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| 1 | TME术前短程放疗后化疗对比术前放化疗联合术后辅助化疗治疗局部晚期直肠癌(RAPIDO研究)—一项随机、开放的Ⅲ期临床试验显示文摘背景:全身复发仍然是局部晚期直肠癌患者需要面临的难题。该研究是采用短程放疗后行化疗和延迟手术对比术前诱导治疗后直接手术疗效的临床试验(the Rectal cancer And Preoperative Induction therapy followed by Dedicated Operation,RAPIDO),旨在不影响局部控制效果的前提下减少远处转移。方法:在这项多中心、随机、开放的Ⅲ期试验中,参与者来自于荷兰、瑞典、西班牙、斯洛文尼亚、丹麦、挪威和美国的共54个医学中心。纳入患者年龄在18岁及以上,ECOG评分为0~1分,且为经活检确诊局部晚期原发直肠腺癌的初诊患者,盆腔MRI评估为高危(至少符合一项标准:cT4a或cT4b,壁外血管侵犯,cN2,直肠系膜筋膜受累,或侧方淋巴结增大)。患者具备化疗适应证,并可在随机分组前5周内完成分期评估。 | 李来元 张维胜 BAHADOER R R DIJKSTRA E A VAN ETTEN B | 2021 | 结直肠肛门外科2021，27，1： | 72 |
| 2 | 癌症治疗的靶点——酪氨酸激酶显示文摘蛋白酪氨酸激酶家族(TKs)催化磷酸从ATP转移至多肽链酪氨酸残基上.人类基因组包括了90个TK和43个类似TK的基因,这些基因的产物调节细胞的增生、存活、分化、功能和运动.早在25年前,在逆转录病毒诱导产生的动物肿瘤中,就认为TKs可能是癌基因.然而,因为仅有极少的证据说明其在人类癌症中发挥始动作用,并且考虑到药物的特异性和毒性,所以在开发癌症治疗药物时被忽视了.但随着TK融合蛋白BCR-ABL抑制剂甲磺酸伊马替尼(imatinib mesylate,商品名为格列卫)在慢性粒细胞白血病(CML)中的成功应用,TKs的前景发生了根本的改变.现在认为TKs是癌症化疗很好的靶点.本文综述了TKs靶向治疗癌症的情况,并探讨了其面临的挑战和将来的发展前景. | Krause DS Van Etten RA 黄艳 | 2005 | 中国处方药2005，，10： | 45 |
| 3 | Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice显示文摘 | Roger Bouillon Geert Carmeliet Lieve Verlinden Evelyne van Etten Annemieke Verstuyf Hilary F. Luderer Liesbet Lieben Chantal Mathieu Marie Demay | 2008 | Endocrine Reviews2008，，6： | 2 |
| 4 | Monocytes from type 2 diabetic patients have a pro-inflammatory profile显示文摘 | Annapaula Giulietti Evelyne van Etten Lut Overbergh Katinka Stoffels Roger Bouillon Chantal Mathieu | 2006 | Diabetes Research and Clinical Practice2006，，1： | 2 |
| 5 | Treatment ofautoimmune diabetes recurrence in non-obese diabetic mice bymouse interferon-beta in combination with an analogue of lalpha,25-dihydroxyvitamin-D-3显示文摘 | Gysemans C Van Etten E Overbergh L | 2002 | Clin Exp Iinnunol2002，128，2： | 1 |
| 6 | Sphingosine 1-phosphate signalling through the G protein-coupled receptor Edg-1 显示文摘 | Zondag C Postma R Etten V | 1998 | Bio- chem J1998，330，2： | 1 |
| 7 | Blast crisis in a murine model of chronic myelogenous leukemia 显示文摘 | Daley GQ Van Etten RA Baltimore D | 1991 | Proc Natl Acad Sci USA1991，88，11： | 1 |
| 8 | Habitat use of red foxes in Yellowstone National Park based on snow tracking and telemetry显示文摘 | VAN ETTEN K W WILSON K R CRABTREE R L | 2007 | Journal of Mammalogy2007，88，6： | 1 |
| 9 | 1 al- pha, 25-dihydroxyvitamin D3 or analogue treated den- dritic cells modulate autoreactive T cells via the selective induction of apoptosis 显示文摘 | van Haheren AG Tysma OM van Etten E | 2004 | J Autoimmun2004，23，3： | 1 |
| 10 | In vitro and in vivo analysis of the immune system of vitamin D receptor knockout mice 显示文摘 | Mathieu C Van Etten E Gysemans C | 2001 | J Bone Miner Res2001，16，11： | 1 |
| 11 | Induction of chronic myelogenous leukemia in mice by he P210bcr/abl gene of the Philadelphia chromosome 显示文摘 | Daley G Q Van Etten R A Baltimore D | 1990 | Science1990，247，4944： | 1 |
| 12 | Treatment of autoimmune dia- betes recurrence in non-obese diab- etic mice by mouse interferon-beta in combination with an analogue of 1 alpha, 25- dihydro- xyvitamin-D-3显示文摘 | Gysemans C Van Etten E Overbergh L | 2002 | Clinl Exp Immunol2002，128，2： | 1 |
| 13 | Unaltered diabetes presentation in NOD mice lacking the vitamin D receptor显示文摘 | Gysemans C van Etten E Overbergh L | 2008 | Diabetes2008，57，1： | 1 |
| 14 | Reversibility of acute B-cell leukaemia induced by BCR-ABL 1 显示文摘 | Huettner CS Zhang P Van Etten RA | 2000 | Nature Genet2000，24，1： | 1 |
| 15 | Sequence and gene organization of mouse mitochondrial DNA 显示文摘 | Bibb MJ Van Etten RA Wright | 1981 | Cell1981，26，2： | 1 |
| 16 | Heterologous expression of human prostatic acid phosphatase and site-directed mutagenesis of the enzyme active site 显示文摘 | OSTANIN K SAEED A VAN ETTEN R L | 1994 | Journal of Biological Chemistry1994，269，12： | 1 |
| 17 | P210 and P190BCR/ABL induce the tyrosine phosphorylation and DNA binding activity of multiple specific STAT family members显示文摘 | Ilaria RL Van Etten RA | 1996 | J Biol Chem1996，271，31： | 1 |
| 18 | Vitamin D signaling in immune - mediated disorders: Evolving insights and therapeutic opportunities 显示文摘 | Baeke F Etten EV Gysemans C | 2008 | Mol Aspects Med2008，29，： | 1 |
| 19 | Sequence and gene organization of mouse mitochondrial DNA显示文摘 | Bibb MJ Van Etten RA Wright CT et a1 | 1981 | Cell1981，26，22： | 1 |
| 20 | Impaired NO-dependent vasodilation in patients with Type II(non-insulin-dependent)diabetes mellitus is restored by acute administration of folate显示文摘 | van Etten RW de Koning EJ Verhaar MC | 2002 | Diabetologia2002，45，7： | 1 |
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