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| 1 | Synthesis and properties of phosphorus-containing bio-based epoxy resin from itaconic acid显示文摘A phosphorus-containing bio-based epoxy resin(EADI)was synthesized from itaconic acid(IA)and 9,10-dihydro-9-oxa-10-phosphaphenanthrene 10-oxide(DOPO).As a matrix,its cured epoxy network with methyl hexahydrophthalic anhydride(MHHPA)as the curing agent showed comparable glass-transition temperature and mechanical properties to diglycidyl ether in a bisphenol A(DGEBA)system as well as good flame retardancy with UL94 V-0 grade during a vertical burning test.As a reactive flame retardant,its flame-resistant effect on DGEBA/MHHPA system as well as its influence on the curing behavior and the thermal and mechanical properties of the modified epoxy resin were investigated.Results showed that after the introduction of EADI,not only were the flame retardancy determined by vertical burning test,LOI measurement,and thermogravimetric analysis significantly improved,but also the curing reactivity,glass transition temperature(T g),initial degradation temperature for 5%weight loss(T d(5%)),and flexural modulus of the cured system improved as well.EADI has great potential to be used as a green flame retardant in epoxy resin systems. | MA SongQi LIU XiaoQing JIANG YanHua FAN LiBo FENG JianXiang ZHU Jin | 2014 | Science China Chemistry2014，57，3： | 33 |
| 2 | Chemical compound cinobufotalin potently induces FOXO1-stimulated cisplatin sensitivity by antagonizing its binding partner MYH9显示文摘In this study,we present novel molecular mechanisms by which FOXO1 functions as a tumor suppressor to prevent the pathogenesis of nasopharyngeal carcinoma(NPC).First,we observed that FOXO1 not only controlled tumor stemness and metastasis,but also sensitized NPC cells to cisplatin(DDP)in vitro and in vivo.Mechanistic studies demonstrated that FOXO1-induced miR-200b expression through the GSK3β/β-catenin/TCF4 network-mediated stimulation of ZEB1,which reduced tumor stemness and the epithelial–mesenchymal transition(EMT)signal.Furthermore,we observed FOXO1 interaction with MYH9 and suppression of MYH9 expression by modulating the PI3K/AKT/c-Myc/P53/miR-133a-3p pathway.Decreased MYH9 expression not only reduced its interactions with GSK3β,but also attenuated TRAF6 expression,which then decreased the ubiquitin-mediated degradation of GSK3βprotein.Increased GSK3βexpression stimulated theβ-catenin/TCF4/ZEB1/miR-200b network,which increased the downstream tumor stemness and EMT signals.Subsequently,we observed that chemically synthesized cinobufotalin(CB)strongly increased FOXO1-induced DDP chemosensitivity by reducing MYH9 expression,and the reduction in MYH9 modulated GSK3β/β-catenin and its downstream tumor stemness and EMT signal in NPC.In clinical samples,the combination of low FOXO1 expression and high MYH9 expression indicated the worst overall survival rates.Our studies demonstrated that CB potently induced FOXO1-mediated DDP sensitivity by antagonizing its binding partner MYH9 to modulate tumor stemness in NPC. | YongHao Li Xiong Liu Xian Lin Menyang Zhao Yanyi Xiao Chen Liu Zixi Liang Zelong Lin Renhui Yi Zibo Tang Jiahao Liu Xin Li Qingping Jiang Libo Li Yinyin Xie Zhen Liu Weiyi Fang | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 6 |
| 3 | Effects of purified zearalenone on selected immunological and histopathologic measurements of spleen in post-weanling gilts显示文摘The present study was aimed at investigating the adverse effects of dietary zearalenone(ZEA) on the lymphocyte proliferation rate(LPR), interleukin-2(IL-2), mRNA expressions of pro-inflammatory cytokines, and histopathologic changes of spleen in post-weanling gilts. A total of 20 crossbred piglets(Yorkshire × Landrace × Duroc) with an initial BW of 10.36 ± 1.21 kg(21 d of age) were used in the study.Piglets were fed a basal diet with an addition of 0.1.1,2.0, or 3.2 mg/kg purified ZEA for 18 d ad libitum.The results showed that LPR and IL-2 production of spleen decreased linearly(P < 0.05) as dietary ZEA increased. Splenic mRNA expressions of interleukin-1β(IL-1β) and interleukin-6(IL-6) were linearly upregulated(P < 0.05) as dietary ZEA increased. On the contrary, linear down-regulation(P<0.05) of mRNA expression of interferon-γ(IFN-γ) was observed as dietary ZEA increased. Swelling splenocyte in1.1 mg/kg ZEA treatments, atrophy of white pulp and swelling of red pulp in 2.0 and 3.2 mg/kg ZEA treatments were observed. The cytoplasmic edema in 1.1 mg/kg ZEA treatments, significant chromatin deformation in 2.0 mg/kg ZEA treatment and phagocytosis in 3.2 mg/kg ZEA treatment were observed.Results suggested that dietary ZEA at 1.1 to 3.2 mg/kg can induce splenic damages and negatively affect immune function of spleen in post-weanling gilts. | Peng Chen Tingjun Liu Shuzhen Jiang Zaibin Yang Libo Huang Faxiao Liu | 2017 | Animal Nutrition2017，，3： | 5 |
| 4 | Rare-earth element geochemistry reveals the provenance of sediments on the southwestern margin of the Challenger Deep显示文摘The hadal zone represents one of the last great frontiers in modern marine science,and deciphering the provenance of sediment that is supplied to these trench settings remains a largely unanswered question.Here,we examine the mineralogical and geochemical composition of a sediment core(core CD-1)that was recovered from the southwestern margin of the Challenger Deep within the Mariana Trench.Major element abundances and rare-earth element patterns from these sediments require inputs from both terrigenous dust and locally sourced volcanic debris.We exploit a two-endmember mixing model to demonstrate that locally sourced volcanic material dominates the sediment supply to the Challenger Deep(averaging^72%).The remainder,however,is supplied by aeolian dust(averaging^28%),which is consistent with adjacent studies that utilized Sr-Nd isotopic data.Building on a growing database,we strengthen our understanding of Asian aeolian dust input into the northwestern Pacific,which ultimately improves our appreciation of sedimentation in,and around,the hadal zone. | JIANG Zuzhou SUN Zhilei LIU Zhaoqing CAO Hong GENG Wei XU Haixia WANG Lisheng WANG Libo | 2019 | Journal of Oceanology and Limnology2019，37，3： | 5 |
| 5 | Effects of purified zearalenone on selected immunological measurements of blood in post-weaning gilts显示文摘Zearalenone(ZEA), an estrogenic mycotoxin, is produced mainly by Fusarium fungi. Previous studies have indicated that acute ZEA exposure induced various damages in different species; however, its transparent hematotoxicity in female piglets at dietary levels of 1.1 to 3.2 mg/kg has not been shown. The present study was conducted to investigate the effects of dietary ZEA(1.1—3.2 mg/kg) on hematology, T lymphocyte subset, immunoglobulin, antibody titer, lymphocyte proliferation rate(LPR), and interleukin-2(IL-2) in peripheral blood of post-weaning gilts. A total of 20 female piglets(Landrace × Yorkshire × Duroc),weaned at 42 d with an average body weight of 10.36 ± 1.21 kg were used in the study. Female piglets were kept in a temperature controlled room, divided into four treatments, and fed a diet based on corn-soybean meal-fishmeal-whey, with an addition of 0, 1.1, 2.0, or3.2 mg/kg purified ZEA for 18 d ad libitum. Feed intake and refusal were measured daily and individual pigs were weighed weekly. Blood and serum samples were collected for selected immunological measurements. Female piglets fed different levels of dietary ZEA grew similarly with no difference in feed intake. Hematological values including leukocytes, platelets, lymphocytes, hematocrit, and mean corpuscular hemoglobin(MCH) decreased linearly(P < 0.05) as dietary ZEA increased. Female piglets fed diets containing 2.0 mg/kg ZEA or greater showed significantly decreased CD4+CD8+, CD4+, and CD4+/CD8^+ in comparison to the control(P < 0.05), whereas CD8^+ was significantly increased(P = 0.026) in the gilts which were fed the diet containing 3.2 mg/kg ZEA. Serum immunoglobulin G(IgG) and the antibody titer on d 18 were reduced linearly as dietary ZEA levels increased(P < 0.001). Linear decrease in LPR was observed(P < 0.05). Female piglets fed diets containing 2.0 mg/kg ZEA or more showed significantly decreased IL-2 in comparison to the control(P < 0.05). The results suggested that dietary ZEA at the levels of 1.1 to 3.2 mg/kg can induce different degrees of hematotoxicity and negatively affect immune function in female piglets. | Lijie Yang Weiren Yang Qiang Feng Libo Huang Guiguo Zhang Faxiao Liu Shuzhen Jiang Zaibin Yang | 2016 | Animal Nutrition2016，，3： | 5 |
| 6 | Properties of three seismic events in September 2017 in the northern Korean Peninsula from moment tensor inversion显示文摘In September 2017 three noticeable seismic events occurred in the northern Korean Peninsula(Fig.1;Table 1).Democratic People’s Republic of Korea(DPRK)authorities announced that the first M6.3 event on September 3rd was a‘‘successfully conducted hydrogen-bomb test'.The M4.6 event,some 8 min followed,was regarded as an implosion.However,it is still not clear | Libo Han Zhongliang Wu Changsheng Jiang Jie Liu | 2017 | Science Bulletin2017，62，23： | 5 |
| 7 | Novel resonant pressure sensor based on piezoresistive detection and symmetrical in-plane mode vibration显示文摘In this paper,a novel resonant pressure sensor is developed based on electrostatic excitation and piezoresistive detection.The measured pressure applied to the diaphragm will cause the resonant frequency shift of the resonator.The working mode stress–frequency theory of a double-ended tuning fork with an enhanced coupling beam is proposed,which is compatible with the simulation and experiment.A unique piezoresistive detection method based on small axially deformed beams with a resonant status is proposed,and other adjacent mode outputs are easily shielded.According to the structure design,high-vacuum wafer-level packaging with different doping in the anodic bonding interface is fabricated to ensure the high quality of the resonator.The pressure sensor chip is fabricated by dry/wet etching,high-temperature silicon bonding,ion implantation,and wafer-level anodic bonding.The results show that the fabricated sensor has a measuring sensitivity of~19 Hz/kPa and a nonlinearity of 0.02%full scale in the pressure range of 0–200 kPa at a full temperature range of−40 to 80°C.The sensor also shows a good quality factor>25,000,which demonstrates the good vacuum performance.Thus,the feasibility of the design is a commendable solution for high-accuracy pressure measurements. | Xiangguang Han Qi Mao Libo Zhao Xuejiao Li Li Wang Ping Yang Dejiang Lu Yonglu Wang Xin Yan Songli Wang Nan Zhu Zhuangde Jiang | 2020 | Microsystems & Nanoengineering2020，6，1： | 4 |
| 8 | 3D bioprinting of a biomimetic meniscal scaffold for application in tissue engineering显示文摘Appropriate biomimetic scaffolds created via 3D bioprinting are promising methods for treating damaged menisci.However,given the unique anatomical structure and complex stress environment of the meniscus,many studies have adopted various techniques to take full advantage of different materials,such as the printing combined with infusion,or electrospining,to chase the biomimetic meniscus,which makes the process complicated to some extent.Some researchers have tried to tackle the challenges only by 3D biopringting,while its alternative materials and models have been constrained.In this study,based on a multilayer biomimetic strategy,we optimized the preparation of meniscus-derived bioink,gelatin methacrylate(GelMA)/meniscal extracellular matrix(MECM),to take printability and cytocompatibility into account together.Subsequently,a customized 3D bioprinting system featuring a dual nozzle+multitemperature printing was used to integrate the advantages of polycaprolactone(PCL)and meniscal fibrocartilage chondrocytes(MFCs)-laden GelMA/MECM bioink to complete the biomimetic meniscal scaffold,which had the best biomimetic features in terms of morphology and components.Furthermore,cell viability,mechanics,biodegradation and tissue formation in vivo were performed to ensure that the scaffold had sufficient feasibility and functionality,thereby providing a reliable basis for its application in tissue engineering. | Zhou Jian Tian Zhuang Tian Qinyu Peng Liqing Li Kun Luo Xujiang Wang Diaodiao Yang Zhen Jiang Shuangpeng Sui Xiang Huang Jingxiang Liu Shuyun Hao Libo Tang Peifu Yao Qi Guo Quanyi | 2021 | Bioactive Materials2021，6，6： | 3 |
| 9 | Capacitive micromachined ultrasonic transducer as a resonant temperature sensor显示文摘Resonant temperature sensors have drawn considerable attention for their advantages such as high sensitivity,digitized signal output and high precision.This paper presents a new type of resonant temperature sensor,which uses capacitive micromachined ultrasonic transducer(CMUT)as the sensing element.A lumped electro-mechanical-thermal model was established to show its working principle for temperature measurement.The theoretical model explicitly explains the thermally induced changes in the resonant frequency of the CMUT.Then,the finite element method was used to further investigate the sensing performance.The numerical results agree well with the established analytical model qualitatively.The numerical results show that the resonant frequency varies linearly with the temperature over the range of 20℃to 140℃ at the first four vibrating modes.However,the first order vibrating mode shows a higher sensitivity than the other three higher modes.When working at the first order vibrating mode,the temperature coefficient of the resonance frequency(TCf)can reach as high as-1114.3 ppm/℃ at a bias voltage equal to 90%of the collapse voltage of the MCUT.The corresponding nonlinear error was as low as 1.18%.It is discovered that the sensing sensitivity is dependent on the applied bias voltages.A higher sensitivity can be achieved by increasing the bias voltages. | LI Zhikang Rahman hebibul ZHAO Libo YE Zhiying ZHAO Yulong JIANG Zhuangde | 2014 | Instrumentation2014，1，3： | 3 |
| 10 | Nickel Complexes Based on Salicylaldehyde-imine Ligands: Synthesis, Characterization and Catalytic Oligomerization of Ethylene显示文摘 | CHEN Liduo HUO Hongliang WANG Libo MA Lili JIANG Yan XIE Junyi WANG Jun | 2018 | Chemical Research in Chinese Universities2018，34，6： | 3 |
| 11 | Hybrid Dirac semimetal-based photodetector with efficient low-energy photon harvesting显示文摘Despite the considerable effort,fast and highly sensitive photodetection is not widely available at the low-photon-energy range(~meV)of the electromagnetic spectrum,owing to the challenging light funneling into small active areas with efficient conversion into an electrical signal.Here,we provide an alternative strategy by efficiently integrating and manipulating at the nanoscale the optoelectronic properties of topological Dirac semimetal PtSe_(2)and its van der Waals heterostructures.Explicitly,we realize strong plasmonic antenna coupling to semimetal states near the skin-depth regime(λ/10^(4)),featuring colossal photoresponse by in-plane symmetry breaking.The observed spontaneous and polarization-sensitive photocurrent are correlated to strong coupling with the nonequilibrium states in PtSe_(2)Dirac semimetal,yielding efficient light absorption in the photon range below 1.24 meV with responsivity exceeding∼0.2 A/W and noise-equivalent power(NEP)less than~38 pW/Hz^(0.5),as well as superb ambient stability.Present results pave the way to efficient engineering of a topological semimetal for high-speed and low-energy photon harvesting in areas such as biomedical imaging,remote sensing or security applications. | Lin Wang Li Han Wanlong Guo Libo Zhang Chenyu Yao Zhiqingzi Chen Yulu Chen Cheng Guo Kaixuan Zhang Chia-Nung Kuo Chin Shan Lue Antonio Politano Huaizhong Xing Mengjie Jiang Xianbin Yu Xiaoshuang Chen Wei Lu | 2022 | Light(Science & Applications)2022，11，3： | 2 |
| 12 | Dielectric Characterization and Microwave Roasting of Molybdenite Concentrates at 915 MHz Frequency显示文摘The magnetic hysteresis loop was measured to know the magnetic property of molybdenite concentrate.In order to evaluate its microwave absorption capacity, the dielectric properties of molybdenite concentrate was investigated using cavity perturbation method at 915 MHz dependent on densities and temperatures.The parameter data were fitted using regression fit and a model related to the same density and temperature ranges was developed.A nonlinear surface fitting was used to present visually the effect of dielectric parameters on the microwave penetrate depth of molybdnite concentrate.The crystal products of MoO 3 obtained from microwave roasting at different temperatures were examined by scanning electron microscopy (SEM) and X-ray diffraction (XRD).The results show both the dielectric constants and loss factors increase in the increase of apparent densities and temperatures with different growth rates in the experimental range.Due to the distinguished trend of dielectric performance dependent on temperatures, two parts in the heating scenario for the molybdenite concentrate samples were divided.The microwave penetration depth is inversely proportional to both apparent densities and temperatures.The nonlinear fitting surfaces indicate the increase of dielectric loss provides an enough decrease in microwave penetration depth.In contrast, the dielectric constant has a positive effect for it.Pure MoO 3 was produced at 800 ℃ by using microwave energy.This work can be helpful to design and simulate microwave system for efficient beneficiation of molybdenite concentrate and to prepare molybdenum products from this concentrate. | Yonglin Jiang Bingguo Liu Peng Liu Jinhui Peng Libo Zhang | 2019 | Journal of Harbin Institute of Technology(New Series)2019，26，3： | 2 |
| 13 | Isolation and expres- sion of grass carp toll-like receptor 5a (CiTLRSa) and 5h (CiTLR5b) gene involved in the response to flagellin stimula- tion and grass carp reovirus infection 显示文摘 | Jiang Yao He Libo Ju Changsong | 2015 | Fish Shellfish Im- munol2015，44，： | 1 |
| 14 | A novel high temperature pressure sensor on the basis of SOI layers显示文摘 | Zhao Yulong Zhao Libo Jiang Zhuangde | 2003 | Sensors and Actuators A2003，108，： | 1 |
| 15 | Piezoresistive pressure sensor with high sensitivity for medical application using peninsula-island structure显示文摘 | Tingzhong XU Hongyan WANG Yong XIA Zhiming ZHAO Mimi HUANG Jiuhong WANG Libo ZHAO Yulong ZHAO Zhuangde JIANG | 2017 | Frontiers of Mechanical Engineering2017，12，4： | 1 |
| 16 | High temperature and frequency pressure sensor based on silicon-on-insulator layers显示文摘 | Zhao Yulong Zhao Libo Jiang Zhuangde | 2006 | Measurement Science and Technology2006，17，： | 1 |
| 17 | A flexible and wearable NO_(2)gas detection and early warning device based on a spraying process and an interdigital electrode at room temperature显示文摘Flexible sensors used to detect NO_(2) gas generally have problems such as poor repeatability,high operating temperature,poor selectivity,and small detection range.In this work,a new spraying platform with a simple structure,low cost,and good film-forming consistency was designed and built to make a sensitive film(rGO/SnO_(2))for NO_(2) gas sensors.The relationship between the solid content of rGO and SnO_(2)nanoparticles,annealing temperature,and sensor performance was studied.The results show that the interdigital electrode-sensitive film formed by spraying 0.25 ml of a 0.4 wt%rGO/SnO_(2)mixture and annealing at 250℃exhibited the best comprehensive performance for NO_(2) detection.The sensor's response value for 100 ppm NO_(2) gas was 0.2640 at room temperature(25℃),and the response time and recovery time were 412.4 s and 587.3 s,respectively.In the range of 20-100 ppm,the relationship between the response and NO_(2) concentration was linear,and the correlation coefficient was 0.9851.In addition,a soft-monitoring node module with an overlimit warning function for NO_(2) gas was designed and manufactured based on flexible electronics.Finally,the flexible sensor and node module were embedded into woven fabric that could be used to make a mask or a watch that could detect NO_(2) gas,realizing the practical application of flexible NO_(2) gas sensors in the field of wearable electronics. | Fuzheng Zhang Qijing Lin Feng Flan Zuowei Wang Bian Tian Libo Zhao Tao Dong Zhuangde Jiang | 2022 | Microsystems & Nanoengineering2022，8，2： | 1 |
| 18 | Synthesis of high-quality graphene with a pre-determined number of layers显示文摘 | Zhong-Shuai Wu Wencai Ren Libo Gao Bilu Liu Chuanbin Jiang Hui-Ming Cheng | 2008 | Carbon2008，，2： | 1 |
| 19 | A novel high temperature pressure sensor on the basis of SOI layers显示文摘 | Zhao Yulong Zhao Libo Jiang Zhuangde | 2003 | Sensors and Actuators A: Physical2003，108，： | 1 |
| 20 | 3D-printed cell-free PCL-MECM scaffold with biomimetic micro-structure and micro-environment to enhance in situ meniscus regeneration显示文摘Despite intensive effort was made to regenerate injured meniscus by cell-free strategies through recruiting endogenous stem/progenitor cells,meniscus regeneration remains a great challenge in clinic.In this study,we found decellularized meniscal extracellular matrix(MECM)preserved native meniscal collagen and glycosaminoglycans which could be a good endogenous regeneration guider for stem cells.Moreover,MECM significantly promoted meniscal fibrochondrocytes viability and proliferation,increased the expression of type II collagen and proteoglycans in vitro.Meanwhile,we designed 3D-printed polycaprolactone(PCL)scaffolds which mimic the circumferential and radial collagen orientation in native meniscus.Taken these two advantages together,a micro-structure and micro-environment dually biomimetic cell-free scaffold was manipulated.This cell-free PCL-MECM scaffold displayed superior biocompatibility and yielded favorable biomechanical capacities closely to native meniscus.Strikingly,neo-menisci were regenerated within PCL-MECM scaffolds which were transplanted into knee joints underwent medial meniscectomy in rabbits and sheep models.Histological staining confirmed neo-menisci showed meniscus-like heterogeneous staining.Mankin scores showed PCL-MECM scaffold could protect articular cartilage well,and knee X-ray examination revealed same results.Knee magnetic resonance imaging(MRI)scanning also showed some neo-menisci in PCL-MECM scaffold group.In conclusion,PCL-MECM scaffold appears to optimize meniscus regeneration.This could represent a promising approach worthy of further investigation in preclinical applications. | Weimin Guo Mingxue Chen Zhenyong Wang Yue Tian Jinxuan Zheng Shuang Gao Yangyang Li Yufeng Zheng Xu Li Jingxiang Huang Wei Niu Shuangpeng Jiang Chunxiang Hao Zhiguo Yuan Yu Zhang Mingjie Wang Zehao Wang Jiang Peng Aiyuan Wang Yu Wang Xiang Sui Wenjing Xu Libo Hao Xifu Zheng Shuyun Liu Quanyi Guo | 2021 | Bioactive Materials2021，6，10： | 1 |
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