| 1 | 青光眼患者房水中MMPs/TIMPs表达与氧化应激、血管新生的相关性显示文摘目的:探讨青光眼患者房水中MMPs/TIMPs表达与氧化应激、血管新生的相关性。方法:选取在本院确诊并接受治疗的原发性青光眼患者110例作为青光眼组,同期在本院进行治疗的原发性白内障患者68例作为白内障组。对比两组房水中MMP-2、TIMP-2含量及MMP-2/TIMP-2比值,氧化应激相关指标、血管新生相关指标的差异,进一步经相关性分析评估青光眼患者MMP-2、TIMP-2含量及MMP-2/TIMP-2比值与氧化应激、血管新生的相关关系。结果:青光眼组房水中MMP-2、TIMP-2的含量及MMP-2/TIMP-2的比值均高于白内障组;房水中抗氧化指标T-AOC、CAT的含量低于白内障组,氧化指标ROS、AOPPs的含量高于白内障组;房水中血管新生相关指标PEDF的含量低于白内障组,VEGF、bFGF的含量高于白内障组(P <0.05)。Pearson检验发现,青光眼患者房水中MMP-2、TIMP-2含量及MMP-2/TIMP-2比值与机体氧化应激、血管新生程度均直接相关。结论:青光眼患者房水中MMP-2、TIMP-2含量及MMP-2/TIMP-2比值均异常增高,与眼部氧化应激及血管新生程度均呈正相关。 | 马雄雄 冯婷 王理论 | 2018 | 海南医学院学报2018，24，20： | 4 |
| 2 | The effect of increased intra-abdominal pressure on orbital subarachnoid space width and intraocular pressure显示文摘In accordance with the trans-lamina cribrosa pressure difference theory, decreasing the trans-lamina cribrosa pressure difference can relieve glaucomatous optic neuropathy. Increased intracranial pressure can also reduce optic nerve damage in glaucoma patients, and a safe, effective and noninvasive way to achieve this is by increasing the intra-abdominal pressure. The purpose of this study was to observe the changes in orbital subarachnoid space width and intraocular pressure at elevated intra-abdominal pressure. An inflatable abdominal belt was tied to each of 15 healthy volunteers, aged 22–30 years(12 females and 3 males), at the navel level, without applying pressure to the abdomen, before they laid in the magnetic resonance imaging machine. The baseline orbital subarachnoid space width around the optic nerve was measured by magnetic resonance imaging at 1, 3, 9, and 15 mm behind the globe. The abdominal belt was inflated to increase the pressure to 40 mm Hg(1 mm Hg = 0.133 k Pa), then the orbital subarachnoid space width was measured every 10 minutes for 2 hours. After removal of the pressure, the measurement was repeated 10 and 20 minutes later. In a separate trial, the intraocular pressure was measured for all the subjects at the same time points, before, during and after elevated intra-abdominal pressure. Results showed that the baseline mean orbital subarachnoid space width was 0.88 ± 0.1 mm(range: 0.77–1.05 mm), 0.77 ± 0.11 mm(range: 0.60–0.94 mm), 0.70 ± 0.08 mm(range: 0.62–0.80 mm), and 0.68 ± 0.08 mm(range: 0.57–0.77 mm) at 1, 3, 9, and 15 mm behind the globe, respectively. During the elevated intra-abdominal pressure, the orbital subarachnoid space width increased from the baseline and dilation of the optic nerve sheath was significant at 1, 3 and 9 mm behind the globe. After decompression of the abdominal pressure, the orbital subarachnoid space width normalized and returned to the baseline value. There was no significant difference in the intraocular pressure before, during and after the intra-abdominal pressure elevation. These results verified that the increased intra-abdominal pressure widens the orbital subarachnoid space in this acute trial, but does not alter the intraocular pressure, indicating that intraocular pressure is not affected by rapid increased intra-abdominal pressure. | Su-meng Liu Ning-li Wang Zhen-tao Zuo Wei-wei Chen Di-ya Yang Zhen Li Yi-wen Cao | 2018 | Neural Regeneration Research2018，13，2： | 2 |
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