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| 1 | Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages显示文摘How the innate and adaptive host immune system miscommunicate to worsen COVID-19 immunopathology has not been fully elucidated.Here,we perform single-cell deep-immune profiling of bronchoalveolar lavage(BAL)samples from 5 patients with mild and 26 with critical COVID-19 in comparison to BALs from non-COVID-19 pneumonia and normal lung.We use pseudotime inference to build T-cell and monocyte-to-macrophage trajectories and model gene expression changes along them.In mild COVID-19,CD8^(+)resident-memory(TRM)and CD4^(+)T-helper-17(T_(H17))cells undergo active(presumably antigen-driven)expansion towards the end of the trajectory,and are characterized by good effector functions,while in critical COVID-19 they remain more naïve.Vice versa,CD4^(+)T-cells with T-helper-1 characteristics(TH1-like)and CD8^(+)T-cells expressing exhaustion markers(T_(EX)-like)are enriched halfway their trajectories in mild COVID-19,where they also exhibit good effector functions,while in critical COVID-19 they show evidence of inflammation-associated stress at the end of their trajectories.Monocyte-to-macrophage trajectories show that chronic hyperinflammatory monocytes are enriched in critical COVID-19,while alveolar macrophages,otherwise characterized by anti-inflammatory and antigen-presenting characteristics,are depleted.In critical COVID-19,monocytes contribute to an ATP-purinergic signaling-inflammasome footprint that could enable COVID-19 associated fibrosis and worsen disease-severity.Finally,viral RNA-tracking reveals infected lung epithelial cells,and a significant proportion of neutrophils and macrophages that are involved in viral clearance. | Els Wauters Pierre Van Mol Abhishek Dinkarnath Garg Sander Jansen Yannick Van Herck Lore Vanderbeke Ayse Bassez Bram Boeckx Bert Malengier-Devlies Anna Timmerman Thomas Van Brussel Tina Van Buyten Rogier Schepers Elisabeth Heylen Dieter Dauwe Christophe Dooms Jan Gunst Greet Hermans Philippe Meersseman Dries Testelmans Jonas Yserbyt Sabine Tejpar Walter De Wever Patrick Matthys CONTAGIOUS collaborators Johan Neyts Joost Wauters Junbin Qian Diether Lambrechts | 2021 | Cell Research2021，31，3： | 11 |
| 2 | Data-driven estimates of global nitrous oxide emissions from croplands显示文摘Croplands are the single largest anthropogenic source of nitrous oxide(N2O) globally, yet their estimates remain difficult to verify when using Tier 1 and 3 methods of the Intergovernmental Panel on Climate Change(IPCC). Here, we re-evaluate global cropland-N2O emissions in 1961–2014, using N-rate-dependent emission factors(EFs) upscaled from 1206 field observations in 180 global distributed sites and high-resolution N inputs disaggregated from sub-national surveys covering 15593 administrative units. Our results confirm IPCC Tier 1 default EFs for upland crops in 1990–2014, but give a ~15% lower EF in 1961–1989 and a ~67% larger EF for paddy rice over the full period. Associated emissions(0.82 ±0.34 Tg N yr–1) are probably one-quarter lower than IPCC Tier 1 global inventories but close to Tier 3 estimates. The use of survey-based gridded N-input data contributes 58% of this emission reduction, the rest being explained by the use of observation-based non-linear EFs. We conclude that upscaling N2O emissions from site-level observations to global croplands provides a new benchmark for constraining IPCC Tier 1 and 3 methods. The detailed spatial distribution of emission data is expected to inform advancement towards more realistic and effective mitigation pathways. | Qihui Wang Feng Zhou Ziyin Shang Philippe Ciais Wilfried Winiwarter Robert B.Jackson Francesco N.Tubiello Greet Janssens-Maenhout Hanqin Tian Xiaoqing Cui Josep G.Canadell Shilong Piao Shu Tao | 2020 | National Science Review2020，7，2： | 7 |
| 3 | Why have youth physical activity trends flatlined in the last decade? Opinion piece on “Global trends in insufficient physical activity among adolescents: a pooled analysis of 298 population-based surveys with 1.6 million participants” by Guthold et al.显示文摘1.No global progress on youth physical activity prevalenceTagedEnd TagedPDespite hundreds of intervention studies over decennia that have been dedicated to developing and testing programs and strategies to promote physical activity(PA)in adolescents,14 global inactivity levels remain persistently high.Based on self-report data from 1.6 million schoolgoing adolescents from 146 countries,Guthold et al.5 confirmed previous urgent calls to get adolescents more active.Researchers from the World Health Organization(WHO)recently published global prevalence rates and the first ever global time trends for insufficient PA in youth.They reported that more than 80%of school-going adolescents globally did not meet the current recommendations of at least 1 h of PA per day. | Greet Cardon Jo Salmon | 2020 | Journal of Sport and Health Science2020，9，4： | 6 |
| 4 | Maize biochars accelerate short-term soil nitrogen dynamics in a loamy sand soil显示文摘 | Victoria Nelissen Tobias Rütting Dries Huygens Jeroen Staelens Greet Ruysschaert Pascal Boeckx | 2012 | Soil Biology and Biochemistry2012，，： | 4 |
| 5 | Gibberellins Regulate Seed Germination in Tomato by endosperm weakening: aStudy with Gibberellin-Deficient Mutant 显示文摘 | Greet S P C Karssan C M | 1987 | Planta1987，171，： | 1 |
| 6 | Prevention of ve- nous throm - boembulism 显示文摘 | GREETS W H HE1T J A CLAGETT G P | 2001 | Chest2001，，： | 1 |
| 7 | The aerobic growth of Aeromonas hydrophila and Listeria monocytogenes in broths and on pork 显示文摘 | Gill C O Greet G G Dilts B D | 1997 | Intemational Journal of Food Microbiolgy1997，35，1： | 1 |
| 8 | Prevention of venous thromboembolism:a key patient safety priority显示文摘 | GREETS W | 2009 | J Thromb Haemost2009，7，： | 1 |
| 9 | Suppression of serum vascular endothelial growth factor immunoreactivity in normal pregnancy and in pre - eclampsia 显示文摘 | Lyall F Greet IA Boswell F | 1997 | Br J Obstet Gynecol1997，104，2： | 1 |
| 10 | Children' s use of subtraction by ad- dition on large single - digit subtractions 显示文摘 | Greet Peters Bert De Smedt Joke Torbeyns Pol Ghesquiere & Lieven Verschaffel | 2012 | Educ Stud Math2012，79，： | 1 |
| 11 | Preschooler's physical activity levels and associations with lesson context,teacher's behavior,and environment during preschool physical education显示文摘 | Van Cauwenberghe E Valery L Jessica G Ilse D B Greet C | 2012 | Early Childhood Research Quarterly2012，27，2： | 1 |
| 12 | Intensive insulin therapy in critically ill patients 显示文摘 | Greet VB Woulers D Weekers F | 2001 | N EngI J Med2001，345，19： | 1 |
| 13 | Food -related personality traits, food choice motives and food intake: Mediator and moderator relationships显示文摘 | Audrey Eertmans An Vietoir Greet Vansant Omer Van den Bergh | 2005 | Food Quality and Preference2005，16，： | 1 |
| 14 | Prevention of rickets and vitamin D deficiency in infants, children, and adolescents 显示文摘 | Wagner CL Greet FR | 2008 | Pediat tics2008，122，5： | 1 |
| 15 | Is z-disk degradation responsible for postmortem tenderization?显示文摘 | RICHARD G T GREET H G VALERY F T | 1995 | J Anim Sci1995，73，： | 1 |
| 16 | How does blood glucose control with insulin save lives in intensive care?显示文摘 | Greet Van den Berghe | 2004 | J Clin Invest2004，11，4： | 1 |
| 17 | American academy of pediatrics committee on use of soy protein-based formulas in infant feeding 显示文摘 | Bhatia J Greet F | 2008 | Pediatrics2008，121，： | 1 |
| 18 | Tissue distribution quantitation and proliferation kinetics of fat-storing cells in carbon tetrachloride-induce rat liver显示文摘 | Greets A Lazou J M De bleser P Wisse E | 1997 | Hepatology1997，13，： | 1 |
| 19 | Gibberellins regulate seed germination in tomato by endosperm weake-ning: a study with gibberellin-deficient mutant 显示文摘 | GREET S P C KARSSAN C M | 1987 | Planta1987，171，： | 1 |
| 20 | Microbial diversi- ty and activity through a permafrost/ground ice core profile from the Canadian high Arctic显示文摘 | Steven B Pollard W H Greet C W | 2008 | Environmental Microbiol ogy2008，10，12： | 1 |
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