory compounds released from cell lyses. | XU Suyun,HE Pinjing,LU Fan,LI Min,SHAO Liming State Key Laboratory of Pollution Control and Resources Reuse,Key Laboratory of Yangtze River Water Environment,College of Environmental Science and Engineering,Tongji University,Shanghai 200092,China | 2009 | Journal of Environmental Sciences2009，21，9： | 5 |
| 14 | Biofilm from a clinical strain of Cryptococcus neoformans activates the NLRP3 inflammasome显示文摘 | Guowei Lei Mingkuan Chen Hua Li Jun-Ling Niu Shuxian Wu Liming Mao Ailing Lu Hongbin Wang Wei Chen Bin Xu Qibin-Leng Cunshuan Xu Guiwen Yang Liguo An Li-Ping Zhu Guangxun Meng | 2013 | Cell Research2013，23，7： | 5 |
| 15 | Chromatographic Resolution of a-Amino Acids by (R)-(3,3'-Halogen Substituted-l,l'-binaphthyl)-20-crown-6 Stationary Phase in HPLC显示文摘三新 chiral 为高效的液体层析的静止阶段(CSP ) 从 R-(3,3 卤素 substituted-1,1-binaphthyl ) 被准备 -20-crown-6 (卤素 = Cl, Br 并且我) 。试验性的结果证明 R-(3,3-dibromo-1,1-binaphthyl )-20-crown-6 (CSP-1 ) 比二另外的代替卤素的王冠醚衍生物拥有更突出的 enantioselectivity。所有 21 氨基酸在房间温度在 R-(3,3-dibromo-1,1-binaphthyl )-20-crown-6-based CSP-1 上有分离的不同的度。CSP-1 的 enantioselectivity 也比一些商业 R-(1,1-binaphthyl )-20-crown-6 衍生物的那些好。两分离因素()并且决定( R s )比商业王冠的那些好基于醚的 CSP [从 Daicel 的 CROWNPAK CR (+)]在为天门冬素, threonine ,脯氨酸,精氨酸,丝氨酸, histidine 和缬氨酸的一样的条件下面,它不能被商业 CR (+)分开。这研究证明 R-(3,3-dibromo-1,1-binaphthyl )-20-crown-6 chiral 的商业实用性是静止阶段。 | Peng Wu Yuping Wu JunhuiZhang Zhenyu Lu Mei Zhang Xuexian Chen Liming Yuan | 2017 | Chinese Journal of Chemistry2017，35，7： | 4 |
| 16 | Fast algorithm based on triplet Markov fields for unsupervised multi-class segmentation of SAR images显示文摘Non-Gaussian triplet Markov fields (TMF) model is suitable for dealing with multi-class segmentation of non-stationary and non-Gaussian synthetic aperture radar (SAR) images.Considering the complexity of the model and algorithm,as well as the requirement of real-time,and robust and efficient processing of SAR images,a fast algorithm based on TMF for unsupervised multi-class segmentation of SAR images is proposed in this paper.For the speckle noise in SAR images,numerical characteristic,threshold selection and QuadTree decomposition criterion are researched firstly.With the new method,a SAR image can quickly be mapped into an edge-based pixon-representation,which results in a coarse decomposition in smooth regions,and a fine decomposition in edges.Then by combining TMF model with the pixon-representation of SAR image,a new potential energy function of TMF based on pixon-representation is derived.Finally,the segmentation is finished by Bayesian maximum posterior mode (MPM).The effectiveness of the fast TMF algorithm is demonstrated by applying it to simulated data and real SAR images. | WU Yan WANG Xin XIAO Ping GAN Lu LIU ChunYan LIMing | 2011 | Science China(Information Sciences)2011，54，7： | 4 |
| 17 | Mussel‑Inspired Redox‑Active and Hydrophilic Conductive Polymer Nanoparticles for Adhesive Hydrogel Bioelectronics显示文摘Conductive polymers(CPs)are generally insoluble,and developing hydrophilic CPs is significant to broaden the applications of CPs.In this work,a mussel-inspired strategy was proposed to construct hydrophilic CP nanoparticles(CP NPs),while endowing the CP NPs with redox activity and biocompatibility.This is a universal strategy applicable for a series of CPs,including polyaniline,polypyrrole,and poly(3,4-ethylenedioxythiophene).The catechol/quinone contained sulfonated lignin(LS)was doped into various CPs to form CP/LS NPs with hydrophilicity,conductivity,and redox activity.These CP/LS NPs were used as versatile nanofillers to prepare the conductive hydrogels with long-term adhesiveness.The CP/LS NPs-incorporated hydrogels have a good conductivity because of the uniform distribution of the hydrophilic NPs in the hydrogel network,forming a well-connected electric path.The hydrogel exhibits long-term adhesiveness,which is attributed to the mussel-inspired dynamic redox balance of catechol/quinone groups on the CP/LS NPs.This conductive and adhesive hydrogel shows good electroactivity and biocompatibility and therefore has broad applications in electrostimulation of tissue regeneration and implantable bioelectronics. | Donglin Gan Tao Shuai Xiao Wang Ziqiang Huang Fuzeng Ren Liming Fang Kefeng Wang Chaoming Xie Xiong Lu | 2020 | Nano-Micro Letters2020，12，12： | 4 |
| 18 | LA-ICP-MS U–Pb geochronology of detrital zircons from the Zhaochigou Formation-complex in the Helan Mountain and its tectonic significance显示文摘This paper carries out studies about LA-ICPMS U–Pb dating and Hf isotopic compositional analysis for detrital zircons in two metasedimentary samples that were taken from the Zhaochigou Formation-complex in the Helan Mountain.The results show that the Zhaochigou Formation-complex formed*1.96 Ga,and it is a part of the Khondalite Series that is widespread in the North China Craton(NCC).The age spectrum of the detrital zircons indicates that the Zhaochigou Formation-complex shared the same provenance with the eastern edge of the Khondalite Series.Products of ancient magmatic activities within the Khondalite Belt may be the major source for the sedimentary materials that formed the Khondalite Series.Our age-dating results suggest that the Khondalite Series in the NCC may have experienced two stages of metamorphism,as the early stage occurred during 1.96–1.95 Ga,and the later stage occurred at about 1.87 Ga.The Hfisotopic data indicate that the Western Block of the NCC endured a stage of crustal growth at 2.5–2.3 Ga. | Liming Li Zuoxun Zeng Yanjun Lu Yunxu Wei Shimin Xiang Lili Pan | 2014 | Chinese Science Bulletin2014，59，13： | 3 |
| 19 | Conceptual design of the HIRFL-CSR external-target experiment显示文摘One of the main purposes of heavy-ion collisions over a wide range of beam energy is to study the bulk properties of strong interaction matter and understand the Quantum Chromo Dynamics(QCD)phase diagram,which carries wealth of information of the phase transition and the possibly existing critical point of the strongly interacting system[1].Such system exists as hadron gases at lower temperature and low baryon density.By increasing the temperature or density,the boundary of the hadrons disappears and the confined quarks | LiMing Lu Hart Yi ZhiGang Xiao Ming Shao Song Zhang GuoQing Xiao Nu Xu | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，1： | 3 |
| 20 | Size-tunable synthesis of gold nanorods using pyrogallol as a reducing agent显示文摘A novel and facile seed-mediated method for the preparation of monodispersed gold nanorods(GNRs) is presented by introducing pyrogallol as a reductant. Fast Fourier transformation of high-resolution transmission electron microscopy reveals that the synthesized GNRs are single crystalline. The longitudinal surface plasmon resonance of GNRs can be finely tuned by varying silver ion concentrations or seed amounts. Also, both thick(diameter >30 nm) and thin(diameter <10 nm) GNRs with exceptional monodispersity can be well prepared by this method. These findings indicate that this method has a greater performance in controlling the morphology of GNRs than that of traditional approach with ascorbic acid as a reductant. | Yuanfu Huang Kai Xia Nongyue He Zhuoxuan Lu Liming Zhang Yan Deng Libo Nie | 2015 | Science China Chemistry2015，58，11： | 3 |
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